Alteration of integrin-dependent adhesion and signaling in EMT-like MDCK cells established through overexpression of calreticulin

Journal of Cellular Biochemistry

Volumn 112, Issue 9, 2011, Pages 2518-2528

  Ihara, Yoshito ^a   Inai, Yoko ^a   Ikezaki, Midori ^a  

^a WAKAYAMA MEDICAL UNIVERSITY   (Japan)

Author keywords

Calreticulin; Epithelial mesenchymal transition; Integrin; Integrin linked kinase

Indexed keywords

BETA1 INTEGRIN; CALRETICULIN; COLLAGEN TYPE 4; FIBRONECTIN; INTEGRIN; PROTEIN KINASE B; VERY LATE ACTIVATION ANTIGEN 5; VITRONECTIN RECEPTOR;

ARTICLE; CELL ADHESION; CELL CULTURE; CELL STRAIN; CONTROLLED STUDY; EPITHELIAL MESENCHYMAL TRANSITION; EXTRACELLULAR MATRIX; INTRACELLULAR SIGNALING; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ANIMALS; CALCIUM; CALCIUM IONOPHORES; CALRETICULIN; CELL ADHESION; CELL LINE; CHELATING AGENTS; DOGS; EGTAZIC ACID; EPITHELIAL-MESENCHYMAL TRANSITION; EXTRACELLULAR MATRIX; FIBRONECTINS; INTEGRIN ALPHA5BETA1; INTEGRIN ALPHAVBETA3; IONOMYCIN; MULTIPROTEIN COMPLEXES; PROTEIN BINDING; PROTEIN TRANSPORT; PROTEIN-SERINE-THREONINE KINASES; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION;

TETRA;

EID: 84860397154     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.23176     Document Type: Article

References (35)

