메뉴 건너뛰기




Volumn 4, Issue 10, 2013, Pages 735-746

The evolving landscape in the therapy of acute myeloid leukemia

Author keywords

acute myeloid leukemia; FLT3; gemtuzumab ozogamicin; hypomethylating

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; AEG 35156; ALISERTIB; ANTISENSE OLIGONUCLEOTIDE; ARSENIC TRIOXIDE; AZACITIDINE; BARASERTIB; CCAAT ENHANCER BINDING PROTEIN ALPHA; CD135 ANTIGEN; CYTARABINE; DAUNORUBICIN; GEMTUZUMAB OZOGAMICIN; IDARUBICIN; ISOCITRATE DEHYDROGENASE; MICRORNA; QUIZARTINIB; RETINOIC ACID; X LINKED INHIBITOR OF APOPTOSIS;

EID: 84887553781     PISSN: 1674800X     EISSN: 16748018     Source Type: Journal    
DOI: 10.1007/s13238-013-3057-2     Document Type: Review
Times cited : (21)

References (111)
  • 1
    • 0034817075 scopus 로고    scopus 로고
    • ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain
    • Amann, J. M., Nip, J., Strom, D. K., Lutterbach, B., Harada, H., Lenny, N., Downing, J. R., Meyers, S., and Hiebert, S. W. (2001). ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain. Mol Cell Biol 21, 6470-6483.
    • (2001) Mol Cell Biol , vol.21 , pp. 6470-6483
    • Amann, J.M.1    Nip, J.2    Strom, D.K.3    Lutterbach, B.4    Harada, H.5    Lenny, N.6    Downing, J.R.7    Meyers, S.8    Hiebert, S.W.9
  • 3
    • 0025275742 scopus 로고
    • Randomized multicenter trial of cytosine arabinoside with mitoxantrone or daunorubicin in previously untreated adult patients with acute nonlymphocytic leukemia (ANLL)
    • Arlin, Z., Case, D. C., Moore, J., Wiernik, P., Feldman, E., Saletan, S., Desai, P., Sia, L., and Cartwright, K. (1990). Randomized multicenter trial of cytosine arabinoside with mitoxantrone or daunorubicin in previously untreated adult patients with acute nonlymphocytic leukemia (ANLL). Lederle Cooperative Group. Leukemia 4, 177-183.
    • (1990) Lederle Cooperative Group. Leukemia , vol.4 , pp. 177-183
    • Arlin, Z.1    Case, D.C.2    Moore, J.3    Wiernik, P.4    Feldman, E.5    Saletan, S.6    Desai, P.7    Sia, L.8    Cartwright, K.9
  • 5
    • 79952832445 scopus 로고    scopus 로고
    • Outcomes after induction chemotherapy in patients with acute myeloid leukemia arising from myelodysplastic syndrome
    • Bello, C., Yu, D., Komrokji, R. S., Zhu, W., Wetzstein, G. A., List, A. F., and Lancet, J. E. (2011). Outcomes after induction chemotherapy in patients with acute myeloid leukemia arising from myelodysplastic syndrome. Cancer 117, 1463-1469.
    • (2011) Cancer , vol.117 , pp. 1463-1469
    • Bello, C.1    Yu, D.2    Komrokji, R.S.3    Zhu, W.4    Wetzstein, G.A.5    List, A.F.6    Lancet, J.E.7
  • 6
    • 77949512140 scopus 로고    scopus 로고
    • RNA targeting therapeutics: molecular mechanisms of antisense oligonucleotides as a therapeutic platform
    • Bennett, C. F., and Swayze, E. E. (2010). RNA targeting therapeutics: molecular mechanisms of antisense oligonucleotides as a therapeutic platform. Annu Rev Pharmacol Toxicol 50, 259-293.
    • (2010) Annu Rev Pharmacol Toxicol , vol.50 , pp. 259-293
    • Bennett, C.F.1    Swayze, E.E.2
  • 7
    • 0025907179 scopus 로고
    • Results of a randomized trial comparing idarubicin and cytosine arabinoside with daunorubicin and cytosine arabinoside in adult patients with newly diagnosed acute myelogenous leukemia
    • Berman, E., Heller, G., Santorsa, J., McKenzie, S., Gee, T., Kempin, S., Gulati, S., Andreeff, M., Kolitz, J., and Gabrilove, J. (1991). Results of a randomized trial comparing idarubicin and cytosine arabinoside with daunorubicin and cytosine arabinoside in adult patients with newly diagnosed acute myelogenous leukemia. Blood 77, 1666-1674.
    • (1991) Blood , vol.77 , pp. 1666-1674
    • Berman, E.1    Heller, G.2    Santorsa, J.3    McKenzie, S.4    Gee, T.5    Kempin, S.6    Gulati, S.7    Andreeff, M.8    Kolitz, J.9    Gabrilove, J.10
  • 13
    • 77957286222 scopus 로고    scopus 로고
    • Prognostic impact of isocitrate dehydrogenase enzyme isoforms 1 and 2 mutations in acute myeloid leukemia: a study by the Acute Leukemia French Association group
    • Boissel N., Nibourel O., Renneville A., Gardin C., Reman O., Contentin N., Bordessoule D., Pautas C., de Revel T., Quesnel B., et al. (2010). Prognostic impact of isocitrate dehydrogenase enzyme isoforms 1 and 2 mutations in acute myeloid leukemia: a study by the Acute Leukemia French Association group. J Clin Oncol 28, 3717-3723.
    • (2010) J Clin Oncol , vol.28 , pp. 3717-3723
    • Boissel, N.1    Nibourel, O.2    Renneville, A.3    Gardin, C.4    Reman, O.5    Contentin, N.6    Bordessoule, D.7    Pautas, C.8    de Revel, T.9    Quesnel, B.10
  • 14
    • 27544450742 scopus 로고    scopus 로고
    • Constitutive activation of Akt by Flt3 internal tandem duplications is necessary for increased survival, proliferation, and myeloid transformation
    • Brandts C. H., Sargin B., Rode M., Biermann C., Lindtner B., Schwäble J., Buerger H., Müller-Tidow C., Choudhary C., McMahon M., et al. (2005). Constitutive activation of Akt by Flt3 internal tandem duplications is necessary for increased survival, proliferation, and myeloid transformation. Cancer Res 65, 9643-9650.
    • (2005) Cancer Res , vol.65 , pp. 9643-9650
    • Brandts, C.H.1    Sargin, B.2    Rode, M.3    Biermann, C.4    Lindtner, B.5    Schwäble, J.6    Buerger, H.7    Müller-Tidow, C.8    Choudhary, C.9    McMahon, M.10
  • 17
    • 79952099282 scopus 로고    scopus 로고
    • Identification of patients with acute myeloblastic leukemia who benefit from the addition of gemtuzumab ozogamicin: results of the MRC AML15 trial
    • Burnett, A. K., Hills, R. K., Milligan, D., Kjeldsen, L., Kell, J., Russell, N. H., Yin, J. A., Hunter, A., Goldstone, A. H., and Wheatley, K. (2011). Identification of patients with acute myeloblastic leukemia who benefit from the addition of gemtuzumab ozogamicin: results of the MRC AML15 trial. J Clin Oncol 29, 369-377.
    • (2011) J Clin Oncol , vol.29 , pp. 369-377
    • Burnett, A.K.1    Hills, R.K.2    Milligan, D.3    Kjeldsen, L.4    Kell, J.5    Russell, N.H.6    Yin, J.A.7    Hunter, A.8    Goldstone, A.H.9    Wheatley, K.10
  • 18
    • 33947205565 scopus 로고    scopus 로고
    • A comparison of low-dose cytarabine and hydroxyurea with or without all-trans retinoic acid for acute myeloid leukemia and high-risk myelodysplastic syndrome in patients not considered fit for intensive treatment
    • Burnett, A. K., Milligan, D., Prentice, A. G., Goldstone, A. H., McMullin, M. F., Hills, R. K., and Wheatley, K. (2007). A comparison of low-dose cytarabine and hydroxyurea with or without all-trans retinoic acid for acute myeloid leukemia and high-risk myelodysplastic syndrome in patients not considered fit for intensive treatment. Cancer 109, 1114-1124.
