Loss of TAK1 increases cell traction force in a ROS-dependent manner to drive epithelialmesenchymal transition of cancer cells

Cell Death and Disease

Volumn 4, Issue 10, 2013, Pages

  Lam, C R I ^a   Tan, C ^a   Teo, Z ^a   Tay, C Y ^a   Phua, T ^a   Wu, Y L ^b,c   Cai, P Q ^b   Tan, L P ^b   Chen, X ^b   Zhu, P ^a   Tan, N S ^a,d  

^a NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

^b NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

^c XIAMEN UNIVERSITY   (China)

^d INSTITUTE OF MOLECULAR AND CELL BIOLOGY   (Singapore)

Author keywords

Cell traction force; Epithelialmesenchymal transition; Reactive oxygen species

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; ACETYLCYSTEINE; MESSENGER RNA; PROTEIN TYROSINE PHOSPHATASE; RAC1 PROTEIN; REACTIVE OXYGEN METABOLITE; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; TRANSCRIPTION FACTOR SNAIL; TRANSCRIPTION FACTOR ZEB1; TRANSFORMING GROWTH FACTOR BETA ACTIVATED KINASE 1; TRANSFORMING GROWTH FACTOR BETA1; VERY LATE ACTIVATION ANTIGEN 5;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL; CELL STRUCTURE; CELL TRACTION FORCE; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; EPITHELIAL MESENCHYMAL TRANSITION; FOCAL ADHESION; FORCE; HUMAN; HUMAN CELL; METASTASIS; MOUSE; NONHUMAN; OXIDATION REDUCTION REACTION; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SKIN BIOPSY; SKIN SQUAMOUS CELL CARCINOMA; SQUAMOUS CELL CARCINOMA; UPREGULATION;

ANIMALS; ANTIGENS, CD29; BIOMECHANICAL PHENOMENA; CELL LINE, TUMOR; CELL MEMBRANE; EPITHELIAL-MESENCHYMAL TRANSITION; HEK293 CELLS; HUMANS; INTEGRIN BETA3; MAP KINASE KINASE KINASES; MICE; MODELS, BIOLOGICAL; NEOPLASM INVASIVENESS; NEOPLASMS, SQUAMOUS CELL; OXIDATION-REDUCTION; RAC1 GTP-BINDING PROTEIN; REACTIVE OXYGEN SPECIES; RHO GTP-BINDING PROTEINS; SIGNAL TRANSDUCTION; SKIN NEOPLASMS; SMAD PROTEINS; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84887468122     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2013.339     Document Type: Article

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