Fragmentation study on the phenolic alkaloid neferine and its analogues with anti-HIV activities by electrospray ionization tandem mass spectrometry with hydrogen/deuterium exchange and its application for rapid identification of in vitro microsomal metabolites of neferine

Rapid Communications in Mass Spectrometry

Volumn 21, Issue 13, 2007, Pages 2120-2128

  Zhou, Hui ^a   Jiang, Huidi ^a   Yao, Tongwei ^a   Zeng, Su ^a  

^a ZHEJIANG UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALOIDS; BIOMOLECULES; DRUG PRODUCTS; ELECTRODEPOSITION; ELECTROSPRAY IONIZATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLISM;

ANTI-HIV ACTIVITY; ELECTROSPRAY IONIZATION TANDEM MASS SPECTROMETRY; ESI-MS-MS; FRAGMENTATIONS PATTERN; HYDROGEN/DEUTERIUM EXCHANGE; IN-VITRO; ITS APPLICATIONS; METABOLIC PATHWAYS; PHENOLICS; RAPID IDENTIFICATION;

METABOLITES;

EID: 34347214118     PISSN: 09514198     EISSN: 10970231     Source Type: Journal    
DOI: 10.1002/rcm.3070     Document Type: Article

References (36)

1. Xiong YQ, Zeng FD. Acta Pharmcol. Sinica 2003; 24: 332.
2. Feng X, Yu X, Xiao J, Wang J. Huazhong Keji Daxue Xuebao, Yixueban 2002; 31: 608.
3. Wang JL, Nong Y, Jing MX. Yaoxue Xuebao 1992; 27: 881.
4. Chen WZ, Ling SJ, Ting KS. Yaoxue Xuebao 1962; 13: 277.
5. Fu Li, Deng Z, Pan Q, Fan W. Anticancer Res. 2001; 21: 2273.
6. Xian X, Xie Z, Chen J, Qin Q, Zhu Y. Zhongnan Daxue Xuebao, Yixueban 2005; 30: 558.
7. Liu G, Zhang Y, He D, Chinese J. Cancer Res. 2006; 18: 183.
8. Bao J, Zhou J, Tang X, Cao J. Zhongguo Yaolixue Tongbao 2003; 19: 80.
9. Kashiwada Y, Aoshima A, Ikeshiro Y, Chen YP, Furukawa H, Itoigawa M, Fujioka T, Mihashi K, Cosentino LM, Morris-Natschke SL, Lee KH. Bioorg. Med. Chem. 2005; 13: 443.
10. Zhang X, Hu X, Luo S, Cai H, Yin W. Yaowu Fenxi Zazhi 1997; 17: 110.
11. Ni Z. Acta Hortic. Sinica 1983; 10: 207.
12. Wu W, Zheng H, Ge X. Zhongcaoyao 1996; 27: 438.
13. Luo S, Wang H. Zhongguo Yao Fang 2001; 12: 624.
14. Chen Y, Fan G, Wu H, Wu Y, Mitchell A. J. Pharm. Biomed. Anal. 2007; 43: 99.
15. Wu J, Yuan H, Wang J. Zhongcaoyao 1998; 29: 364.
16. Kametani T, Nemoto H, Kobari T, Takano S. J. Heterocycl. Chem. 1970; 7: 181.
17. Wu S, Sun C, Cao X, Zhou H, Zhang H, Pan Y. J. Chromatogr. A 2004; 1041: 153.
18. Hu X, Zhang X, Cai H, Luo S, Wang J. Zhongguo Yiyuan Yaoxue Zhazhi 1993; 13: 105.
19. Hu X, Zhang X, Cai H, Luo S, Yin W. Zhongguo Zhongyao Zhazhi 1992; 17: 622.
20. Xu L, Wang S, Chen J, Yao C. Shengyang Yaoke Daxue Xuebao 2001; 18: 244.
21. Jiang M, Liang X, Xiong Y. Chinese Pharmcol. Bull. 2006; 22: 739.
22. Gibson GG, Skett P. Introduction to Drug Metabolism. Chapman and Hall Ltd.: London, New York, 1986; 240.
23. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. J. Biol. Chem. 1951; 193: 265.
24. Adejare A, Brown PW. Anal. Chem. 1997; 69: 1525.
25. Kamel A, Fouda H, Brown P, Munson B. J. Am. Soc. Mass Spectrom. 2002; 13: 543.
26. Kamel A, Munson B. Eur. J. Mass Spectrom. 2004; 10: 239.
27. Miao Z, Kamel A, Prakash C. Drug. Metab. Dispos. 2005; 33: 879.
28. Nassar AEF. J. Chromatogr. Sci. 2003; 41: 398.
29. Lam W, Ramanathan R. J. Am. Soc. Mass Spectrom. 2002; 13: 345.
30. Wu W, Mckown LA. J. Pharm. Biomed. Anal. 2002; 30: 141.
31. Anari MR, Sanchez RI, Bakhtiar R, Franklin RB, Baillie TA. Anal. Chem. 2004; 76: 823.
32. Ma S, Chowdhury SK, Alton KB. Curr. Drug Metab. 2006; 7: 503.
33. Anari MR, Sanchez RI, Bakhtiar R, Franklin RB, Baillie TA. Anal. Chem. 2004; 76: 823.
34. Triolo A, Altamura M, Dimoulas T, Guidi A, Lecci A, Tramontana M. J. Mass Spectrom. 2005; 40: 1572.
35. Hollenberg PF. FASEB J. 1992; 6: 686.
36. Chen S, Liu L, Yang Y, Dai Z, Zeng F. J. Tongji Med. Univ. 2000; 20: 253.