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Volumn 1, Issue 8, 1998, Pages 659-667

Phenylethanolamines inhibit NMDA receptors by enhancing proton inhibition

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID RECEPTOR BLOCKING AGENT; IFENPRODIL; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NEUROPROTECTIVE AGENT; PIPERIDINE DERIVATIVE; PROTON; RECOMBINANT PROTEIN; TRAXOPRODIL;

EID: 0032234177     PISSN: 10976256     EISSN: None     Source Type: Journal    
DOI: 10.1038/3661     Document Type: Article
Times cited : (203)

References (48)
  • 1
    • 0026497926 scopus 로고
    • Excitotoxic cell death
    • Choi, D. W. Excitotoxic cell death. J. Neurobiol. 23, 1261-1276 (1992).
    • (1992) J. Neurobiol. , vol.23 , pp. 1261-1276
    • Choi, D.W.1
  • 3
    • 0025063609 scopus 로고
    • Excitatory amino acid neurotoxicity and neurodegenerative disease
    • Meldrum, B. & Garthwaite, J. Excitatory amino acid neurotoxicity and neurodegenerative disease. Trends Pharmacol. Sci. 11, 379-387 (1990).
    • (1990) Trends Pharmacol. Sci. , vol.11 , pp. 379-387
    • Meldrum, B.1    Garthwaite, J.2
  • 4
    • 0025129130 scopus 로고
    • Acidosis reduces NMDA receptor activation, glutamate neurotoxicity, and oxygen-glucose deprivation neuronal injury in cortical cultures
    • Giffard, R. G., Monyer, H., Christine, C. W. & Choi, D. W. Acidosis reduces NMDA receptor activation, glutamate neurotoxicity, and oxygen-glucose deprivation neuronal injury in cortical cultures. Brain Res. 506, 339-342 (1990).
    • (1990) Brain Res. , vol.506 , pp. 339-342
    • Giffard, R.G.1    Monyer, H.2    Christine, C.W.3    Choi, D.W.4
  • 6
    • 0025350861 scopus 로고
    • Proton inhibition of N-methyl-D-aspartate receptors in cerebellar neurons
    • Traynelis, S. F. & Cull-Candy, S. G. Proton inhibition of N-methyl-D-aspartate receptors in cerebellar neurons. Nature 345, 347-350 (1990).
    • (1990) Nature , vol.345 , pp. 347-350
    • Traynelis, S.F.1    Cull-Candy, S.G.2
  • 7
    • 0026082757 scopus 로고
    • + sensitivity of excitatory amino acid receptor channels in rat cerebellar granule neurones
    • + sensitivity of excitatory amino acid receptor channels in rat cerebellar granule neurones. J. Physiol. (Lond.) 433, 727-763 (1991).
    • (1991) J. Physiol. (Lond.) , vol.433 , pp. 727-763
    • Traynelis, S.F.1    Cull-Candy, S.G.2
  • 8
    • 0025089514 scopus 로고
    • The effect of external pH changes on responses to excitatory amino acids in mouse hippocampal neurones
    • Vyklický, L. Jr, Vlachová, V. & Krusek, J. The effect of external pH changes on responses to excitatory amino acids in mouse hippocampal neurones. J. Physiol. (Lond.) 430, 497-517 (1990).
    • (1990) J. Physiol. (Lond.) , vol.430 , pp. 497-517
    • Vyklický L., Jr.1    Vlachová, V.2    Krusek, J.3
  • 9
    • 0026705552 scopus 로고
    • Modulation of pH by neuronal activity
    • Chesler, M. & Kaila, K. Modulation of pH by neuronal activity. Trends Neurosci. 15, 396-402 (1992).
    • (1992) Trends Neurosci. , vol.15 , pp. 396-402
    • Chesler, M.1    Kaila, K.2
  • 10
    • 0022308254 scopus 로고
    • Acid-base homoeostasis in the brain: Physiology, chemistry and neurochemical pathology
    • Siesjo, B. K. Acid-base homoeostasis in the brain: physiology, chemistry and neurochemical pathology. Prog. Brain Res. 63, 121-153 (1985).
    • (1985) Prog. Brain Res. , vol.63 , pp. 121-153
    • Siesjo, B.K.1
  • 11
    • 0026672262 scopus 로고
    • +] in the hippocampus during recovery from short-term, transient ischemia
    • +] in the hippocampus during recovery from short-term, transient ischemia. J. Cereb. Blood Flow Metab. 12, 759-772 (1992).
