RS-Glucoraphanin bioactivated with myrosinase treatment counteracts proinflammatory cascade and apoptosis associated to spinal cord injury in an experimental mouse model

Journal of the Neurological Sciences

Volumn 334, Issue 1-2, 2013, Pages 88-96

  Galuppo, Maria ^a   Giacoppo, Sabrina ^a   De Nicola, Gina Rosalinda ^b   Iori, Renato ^b   Mazzon, Emanuela ^a   Bramanti, Placido ^a  

^a IRCCS CENTRO NEUROLESI BONINO PULEJO   (Italy)

^b ISTITUTO NAZIONALE DELLA NUTRIZIONE   (Italy)

Author keywords

Apoptosis; Bioactive (RS) glucoraphanin; Inflammation; Myrosinase enzyme; Proinflammatory cytokines; Spinal cord injury

Indexed keywords

CASPASE 3; FAS LIGAND; GLIAL FIBRILLARY ACIDIC PROTEIN; GLUCOSINOLATE; GLUCOSINOLATE GLUCORAPHANIN; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; NEUROPROTECTIVE AGENT; PROTEIN BAX; THIOGLUCOSIDASE; UNCLASSIFIED DRUG; AUTACOID; GLUCORAPHANIN; GLYCOSIDASE; IMIDOESTER;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; ASTROCYTE; CELL ACTIVITY; CELL DEATH; CONTROLLED STUDY; DISEASE SEVERITY; ENZYME ACTIVATION; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; LAMINECTOMY; MALE; MOUSE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; SPINAL CORD INJURY; STAINING; TISSUE DISTRIBUTION; ANIMAL; BIOACTIVE (R(S))-GLUCORAPHANIN; DISEASE MODEL; DRUG EFFECT; INFLAMMATION; INJURY; METABOLISM; MYROSINASE ENZYME; PATHOLOGY; PROINFLAMMATORY CYTOKINES; VERTEBRA;

APOPTOSIS; BIOACTIVE (R(S))-GLUCORAPHANIN; INFLAMMATION; MYROSINASE ENZYME; PROINFLAMMATORY CYTOKINES; SPINAL CORD INJURY;

ANIMALS; APOPTOSIS; DISEASE MODELS, ANIMAL; ENZYME ACTIVATION; GLUCOSINOLATES; GLYCOSIDE HYDROLASES; IMIDOESTERS; INFLAMMATION MEDIATORS; MALE; MICE; NEUROPROTECTIVE AGENTS; SPINAL CORD INJURIES; THORACIC VERTEBRAE;

EID: 84887465716     PISSN: 0022510X     EISSN: 18785883     Source Type: Journal    
DOI: 10.1016/j.jns.2013.07.2514     Document Type: Article

References (47)