    • (2007) Cancer , vol.109 , pp. 1114-1124
    • Burnett, A.K.1    Milligan, D.2    Prentice, A.G.3    Goldstone, A.H.4    McMullin, M.F.5    Hills, R.K.6    Wheatley, K.7
  • 20
    • 0345104178 scopus 로고    scopus 로고
    • Double induction strategy for acute myeloid leukemia: the effect of high-dose cytarabine with mitoxantrone instead of standard-dose cytarabine with daunorubicin and 6-thioguanine: a randomized trial by the German AML Cooperative Group
    • Büchner T., Hiddemann W., Wörmann B., Löffler H., Gassmann W., Haferlach T., Fonatsch C., Haase D., Schoch C., Hossfeld D., et al. (1999). Double induction strategy for acute myeloid leukemia: the effect of high-dose cytarabine with mitoxantrone instead of standard-dose cytarabine with daunorubicin and 6-thioguanine: a randomized trial by the German AML Cooperative Group. Blood 93, 4116-4124.
    • (1999) Blood , vol.93 , pp. 4116-4124
    • Büchner, T.1    Hiddemann, W.2    Wörmann, B.3    Löffler, H.4    Gassmann, W.5    Haferlach, T.6    Fonatsch, C.7    Haase, D.8    Schoch, C.9    Hossfeld, D.10
  • 21
    • 44749089794 scopus 로고    scopus 로고
    • Lack of antileukemic activity of rapamycin in elderly patients with acute myeloid leukemia evolving from a myelodysplastic syndrome
    • Callera, F., Lopes, C. O., Rosa, E. S., and Mulin, C. C. (2008). Lack of antileukemic activity of rapamycin in elderly patients with acute myeloid leukemia evolving from a myelodysplastic syndrome. Leuk Res 32, 1633-1634.
    • (2008) Leuk Res , vol.32 , pp. 1633-1634
    • Callera, F.1    Lopes, C.O.2    Rosa, E.S.3    Mulin, C.C.4
  • 22
    • 77449149374 scopus 로고    scopus 로고
    • Multicenter, phase II study of decitabine for the first-line treatment of older patients with acute myeloid leukemia
    • Cashen, A. F., Schiller, G. J., O'Donnell, M. R., and DiPersio, J. F. (2010). Multicenter, phase II study of decitabine for the first-line treatment of older patients with acute myeloid leukemia. J Clin Oncol 28, 556-561.
    • (2010) J Clin Oncol , vol.28 , pp. 556-561
    • Cashen, A.F.1    Schiller, G.J.2    O'Donnell, M.R.3    DiPersio, J.F.4
  • 23
    • 84859911350 scopus 로고    scopus 로고
    • Effect of gemtuzumab ozogamicin on survival of adult patients with de-novo acute myeloid leukaemia (ALFA-0701): a randomised, open-label, phase 3 study
    • Castaigne S., Pautas C., Terré C., Raffoux E., Bordessoule D., Bastie J. N., Legrand O., Thomas X., Turlure P., Reman O., et al. (2012). Effect of gemtuzumab ozogamicin on survival of adult patients with de-novo acute myeloid leukaemia (ALFA-0701): a randomised, open-label, phase 3 study. Lancet 379, 1508-1516.
    • (2012) Lancet , vol.379 , pp. 1508-1516
    • Castaigne, S.1    Pautas, C.2    Terré, C.3    Raffoux, E.4    Bordessoule, D.5    Bastie, J.N.6    Legrand, O.7    Thomas, X.8    Turlure, P.9    Reman, O.10
  • 24
    • 72249087752 scopus 로고    scopus 로고
    • Identification of N-(5-tert-butyl-isoxazol-3-yl)-N′-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl} urea dihydrochloride (AC220), a uniquely potent, selective, and efficacious FMS-like tyrosine kinase-3 (FLT3) inhibitor
    • Chao Q., Sprankle K. G., Grotzfeld R. M., Lai A. G., Carter T. A., Velasco A. M., Gunawardane R. N., Cramer M. D., Gardner M. F., James J., et al. (2009). Identification of N-(5-tert-butyl-isoxazol-3-yl)-N′-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2, 1-b][1, 3]benzothiazol-2-yl]phenyl} urea dihydrochloride (AC220), a uniquely potent, selective, and efficacious FMS-like tyrosine kinase-3 (FLT3) inhibitor. J Med Chem 52, 7808-7816.
    • (2009) J Med Chem , vol.52 , pp. 7808-7816
    • Chao, Q.1    Sprankle, K.G.2    Grotzfeld, R.M.3    Lai, A.G.4    Carter, T.A.5    Velasco, A.M.6    Gunawardane, R.N.7    Cramer, M.D.8    Gardner, M.F.9    James, J.10
  • 25
    • 84887521742 scopus 로고    scopus 로고
    • A phase II open-label, AC220 monotherapy efficacy (ACE) study in patients with acute myeloid leukemia (AML) with FLT3-ITD activating mutations: Updated interim results
    • Abstract 2576
    • Cortes, J., Perl, A., Smith, C., Kovacsovics, T., Dombret, H., Dohner, H., Steffen, B., Pigneux, A., Rousselot, P., Krauter, J., et al. (2011). A phase II open-label, AC220 monotherapy efficacy (ACE) study in patients with acute myeloid leukemia (AML) with FLT3-ITD activating mutations: Updated interim results. Blood 118, Abstract 2576.
    • (2011) Blood , pp. 118
    • Cortes, J.1    Perl, A.2    Smith, C.3    Kovacsovics, T.4    Dombret, H.5    Dohner, H.6    Steffen, B.7    Pigneux, A.8    Rousselot, P.9    Krauter, J.10
  • 26
    • 0025719792 scopus 로고
    • A comparative study of two different doses of cytarabine for acute myeloid leukemia: a phase III trial of Cancer and Leukemia Group B
    • Dillman, R. O., Davis, R. B., Green, M. R., Weiss, R. B., Gottlieb, A. J., Caplan, S., Kopel, S., Preisler, H., McIntyre, O. R., and Schiffer, C. (1991). A comparative study of two different doses of cytarabine for acute myeloid leukemia: a phase III trial of Cancer and Leukemia Group B. Blood 78, 2520-2526.
    • (1991) Blood , vol.78 , pp. 2520-2526
    • Dillman, R.O.1    Davis, R.B.2    Green, M.R.3    Weiss, R.B.4    Gottlieb, A.J.5    Caplan, S.6    Kopel, S.7    Preisler, H.8    McIntyre, O.R.9    Schiffer, C.10
  • 27
    • 0035446823 scopus 로고    scopus 로고
    • Therapeutic options for acute myelogenous leukemia
    • Estey, E. H. (2001). Therapeutic options for acute myelogenous leukemia. Cancer 92, 1059-1073.
    • (2001) Cancer , vol.92 , pp. 1059-1073
    • Estey, E.H.1
  • 28
    • 0035895052 scopus 로고    scopus 로고
    • Comparison of idarubicin + ara-C-, fludarabine + ara-C-, and topotecan + ara-C-based regimens in treatment of newly diagnosed acute myeloid leukemia, refractory anemia with excess blasts in transformation, or refractory anemia with excess blasts
    • Estey, E. H., Thall, P. F., Cortes, J. E., Giles, F. J., O'Brien, S., Pierce, S. A., Wang, X., Kantarjian, H. M., and Beran, M. (2001). Comparison of idarubicin + ara-C-, fludarabine + ara-C-, and topotecan + ara-C-based regimens in treatment of newly diagnosed acute myeloid leukemia, refractory anemia with excess blasts in transformation, or refractory anemia with excess blasts. Blood 98, 3575-3583.
