Intravenous HOE-642 reduces brain edema and Na uptake in the rat permanent middle cerebral artery occlusion model of stroke: Evidence for participation of the blood-brain barrier Na/H exchanger

Journal of Cerebral Blood Flow and Metabolism

Volumn 33, Issue 2, 2013, Pages 225-234

  O'Donnell, Martha E ^a   Chen, Yi Je ^a   Lam, Tina I ^a   Taylor, Kelleen C ^a   Walton, Jeffrey H ^a   Anderson, Steven E ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

bloodbrain barrier; brain edema; cerebral ischemia; Na H exchange; stroke

Indexed keywords

BUMETANIDE; CARIPORIDE; SODIUM; SODIUM POTASSIUM CHLORIDE COTRANSPORTER;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN EDEMA; BRAIN INFARCTION SIZE; CEREBROVASCULAR ACCIDENT; CONTROLLED STUDY; DIFFUSION WEIGHTED IMAGING; GLUCOSE BLOOD LEVEL; HYPOXIA; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; RAT; SODIUM TRANSPORT;

ADMINISTRATION, INTRAVENOUS; ANIMALS; ANTI-ARRHYTHMIA AGENTS; BLOOD-BRAIN BARRIER; BRAIN EDEMA; BRAIN INFARCTION; DISEASE MODELS, ANIMAL; GUANIDINES; INFARCTION, MIDDLE CEREBRAL ARTERY; MAGNETIC RESONANCE SPECTROSCOPY; MALE; NERVE TISSUE PROTEINS; RATS; RATS, SPRAGUE-DAWLEY; SODIUM; SODIUM-HYDROGEN ANTIPORTER; STROKE; SULFONES;

EID: 84873409066     PISSN: 0271678X     EISSN: 15597016     Source Type: Journal    
DOI: 10.1038/jcbfm.2012.160     Document Type: Article

References (40)

