Effect of neferine on the chemotherapic sensitivity of STI 571 to K562/A02 cells

Journal of Central South University (Medical Sciences)

Volumn 30, Issue 5, 2005, Pages 558-561

  Xiao, Xi Bin ^a   Xie, Zhao Xia ^a   Chen, Jie ^b   Qin, Qun ^a   Zhu, Yan ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

^b SUN YAT SEN UNIVERSITY   (China)

Author keywords

Gene, bcr abl; K562 A02; Multi drug resistance; Neferine; STI 571

Indexed keywords

GLYCOPROTEIN P; IMATINIB; MESSENGER RNA; NEFERINE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CHEMOTHERAPY; CELL PROLIFERATION; CONTROLLED STUDY; CYTOTOXICITY; GENE; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HUMAN TISSUE; IC 50; MDR1 GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STATISTICAL SIGNIFICANCE; TRANSCRIPTION REGULATION; WESTERN BLOTTING;

EID: 28144464339     PISSN: 16727347     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (11)

1. Goldman JM, Melo JV. Targeting the BCR-ABL tyrosine kinase in chronic myeloid leukemia[J]. N Engl J Med, 2001, 344(14):1084-1086.
2. Thiesing JT, Jones O, Kolibaba KS, et al. Efficacy of STI 571, an abl tyrosine kinase inhibitor, in conjunction with other antileukemic agents against bcr-abl- positive cells[J]. Blood, 2000, 96(9):3195-3199.
3. Mahon FX, Deininger MW, Schultheis B, et al. Selection and characterization of BCR-ABL positive cell lines with differential sensitivity to the tyrosine kinase inhibitor STI 571: diverse mechanisms of resistance[J]. Blood, 2000, 96(3):1070-1079.
4. le Coutre P, Tassi E, Varella-Garcia M, et al. Induction of resistance to the abelson inhibitor STI 571 in human leukemic cells through gene amplification[J]. Blood, 2000, 95(5):1758-1766.
5. Gorre ME, Mohammed M, Ellwood K, et al. Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification [J]. Science, 2001, 293(5531):876-880.
6. Druker BJ, Talpaz M, Resta DJ, et al. Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myleoid leukemia[J]. N Engl J Med, 2001, 344(14):1031-1037.
7. Yang CZ, Luan FJ, Xiong DS, et al. Multidrug resistance in leukemic cell line K562/A02 induced by doxorubicin[J]. Zhongguo Yao Li Xue Bao, 1995, 16(4):333-337.