    • (2001) Blood , vol.98 , pp. 3575-3583
    • Estey, E.H.1    Thall, P.F.2    Cortes, J.E.3    Giles, F.J.4    O'Brien, S.5    Pierce, S.A.6    Wang, X.7    Kantarjian, H.M.8    Beran, M.9
  • 30
    • 62849104641 scopus 로고    scopus 로고
    • Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: a randomised, open-label, phase III study
    • Fenaux P., Mufti G. J., Hellstrom-Lindberg E., Santini V., Finelli C., Giagounidis A., Schoch R., Gattermann N., Sanz G., List A., et al. (2009). Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: a randomised, open-label, phase III study. Lancet Oncol 10, 223-232.
    • (2009) Lancet Oncol , vol.10 , pp. 223-232
    • Fenaux, P.1    Mufti, G.J.2    Hellstrom-Lindberg, E.3    Santini, V.4    Finelli, C.5    Giagounidis, A.6    Schoch, R.7    Gattermann, N.8    Sanz, G.9    List, A.10
  • 32
    • 78650019179 scopus 로고    scopus 로고
    • Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation
    • Figueroa M. E., Abdel-Wahab O., Lu C., Ward P. S., Patel J., Shih A., Li Y., Bhagwat N., Vasanthakumar A., Fernandez H. F., et al. (2010b). Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation. Cancer Cell 18, 553-567.
    • (2010) Cancer Cell , vol.18 , pp. 553-567
    • Figueroa, M.E.1    Abdel-Wahab, O.2    Lu, C.3    Ward, P.S.4    Patel, J.5    Shih, A.6    Li, Y.7    Bhagwat, N.8    Vasanthakumar, A.9    Fernandez, H.F.10
  • 34
    • 41949090673 scopus 로고    scopus 로고
    • The impact of FLT3 internal tandem duplication mutant level, number, size, and interaction with NPM1 mutations in a large cohort of young adult patients with acute myeloid leukemia
    • Medical Research Council Adult Leukaemia Working Party
    • Gale, R. E., Green, C., Allen, C., Mead, A. J., Burnett, A. K., Hills, R. K., Linch, D. C., and Medical Research Council Adult Leukaemia Working Party. (2008). The impact of FLT3 internal tandem duplication mutant level, number, size, and interaction with NPM1 mutations in a large cohort of young adult patients with acute myeloid leukemia. Blood 111, 2776-2784.
    • (2008) Blood , vol.111 , pp. 2776-2784
    • Gale, R.E.1    Green, C.2    Allen, C.3    Mead, A.J.4    Burnett, A.K.5    Hills, R.K.6    Linch, D.C.7
  • 35
    • 0031723957 scopus 로고    scopus 로고
    • Aberrant recruitment of the nuclear receptor corepressor-histone deacetylase complex by the acute myeloid leukemia fusion partner ETO
    • Gelmetti, V., Zhang, J., Fanelli, M., Minucci, S., Pelicci, P. G., and Lazar, M. A. (1998). Aberrant recruitment of the nuclear receptor corepressor-histone deacetylase complex by the acute myeloid leukemia fusion partner ETO. Mol Cell Biol 18, 7185-7191.
    • (1998) Mol Cell Biol , vol.18 , pp. 7185-7191
    • Gelmetti, V.1    Zhang, J.2    Fanelli, M.3    Minucci, S.4    Pelicci, P.G.5    Lazar, M.A.6
  • 36
    • 17144387901 scopus 로고    scopus 로고
    • PI3-kinase/Akt is constitutively active in primary acute myeloid leukaemia cells and regulates survival and chemoresistance via NFkappaB, Mapkinase and p53 pathways
    • Grandage, V. L., Gale, R. E., Linch, D. C., and Khwaja, A. (2005). PI3-kinase/Akt is constitutively active in primary acute myeloid leukaemia cells and regulates survival and chemoresistance via NFkappaB, Mapkinase and p53 pathways. Leukemia 19, 586-594.
    • (2005) Leukemia , vol.19 , pp. 586-594
    • Grandage, V.L.1    Gale, R.E.2    Linch, D.C.3    Khwaja, A.4
  • 37
    • 77957759961 scopus 로고    scopus 로고
    • The prognostic significance of IDH1 mutations in younger adult patients with acute myeloid leukemia is dependent on FLT3/ITD status
    • Green, C. L., Evans, C. M., Hills, R. K., Burnett, A. K., Linch, D. C., and Gale, R. E. (2010). The prognostic significance of IDH1 mutations in younger adult patients with acute myeloid leukemia is dependent on FLT3/ITD status. Blood 116, 2779-2782.
    • (2010) Blood , vol.116 , pp. 2779-2782
    • Green, C.L.1    Evans, C.M.2    Hills, R.K.3    Burnett, A.K.4    Linch, D.C.5    Gale, R.E.6
  • 38
    • 79960534917 scopus 로고    scopus 로고
    • The prognostic significance of IDH2 mutations in AML depends on the location of the mutation
    • Green, C. L., Evans, C. M., Zhao, L., Hills, R. K., Burnett, A. K., Linch, D. C., and Gale, R. E. (2011). The prognostic significance of IDH2 mutations in AML depends on the location of the mutation. Blood 118, 409-412.
    • (2011) Blood , vol.118 , pp. 409-412
    • Green, C.L.1    Evans, C.M.2    Zhao, L.3    Hills, R.K.4    Burnett, A.K.5    Linch, D.C.6    Gale, R.E.7
  • 39
    • 77955914238 scopus 로고    scopus 로고
    • Refinement of cytogenetic classification in acute myeloid leukemia: determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom Medical Research Council trials
    • National Cancer Research Institute Adult Leukaemia Working Group
    • Grimwade, D., Hills, R. K., Moorman, A. V., Walker, H., Chatters, S., Goldstone, A. H., Wheatley, K., Harrison, C. J., Burnett, A. K., and National Cancer Research Institute Adult Leukaemia Working Group. (2010). Refinement of cytogenetic classification in acute myeloid leukemia: determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom Medical Research Council trials. Blood 116, 354-365.
    • (2010) Blood , vol.116 , pp. 354-365
    • Grimwade, D.1    Hills, R.K.2    Moorman, A.V.3    Walker, H.4    Chatters, S.5    Goldstone, A.H.6    Wheatley, K.7    Harrison, C.J.8    Burnett, A.K.9
  • 41
  • 42
    • 0030895252 scopus 로고    scopus 로고
    • Randomized comparison of DAT versus ADE as induction chemotherapy in children and younger adults with acute myeloid leukemia. Results of the Medical Research Council's 10th AML trial (MRC AML10). Adult and Childhood Leukaemia Working Parties of the Medical Research Council
    • Hann, I. M., Stevens, R. F., Goldstone, A. H., Rees, J. K., Wheatley, K., Gray, R. G., and Burnett, A. K. (1997). Randomized comparison of DAT versus ADE as induction chemotherapy in children and younger adults with acute myeloid leukemia. Results of the Medical Research Council's 10th AML trial (MRC AML10). Adult and Childhood Leukaemia Working Parties of the Medical Research Council. Blood 89, 2311-2318.