1. M. Maegele, P. Riess, S. Sauerland, B. Bouillon, S. Hess, and T.K. McIntosh Characterization of a new rat model of experimental combined neurotrauma Shock 23 2005 476 481
2. L.J. Zai, and J.R. Wrathall Cell proliferation and replacement following contusive spinal cord injury Glia 50 2005 247 257
3. S.L. Stover, and P.R. Fine The epidemiology and economics of spinal cord injury Paraplegia 25 1987 225 228
4. M.S. Beattie, G.E. Hermann, R.C. Rogers, and J.C. Bresnahan Cell death in models of spinal cord injury Prog Brain Res 137 2002 37 47
5. C.H. Tator, and M.G. Fehlings Review of the secondary injury theory of acute spinal cord trauma with emphasis on vascular mechanisms J Neurosurg 75 1991 15 26
6. C. Profyris, S.S. Cheema, D. Zang, M.F. Azari, K. Boyle, and S. Petratos Degenerative and regenerative mechanisms governing spinal cord injury Neurobiol Dis 15 2004 415 436
7. M.S. Beattie, Q. Li, and J.C. Bresnahan Cell death and plasticity after experimental spinal cord injury Prog Brain Res 128 2000 9 21
8. O.N. Hausmann Post-traumatic inflammation following spinal cord injury Spinal Cord 41 2003 369 378
9. E. Park, A.A. Velumian, and M.G. Fehlings The role of excitotoxicity in secondary mechanisms of spinal cord injury: a review with an emphasis on the implications for white matter degeneration J Neurotrauma 21 2004 754 774
10. V. Calabrese, C. Cornelius, L. Maiolino, M. Luca, R. Chiaramonte, and M.A. Toscano Oxidative stress, redox homeostasis and cellular stress response in Meniere's disease: role of vitagenes Neurochem Res 35 2010 2208 2217
11. G.D. Carlson, and C. Gorden Current developments in spinal cord injury research Spine J 2 2002 116 128
12. E.J. Calabrese, M.P. Mattson, and V. Calabrese Resveratrol commonly displays hormesis: occurrence and biomedical significance Hum Exp Toxicol 29 2010 980 1015
13. V. Calabrese, C. Cornelius, A.T. Dinkova-Kostova, E.J. Calabrese, and M.P. Mattson Cellular stress responses, the hormesis paradigm, and vitagenes: novel targets for therapeutic intervention in neurodegenerative disorders Antioxid Redox Signal 13 2010 1763 1811
14. T. Genovese, E. Mazzon, R. Di Paola, C. Crisafulli, C. Muia, and P. Bramanti Increased oxidative-related mechanisms in the spinal cord injury in old rats Neurosci Lett 393 2006 141 146
15. M. Perluigi, F. Di Domenico, A. Giorgi, M.E. Schinina, R. Coccia, and C. Cini Redox proteomics in aging rat brain: involvement of mitochondrial reduced glutathione status and mitochondrial protein oxidation in the aging process J Neurosci Res 88 2010 3498 3507
16. A.M. Bones, and J.T. Rossiter The enzymic and chemically induced decomposition of glucosinolates Phytochemistry 67 2006 1053 1067
17. O. Leoni, R. Iori, and S. Palmieri Hydrolysis of glucosinolates using nylon-immobilized myrosinase to produce pure bioactive molecules Biotechnol Bioeng 68 2000 660 664
18. A.F. Abdull Razis, R. Iori, and C. Ioannides The natural chemopreventive phytochemical R-sulforaphane is a far more potent inducer of the carcinogen-detoxifying enzyme systems in rat liver and lung than the S-isomer Int J Cancer 128 2011 2775 2782
19. L.E. Voorrips, R.A. Goldbohm, D.T. Verhoeven, G.A. van Poppel, F. Sturmans, and R.J. Hermus Vegetable and fruit consumption and lung cancer risk in the Netherlands Cohort Study on diet and cancer Cancer Causes Control 11 2000 101 115
20. T.K. Lam, L. Gallicchio, K. Lindsley, M. Shiels, E. Hammond, and X.G. Tao Cruciferous vegetable consumption and lung cancer risk: a systematic review Cancer Epidemiol Biomarkers Prev 18 2009 184 195
21. T.W. Kensler, N. Wakabayashi, and S. Biswal Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway Annu Rev Pharmacol Toxicol 47 2007 89 116
22. J.D. Hayes, M.O. Kelleher, and I.M. Eggleston The cancer chemopreventive actions of phytochemicals derived from glucosinolates Eur J Nutr 47 Suppl. 2 2008 73 88
23. S)-glucoraphanin bioactivated with myrosinase in an experimental model of multiple sclerosis CNS Neurosci Ther 19 2013 577 584
24. A.S. Rivlin, and C.H. Tator Effect of duration of acute spinal cord compression in a new acute cord injury model in the rat Surg Neurol 10 1978 38 43
