Transport characteristics of zolmitriptan in a human intestinal epithelial cell line Caco-2

Journal of Pharmacy and Pharmacology

Volumn 59, Issue 5, 2007, Pages 655-660

  Yu, Lushan ^a   Zeng, Su ^a  

^a ZHEJIANG UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ATENOLOL; CETIRIZINE; CIMETIDINE; FLUNARIZINE; GLYCOPROTEIN P; NIFEDIPINE; NIMODIPINE; PROPRANOLOL; SEROTONIN 1D AGONIST; SODIUM; VERAPAMIL; ZOLMITRIPTAN;

ARTICLE; CELL STRAIN CACO 2; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG INHIBITION; DRUG PENETRATION; DRUG POTENTIATION; DRUG TRANSPORT; EFFUSION; HUMAN; HUMAN CELL; IN VITRO STUDY; INTESTINE ABSORPTION; INTESTINE EPITHELIUM CELL; INTESTINE MUCOSA; MIGRAINE;

ASPIRIN; ATENOLOL; BIOLOGICAL AVAILABILITY; BIOLOGICAL TRANSPORT; CACO-2 CELLS; CETIRIZINE; CIMETIDINE; DIFFUSION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; FLUNARIZINE; HUMANS; HYDROGEN-ION CONCENTRATION; INTESTINAL ABSORPTION; INTESTINAL MUCOSA; OXAZOLIDINONES; P-GLYCOPROTEIN; PERMEABILITY; PROPRANOLOL; SEROTONIN AGONISTS; SODIUM-HYDROGEN ANTIPORTER; TRYPTAMINES;

EID: 34447336731     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/jpp.59.5.0005     Document Type: Article

References (27)

1. Artursson, P., Karlsson, J. (1991) Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells. Biochem. Biophys. Res. Commun. 175: 880-885
2. 2+)-entry blockers, neuroleptics and local anaesthetics on P-glycoprotein-mediated vincristine resistance of L1210/VCR mouse leukaemic cell line. Drugs Exp. Clin. Res. 20: 13-18
3. Chen, C., Hanson, E., Watson, J. W., Lee, J. S. (2003) P-glycoprotein limits the brain penetration of nonsedating but not sedating H1-antagonists. Drug Metab. Dispos. 31: 312-318
4. Doherty, M. M., Charman, W. N. (2002) The mucosa of the small intestine: how clinically relevant as an organ of drug metabolism? Clin. Pharmacokinet. 41: 235-253
5. Evans, D. C., O'Connor, D., Lake, B. G. (2003) Eletriptan metabolism by human hepatic CYP450 enzymes and transport by human P-glycoprotein. Drug Metab. Dispos. 31: 861-869
6. Food and Drug Administration (2004) Drug interaction studies: study design, data analysis, and implications for dosing and labeling. CDER, Department of Health and Human Services, CBER, FDA
7. He, L., Liu, G. Q. (2002) Effects of various principles from Chinese herbal medicine on rhodamine123 accumulation in brain capillary endothelial cells. Acta Pharmacol. Sin. 23: 591-596
8. Hidalgo, I. J., Li, J. (1996) Carrier-mediated transport and efflux mechanisms in Caco-2 cells. Adv. Drug Deliv. Res. 22: 53-66
9. Hidalgo, I. J., Raub, T. J., Borchardt, R. T. (1989) Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability. Gastroenterology 96: 736-749
10. Hootman, S. R., Hobbs, E. C., Luckie, D. B. (2005) Direct measurement of acid efflux from isolated guinea pig pancreatic ducts. Pancreas 30: 363-368
11. Karlsson, J., Kuo, S. M., Ziemniak, J., Artursson, P. (1993) Transport of celiprolol across human intestinal epithelial (Caco-2) cells: mediation of secretion by multiple transporters including P-glycoprotein. Br. J. Pharmacol. 110: 1009-1016
12. Kim, R. B., Wandel, C., Leake, B. (1999) Interrelationship between substrates and inhibitors of human CYP3A and P-glycoprotein. Pharm. Res. 16: 408-414
13. Liu, X. D., Pan, G. Y., Xie, L., Hou, Y. Y., Lan, W., Su, Q., Liu, G. Q. (2002) Cyclosporin A enhanced protection of nimodipine against brain damage induced by hypoxia-ischemia in mice and rats. Acta Pharmacol. Sin. 23: 225-229
14. Peck, R. W., Seaber, E. J., Dixon, R., Gillotin, C. G., Weatherley, B. C., Layton, G., Posner, J. (1997) The interaction between propranolol and the novel antimigraine agent zolmitriptan (311C90). Br. J. Clin. Pharmacol. 44: 595-599
15. Polli, J. W., Wring, S. A., Humphreys, J. E., Huang, L., Morgan, J. B., Webster, L. O., Serabjit-Singh, C. S. (2001) Rational use of in vitro P-glycoprotein assays in drug discovery. J. Pharmacol. Exp. Ther. 299: 620-628
16. Polli, J. W., Baughman, T. M., Humphreys, J. E., Jordan, K. H., Mote, A. L., Salisbury, J. A., Tippin, T. K., Serabjit-Singh, C. J. (2003) P-glycoprotein influences the brain concentrations of cetirizine (Zyrtec), a second-generation non-sedating antihistamine. J. Pharm. Sci. 92: 2082-2089
17. Rolan, P. (1997) Potential drug interaction with the novel anti-migraine compound zolmitriptan (zomig, 311c90). Cephalalgia 18: 21-27
18. Schoenen, J., Sawyer, J. (1997) Zolmitriptan (Zomig, 311C90), a novel dual central and peripheral 5HT1B/1D agonist: an overview of efficacy. Cephalalgia 17: 28-40
19. Seaber, E., On, N., Phillips, S., Churchus, R., Posner, J., Rolan, P. (1996) The tolerability and pharmacokinetics of the novel antimigraine compound 311C90 in healthy male volunteers. Br. J. Clin. Pharmacol. 41: 141-147
20. Tsuji, A., Takanaga, H. (1994) Transcellular transport of benzoic acid across Caco-2 cells by a pH-dependent and carrier-mediated transport mechanism. Pharm. Res. 11: 30-37
21. Walgren, R. A., Walle, U. K., Walle, T. (1998) Transport of quercetin and its glucosides across human intestinal epithelial Caco-2 cells. Biochem. Pharmacol. 55: 1721-1727
22. Walle, U. K., Walle, T. (1998) Taxol transport by human intestinal epithelial Caco-2 cells. Drug Metab. Dispos. 26: 343-346
23. + exchanger from Caco-2 cells, a human intestinal cell line. Am. J. Physiol. 261: G229-G238
24. Whale, R., Bhagwagar, Z., Cowen P. J. (1999) Zolmitriptan-induced growth hormone release in humans: mediation by 5-HT1D receptors? Psychopharmacology (Berl.) 145: 223-226
25. Yu, L. S., Yao, T. W., Zeng, S. (2003) In vitro metabolism of zolmitriptan in rat cytochromes induced with β-naphthoflavone and the interaction between six drugs and zolmitriptan. Chem. Biol. Interact. 146: 263-272
26. Yu, L. S., Zhao, N. P., Yao, T. W., Zeng, S. (2006) Zolmitripan uptake by human intestinal epithelial Caco-2 cells. Pharmazie 61: 862-865
27. Zhang, L., Liu, X. D., Xie, L., Wang, G. J. (2003) P-glycoprotein restricted transport of nimodipine across blood-brain barrier. Acta Pharmacol. Sin. 24: 903-906