    • (1997) Blood , vol.89 , pp. 2311-2318
    • Hann, I.M.1    Stevens, R.F.2    Goldstone, A.H.3    Rees, J.K.4    Wheatley, K.5    Gray, R.G.6    Burnett, A.K.7
  • 43
    • 0038300381 scopus 로고    scopus 로고
    • The t(8;21) fusion protein contacts corepressors and histone deacetylases to repress the transcription of the p14ARF tumor suppressor
    • Hiebert, S. W., Reed-Inderbitzin, E. F., Amann, J., Irvin, B., Durst, K., and Linggi, B. (2003). The t(8;21) fusion protein contacts corepressors and histone deacetylases to repress the transcription of the p14ARF tumor suppressor. Blood Cells Mol Dis 30, 177-183.
    • (2003) Blood Cells Mol Dis , vol.30 , pp. 177-183
    • Hiebert, S.W.1    Reed-Inderbitzin, E.F.2    Amann, J.3    Irvin, B.4    Durst, K.5    Linggi, B.6
  • 44
    • 0027194197 scopus 로고
    • Preparation and characterization of monoclonal antibody conjugates of the calicheamicins: a novel and potent family of antitumor antibiotics
    • Hinman, L. M., Hamann, P. R., Wallace, R., Menendez, A. T., Durr, F. E., and Upeslacis, J. (1993). Preparation and characterization of monoclonal antibody conjugates of the calicheamicins: a novel and potent family of antitumor antibiotics. Cancer Res 53, 3336-3342.
    • (1993) Cancer Res , vol.53 , pp. 3336-3342
    • Hinman, L.M.1    Hamann, P.R.2    Wallace, R.3    Menendez, A.T.4    Durr, F.E.5    Upeslacis, J.6
  • 45
    • 0030909701 scopus 로고    scopus 로고
    • DNA methylation changes in hematologic malignancies: biologic and clinical implications
    • Issa, J. P., Baylin, S. B., and Herman, J. G. (1997). DNA methylation changes in hematologic malignancies: biologic and clinical implications. Leukemia 11 Suppl 1, S7-11.
    • (1997) Leukemia , vol.11 , Issue.1 , pp. 7-11
    • Issa, J.P.1    Baylin, S.B.2    Herman, J.G.3
  • 46
    • 10744233452 scopus 로고    scopus 로고
    • Phase 1 study of low-dose prolonged exposure schedules of the hypomethylating agent 5-aza-2′-deoxycytidine (decitabine) in hematopoietic alignancies
    • Issa J. P., Garcia-Manero G., Giles F. J., Mannari R., Thomas D., Faderl S., Bayar E., Lyons J., Rosenfeld C. S., Cortes J., et al. (2004). Phase 1 study of low-dose prolonged exposure schedules of the hypomethylating agent 5-aza-2′-deoxycytidine (decitabine) in hematopoietic alignancies. Blood 103, 1635-1640.
    • (2004) Blood , vol.103 , pp. 1635-1640
    • Issa, J.P.1    Garcia-Manero, G.2    Giles, F.J.3    Mannari, R.4    Thomas, D.5    Faderl, S.6    Bayar, E.7    Lyons, J.8    Rosenfeld, C.S.9    Cortes, J.10
  • 49
    • 13544268345 scopus 로고    scopus 로고
    • Pim-1 is up-regulated by constitutively activated FLT3 and plays a role in FLT3-mediated cell survival
    • Kim, K. T., Baird, K., Ahn, J. Y., Meltzer, P., Lilly, M., Levis, M., and Small, D. (2005). Pim-1 is up-regulated by constitutively activated FLT3 and plays a role in FLT3-mediated cell survival. Blood 105, 1759-1767.
    • (2005) Blood , vol.105 , pp. 1759-1767
    • Kim, K.T.1    Baird, K.2    Ahn, J.Y.3    Meltzer, P.4    Lilly, M.5    Levis, M.6    Small, D.7
  • 50
    • 33746471790 scopus 로고    scopus 로고
    • Constitutively activated FLT3 phosphorylates BAD partially through pim-1
    • Kim, K. T., Levis, M., and Small, D. (2006). Constitutively activated FLT3 phosphorylates BAD partially through pim-1. Br J Haematol 134, 500-509.
    • (2006) Br J Haematol , vol.134 , pp. 500-509
    • Kim, K.T.1    Levis, M.2    Small, D.3
  • 51
    • 0032879920 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors are the potent inducer/enhancer of differentiation in acute myeloid leukemia: a new approach to antileukemia therapy
    • Kosugi H., Towatari M., Hatano S., Kitamura K., Kiyoi H., Kinoshita T., Tanimoto M., Murate T., Kawashima K., Saito H., et al. (1999). Histone deacetylase inhibitors are the potent inducer/enhancer of differentiation in acute myeloid leukemia: a new approach to antileukemia therapy. Leukemia 13, 1316-1324.
    • (1999) Leukemia , vol.13 , pp. 1316-1324
    • Kosugi, H.1    Towatari, M.2    Hatano, S.3    Kitamura, K.4    Kiyoi, H.5    Kinoshita, T.6    Tanimoto, M.7    Murate, T.8    Kawashima, K.9    Saito, H.10
  • 52
    • 0035885955 scopus 로고    scopus 로고
    • The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: analysis of 854 patients from the United Kingdom Medical Research Council AML 10 and 12 trials
    • Kottaridis P. D., Gale R. E., Frew M. E., Harrison G., Langabeer S. E., Belton A. A., Walker H., Wheatley K., Bowen D. T., Burnett A. K., et al. (2001). The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: analysis of 854 patients from the United Kingdom Medical Research Council AML 10 and 12 trials. Blood 98, 1752-1759.
    • (2001) Blood , vol.98 , pp. 1752-1759
    • Kottaridis, P.D.1    Gale, R.E.2    Frew, M.E.3    Harrison, G.4    Langabeer, S.E.5    Belton, A.A.6    Walker, H.7    Wheatley, K.8    Bowen, D.T.9    Burnett, A.K.10
  • 53
  • 54
    • 0031005627 scopus 로고    scopus 로고
    • Acute myeloid leukemia in the elderly: assessment of multidrug resistance (MDR1) and cytogenetics distinguishes biologic subgroups with remarkably distinct responses to standard chemotherapy. A Southwest Oncology Group study
    • Leith, C. P., Kopecky, K. J., Godwin, J., McConnell, T., Slovak, M. L., Chen, I. M., Head, D. R., Appelbaum, F. R., and Willman, C. L. (1997). Acute myeloid leukemia in the elderly: assessment of multidrug resistance (MDR1) and cytogenetics distinguishes biologic subgroups with remarkably distinct responses to standard chemotherapy. A Southwest Oncology Group study. Blood 89, 3323-3329.
    • (1997) Blood , vol.89 , pp. 3323-3329
    • Leith, C.P.1    Kopecky, K.J.2    Godwin, J.3    McConnell, T.4    Slovak, M.L.5    Chen, I.M.6    Head, D.R.7    Appelbaum, F.R.8    Willman, C.L.9
  • 55
    • 84860378609 scopus 로고    scopus 로고
    • Cancer-associated isocitrate dehydrogenase mutations inactivate NADPH-dependent reductive carboxylation
    • Leonardi, R., Subramanian, C., Jackowski, S., and Rock, C. O. (2012). Cancer-associated isocitrate dehydrogenase mutations inactivate NADPH-dependent reductive carboxylation. J Biol Chem 287, 14615-14620.
    • (2012) J Biol Chem , vol.287 , pp. 14615-14620
    • Leonardi, R.1    Subramanian, C.2    Jackowski, S.3    Rock, C.O.4
  • 56
    • 0036902962 scopus 로고    scopus 로고
    • DNA methylation and demethylating drugs in myelodysplastic syndromes and secondary leukemias
    • Leone, G., Teofili, L., Voso, M. T., and Lübbert, M. (2002). DNA methylation and demethylating drugs in myelodysplastic syndromes and secondary leukemias. Haematologica 87, 1324-1341.
