Neferine, an alkaloid ingredient in lotus seed embryo, inhibits proliferation of human osteosarcoma cells by promoting p38 MAPK-mediated p21 stabilization

European Journal of Pharmacology

Volumn 677, Issue 1-3, 2012, Pages 47-54

  Zhang, Xiyu ^a   Liu, Zhaojian ^a   Xu, Bing ^a   Sun, Zhaoliang ^a   Gong, Yaoqin ^a   Shao, Changshun ^a  

^a SHANDONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Cell cycle arrest; Neferine; Osteosarcoma; p21; p38MAPK

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; CYCLIN DEPENDENT KINASE INHIBITOR 1; MITOGEN ACTIVATED PROTEIN KINASE P38; NEFERINE; PROTEIN P21; PROTEIN P53; RETINOBLASTOMA PROTEIN; SERINE; STRESS ACTIVATED PROTEIN KINASE;

ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL PROLIFERATION; CONTROLLED STUDY; DRUG STRUCTURE; DRUG TARGETING; EMBRYONIC STRUCTURES; GENE SILENCING; HUMAN; HUMAN CELL; LOTUS; OSTEOSARCOMA; PLANT SEED; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY; RNA INTERFERENCE; UPREGULATION;

BENZYLISOQUINOLINES; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLIN E; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DOWN-REGULATION; ENZYME ACTIVATION; G1 PHASE CELL CYCLE CHECKPOINTS; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LOTUS; OSTEOSARCOMA; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROTEIN STABILITY; SEEDS; TUMOR SUPPRESSOR PROTEIN P53; UP-REGULATION;

EID: 84862831138     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2011.12.035     Document Type: Article

References (29)

