Evidence supporting the role of calpain in the α-processing of amyloid-β precursor protein

Biochemical and Biophysical Research Communications

Volumn 420, Issue 3, 2012, Pages 530-535

  Nguyen, Huey T ^a   Sawmiller, Darrell R ^a   Wu, Qi ^a   Maleski, Jerome J ^a   Chen, Ming ^a,b  

^a Bay Pines VA Medical Center   (United States)

^b UNIVERSITY OF SOUTH FLORIDA   (United States)

Author keywords

Aging; Alzheimer's disease; Amyloid; Calcium; Calpain

Indexed keywords

AMYLOID PRECURSOR PROTEIN; CALPAIN; CALPAIN 1; CALPEPTIN; CELL SURFACE PROTEIN; GLUTAMIC ACID; NICOTINE; PHORBOL 12,13 DIBUTYL ESTER; PHORBOL DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BIOTINYLATION; CELL STIMULATION; CELL STRAIN HEK293; CELL SURFACE; CONTROLLED STUDY; ENZYME ACTIVITY; GENE EXPRESSION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; INTRACELLULAR MEMBRANE; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN PROCESSING; PROTEIN SECRETION; UBIQUITINATION; WILD TYPE;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; BIOTINYLATION; CALPAIN; CELL MEMBRANE; GENETIC VECTORS; GLUTAMIC ACID; HEK293 CELLS; HUMANS; NICOTINE; PHORBOL 12,13-DIBUTYRATE; SUBSTRATE SPECIFICITY;

EID: 84859583347     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2012.03.026     Document Type: Article

References (40)