    • (2002) Haematologica , vol.87 , pp. 1324-1341
    • Leone, G.1    Teofili, L.2    Voso, M.T.3    Lübbert, M.4
  • 57
    • 0031921327 scopus 로고    scopus 로고
    • Treatment of acute myelogenous leukemia in the older patient with attenuated high-dose ara-C
    • Letendre, L., Noel, P., Litzow, M. R., Hoagland, H. C., and Tefferi, A. (1998). Treatment of acute myelogenous leukemia in the older patient with attenuated high-dose ara-C. Am J Clin Oncol 21, 142-144.
    • (1998) Am J Clin Oncol , vol.21 , pp. 142-144
    • Letendre, L.1    Noel, P.2    Litzow, M.R.3    Hoagland, H.C.4    Tefferi, A.5
  • 58
    • 0141836914 scopus 로고    scopus 로고
    • FLT3: ITDoes matter in leukemia
    • Levis, M. and Small, D. (2003). FLT3: ITDoes matter in leukemia. Leukemia. 17(9), 1738-1752.
    • (2003) Leukemia , vol.17 , Issue.9 , pp. 1738-1752
    • Levis, M.1    Small, D.2
  • 59
    • 84875635430 scopus 로고    scopus 로고
    • Final results of a phase 2 open-label, monotherapy efficacy and safety study of quizartinib (AC22) in patients with FLT3-ITD positive or negative relapsed/refractory acute myeloid leukemia after second-line chemotherapy or hematopoietic stem cell transplantation
    • Abstract 673
    • Levis, M. J., Perl, A. E., Dombret, H., Döhner, H., Steffen, B., Rousselot, P., Martinelli, P., Estey, E. H., Burnett, A. K., Gammon, G., et al. (2012). Final results of a phase 2 open-label, monotherapy efficacy and safety study of quizartinib (AC22) in patients with FLT3-ITD positive or negative relapsed/refractory acute myeloid leukemia after second-line chemotherapy or hematopoietic stem cell transplantation. Blood 120, Abstract 673.
    • (2012) Blood , pp. 120
    • Levis, M.J.1    Perl, A.E.2    Dombret, H.3    Döhner, H.4    Steffen, B.5    Rousselot, P.6    Martinelli, P.7    Estey, E.H.8    Burnett, A.K.9    Gammon, G.10
  • 60
    • 84878372012 scopus 로고    scopus 로고
    • Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia
    • Ley, T. J. (2013). Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia. N Engl J Med 368, 2059-2074.
    • (2013) N Engl J Med , vol.368 , pp. 2059-2074
    • Ley, T.J.1
  • 62
    • 0035760302 scopus 로고    scopus 로고
    • Benefit of cyclosporine modulation of drug resistance in patients with poor-risk acute myeloid leukemia: a Southwest Oncology Group study
    • List A. F., Kopecky K. J., Willman C. L., Head D. R., Persons D. L., Slovak M. L., Dorr R., Karanes C., Hynes H. E., Doroshow J. H., et al. (2001). Benefit of cyclosporine modulation of drug resistance in patients with poor-risk acute myeloid leukemia: a Southwest Oncology Group study. Blood 98, 3212-3220.
    • (2001) Blood , vol.98 , pp. 3212-3220
    • List, A.F.1    Kopecky, K.J.2    Willman, C.L.3    Head, D.R.4    Persons, D.L.5    Slovak, M.L.6    Dorr, R.7    Karanes, C.8    Hynes, H.E.9    Doroshow, J.H.10
  • 64
    • 61549137657 scopus 로고    scopus 로고
    • Continued low-dose decitabine (DAC) is an active first-line treatment in all cytogenetic subgroups of older AML patients: Results of the FR00331 multi center phase II study
    • Lubbert, M., Ruter, B., Claus, R., Schmid, M., Germing, U., Eimermacher, H., Ganser, A., Platzbecker, U., Galm, O., Brugger, W., et al. (2007). Continued low-dose decitabine (DAC) is an active first-line treatment in all cytogenetic subgroups of older AML patients: Results of the FR00331 multi center phase II study. ASH Annual Meeting Abstracts 110, 300.
    • (2007) ASH Annual Meeting Abstracts , vol.110 , pp. 300
    • Lubbert, M.1    Ruter, B.2    Claus, R.3    Schmid, M.4    Germing, U.5    Eimermacher, H.6    Ganser, A.7    Platzbecker, U.8    Galm, O.9    Brugger, W.10
  • 65
    • 0029981308 scopus 로고    scopus 로고
    • Treatment of the elderly patient with acute myeloid leukaemia
    • Löwenberg, B. (1996). Treatment of the elderly patient with acute myeloid leukaemia. Baillière's clinical haematology 9, 147-159.
    • (1996) Baillière's Clinical Haematology , vol.9 , pp. 147-159
    • Löwenberg, B.1
  • 68
    • 0343045296 scopus 로고    scopus 로고
    • Mitox antrone versus daunorubicin in induction-consolidation chemotherapy-the value of low-dose cytarabine for maintenance of remission, and an assessment of prognostic factors in acute myeloid leukemia in the elderly: final report. European Organization for the Research and Treatment of Cancer and the Dutch-Belgian Hemato-Oncology Cooperative Hovon Group
    • Löwenberg, B., Suciu, S., Archimbaud, E., Haak H., Stryckmans P., de Cataldo R., Dekker A. W., Berneman Z. N., Thyss A., van der Lelie J., et al. (1998). Mitox antrone versus daunorubicin in induction-consolidation chemotherapy-the value of low-dose cytarabine for maintenance of remission, and an assessment of prognostic factors in acute myeloid leukemia in the elderly: final report. European Organization for the Research and Treatment of Cancer and the Dutch-Belgian Hemato-Oncology Cooperative Hovon Group. J Clin Oncol 16, 872-881.
    • (1998) J Clin Oncol , vol.16 , pp. 872-881
    • Löwenberg, B.1    Suciu, S.2    Archimbaud, E.3    Haak, H.4    Stryckmans, P.5    de Cataldo, R.6    Dekker, A.W.7    Berneman, Z.N.8    Thyss, A.9    van der Lelie, J.10
  • 70
    • 34548234969 scopus 로고    scopus 로고
    • High exp ression levels of the ETS-related gene, ERG, predict adverse outcome and improve molecular risk-based classification of cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B Study
    • Marcucci, G., Maharry, K., Whitman, S. P., Vukosavljevic T., Paschka P., Langer C., Mrózek K., Baldus C. D., Carroll A. J., Powell B. L., et al. (2007). High exp ression levels of the ETS-related gene, ERG, predict adverse outcome and improve molecular risk-based classification of cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B Study. J Clin Oncol 25, 3337-3343.
    • (2007) J Clin Oncol , vol.25 , pp. 3337-3343
    • Marcucci, G.1    Maharry, K.2    Whitman, S.P.3    Vukosavljevic, T.4    Paschka, P.5    Langer, C.6    Mrózek, K.7    Baldus, C.D.8    Carroll, A.J.9    Powell, B.L.10
  • 71
    • 77952536841 scopus 로고    scopus 로고
    • IDH1 and IDH2 gene mutations identify novel molecular subsets within de novo cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study
    • Marcucci, G., Maharry, K., Wu, Y. Z., Radmacher M. D., Mrózekzek KK., Margeson D., Holland K. B., Whitman S. P., Becker H., Schwind S., et al. (2010). IDH1 and IDH2 gene mutations identify novel molecular subsets within de novo cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study. J Clin Oncol 28, 2348-2355.