1. Betz AL. Alterations in cerebral endothelial cell function in ischemia. Adv Neurol 1996; 71: 301-313.
2. Foroutan S, Brillault J, Forbush B, O'Donnell ME. Moderate-to-severe ischemic conditions increase activity and phosphorylation of the cerebral microvascular endothelial cell Na +-K +-Cl-cotransporter. Am J Physiol Cell Physiol 2005; 289: C1492-C1501.
3. O'Donnell ME, Tran L, Lam TI, Liu XB, Anderson SE. Bumetanide inhibition of the blood-brain barrier Na-K-Cl cotransporter reduces edema formation in the rat middle cerebral artery occlusion model of stroke. J Cereb Blood Flow Metab 2004; 24: 1046-1056.
4. Brillault J, Lam TI, Rutkowsky JM, Foroutan S, O'Donnell ME. Hypoxia effects on cell volume and ion uptake of cerebral microvascular endothelial cells. Am J Physiol Cell Physiol 2008; 294: C88-C96.
5. O'Donnell ME, Lam TI, Tran LQ, Foroutan S, Anderson SE. Estradiol reduces activity of the blood-brain barrier Na-K-Cl cotransporter and decreases edema formation in permanent middle cerebral artery occlusion. J Cereb Blood Flow Metab 2006; 26: 1234-1249.
6. Lam TI, Wise PM, O'Donnell ME. Cerebral microvascular endothelial cell Na/H exchange: evidence for the presence of NHE1 and NHE2 isoforms and regulation by arginine vasopressin. Am J Physiol Cell Physiol 2009; 297: C278-C289.
7. Cserr HF, Cooper DN, Milhorat TH. Flow of cerebral interstitial fluid as indicated by the removal of extracellular markers from rat caudate nucleus. Exp Eye Res 1977; 25(Suppl): 461-473.
8. Ennis SR, Ren XD, Betz AL. Mechanisms of sodium transport at the blood-brain barrier studied with in situ perfusion of rat brain. J Neurochem 1996; 66: 756-763.
9. Betz AL. Sodium transport from blood to brain: inhibition by furosemide and amiloride. J Neurochem 1983; 41: 1158-1164.
10. + exchange inhibitor SM-20220 improves endothelial dysfunction induced by ischemia-reperfusion. Jpn J Pharmacol 2001; 85: 271-277.
11. Horikawa N, Kurobayashi Y, Matsui K, Ohashi N. Relationship between the neu-roprotective effect of Na +/H + exchanger inhibitor SM-20220 and the timing of its administration in a transient middle cerebral artery occlusion model of rats. Biol Pharm Bull 2001; 24: 767-771.
12. + exchanger inhibitor: effects on ischemic brain damage through edema and neutrophil accumulation in a rat middle cerebral artery occlusion model. Brain Res 2002; 945: 242-248.
13. + exchanger reduces infarct volume of focal cerebral ischemia in rats. Brain Res 2001; 922: 223-228.
14. Ferrazzano P, Shi Y, Manhas N, Wang Y, Hutchinson B, Chen X et al. Inhibiting the Na +/H + exchanger reduces reperfusion injury: a small animal MRI study. Front Biosci 2011; 3: 81-88.
15. Chen H, Luo J, Kintner DB, Shull GE, Sun D. Na (+)-dependent chloride transporter (NKCC1)-null mice exhibit less gray and white matter damage after focal cerebral ischemia. J Cereb Blood Flow Metab 2005; 25: 54-66.
16. + exchanger isoform 1-null mice after in vitro and in vivo ischemia. J Neurosci 2005; 25: 11256-11268.
17. Hom S, Fleegal MA, Egleton RD, Campos CR, Hawkins BT, Davis TP. Comparative changes in the blood-brain barrier and cerebral infarction of SHR and WKY rats. Am J Physiol Regul Integr Comp Physiol 2007; 292: R1881-R1892.
18. Chang E, O'Donnell ME, Barakat AI. Shear stress and 17beta-estradiol modulate cerebral microvascular endothelial Na-K-Cl cotransporter and Na/H exchanger protein levels. Am J Physiol Cell Physiol 2008; 294: C363-C371.
19. Zea Longa E, Weinstein PR, Carlson S, Cummins R. Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke 1989; 20: 84-91.
20. Golshani P, Liu XB, Jones EG. Differences in quantal amplitude reflect GluR4-subunit number at corticothalamic synapses on two populations of thalamic neurons. Proc Natl Acad Sci USA 2001; 98: 4172-4177.
21. Tatlisumak T, Takano K, Carano RAD, Fisher M. Effect of basic fibroblast growth factor on experimental focal ischemia studied by diffusion-weighted and perfusion imaging. Stroke 1996; 27: 2292-2298.
22. Anderson SE, Murphy E, Steenbergen C, London RE, Cala PM. Na/H exchange in myocardium: effects of hypoxia and acidification on Na and Ca. Am J Physiol Cell Physiol 1990; 259: (Cell Physiology 28) C940-C948.
23. Balschi JA. 23Na NMR demonstrates prolonged increase of intracellular sodium following transient regional ischemia in the in situ pig heart. Basic Res Cardiol 1999; 94: 60-69.
24. 5- infusion. J Magn Reson Imaging 1992; 2: 385-391.
25. Preston E, Foster DO. Diffusion into rat brain of contrast and shift reagents for magnetic resonance imaging and spectroscopy. NMR Biomed 1993; 6: 339-344.
26. Swanson RA, Morton MT, Tsao-Wu G, Savalos RA, Davidson C, Sharp FR. A semi-automated method for measuring brain infarct volume. J Cereb Blood Flow Metab 1990; 10: 290-293.
27. De Ryck B, Van Reempts J, Borgers M, Wauquier A, Janssen PA. Photochemical stroke model: flunarizine prevents sensorimotor deficits after neocortical infarcts in rats. Stroke 1989; 20: 1383-1390.
28. Hamm RJ, Pike BR, O'Dell DM, Lyeth BG, Jenkins LW. The rotarod test: an evaluation of its effectiveness in assessing motor deficits following traumatic brain injury. J Neurotrauma 1994; 11: 187-196.
29. Scholz W, Albus U, Counillon L, Gögelein H, Lang H-J, Linz W et al. Protective effects of HOE642, a selective sodium-hydrogen exchange subtype 1 inhibitor, on cardiac ischaemia and reperfusion. Cardiovasc Res 1995; 29: 260-268.
30. Chen BP. Loop diuretics: comparison of torasemide, furosemide, and bumetanide. Drug Inform Update 1996; 60: 343-354.
31. Fischer H, Gottschlich R, Seelig A. Blood-brain barrier permeation: molecular parameters governing passive diffusion. J Membr Biol 1998; 165: 201-211.
32. Seelig A, Gottschlich R, Devant RM. A method to determine the ability of drugs to diffuse through the blood-brain barrier. Proc Natl Acad Sci 1994; 91: 68-72.
33. Betz AL, Keep RF, Beer ME, Ren XD. Blood-brain barrier permeability and brain concentration of sodium, potassium, and chloride during focal ischemia. J Cereb Blood Flow Metab 1994; 14: 29-37.
34. Menzies SA, Betz AL, Hoff JT. Contributions of ions and albumin to the formation and resolution of ischemic brain edema. J Neurosurg 1993; 78: 257-266.
35. Jones SC, Kharlamov A, Yanovski B, Kim DK, Easley KA, Yushmanov VE et al. Stroke onset time using sodium MRI in rat focal cerebral ischemia. Stroke 2006; 37: 883-888.
36. Yushmanov VE, Kharlamov A, Yanovski B, LaVerde GC, Boada FE, Jones SC. Inhomogeneous sodium accumulation in the ischemic core in rat focal cerebral ischemia by 23Na MRI. J Magn Reson Imaging 2009; 30: 18-24.
37. LaVerde GC, Jungreis CA, Nemoto E, Boada FE. Sodium time course using 23Na MRI in reversible focal brain ischemia in the monkey. J Magn Reson Imaging 2009; 30: 219-223.
38. Eleff SM, Mclennan IJ, Hart GK, Maruki Y, Traystman RJ, Koehler RC. Shift reagent enhanced concurrent 23Na and 1H magnetic resonance spectroscopic studies of transcellular sodium distribution in the dog brain in vivo. Magn Reson Imaging 1993; 30: 11-17.
39. + exchanger. Eur J Med Chem 2003; 38: 547-554.
40. Ca-ATP channel mediates cerebral edema after ischemic stroke. Nat Med 2006; 12: 433-440.