Korean red ginseng extract induces proliferation to differentiation transition of human acute promyelocytic leukemia cells via MYC-SKP2-CDKN1B axis

Journal of Ethnopharmacology

Volumn 150, Issue 2, 2013, Pages 700-707

  Jo, Sungsin ^a   Lee, Hongki ^a   Kim, Sojin ^a,b   Lee, Chang Ho ^a   Chung, Heekyoung ^a  

^a Hanyang University   (South Korea)

^b Yonsei University Wonju   (South Korea)

Author keywords

Acute promyelocytic leukemia (APL); CDKN1B; Differentiation; Korean red ginseng extract (KRGE); SKP2

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 1B; CYCLOHEXIMIDE; GINSENG EXTRACT; GINSENOSIDE RB 1; GINSENOSIDE RB 2; GINSENOSIDE RE; GINSENOSIDE RG 1; MYC PROTEIN; RETINOIC ACID; S PHASE KINASE ASSOCIATED PROTEIN 2;

ANTINEOPLASTIC ACTIVITY; ARTICLE; ASIA; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; DRUG MECHANISM; GENE INDUCTION; GENE OVEREXPRESSION; GINSENG; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PROMYELOCYTIC LEUKEMIA; PROTEIN DEGRADATION; TRADITIONAL MEDICINE;

PANAX GINSENG;

ACUTE MYELOID LEUKEMIA; ACUTE PROMYELOCYTIC LEUKEMIA; ACUTE PROMYELOCYTIC LEUKEMIA (APL); ALL-TRANS RETINOIC ACID; AML; APL; ARSENIC TRIOXIDE; ATO; ATRA; BOVINE SERUM ALBUMIN; BSA; CDKN1B; CHX; CYCLOHEXIMIDE; DIFFERENTIATION; FBS; FETAL BOVINE SERUM; KOREAN RED GINSENG EXTRACT; KOREAN RED GINSENG EXTRACT (KRGE); KRGE; NBT; NITRO BLUE TETRAZOLIUM; P/D TRANSITION; PBS; PCR; PHOSPHATE-BUFFERED SALINE; PML-RARA; POLYMERASE CHAIN REACTION; PROLIFERATION/DIFFERENTIATION TRANSITION; PROMYELOCYTIC LEUKEMIA-RETINOIC ACID RECEPTOR ALPHA; REVERSE TRANSCRIPTION- POLYMERASE CHAIN REACTION; RT-PCR; SKP2; WATER-SOLUBLE TETRAZOLIUM SALT; WST;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; CELL DIFFERENTIATION; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLIN-DEPENDENT KINASE INHIBITOR P27; DOWN-REGULATION; HUMANS; LEUKEMIA, PROMYELOCYTIC, ACUTE; PANAX; PLANT EXTRACTS; PROTO-ONCOGENE PROTEINS C-MYC; S-PHASE KINASE-ASSOCIATED PROTEINS;

EID: 84887501803     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2013.09.036     Document Type: Article

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