1. Aldehni F, Spitzner M, Martins JR, Barro-Soria R, Schreiber R, Kunzelmann K,. 2009. Bestrophin 1 promotes epithelial-to-mesenchymal transition of renal collecting duct cells. J Am Soc Nephrol 20: 1556-1564.
2. Bailey KM, Liu J,. 2008. Caveolin-1 up-regulation during epithelial to mesenchymal transition is mediated by focal adhesion kinase. J Biol Chem 283: 13714-13724.
3. Chan KT, Bennin DA, Huttenlocher A,. 2010. Regulation of adhesion dynamics by calpain-mediated proteolysis of focal adhesion kinase (FAK). J Biol Chem 285: 11418-11426.
4. Chen WT, Singer SJ,. 1982. Immunoelectron microscopic studies of the sites of cell-substratum and cell-cell contacts in cultured fibroblasts. J Cell Biol 95: 205-222. (Pubitemid 13197091)
5. Cicchini C, Laudadio I, Citarella F, Corazzari M, Steindler C, Conigliaro A, Fantoni A, Amicone L, Tripodi M,. 2008. TGFβ-induced EMT requires focal adhesion kinase (FAK) signaling. Exp Cell Res 314: 143-152. (Pubitemid 350180782)
6. Cooray P, Yuan Y, Schoenwaelder SM, Mitchell CA, Salem HH, Jackson SP,. 1996. Focal adhesion kinase (pp125FAK) cleavage and regulation by calpain. Biochem J 318 (Pt 1): 41-47.
7. Coppolino MG, Woodside MJ, Demaurex N, Grinstein S, St-Arnaud R, Dedhar S,. 1997. Calreticulin is essential for integrin-mediated calcium signalling and cell adhesion. Nature 386: 843-847. (Pubitemid 27181259)
8. Delcommenne M, Tan C, Gray V, Rue L, Woodgett J, Dedhar S,. 1998. Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase. Proc Natl Acad Sci USA 95: 11211-11216. (Pubitemid 28450107)
9. Fukuda K, Gupta S, Chen K, Wu C, Qin J,. 2009. The pseudoactive site of ILK is essential for its binding to α-Parvin and localization to focal adhesions. Mol Cell 36: 819-830.
10. Grille SJ, Bellacosa A, Upson J, Klein-Szanto AJ, van Roy F, Lee-Kwon W, Donowitz M, Tsichlis PN, Larue L,. 2003. The protein kinase Akt induces epithelial mesenchymal transition and promotes enhanced motility and invasiveness of squamous cell carcinoma lines. Cancer Res 63: 2172-2178. (Pubitemid 36538623)
11. Hannigan GE, Leung-Hagesteijn C, Fitz-Gibbon L, Coppolino MG, Radeva G, Filmus J, Bell JC, Dedhar S,. 1996. Regulation of cell adhesion and anchorage-dependent growth by a new β1-integrin-linked protein kinase. Nature 379: 91-96. (Pubitemid 26008142)
12. Hay ED,. 1995. An overview of epithelio-mesenchymal transformation. Acta Anat (Basel) 154: 8-20. (Pubitemid 26101385)
13. Hayashida Y, Urata Y, Muroi E, Kono T, Miyata Y, Nomata K, Kanetake H, Kondo T, Ihara Y,. 2006. Calreticulin represses E-cadherin gene expression in Madin-Darby canine kidney cells via Slug. J Biol Chem 281: 32469-32484. (Pubitemid 46036802)
14. Hynes RO,. 2002. Integrins: Bidirectional, allosteric signaling machines. Cell 110: 673-687. (Pubitemid 35283958)
15. Ihara Y, Urata Y, Goto S, Kondo T,. 2006. Role of calreticulin in the sensitivity of myocardiac H9c2cells to oxidative stress caused by hydrogen peroxide. Am J Physiol Cell Physiol 290: C208-C221.
16. Kwon MS, Park CS, Choi K, Ahnn J, Kim JI, Eom SH, Kaufman SJ, Song WK,. 2000. Calreticulin couples calcium release and calcium influx in integrin-mediated calcium signaling. Mol Biol Cell 11: 1433-1443. (Pubitemid 30211040)
17. Kypreou KP, Kavvadas P, Karamessinis P, Peroulis M, Alberti A, Sideras P, Psarras S, Capetanaki Y, Politis PK, Charonis AS,. 2008. Altered expression of calreticulin during the development of fibrosis. Proteomics 8: 2407-2419.
18. Lange A, Wickstrom SA, Jakobson M, Zent R, Sainio K, Fassler R,. 2009. Integrin-linked kinase is an adaptor with essential functions during mouse development. Nature 461: 1002-1006.
19. Li Y, Tan X, Dai C, Stolz DB, Wang D, Liu Y,. 2009. Inhibition of integrin-linked kinase attenuates renal interstitial fibrosis. J Am Soc Nephrol 20: 1907-1918.
20. Li Y, Yang J, Dai C, Wu C, Liu Y,. 2003. Role for integrin-linked kinase in mediating tubular epithelial to mesenchymal transition and renal interstitial fibrogenesis. J Clin Invest 112: 503-516. (Pubitemid 38056335)
21. Liu Y,. 2010. New insights into epithelial-mesenchymal transition in kidney fibrosis. J Am Soc Nephrol 21: 212-222.
22. McDonald PC, Fielding AB, Dedhar S,. 2008. Integrin-linked kinase-essential roles in physiology and cancer biology. J Cell Sci 121: 3121-3132.
23. Michalak M, Groenendyk J, Szabo E, Gold LI, Opas M,. 2009. Calreticulin, a multi-process calcium-buffering chaperone of the endoplasmic reticulum. Biochem J 417: 651-666.
24. Moustakas A, Heldin CH,. 2007. Signaling networks guiding epithelial-mesenchymal transitions during embryogenesis and cancer progression. Cancer Sci 98: 1512-1520. (Pubitemid 47308444)
25. Papp S, Fadel MP, Kim H, McCulloch CA, Opas M,. 2007. Calreticulin affects fibronectin-based cell-substratum adhesion via the regulation of c-Src activity. J Biol Chem 282: 16585-16598. (Pubitemid 47100404)
26. Plisov SY, Ivanov SV, Yoshino K, Dove LF, Plisova TM, Higinbotham KG, Karavanova I, Lerman M, Perantoni AO,. 2000. Mesenchymal-epithelial transition in the developing metanephric kidney: Gene expression study by differential display. Genesis 27: 22-31. (Pubitemid 30459208)
27. Somasiri A, Howarth A, Goswami D, Dedhar S, Roskelley CD,. 2001. Overexpression of the integrin-linked kinase mesenchymally transforms mammary epithelial cells. J Cell Sci 114: 1125-1136. (Pubitemid 32288526)
28. Takada Y, Ye X, Simon S,. 2007. The integrins. Genome Biol 8: 215.
29. 2+-ATPase. Proc Natl Acad Sci USA 87: 2466-2470.
30. Thiery JP, Acloque H, Huang RY, Nieto MA,. 2009. Epithelial-mesenchymal transitions in development and disease. Cell 139: 871-890.
31. Thiery JP, Sleeman JP,. 2006. Complex networks orchestrate epithelial-mesenchymal transitions. Nat Rev Mol Cell Biol 7: 131-142. (Pubitemid 43278296)
32. Ulianich L, Garbi C, Treglia AS, Punzi D, Miele C, Raciti GA, Beguinot F, Consiglio E, Di Jeso B,. 2008. ER stress is associated with dedifferentiation and an epithelial-to-mesenchymal transition-like phenotype in PC Cl3 thyroid cells. J Cell Sci 121: 477-486. (Pubitemid 351405056)
33. Waisman DM, Salimath BP, Anderson MJ,. 1985. Isolation and characterization of CAB-63, a novel calcium-binding protein. J Biol Chem 260: 1652-1660. (Pubitemid 15145441)
34. Wen LP, Fahrni JA, Troie S, Guan JL, Orth K, Rosen GD,. 1997. Cleavage of focal adhesion kinase by caspases during apoptosis. J Biol Chem 272: 26056-26061. (Pubitemid 27438936)
35. Zeisberg M, Neilson EG,. 2009. Biomarkers for epithelial-mesenchymal transitions. J Clin Invest 119: 1429-1437.