    • (2010) J Clin Oncol , vol.28 , pp. 2348-2355
    • Marcucci, G.1    Maharry, K.2    Wu, Y.Z.3    Radmacher, M.D.4    Mrózekzek, K.K.5    Margeson, D.6    Holland, K.B.7    Whitman, S.P.8    Becker, H.9    Schwind, S.10
  • 72
    • 33744457653 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase/Akt signaling pathway and its therapeutical implications for human acute myeloid leukemia
    • Martelli, A. M., Nyåkern, M., Tabellini, G., Bortul, R., Tazzari, P. L., Evangelisti, C., and Cocco, L. (2006). Phosphoinositide 3-kinase/Akt signaling pathway and its therapeutical implications for human acute myeloid leukemia. Leukemia 20, 911-928.
    • (2006) Leukemia , vol.20 , pp. 911-928
    • Martelli, A.M.1    Nyåkern, M.2    Tabellini, G.3    Bortul, R.4    Tazzari, P.L.5    Evangelisti, C.6    Cocco, L.7
  • 73
    • 77950836730 scopus 로고    scopus 로고
    • Effects of initial treatment on survival among elderly AML patients: Findings from the SEER-Medicare Database
    • Abstract 1973
    • Menzin, J., Boulenger, L., Karsten, V., and Cahill, A. (2006). Effects of initial treatment on survival among elderly AML patients: Findings from the SEER-Medicare Database. Blood 108, Abstract 1973.
    • (2006) Blood , vol.108
    • Menzin, J.1    Boulenger, L.2    Karsten, V.3    Cahill, A.4
  • 74
    • 0842281498 scopus 로고    scopus 로고
    • Aurora kinases link chromosome segregation and cell division to cancer susceptibility
    • Meraldi, P., Honda, R., and Nigg, E. A. (2004). Aurora kinases link chromosome segregation and cell division to cancer susceptibility. Curr Opin Genet Dev. 14(1), 29-36.
    • (2004) Curr Opin Genet Dev. , vol.14 , Issue.1 , pp. 29-36
    • Meraldi, P.1    Honda, R.2    Nigg, E.A.3
  • 75
    • 1542327671 scopus 로고    scopus 로고
    • Combination of rapamycin and protein tyrosine kinase (PTK) inhibitors for the treatment of leukemias caused by oncogenic PTKs
    • Mohi, M. G., Boulton, C., Gu, T. L., Sternberg, D. W., Neuberg, D., Griffin, J. D., Gilliland, D. G., and Neel, B. G. (2004). Combination of rapamycin and protein tyrosine kinase (PTK) inhibitors for the treatment of leukemias caused by oncogenic PTKs. Proc Natl Acad Sci U S A. 101(9), 3130-3135.
    • (2004) Proc Natl Acad Sci U S A. , vol.101 , Issue.9 , pp. 3130-3135
    • Mohi, M.G.1    Boulton, C.2    Gu, T.L.3    Sternberg, D.W.4    Neuberg, D.5    Griffin, J.D.6    Gilliland, D.G.7    Neel, B.G.8
  • 76
    • 33846230449 scopus 로고    scopus 로고
    • Clinical relevance of mutations and gene-expression changes in adult acute myeloid leukemia with normal cytogenetics: are we ready for a prognostically prioritized molecular classification?
    • Mrózek, K., Marcucci, G., Paschka, P., Whitman, S. P., and Bloomfield, C. D. (2007). Clinical relevance of mutations and gene-expression changes in adult acute myeloid leukemia with normal cytogenetics: are we ready for a prognostically prioritized molecular classification?. Blood 109, 431-448.
    • (2007) Blood , vol.109 , pp. 431-448
    • Mrózek, K.1    Marcucci, G.2    Paschka, P.3    Whitman, S.P.4    Bloomfield, C.D.5
  • 79
    • 33644798659 scopus 로고    scopus 로고
    • Molecular typing of adult acute myeloid leukaemia: significance of translocations, tandem duplications, methylation, and selective gene expression profiling
    • Olesen, L. H., Aggerholm, A., Andersen, B. L., Nyvold, C. G., Guldberg, P., Nørgaard, J. M., and Hokland, P. (2005). Molecular typing of adult acute myeloid leukaemia: significance of translocations, tandem duplications, methylation, and selective gene expression profiling. Br J Haematol 131, 457-467.
    • (2005) Br J Haematol , vol.131 , pp. 457-467
    • Olesen, L.H.1    Aggerholm, A.2    Andersen, B.L.3    Nyvold, C.G.4    Guldberg, P.5    Nørgaard, J.M.6    Hokland, P.7
  • 80
    • 77955907891 scopus 로고    scopus 로고
    • IDH1 and IDH2 m utations are frequent genetic alterations in acute myeloid leukemia and confer adverse prognosis in cytogenetically normal acute myeloid leukemia with NPM1 mutation without FLT3 internal tandem duplication
    • Paschka, P., Schlenk, R. F., Gaidzik, V. I., Habdank M., Krönke J., Bullinger L., Späth D., Kayser S., Zucknick M., Götze K., et al. (2010). IDH1 and IDH2 m utations are frequent genetic alterations in acute myeloid leukemia and confer adverse prognosis in cytogenetically normal acute myeloid leukemia with NPM1 mutation without FLT3 internal tandem duplication. J Clin Oncol 28, 3636-3643.
    • (2010) J Clin Oncol , vol.28 , pp. 3636-3643
    • Paschka, P.1    Schlenk, R.F.2    Gaidzik, V.I.3    Habdank, M.4    Krönke, J.5    Bullinger, L.6    Späth, D.7    Kayser, S.8    Zucknick, M.9    Götze, K.10
  • 83
    • 0025949901 scopus 로고
    • Balanced translocations involving chromosome bands 11q23 and 21q22 are highly characteristic of myelodysplasia and leukemia following therapy with cytostatic agents targeting at DNA-topoisomerase II
    • Pedersen-Bjergaard, J. and Philip, P. (1991). Balanced translocations involving chromosome bands 11q23 and 21q22 are highly characteristic of myelodysplasia and leukemia following therapy with cytostatic agents targeting at DNA-topoisomerase II. Blood 78, 1147-1148.
    • (1991) Blood , vol.78 , pp. 1147-1148
    • Pedersen-Bjergaard, J.1    Philip, P.2
  • 84
    • 84881305790 scopus 로고    scopus 로고
    • A phase 3 study of gemtuzumab ozogamicin during induction and postconsolidation therapy in younger patients with acute myeloid leukemia
    • Petersdorf, S. H., Kopecky, K. J., Slovak, M., Willman C., Nevill T., Brandwein J., Larson R. A., Erba H. P., Stiff P. J., Stuart R. K., et al. (2013). A phase 3 study of gemtuzumab ozogamicin during induction and postconsolidation therapy in younger patients with acute myeloid leukemia. Blood 121, 4854-4860.
    • (2013) Blood , vol.121 , pp. 4854-4860
    • Petersdorf, S.H.1    Kopecky, K.J.2    Slovak, M.3    Willman, C.4    Nevill, T.5    Brandwein, J.6    Larson, R.A.7    Erba, H.P.8    Stiff, P.J.9    Stuart, R.K.10
  • 85
    • 77949887020 scopus 로고    scopus 로고
    • FLT3-mutant allelic burden and clinical status are predictive of response to FLT3 inhibitors in AML
    • Pratz, K. W., Sato, T., Murphy, K. M., Stine, A., Rajkhowa, T., and Levis, M. (2010). FLT3-mutant allelic burden and clinical status are predictive of response to FLT3 inhibitors in AML. Blood 115, 1425-1432.
