In vitro characterization of ABC transporters involved in the absorption and distribution of liensinine and its analogs

Journal of Ethnopharmacology

Volumn 150, Issue 2, 2013, Pages 485-491

  Yu, Lushan ^a   Shen, Qi ^a   Zhou, Quan ^a   Jiang, Huidi ^a   Bi, Huichang ^b   Huang, Min ^b   Zhou, Hui ^a   Zeng, Su ^a  

^a ZHEJIANG UNIVERSITY   (China)

^b SUN YAT SEN UNIVERSITY   (China)

Author keywords

Cellular accumulation; Liensinine; MDR associated protein 2; P glycoprotein; Transcellular transport

Indexed keywords

ABC TRANSPORTER; CYCLOSPORIN A; ELACRIDAR; ISOLIENSININE; LIENSININE; MULTIDRUG RESISTANCE PROTEIN; MULTIDRUG RESISTANCE PROTEIN 2; NATURAL PRODUCT; NEFERINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL STRAIN CACO 2; CHINESE MEDICINE; CONCENTRATION RESPONSE; DRUG ABSORPTION; DRUG ACCUMULATION; DRUG DISTRIBUTION; HUMAN; HUMAN CELL; IN VITRO STUDY; INTRACELLULAR TRANSPORT; MDCK CELL; NONHUMAN;

NELUMBO NUCIFERA; NYMPHAEACEAE;

AP; APICAL SIDE; APPARENT PERMEABILITY COEFFICIENT; BASOLATERAL SIDE; BL; CALCEIN ACETOXYMETHYL ESTER; CALCEIN AM; CELLULAR ACCUMULATION; CSA; CYCLOSPORIN A; EFFLUX RATIO; ER; GF120918; LIENSININE; MADIN-DARBY CANINE KIDNEY CELL LINE; MDCK; MDR-ASSOCIATED PROTEIN 2; MDR1; MRP2; N-(4-[2-(1,2,3,4-TETRAHYDRO-6,7-DIMETHOXY-2-ISOQUINOLINYL)ETHYL]-PHENYL)-9,10-DIHYDRO-5-METHOXY-9-OXO-4-ACRIDINE CARBOXAMIDE; NER; NET EFFLUX RATIO; P(APP); P-GLYCOPROTEIN; P-GP; REVERSE MULTIDRUG RESISTANCE 1; RHO-123; RHODAMINE 123; TEER; TRANSCELLULAR TRANSPORT; TRANSEPITHELIAL ELECTRICAL RESISTANCE;

ABSORPTION; ANIMALS; BENZYLISOQUINOLINES; BIOLOGICAL TRANSPORT; CACO-2 CELLS; CELL SURVIVAL; DOGS; HUMANS; ISOQUINOLINES; MADIN DARBY CANINE KIDNEY CELLS; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; P-GLYCOPROTEIN; PHENOLS;

EID: 84887479188     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2013.08.061     Document Type: Article

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