Overexpression of macrophage inhibitory cytokine-1 induces metastasis of human prostate cancer cells through the FAK-RhoA signaling pathway

Oncogene

Volumn 29, Issue 9, 2010, Pages 1293-1302

  Senapati, S ^a   Rachagani, S ^a   Chaudhary, K ^a   Johansson, S L ^a,b   Singh, R K ^a,b   Batra, S K ^a,b  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

Cancer; Metastasis; MIC 1; Prostate

Indexed keywords

ACTIN; FOCAL ADHESION KINASE; GROWTH DIFFERENTIATION FACTOR 15; RHO KINASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CANCER CELL; CELL INVASION; CELL MOTILITY; CONTROLLED STUDY; DOWN REGULATION; HUMAN; HUMAN CELL; IMPLANT; IN VITRO STUDY; METASTASIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; SIGNAL TRANSDUCTION;

ADULT; ANIMALS; CELL LINE, TUMOR; CELL MOVEMENT; FOCAL ADHESION PROTEIN-TYROSINE KINASES; GENE EXPRESSION REGULATION, NEOPLASTIC; GROWTH DIFFERENTIATION FACTOR 15; HUMANS; MALE; MICE; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; PHOSPHORYLATION; PROSTATIC NEOPLASMS; RHOA GTP-BINDING PROTEIN; SIGNAL TRANSDUCTION;

MUS;

EID: 77949267633     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2009.420     Document Type: Article

References (35)