    • (2010) Blood , vol.115 , pp. 1425-1432
    • Pratz, K.W.1    Sato, T.2    Murphy, K.M.3    Stine, A.4    Rajkhowa, T.5    Levis, M.6
  • 86
    • 0037108111 scopus 로고    scopus 로고
    • Favorable prognostic significance of CEBPA mutations in patients with de novo acute myeloid leukemia: a study from the Acute Leukemia French Association (ALFA)
    • Preudhomme, C., Sagot, C., Boissel, N., Cayuela J. M., Tigaud I., de Botton S., Thomas X., Raffoux E., Lamandin C., Castaigne S., et al. (2002). Favorable prognostic significance of CEBPA mutations in patients with de novo acute myeloid leukemia: a study from the Acute Leukemia French Association (ALFA). Blood 100, 2717-2723.
    • (2002) Blood , vol.100 , pp. 2717-2723
    • Preudhomme, C.1    Sagot, C.2    Boissel, N.3    Cayuela, J.M.4    Tigaud, I.5    de Botton, S.6    Thomas, X.7    Raffoux, E.8    Lamandin, C.9    Castaigne, S.10
  • 87
    • 0034034557 scopus 로고    scopus 로고
    • Topoisomerase II inhibitor-related acute myeloid leukaemia
    • Pui, C. H. and Relling, M. V. (2000). Topoisomerase II inhibitor-related acute myeloid leukaemia. Br J Haematol 109, 13-23.
    • (2000) Br J Haematol , vol.109 , pp. 13-23
    • Pui, C.H.1    Relling, M.V.2
  • 88
    • 51449096670 scopus 로고    scopus 로고
    • A phase 2 clinical trial of deforolimus (AP23573, MK-8669), a novel mammalian target of rapamycin inhibitor, in patients with relapsed or refractory hematologic malignancies
    • Rizzieri, D. A., Feldman, E., Dipersio, J. F., Gabrail, N., Stock, W., Strair, R., Rivera, V. M., Albitar, M., Bedrosian, C. L., and Giles, F. J. (2008). A phase 2 clinical trial of deforolimus (AP23573, MK-8669), a novel mammalian target of rapamycin inhibitor, in patients with relapsed or refractory hematologic malignancies. Clin Cancer Res 14, 2756-2762.
    • (2008) Clin Cancer Res , vol.14 , pp. 2756-2762
    • Rizzieri, D.A.1    Feldman, E.2    Dipersio, J.F.3    Gabrail, N.4    Stock, W.5    Strair, R.6    Rivera, V.M.7    Albitar, M.8    Bedrosian, C.L.9    Giles, F.J.10
  • 89
    • 0030867644 scopus 로고    scopus 로고
    • Intensifying induction therapy in acute myeloid leukemia: has a new standard of care emerged?
    • Rowe, J. M. and Tallman, M. S. (1997). Intensifying induction therapy in acute myeloid leukemia: has a new standard of care emerged?. Blood 90, 2121-2126.
    • (1997) Blood , vol.90 , pp. 2121-2126
    • Rowe, J.M.1    Tallman, M.S.2
  • 91
    • 0035799382 scopus 로고    scopus 로고
    • Changes in DNA methylation in neoplasia: pathophysiology and therapeutic implications
    • Santini, V., Kantarjian, H. M., and Issa, J. P. (2001). Changes in DNA methylation in neoplasia: pathophysiology and therapeutic implications. Ann Intern Med 134, 573-586.
    • (2001) Ann Intern Med , vol.134 , pp. 573-586
    • Santini, V.1    Kantarjian, H.M.2    Issa, J.P.3
  • 92
    • 70350450612 scopus 로고    scopus 로고
    • Phase I/II trial of AEG35156 X-linked inhibitor of apoptosis protein antisense oligonucleotide combined with idarubicin and cytarabine in patients with relapsed or primary refractory acute myeloid leukemia
    • Schimmer, A. D., Estey, E. H., Borthakur, G., Carter B. Z., Schiller G. J., Tallman M. S., Altman J. K., Karp J. E., Kassis J., Hedley D. W., et al. (2009). Phase I/II trial of AEG35156 X-linked inhibitor of apoptosis protein antisense oligonucleotide combined with idarubicin and cytarabine in patients with relapsed or primary refractory acute myeloid leukemia. J Clin Oncol 27, 4741-4746.
    • (2009) J Clin Oncol , vol.27 , pp. 4741-4746
    • Schimmer, A.D.1    Estey, E.H.2    Borthakur, G.3    Carter, B.Z.4    Schiller, G.J.5    Tallman, M.S.6    Altman, J.K.7    Karp, J.E.8    Kassis, J.9    Hedley, D.W.10
  • 93
    • 77957771067 scopus 로고    scopus 로고
    • IDH1 mutations are detected in 6.6% of 1414 AML patients and are associated with intermediate risk karyotype and unfavorable prognosis in adults younger than 60 years and unmutated NPM1 status
    • Schnittger, S., Haferlach, C., Ulke, M., Alpermann, T., Kern, W., and Haferlach, T. (2010). IDH1 mutations are detected in 6. 6% of 1414 AML patients and are associated with intermediate risk karyotype and unfavorable prognosis in adults younger than 60 years and unmutated NPM1 status. Blood 116, 5486-5496.
    • (2010) Blood , vol.116 , pp. 5486-5496
    • Schnittger, S.1    Haferlach, C.2    Ulke, M.3    Alpermann, T.4    Kern, W.5    Haferlach, T.6
  • 95
    • 81555228423 scopus 로고    scopus 로고
    • Gene mutation pa tterns and their prognostic impact in a cohort of 1185 patients with acute myeloid leukemia
    • Shen, Y., Zhu, Y. M., Fan, X., Shi J. Y., Wang Q. R., Yan X. J., Gu Z. H., Wang Y. Y., Chen B., Jiang C. L., et al. (2011). Gene mutation pa tterns and their prognostic impact in a cohort of 1185 patients with acute myeloid leukemia. Blood 118, 5593-5603.
    • (2011) Blood , vol.118 , pp. 5593-5603
    • Shen, Y.1    Zhu, Y.M.2    Fan, X.3    Shi, J.Y.4    Wang, Q.R.5    Yan, X.J.6    Gu, Z.H.7    Wang, Y.Y.8    Chen, B.9    Jiang, C.L.10
  • 97
    • 1842420032 scopus 로고    scopus 로고
    • Single-agent CEP-701, a novel FLT3 inhibitor, shows biologic and clinical activity in patients with relapsed or refractory acute myeloid leukemia
    • Smith, B. D., Levis, M., Beran, M., Giles, F., Kantarjian, H., Berg, K., Murphy, K. M., Dauses, T., Allebach, J., and Small, D. (2004). Single-agent CEP-701, a novel FLT3 inhibitor, shows biologic and clinical activity in patients with relapsed or refractory acute myeloid leukemia. Blood 103, 3669-3676.
    • (2004) Blood , vol.103 , pp. 3669-3676
    • Smith, B.D.1    Levis, M.2    Beran, M.3    Giles, F.4    Kantarjian, H.5    Berg, K.6    Murphy, K.M.7    Dauses, T.8    Allebach, J.9    Small, D.10
  • 98
    • 0029929429 scopus 로고    scopus 로고
    • The secondary leukemias: challenges and research directions
    • Smith, M. A., McCaffrey, R. P., and Karp, J. E. (1996). The secondary leukemias: challenges and research directions. J Natl Cancer Inst 88, 407-418.
    • (1996) J Natl Cancer Inst , vol.88 , pp. 407-418
    • Smith, M.A.1    McCaffrey, R.P.2    Karp, J.E.3
  • 99
    • 0037097716 scopus 로고    scopus 로고
    • Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: association with FAB subtypes and identification of subgroups with poor prognosis
    • Thiede, C., Steudel, C., Mohr, B., Schaich M., Schäkel U., Platzbecker U., Wermke M., Bornhäuser M., Ritter M., Neubauer A., et al. (2002). Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: association with FAB subtypes and identification of subgroups with poor prognosis. Blood 99, 4326-4335.
