The two enantiomers of tetrahydropalmatine are inhibitors of P-gp, but not inhibitors of MRP1 or BCRP

Xenobiotica

Volumn 42, Issue 12, 2012, Pages 1197-1205

  Sun, Siyuan ^a   Chen, Zhongjian ^a   Li, Liping ^a   Sun, Dongli ^a   Tian, Ye ^a   Pan, Hao ^a   Bi, Huichang ^b   Huang, Min ^b   Zeng, Su ^a   Jiang, Huidi ^a  

^a ZHEJIANG UNIVERSITY   (China)

^b SUN YAT SEN UNIVERSITY   (China)

Author keywords

ABC transporter; P gp; Stereoselective; Tetrahydropalmatine

Indexed keywords

ABC TRANSPORTER; BREAST CANCER RESISTANCE PROTEIN; CALCEIN; DOXORUBICIN; ELACRIDAR; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN; MULTIDRUG RESISTANCE PROTEIN 1; RHODAMINE 123; ROSUVASTATIN; TETRAHYDROPALMATINE;

ANIMAL CELL; ARTICLE; CANCER CHEMOTHERAPY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORYDALIS; CYTOTOXICITY TEST; DRUG PROTEIN BINDING; ENANTIOMER; IC 50; IN VITRO STUDY; MULTIDRUG RESISTANCE; NONHUMAN; PERMEABILITY; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STEREOCHEMISTRY; TUMOR CELL;

ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; BERBERINE ALKALOIDS; BIOLOGICAL TRANSPORT; DOGS; DRUG RESISTANCE, MULTIPLE; FLUORESCEINS; FLUOROBENZENES; GENE EXPRESSION REGULATION; HUMANS; INTRACELLULAR SPACE; K562 CELLS; LLC-PK1 CELLS; MADIN DARBY CANINE KIDNEY CELLS; MCF-7 CELLS; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; P-GLYCOPROTEIN; PYRIMIDINES; RHODAMINE 123; RNA, MESSENGER; STEREOISOMERISM; SULFONAMIDES; SWINE;

CORYDALIS;

EID: 84868611850     PISSN: 00498254     EISSN: 13665928     Source Type: Journal    
DOI: 10.3109/00498254.2012.702247     Document Type: Article

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