    • (1992) J. Cereb. Blood Flow Metab. , vol.12 , pp. 759-772
    • Silver, I.A.1    Erecinska, M.2
  • 12
    • 0027179773 scopus 로고
    • Neuroprotective effects of glutamate antagonists and extracellular acidity
    • Kaku, D. A., Giffard, R. G. & Choi, D. W. Neuroprotective effects of glutamate antagonists and extracellular acidity. Science 260, 1516-1518 (1993).
    • (1993) Science , vol.260 , pp. 1516-1518
    • Kaku, D.A.1    Giffard, R.G.2    Choi, D.W.3
  • 13
    • 0024268924 scopus 로고
    • Ifenprodil and SL 82.0175 as cerebral anti-ischemic agents. II. Evidence for N-methyl-D-aspartate receptor antagonist properties
    • Carter, C. J. et al. Ifenprodil and SL 82.0175 as cerebral anti-ischemic agents. II. Evidence for N-methyl-D-aspartate receptor antagonist properties. J. Pharmacol. Exp. Ther. 247, 1222-1232 (1988).
    • (1988) J. Pharmacol. Exp. Ther. , vol.247 , pp. 1222-1232
    • Carter, C.J.1
  • 14
    • 0027525324 scopus 로고
    • Ifenprodil discriminates subtypes of the N-methyl-D-aspartate receptor: Selectivity and mechanisms at recombinant heteromeric receptors
    • Williams, K. Ifenprodil discriminates subtypes of the N-methyl-D-aspartate receptor: Selectivity and mechanisms at recombinant heteromeric receptors. Mol. Pharmacol. 44, 851-859 (1993).
    • (1993) Mol. Pharmacol. , vol.44 , pp. 851-859
    • Williams, K.1
  • 15
    • 0028821024 scopus 로고
    • Pharmacological properties of recombinant N-methyl-D-aspartate (NMDA) receptors containing the ε4 (NR2D) subunit
    • Williams, K. Pharmacological properties of recombinant N-methyl-D-aspartate (NMDA) receptors containing the ε4 (NR2D) subunit. Neurosci. Lett. 184, 181-184 (1995).
    • (1995) Neurosci. Lett. , vol.184 , pp. 181-184
    • Williams, K.1
  • 16
    • 0029934332 scopus 로고    scopus 로고
    • Relationship between N-methyl-D-aspartate receptor NR1 splice variants and NR2 subunits
    • Blahos, J. 2nd & Wenthold, R. J. Relationship between N-methyl-D-aspartate receptor NR1 splice variants and NR2 subunits. J. Biol. Chem. 271, 15669-15674 (1996).
    • (1996) J. Biol. Chem. , vol.271 , pp. 15669-15674
    • Blahos J. II1    Wenthold, R.J.2
  • 17
    • 0031032658 scopus 로고    scopus 로고
    • The majority of N-methyl-D-aspartate receptor complexes in adult rat cerebral cortex contain at least three different subunits (NR1/NR2A/NR2B)
    • Luo, J., Wang, Y., Yasuda, R. P., Dunah, A. W. & Wolfe, B. B. The majority of N-methyl-D-aspartate receptor complexes in adult rat cerebral cortex contain at least three different subunits (NR1/NR2A/NR2B). Mol. Pharmacol. 51, 79-86 (1997).
    • (1997) Mol. Pharmacol. , vol.51 , pp. 79-86
    • Luo, J.1    Wang, Y.2    Yasuda, R.P.3    Dunah, A.W.4    Wolfe, B.B.5
  • 18
    • 0026656546 scopus 로고
    • The neuroprotective properties of ifenprodil, a novel NMDa receptor antagonist, in neuronal cell culture toxicity studies
    • Graham, D., Darles, G. & Langer, S. Z. The neuroprotective properties of ifenprodil, a novel NMDA receptor antagonist, in neuronal cell culture toxicity studies. Eur. J. Pharmacol. 226, 373-376 (1992).