    • (2002) Blood , vol.99 , pp. 4326-4335
    • Thiede, C.1    Steudel, C.2    Mohr, B.3    Schaich, M.4    Schäkel, U.5    Platzbecker, U.6    Wermke, M.7    Bornhäuser, M.8    Ritter, M.9    Neubauer, A.10
  • 100
    • 0026650021 scopus 로고
    • A phase III trial comparing idarubicin and daunorubicin in combination with cytarabine in acute myelogenous leukemia: a Southeastern Cancer Study Group Study
    • Vogler, W. R., Velez-Garcia, E., Weiner, R. S., Flaum, M. A., Bartolucci, A. A., Omura, G. A., Gerber, G. A., and Banks, P. L. (1992). A phase III trial comparing idarubicin and daunorubicin in combination with cytarabine in acute myelogenous leukemia: a Southeastern Cancer Study Group Study. J Clin Oncol 10, 1103-1111.
    • (1992) J Clin Oncol , vol.10 , pp. 1103-1111
    • Vogler, W.R.1    Velez-Garcia, E.2    Weiner, R.S.3    Flaum, M.A.4    Bartolucci, A.A.5    Omura, G.A.6    Gerber, G.A.7    Banks, P.L.8
  • 101
    • 0034773058 scopus 로고    scopus 로고
    • Prognostic significance of risk group stratification in elderly patients with acute myeloid leukaemia
    • Wahlin, A., Markevärn, B., Golovleva, I., and Nilsson, M. (2001). Prognostic significance of risk group stratification in elderly patients with acute myeloid leukaemia. Br J Haematol 115, 25-33.
    • (2001) Br J Haematol , vol.115 , pp. 25-33
    • Wahlin, A.1    Markevärn, B.2    Golovleva, I.3    Nilsson, M.4
  • 102
    • 43449138516 scopus 로고    scopus 로고
    • Effects of the aurora kinase inhibitors AZD1152-HQPA and ZM447439 on growth arrest and polyploidy in acute myeloid leukemia cell lines and primary blasts
    • Walsby, E., Walsh, V., Pepper, C., Burnett, A., and Mills, K. (2008). Effects of the aurora kinase inhibitors AZD1152-HQPA and ZM447439 on growth arrest and polyploidy in acute myeloid leukemia cell lines and primary blasts. Haematologica 93, 662-669.
    • (2008) Haematologica , vol.93 , pp. 662-669
    • Walsby, E.1    Walsh, V.2    Pepper, C.3    Burnett, A.4    Mills, K.5
  • 103
    • 77649305610 scopus 로고    scopus 로고
    • The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alphaketoglutarate to 2-hydroxyglutarate
    • Ward, P. S., Patel, J., Wise, D. R., Abdel-Wahab O., Bennett B. D., Coller H. A., Cross J. R., Fantin V. R., Hedvat C. V., Perl A. E., et al. (2010). The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alphaketoglutarate to 2-hydroxyglutarate. Cancer Cell 17, 225-234.
    • (2010) Cancer Cell , vol.17 , pp. 225-234
    • Ward, P.S.1    Patel, J.2    Wise, D.R.3    Abdel-Wahab, O.4    Bennett, B.D.5    Coller, H.A.6    Cross, J.R.7    Fantin, V.R.8    Hedvat, C.V.9    Perl, A.E.10
  • 104
    • 10244249096 scopus 로고    scopus 로고
    • A randomized investi gation of high-dose versus standard-dose cytosine arabinoside with daunorubicin in patients with previously untreated acute myeloid leukemia: a Southwest Oncology Group study
    • Weick, J. K., Kopecky, K. J., Appelbaum, F. R., Head D. R., Kingsbury L. L., Balcerzak S. P., Bickers J. N., Hynes H. E., Welborn J. L., Simon S. R., et al. (1996). A randomized investi gation of high-dose versus standard-dose cytosine arabinoside with daunorubicin in patients with previously untreated acute myeloid leukemia: a Southwest Oncology Group study. Blood 88, 2841-2851.
    • (1996) Blood , vol.88 , pp. 2841-2851
    • Weick, J.K.1    Kopecky, K.J.2    Appelbaum, F.R.3    Head, D.R.4    Kingsbury, L.L.5    Balcerzak, S.P.6    Bickers, J.N.7    Hynes, H.E.8    Welborn, J.L.9    Simon, S.R.10
  • 105
    • 0026586008 scopus 로고
    • Cytarabine plus idarubicin or daunorubicin as induction and consolidation therapy for previously untreated adult patients with acute myeloid leukemia
    • Wiernik, P. H., Banks, P. L., Case, D. C., Arlin, Z. A., Periman, P. O., Todd, M. B., Ritch, P. S., Enck, R. E., and Weitberg, A. B. (1992). Cytarabine plus idarubicin or daunorubicin as induction and consolidation therapy for previously untreated adult patients with acute myeloid leukemia. Blood 79, 313-319.
    • (1992) Blood , vol.79 , pp. 313-319
    • Wiernik, P.H.1    Banks, P.L.2    Case, D.C.3    Arlin, Z.A.4    Periman, P.O.5    Todd, M.B.6    Ritch, P.S.7    Enck, R.E.8    Weitberg, A.B.9
  • 106
    • 33745909399 scopus 로고    scopus 로고
    • Inhibition of the phosphatidylinositol 3-kinase/mammalian target of rapamycin pathway in hematologic malignancies
    • Witzig, T. E. and Kaufmann, S. H. (2006). Inhibition of the phosphatidylinositol 3-kinase/mammalian target of rapamycin pathway in hematologic malignancies. Curr Treat Options Oncol 7, 285-294.
    • (2006) Curr Treat Options Oncol , vol.7 , pp. 285-294
    • Witzig, T.E.1    Kaufmann, S.H.2
  • 108
    • 34548822673 scopus 로고    scopus 로고
    • AZD1152, a novel and selective aurora B kinase inhibitor, induces growth arrest, apoptosis, and sensitization for tubulin depolymerizing agent or topoisomerase II inhibitor in human acute leukemia cells in vitro and in vivo
    • Yang, J., Ikezoe, T., Nishioka, C., Tasaka T., Taniguchi A., Kuwayama Y., Komatsu N., Bandobashi K., Togitani K., Koeffler H. P., et al. (2007). AZD1152, a novel and selective aurora B kinase inhibitor, induces growth arrest, apoptosis, and sensitization for tubulin depolymerizing agent or topoisomerase II inhibitor in human acute leukemia cells in vitro and in vivo. Blood 110, 2034-2040.
    • (2007) Blood , vol.110 , pp. 2034-2040
    • Yang, J.1    Ikezoe, T.2    Nishioka, C.3    Tasaka, T.4    Taniguchi, A.5    Kuwayama, Y.6    Komatsu, N.7    Bandobashi, K.8    Togitani, K.9    Koeffler, H.P.10
  • 110
    • 33749002279 scopus 로고    scopus 로고
    • Phase I/II study of t he mammalian target of rapamycin inhibitor everolimus (RAD001) in patients with relapsed or refractory hematologic malignancies
    • Yee, K. W., Zeng, Z., Konopleva, M., Verstovsek S., Ravandi F., Ferrajoli A., Thomas D., Wierda W., Apostolidou E., Albitar M., et al. (2006). Phase I/II study of t he mammalian target of rapamycin inhibitor everolimus (RAD001) in patients with relapsed or refractory hematologic malignancies. Clin Cancer Res 12, 5165-5173.
    • (2006) Clin Cancer Res , vol.12 , pp. 5165-5173
    • Yee, K.W.1    Zeng, Z.2    Konopleva, M.3    Verstovsek, S.4    Ravandi, F.5    Ferrajoli, A.6    Thomas, D.7    Wierda, W.8    Apostolidou, E.9    Albitar, M.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.