25. A.F. Abdull Razis, M. Bagatta, G.R. De Nicola, R. Iori, and C. Ioannides Intact glucosinolates modulate hepatic cytochrome P450 and phase II conjugation activities and may contribute directly to the chemopreventive activity of cruciferous vegetables Toxicology 277 2010 74 85
26. EEC Regulation 1864/90 Enclosure VIII Offic J Eur Commun 170 1990 27 34
27. A. Pessina, R.M. Thomas, S. Palmieri, and P.L. Luisi An improved method for the purification of myrosinase and its physicochemical characterization Arch Biochem Biophys 280 1990 383 389
28. H. Liang, and Q. Yuan Natural sulforaphane as a functional chemopreventive agent: including a review of isolation, purification and analysis methods Crit Rev Biotechnol 32 2012 218 234
29. I. Paterniti, D. Impellizzeri, R. Crupi, R. Morabito, M. Campolo, and E. Esposito Molecular evidence for the involvement of PPAR-delta and PPAR-gamma in anti-inflammatory and neuroprotective activities of palmitoylethanolamide after spinal cord trauma J Neuroinflammation 10 2013 20
30. S. Petri, S. Korner, and M. Kiaei Nrf2/ARE signaling pathway: key mediator in oxidative stress and potential therapeutic target in ALS Neurol Res Int 2012 2012 878030
31. B.K. Kwon, W. Tetzlaff, J.N. Grauer, J. Beiner, and A.R. Vaccaro Pathophysiology and pharmacologic treatment of acute spinal cord injury Spine J 4 2004 451 464
32. D.M. Rothwarf, and M. Karin The NF-kappa B activation pathway: a paradigm in information transfer from membrane to nucleus Sci STKE 1999 1999 RE1
33. I.M. Verma Nuclear factor (NF)-kappaB proteins: therapeutic targets Ann Rheum Dis 63 Suppl. 2 2004 ii57 ii61
34. N.A. Thornberry, H.G. Bull, J.R. Calaycay, K.T. Chapman, A.D. Howard, and M.J. Kostura A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes Nature 356 1992 768 774
35. L.F. Eng, and R.S. Ghirnikar GFAP and astrogliosis Brain Pathol 4 1994 229 237
36. F. Aloisi, F. Ria, and L. Adorini Regulation of T-cell responses by CNS antigen-presenting cells: different roles for microglia and astrocytes Immunol Today 21 2000 141 147
37. M. Tani, A.R. Glabinski, V.K. Tuohy, M.H. Stoler, M.L. Estes, and R.M. Ransohoff In situ hybridization analysis of glial fibrillary acidic protein mRNA reveals evidence of biphasic astrocyte activation during acute experimental autoimmune encephalomyelitis Am J Pathol 148 1996 889 896
38. S.J. Davies, D.R. Goucher, C. Doller, and J. Silver Robust regeneration of adult sensory axons in degenerating white matter of the adult rat spinal cord J Neurosci 19 1999 5810 5822
39. C.M. LaPash Daniels, E.V. Austin, D.E. Rockney, E.M. Jacka, T.L. Hagemann, and D.A. Johnson Beneficial effects of Nrf2 overexpression in a mouse model of Alexander disease J Neurosci 32 2012 10507 10515
40. M.J. Calkins, M.R. Vargas, D.A. Johnson, and J.A. Johnson Astrocyte-specific overexpression of Nrf2 protects striatal neurons from mitochondrial complex II inhibition Toxicol Sci 115 2010 557 568
41. G.L. Li, M. Farooque, A. Holtz, and Y. Olsson Apoptosis of oligodendrocytes occurs for long distances away from the primary injury after compression trauma to rat spinal cord Acta Neuropathol 98 1999 473 480
42. M. Li, V.O. Ona, M. Chen, M. Kaul, L. Tenneti, and X. Zhang Functional role and therapeutic implications of neuronal caspase-1 and -3 in a mouse model of traumatic spinal cord injury Neuroscience 99 2000 333 342
43. G.A. Dosreis, V.M. Borges, and W.A. Zin The central role of Fas-ligand cell signaling in inflammatory lung diseases J Cell Mol Med 8 2004 285 293
44. A. Ackery, S. Robins, and M.G. Fehlings Inhibition of Fas-mediated apoptosis through administration of soluble Fas receptor improves functional outcome and reduces posttraumatic axonal degeneration after acute spinal cord injury J Neurotrauma 23 2006 604 616
45. M.S. Beattie Inflammation and apoptosis: linked therapeutic targets in spinal cord injury Trends Mol Med 10 2004 580 583
46. T. Chittenden, E.A. Harrington, R. O'Connor, C. Flemington, R.J. Lutz, and G.I. Evan Induction of apoptosis by the Bcl-2 homologue Bak Nature 374 1995 733 736
47. F.A. White, C.R. Keller-Peck, C.M. Knudson, S.J. Korsmeyer, and W.D. Snider Widespread elimination of naturally occurring neuronal death in Bax-deficient mice J Neurosci 18 1998 1428 1439