1. T. Abbas, and A. Dutta p21 in cancer: intricate networks and multiple activities Nat. Rev. Cancer 9 2009 400 414
2. X.H. Ai, X.Q. Tang, Y.P. Liu, H.Q. Liu, and L. Dong Effect of neferine on adriamycin-resistance of thermotolerant hepatocarcinoma cell line HepG2/thermotolerance Ai Zheng 26 2007 357 360
3. J.G. Cao, X.Q. Tang, and S.H. Shi Multidrug resistance reversal in human gastric carcinoma cells by neferine World J. Gastroenterol. 10 2004 3062 3064
4. J. Chen, J.H. Liu, Z.J. Jiang, T. Wang, B. Liu, J. Yang, C.P. Yin, and F. Chen Effects of neferine on cytosolic free calcium concentration in corpus cavernosum smooth muscle cells of rabbits Andrologia 39 2007 141 145 (Pubitemid 47246213)
5. B.H. Choi, C.G. Kim, Y.S. Bae, Y. Lim, Y.H. Lee, and S.Y. Shin p21 Waf1/Cip1 expression by curcumin in U-87MG human glioma cells: role of early growth response-1 expression Cancer Res. 68 2008 1369 1377 (Pubitemid 351346844)
6. M.L. Coleman, C.J. Marshall, and M.F. Olson Ras promotes p21(Waf1/Cip1) protein stability via a cyclin D1-imposed block in proteasome-mediated degradation EMBO J. 22 2003 2036 2046 (Pubitemid 36565529)
7. E. De la Cueva, I. Garcia-Cao, M. Herranz, P. Lopez, P. Garcia-Palencia, J.M. Flores, M. Serrano, J. Fernandez-Piqueras, and J. Martin-Caballero Tumorigenic activity of p21Waf1/Cip1 in thymic lymphoma Oncogene 25 2006 4128 4132 (Pubitemid 44024876)
8. H.Y. Fan, Z. Liu, M. Paquet, J. Wang, J.P. Lydon, F.J. DeMayo, and J.S. Richards Cell type-specific targeted mutations of Kras and Pten document proliferation arrest in granulosa cells versus oncogenic insult to ovarian surface epithelial cells Cancer Res. 69 2009 6463 6472
9. T. Hideshima, D. Chauhan, T. Hayashi, K. Podar, M. Akiyama, C. Mitsiades, N. Mitsiades, B. Gong, L. Bonham, P. de Vries, N. Munshi, P.G. Richardson, J.W. Singer, and K.C. Anderson Antitumor activity of lysophosphatidic acid acyltransferase-beta inhibitors, a novel class of agents, in multiple myeloma Cancer Res. 63 2003 8428 8436 (Pubitemid 37549499)
10. G.Y. Kim, S.E. Mercer, D.Z. Ewton, Z. Yan, K. Jin, and E. Friedman The stress-activated protein kinases p38 alpha and JNK1 stabilize p21(Cip1) by phosphorylation J. Biol. Chem. 277 2002 29792 29802
11. D.I. Kim, S.J. Lee, S.B. Lee, K. Park, W.J. Kim, and S.K. Moon Requirement for Ras/Raf/ERK pathway in naringin-induced G1-cell-cycle arrest via p21WAF1 expression Carcinogenesis 29 2008 1701 1709
12. C. Kuntzen, N. Sonuc, E.N. De Toni, C. Opelz, S.R. Mucha, A.L. Gerbes, and S.T. Eichhorst Inhibition of c-Jun-N-terminal-kinase sensitizes tumor cells to CD95-induced apoptosis and induces G2/M cell cycle arrest Cancer Res. 65 2005 6780 6788 (Pubitemid 41060716)
13. Y. Li, D. Dowbenko, and L.A. Lasky AKT/PKB phosphorylation of p21Cip/WAF1 enhances protein stability of p21Cip/WAF1 and promotes cell survival J. Biol. Chem. 277 2002 11352 11361 (Pubitemid 34952901)
14. X.C. Li, G.X. Tong, Y. Zhang, S.X. Liu, Q.H. Jin, H.H. Chen, and P. Chen Neferine inhibits angiotensin II-stimulated proliferation in vascular smooth muscle cells through heme oxygenase-1 Acta Pharmacol. Sin. 31 2010 679 686
15. Z. Liu, Q. Liu, B. Xu, J. Wu, C. Guo, F. Zhu, Q. Yang, G. Gao, Y. Gong, and C. Shao Berberine induces p53-dependent cell cycle arrest and apoptosis of human osteosarcoma cells by inflicting DNA damage Mutat. Res. 662 2009 75 83
16. J. Martin-Caballero, J.M. Flores, P. Garcia-Palencia, and M. Serrano Tumor susceptibility of p21(Waf1/Cip1)-deficient mice Cancer Res. 61 2001 6234 6238
17. I. Mukhopadhyay, E.A. Sausville, J.H. Doroshow, and K.K. Roy Molecular mechanism of adaphostin-mediated G1 arrest in prostate cancer (PC-3) cells: signaling events mediated by hepatocyte growth factor receptor, c-Met, and p38 MAPK pathways J. Biol. Chem. 281 2006 37330 37344 (Pubitemid 46042037)
18. C. Shao, L. Liang, X. Zhao, Y. Chen, B. Zheng, J. Chen, M. Luo, and J.A. Tischfield Mutagenesis in vivo in T cells of p21-deficient mice Mutat. Res. 670 2009 103 106
19. J.Y. Shew, B.T. Lin, P.L. Chen, B.Y. Tseng, T.L. Yang-Feng, and W.H. Lee C-terminal truncation of the retinoblastoma gene product leads to functional inactivation Proc. Natl. Acad. Sci. U. S. A. 87 1990 6 10
20. E. Stabile, Y.F. Zhou, M. Saji, M. Castagna, M. Shou, T.D. Kinnaird, R. Baffour, M.D. Ringel, S.E. Epstein, and S. Fuchs Akt controls vascular smooth muscle cell proliferation in vitro and in vivo by delaying G1/S exit Circ. Res. 93 2003 1059 1065 (Pubitemid 37485036)
21. S. van den Heuvel, and E. Harlow Distinct roles for cyclin-dependent kinases in cell cycle control Science 262 1993 2050 2054 (Pubitemid 24041887)
22. A. Viale, F. De Franco, A. Orleth, V. Cambiaghi, V. Giuliani, D. Bossi, C. Ronchini, S. Ronzoni, I. Muradore, S. Monestiroli, A. Gobbi, M. Alcalay, S. Minucci, and P.G. Pelicci Cell-cycle restriction limits DNA damage and maintains self-renewal of leukaemia stem cells Nature 457 2009 51 56
23. J.L. Wang, Y. Nong, and M.X. Jing Effects of liensinine on haemodynamics in rats and the physiologic properties of isolated rabbit atria Yao Xue Xue Bao 27 1992 881 885
24. Y.A. Wang, A. Elson, and P. Leder Loss of p21 increases sensitivity to ionizing radiation and delays the onset of lymphoma in atm-deficient mice Proc. Natl. Acad. Sci. U. S. A. 94 1997 14590 14595 (Pubitemid 28041418)
25. L. Weglarz, B. Parfiniewicz, A. Orchel, and Z. Dzierzewicz Anti-proliferative effects of inositol hexaphosphate and verapamil on human colon cancer Caco-2 and HT-29 cells Acta Pol. Pharm. 63 2006 443 445
26. N.P. Young, D. Crowley, and T. Jacks Uncoupling Cancer Mutations Reveals Critical Timing of p53 Loss in Sarcomagenesis Cancer Res. 71 2011 4040 4047
27. J. Yu, and W.S. Hu Effects of neferine on platelet aggregation in rabbits Yao Xue Xue Bao 32 1997 1 4 (Pubitemid 127464572)
28. C.L. Zhang, W.M. Liao, F.B. Li, B.F. Zeng, and Y.X. Zeng Prognostic significance of p21(WAF1) expression in osteosarcoma Zhonghua Bing Li Xue Za Zhi 34 2005 524 527
29. L. Zhao, X. Wang, Q. Chang, J. Xu, Y. Huang, Q. Guo, S. Zhang, W. Wang, X. Chen, and J. Wang Neferine, a bisbenzylisoquinline alkaloid attenuates bleomycin-induced pulmonary fibrosis Eur. J. Pharmacol. 627 2010 304 312