1. Selkoe D.J. Cell biology of protein misfolding: the examples of Alzheimer's and Parkinson's diseases. Nat. Cell Biol. 2004, 6:1054-1061.
2. Kang J., Lemaire H.G., Unterbeck A., et al. The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor. Nature 1987, 325:733-736.
3. Palmert M.R., Usiak M., Mayeux R., et al. Soluble derivatives of the beta amyloid protein precursor in cerebrospinal fluid: alterations in normal aging and in Alzheimer's disease. Neurology 1990, 40:1028-1034.
4. Lannfelt L., Basun H., Wahlund L.O., et al. Decreased alpha-secretase-cleaved amyloid precursor protein as a diagnostic marker for Alzheimer's disease. Nat. Med. 1995, 1:829-832.
5. Savage M.J., Trusko S.P., Howland D.S., et al. Turnover of amyloid beta-protein in mouse brain and acute reduction of its level by phorbol ester. J. Neurosci. 1998, 18:1743-1752.
6. Jacobsen J.S., Spruyt M.A., Brown A.M., et al. Sonnenberg-Reines, The release of Alzheimer's disease beta amyloid peptide is reduced by phorbol treatment. J. Biol. Chem. 1994, 269:8376-8382.
7. Hung A.Y., Selkoe D.J. Selective ectodomain phosphorylation and regulated cleavage of beta-amyloid precursor protein. EMBO J. 1994, 13:534-542.
8. Chen M. Alzheimer's a-secretase may be a calcium-dependent protease. FEBS Lett. 1997, 417:163-167.
9. Chen M., Fernandez H.L. Where do Alzheimer's plaques and tangles come from? Aging-induced protein degradation inefficiency. Front. Biosci. 2001, 6:e1-e11.
10. Buxbaum J.D., Liu K.N., Slack J.L., et al. Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor. J. Biol. Chem. 1998, 273:27765-27767.
11. Lammich S., Kojro E., Postina R., et al. Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease. Proc. Natl. Acad. Sci. USA 1999, 96:3922-3927.
12. Lichtenthaler S.F. Alpha-secretase in Alzheimer's disease: molecular identity, regulation and therapeutic potential. J. Neurochem. 2011, 116:10-21.
13. Chen M., Durr J., Fernandez H.L. Possible role of calpain in normal processing of Alzheimer's beta-amyloid precursor protein in human platelets. Biochem. Biophys. Res. Commun. 2000, 273:170-175.
14. Chen M., Fernandez H.L. Stimulation of beta-amyloid precursor protein alpha-processing by phorbol ester involves calcium and calpain activation. Biochem. Biophys. Res. Commun. 2004, 316:332-340.
15. Chen M., Fernandez H.L. μ-Calpain is functionally required for alpha-processing of Alzheimer's beta-amyloid precursor protein. Biochem. Biophys. Res. Commun. 2005, 330:714-721.
16. Goll D.E., Thompson V.F., Li H., et al. The calpain system. Physiol. Rev. 2003, 83:731-801.
17. Vosler P.S., Brennan C.S., Chen J. Calpain-mediated signaling mechanisms in neuronal injury and neurodegeneration. Mol. Neurobiol. 2008, 38:78-100.
18. Bánóczi Z., Alexa A., Farkas A., et al. Novel cell-penetrating calpain substrate. Bioconjug. Chem. 2008, 19:1375-1381.
19. Towbin H., Staehelin T., Gordon J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc. Natl. Acad. Sci. USA 1979, 76:4350-4354.
20. Kim S.H., Kim Y.K., Jeong S.J., et al. Enhanced release of secreted form of Alzheimer's amyloid precursor protein from PC12 cells by nicotine. Mol. Pharmacol. 1997, 52:430-436.
21. Jolly-Tornetta C., Gao Z.Y., Lee V.M., Wolf B.A. Regulation of amyloid precursor protein secretion by glutamate receptors in human Ntera 2 neurons. J. Biol. Chem. 1998, 273:14015-14021.
22. Grandin N., Charbonneau M. Intracellular pH and intracellular free calcium responses to protein kinase C activators and inhibitors in Xenopus eggs. Development 1991, 112:461-470.
23. McGowan E.B., Yeo K.T., Detwiler T.C. The action of calcium-dependent protease on platelet surface glycoproteins. Arch. Biochem. Biophys. 1983, 227:287-301.
24. Schmaier A.H., Bradford H.N., et al. Membrane expression of platelet calpain. Blood 1990, 75:1273-1281.
25. Li Q.X., Evin G., Small D.H., Multhaup G., Beyreuther K., Masters C.L. Proteolytic processing of Alzheimer's disease beta A4 amyloid precursor protein in human platelets. J. Biol. Chem. 1995, 270:14140-14147.
26. Chen M., Fernandez H.L. The Alzheimer's plaques, tangles and memory deficits may have a common origin. Part IV: can calpain act as α-secretase?. Front. Biosci. 1998, 3:a66-a75.
27. Guttmann R.P., Johnson G.V. Oxidative stress inhibits calpain activity in situ. J Biol Chem. 1998, 273:13331-13338.
28. Gabuzda D., Busciglio J., Chen L.B., et al. Inhibition of energy metabolism alters the processing of amyloid precursor protein and induces a potentially amyloidogenic derivative. J. Biol. Chem. 1994, 269:13623-13628.
29. Kishimoto A., Mikawa K., Hashimoto K., et al. Limited proteolysis of protein kinase C subspecies by calcium-dependent neutral protease (calpain). J. Biol. Chem. 1989, 264:4088-4092.
30. Evans J.S., Turner M.D. Emerging functions of the calpain superfamily of cysteine proteases in neuroendocrine secretory pathways. J. Neurochem 2007, 103:849-859.
31. Hajimohammadreza I., Anderson V.E., Cavanagh J.B., et al. beta-Amyloid precursor protein fragments and lysosomal dense bodies are found in rat brain neurons after ventricular infusion of leupeptin. Brain Res. 1994, 640:25-32.
32. Frautschy S.A., Horn D.L., Sigel J.J., et al. Protease inhibitor coinfusion with amyloid beta-protein results in enhanced deposition and toxicity in rat brain. J. Neurosci. 1998, 188311-188321.
33. Nixon R.A. Calcium-activated neutral proteinases as regulators of cellular function. Implications for Alzheimer's disease pathogenesis. Ann. N. Y. Acad. Sci. 1989, 568:198-208.
34. Sihag R.K., Cataldo A.M. Brain beta-spectrin is a component of senile plaques in Alzheimer's disease. Brain Res. 1996, 743:249-257.
35. David L.L., Shearer T.R., Shih M. Sequence analysis of lens beta-crystallins suggests involvement of calpain in cataract formation. J. Biol. Chem. 1993, 268:1937-1940.
36. Buxbaum J.D., Ruefli A.A., Parker C.A., et al. Calcium regulates processing of the Alzheimer amyloid protein precursor in a protein kinase C-independent manner. Proc. Natl. Acad. Sci. USA 1994, 91:4489-4493.
37. Wolf B.A., Wertkin A.M., Jolly Y.C., et al. Muscarinic regulation of Alzheimer's disease amyloid precursor protein secretion and amyloid beta-protein production in human neuronal NT2N cells. J. Biol. Chem. 1995, 270:4916-4922.
38. Khachaturian Z.S. Calcium hypothesis of Alzheimer's disease and brain ageing. Ann. N. Y. Acad. Sci. 1994, 747:1-11.
39. 2+ signaling. J. Alzheimer's Dis. 2011, 27:3-10.
40. Chen M., Maleski J.J., Sawmiller D.R. Scientific truth or false hope? Understanding Alzheimer's disease from an aging perspective. J. Alzheimer's Dis. 2011, 24:3-10.