The thiol proteinase inhibitor E-64-d ameliorates amyloid-β-induced reduction of sAPPα secretion by reversing ceramide-induced protein kinase C down-regulation in SH-SY5Y neuroblastoma cells

Biochemical and Biophysical Research Communications

Volumn 441, Issue 1, 2013, Pages 256-261

  Tanabe, Fuminori ^a   Nakajima, Tomoko ^a   Ito, Masahiko ^a  

^a UNIVERSITY OF YAMANASHI   (Japan)

Author keywords

Alzheimer's disease; Amyloid precursor protein; Calpain; Ceramide; Protein kinase C

Indexed keywords

ALOXISTATIN; ALPHA SECRETASE; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; CARBACHOL; CERAMIDE; CERAMIDE DERIVATIVE; PROTEIN KINASE C; PROTEIN KINASE C ALPHA; PROTEIN KINASE C BETA; PROTEIN KINASE C BETA1; PROTEIN KINASE C BETA2; SOLUBLE AMYLOID PRECURSOR PROTEIN ALPHA; SPHINGOMYELIN PHOSPHODIESTERASE; UNCLASSIFIED DRUG; ALPHA-SAPP PROTEIN, HUMAN; ISOENZYME; LEUCINE; N [N (3 CARBOXYOXIRANE 2 CARBONYL)LEUCYL]AGMATINE; PEPTIDE FRAGMENT; PROTEINASE INHIBITOR; SPHINGOLIPID;

ARTICLE; CELL DIFFERENTIATION; CELL MEMBRANE PERMEABILITY; CELL STIMULATION; CONTROLLED STUDY; ENZYME ACTIVITY; HUMAN; HUMAN CELL; NEUROBLASTOMA CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN PROCESSING; PROTEIN SECRETION; RECEPTOR DOWN REGULATION; TUMOR CELL LINE; ANALOGS AND DERIVATIVES; DOWN REGULATION; DRUG EFFECTS; ENZYMOLOGY; METABOLISM; NEUROBLASTOMA; PATHOLOGY; SECRETION (PROCESS);

AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; CELL LINE, TUMOR; CELL MEMBRANE PERMEABILITY; CERAMIDES; DOWN-REGULATION; HUMANS; ISOENZYMES; LEUCINE; NEUROBLASTOMA; PEPTIDE FRAGMENTS; PROTEASE INHIBITORS; PROTEIN KINASE C; SPHINGOLIPIDS; SPHINGOMYELIN PHOSPHODIESTERASE;

EID: 84887503490     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2013.10.045     Document Type: Article

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