Intracellular pH reduction prevents excitotoxic and ischemic neuronal death by inhibiting NADPH oxidase

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 46, 2013, Pages

  Lam, Tina I ^a,b   Brennan Minnella, Angela M ^a,b   Won, Seok Joon ^a,b   Shen, Yiguo ^a,b   Hefner, Colleen ^a,b   Shi, Yejie ^c   Sun, Dandan ^c   Swanson, Raymond A ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b SAN FRANCISCO VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Acidosis; Cariporide; Hv1; NOX2

Indexed keywords

N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SODIUM PROTON EXCHANGE PROTEIN 1; SUPEROXIDE;

ACIDIFICATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN ISCHEMIA; BRAIN TISSUE; CELL HYPOXIA; CELL LEVEL; CELL METABOLISM; CELL PH; CONTROLLED STUDY; ENZYME INHIBITION; EXCITOTOXICITY; FEMALE; MALE; METABOLIC REGULATION; MOUSE; NERVE CELL CULTURE; NERVE CELL NECROSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTON SODIUM EXCHANGE; REPERFUSION INJURY;

ACIDOSIS; CARIPORIDE; HV1; NOX2;

ANALYSIS OF VARIANCE; ANIMALS; BRAIN; CATION TRANSPORT PROTEINS; CELL DEATH; CELLS, CULTURED; DNA PRIMERS; FLUORESCENCE; HYDROGEN-ION CONCENTRATION; INTRACELLULAR FLUID; MICE; NADPH OXIDASE; NEURONS; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, N-METHYL-D-ASPARTATE; SODIUM-HYDROGEN ANTIPORTER; SUPEROXIDES;

EID: 84887437050     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1313029110     Document Type: Article

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