1. Baek SJ, Kim KS, Nixon JB, Wilson LC, Eling TE. (2001). Cyclooxygenase inhibitors regulate the expression of a TGF-beta superfamily member that has proapoptotic and antitumorigenic activities. Mol Pharmacol 59: 901-908.
2. Banyard J, Zetter BR. (1998). The role of cell motility in prostate cancer. Cancer Metastasis Rev 17: 449-458.
3. Barrack ER. (1997). TGF beta in prostate cancer: a growth inhibitor that can enhance tumorigenicity. Prostate 31: 61-70.
4. Bauskin AR, Brown DA, Junankar S, Rasiah KK, Eggleton S, Hunter M, et al. (2005). The propeptide mediates formation of stromal stores of PROMIC-1: role in determining prostate cancer outcome. Cancer Res 65: 2330-2336.
5. Bootcov MR, Bauskin AR, Valenzuela SM, Moore AG, Bansal M, He XY, et al. (1997). MIC-1, a novel macrophage inhibitory cytokine, is a divergent member of the TGF-beta superfamily. Proc Natl Acad Sci USA 94: 11514-11519.
6. Bottner M, Suter-Crazzolara C, Schober A, Unsicker K. (1999). Expression of a novel member of the TGF-beta superfamily, growth/differentiation factor-15/macrophage-inhibiting cytokine-1 (GDF-15/MIC-1) in adult rat tissues. Cell Tissue Res 297: 103-110.
7. Chen SJ, Karan D, Johansson SL, Lin FF, Zeckser J, Singh AP, et al. (2007). Prostate-derived factor as a paracrine and autocrine factor for the proliferation of androgen receptor-positive human prostate cancer cells. Prostate 67: 557-571.
8. Chikumi H, Fukuhara S, Gutkind JS. (2002). Regulation of G protein-linked guanine nucleotide exchange factors for Rho, PDZ-Rho-GEF, and LARG by tyrosine phosphorylation: evidence of a role for focal adhesion kinase. J Biol Chem 277: 12463-12473.
9. D'Amico AV, Whittington R, Malkowicz SB, Schultz D, Blank K, Broderick GA, et al. (1998). Biochemical outcome after radical prostatectomy, external beam radiation therapy, or interstitial radiation therapy for clinically localized prostate cancer. JAMA 280: 969-974. (Pubitemid 28445094)
10. Fairlie WD, Moore AG, Bauskin AR, Russell PK, Zhang HP, Breit SN. (1999). MIC-1 is a novel TGF-beta superfamily cytokine associated with macrophage activation. J Leukoc Biol 65: 2-5.
11. Hodge JC, Bub J, Kaul S, Kajdacsy-Balla A, Lindholm PF. (2003). Requirement of RhoA activity for increased nuclear factor kappaB activity and PC-3 human prostate cancer cell invasion. Cancer Res 63: 1359-1364.
12. Hromas R, Hufford M, Sutton J, Xu D, Li Y, Lu L. (1997). PLAB, a novel placental bone morphogenetic protein. Biochim Biophys Acta 1354: 40-44.
13. Jemal A, Siegel R, Ward E, Hao Y, Xu J, Murray T, et al. (2008). Cancer statistics, 2008. CA Cancer J Clin 58: 71-96.
14. Johnen H, Lin S, Kuffner T, Brown DA, Tsai VW, Bauskin AR, et al. (2007). Tumor-induced anorexia and weight loss are mediated by the TGF-beta superfamily cytokine MIC-1. Nat Med 13: 1333-1340.
15. Karan D, Chen SJ, Johansson SL, Singh AP, Paralkar VM, Lin MF, et al. (2003). Dysregulated expression of MIC-1/PDF in human prostate tumor cells. Biochem Biophys Res Commun 305: 598-604.
16. Karan D, Holzbeierlein J, Thrasher JB. (2009). Macrophage inhibitory cytokine-1: possible bridge molecule of inflammation and prostate cancer. Cancer Res 69: 2-5.
17. Karan D, Kelly DL, Rizzino A, Lin MF, Batra SK. (2002). Expression profile of differentially-regulated genes during progression of androgen-independent growth in human prostate cancer cells. Carcinogenesis 23: 967-975.
18. Kozlowski JM, Fidler IJ, Campbell D, Xu ZL, Kaighn ME, Hart IR. (1984). Metastatic behavior of human tumor cell lines grown in the nude mouse. Cancer Res 44: 3522-3529.
19. Lambert JR, Kelly JA, Shim M, Huffer WE, Nordeen SK, Baek SJ, et al. (2006). Prostate derived factor in human prostate cancer cells: gene induction by vitamin D via a p53-dependent mechanism and inhibition of prostate cancer cell growth. J Cell Physiol 208: 566-574.
20. Lawton LN, Bonaldo MF, Jelenc PC, Qiu L, Baumes SA, Marcelino RA, et al. (1997). Identification of a novel member of the TGF-beta superfamily highly expressed in human placenta. Gene 203: 17-26.
21. Lee DH, Yang Y, Lee SJ, Kim KY, Koo TH, Shin SM, et al. (2003). Macrophage inhibitory cytokine-1 induces the invasiveness of gastric cancer cells by up-regulating the urokinase-type plasminogen activator system. Cancer Res 63: 4648-4655.
22. Liu T, Bauskin AR, Zaunders J, Brown DA, Pankhurst S, Russell PJ, et al. (2003). Macrophage inhibitory cytokine 1 reduces cell adhesion and induces apoptosis in prostate cancer cells. Cancer Res 63: 5034-5040.
23. McLean GW, Carragher NO, Avizienyte E, Evans J, Brunton VG, Frame MC. (2005). The role of focal-adhesion kinase in cancer\a new therapeutic opportunity. Nat Rev Cancer 5: 505-515.
24. Padua D, Massague J. (2009). Roles of TGFbeta in metastasis. Cell Res 19: 89-102.
25. Paralkar VM, Vail AL, Grasser WA, Brown TA, Xu H, Vukicevic S, et al. (1998). Cloning and characterization of a novel member of the transforming growth factor-beta/bone morphogenetic protein family. J Biol Chem 273: 13760-13767.
26. Patrikainen L, Porvari K, Kurkela R, Hirvikoski P, Soini Y, Vihko P. (2007). Expression profiling of PC-3 cell line variants and comparison of MIC-1 transcript levels in benign and malignant prostate. Eur J Clin Invest 37: 126-133.
27. Pettaway CA, Pathak S, Greene G, Ramirez E, Wilson MR, Killion JJ, et al. (1996). Selection of highly metastatic variants of different human prostatic carcinomas using orthotopic implantation in nude mice. Clin Cancer Res 2: 1627-1636.
28. Robinson VL, Kauffman EC, Sokoloff MH, Rinker-Schaeffer CW. (2004). The basic biology of metastasis. Cancer Treat Res 118: 1-21.
29. Schlaepfer DD, Mitra SK, Ilic D. (2004). Control of motile and invasive cell phenotypes by focal adhesion kinase. Biochim Biophys Acta 1692: 77-102.
30. Selander KS, Brown DA, Sequeiros GB, Hunter M, Desmond R, Parpala T, et al. (2007). Serum macrophage inhibitory cytokine-1 concentrations correlate with the presence of prostate cancer bone metastases. Cancer Epidemiol Biomarkers Prev 16: 532-537.
31. Sieg DJ, Hauck CR, Ilic D, Klingbeil CK, Schaefer E, Damsky CH, et al. (2000). FAK integrates growth-factor and integrin signals to promote cell migration. Nat Cell Biol 2: 249-256.
32. Sporn MB. (1996). The war on cancer. Lancet 347: 1377-1381.
33. Wakchoure S, Swain TM, Hentunen TA, Bauskin AR, Brown DA, Breit SN, et al. (2009). Expression of macrophage inhibitory cytokine-1 in prostate cancer bone metastases induces osteoclast activation and weight loss. Prostate 69: 652-661.
34. Welsh JB, Sapinoso LM, Kern SG, Brown DA, Liu T, Bauskin AR, et al. (2003). Large-scale delineation of secreted protein biomarkers overexpressed in cancer tissue and serum. Proc Natl Acad Sci USA 100: 3410-3415.
35. Zhai J, Lin H, Nie Z, Wu J, Canete-Soler R, Schlaepfer WW, et al. (2003). Direct interaction of focal adhesion kinase with p190Rho-GEF. J Biol Chem 278: 24865-24873.