    • (1992) Eur. J. Pharmacol. , vol.226 , pp. 373-376
    • Graham, D.1    Darles, G.2    Langer, S.Z.3
  • 19
    • 0024235996 scopus 로고
    • Ifenprodil and SL 82.0715 as cerebral anti-ischemic agents. I. Evidence for efficacy in models of focal cerebral ischemia
    • Gotti, B. et al. Ifenprodil and SL 82.0715 as cerebral anti-ischemic agents. I. Evidence for efficacy in models of focal cerebral ischemia. J. Pharmacol. Exp. Ther. 247, 1211-1221 (1988).
    • (1988) J. Pharmacol. Exp. Ther. , vol.247 , pp. 1211-1221
    • Gotti, B.1
  • 20
    • 0027496763 scopus 로고
    • Ifenprodil prevents glutamate cytotoxicity via polyamine modulatory sites of N-methyl-D-aspartate receptors in cultured cortical neurons
    • Tamura, Y. et al. Ifenprodil prevents glutamate cytotoxicity via polyamine modulatory sites of N-methyl-D-aspartate receptors in cultured cortical neurons. J. Pharmacol Exp. Ther. 265, 1017-1025 (1993).
    • (1993) J. Pharmacol Exp. Ther. , vol.265 , pp. 1017-1025
    • Tamura, Y.1
  • 21
    • 0024316832 scopus 로고
    • Ifenprodil is a novel type of N-methyl-D-aspartate receptor antagonist: Interaction with polyamines
    • Reynolds, I. J. & Miller, R. J. Ifenprodil is a novel type of N-methyl-D-aspartate receptor antagonist: interaction with polyamines. Mol. Pharmacol. 36, 758-765 (1989).
    • (1989) Mol. Pharmacol. , vol.36 , pp. 758-765
    • Reynolds, I.J.1    Miller, R.J.2
  • 22
    • 0025315206 scopus 로고
    • Ifenprodil and SL 82.0715 as cerebral antiischemic agents. III. Evidence for antagonistic effects at the polyamine modulatory site within the N-methyl-D-aspartate receptor complex
    • Carter, C. J., Lloyd, K. G., Żivkovic, B. & Scatton, B. Ifenprodil and SL 82.0715 as cerebral antiischemic agents. III. Evidence for antagonistic effects at the polyamine modulatory site within the N-methyl-D-aspartate receptor complex. J. Pharmacol. Exp. Ther. 253, 475-482 (1990).
    • (1990) J. Pharmacol. Exp. Ther. , vol.253 , pp. 475-482
    • Carter, C.J.1    Lloyd, K.G.2    Zivkovic, B.3    Scatton, B.4
  • 23
    • 0025951641 scopus 로고
    • Ifenprodil blocks N-methyl-D-aspartate receptors by a two-component mechanism
    • Legendre, P. & Westbrook, G. L. Ifenprodil blocks N-methyl-D-aspartate receptors by a two-component mechanism. Mol. Pharmacol. 40, 289-298 (1991).
    • (1991) Mol. Pharmacol. , vol.40 , pp. 289-298
    • Legendre, P.1    Westbrook, G.L.2
  • 24
    • 0030450983 scopus 로고    scopus 로고
    • A novel mechanism of activity-dependent NMDA receptor antagonism describes the effect of ifenprodil in rat cultured cortical neurones
    • Kew, J. N. C., Trube, G. & Kemp, J. A. A novel mechanism of activity-dependent NMDA receptor antagonism describes the effect of ifenprodil in rat cultured cortical neurones. J. Physiol. (Lond.) 497, 761-772 (1996).
    • (1996) J. Physiol. (Lond.) , vol.497 , pp. 761-772
    • Kew, J.N.C.1    Trube, G.2    Kemp, J.A.3
  • 25
    • 0026088184 scopus 로고
    • Separation of α adrenergic and N-methyl-D-aspartate antagonist activity in a series of ifenprodil compounds
    • Chenard, B. L. et al. Separation of α adrenergic and N-methyl-D-aspartate antagonist activity in a series of ifenprodil compounds. J. Med. Chem. 34, 3085-3090 (1991).
    • (1991) J. Med. Chem. , vol.34 , pp. 3085-3090
    • Chenard, B.L.1
  • 27
    • 0031443289 scopus 로고    scopus 로고
    • Ro 25-6981, a highly potent and selective blocker of N-methyl-D-aspartate receptors containing the NR2B subunit. Characterization in vitro
    • Fischer, G. et al. Ro 25-6981, a highly potent and selective blocker of N-methyl-D-aspartate receptors containing the NR2B subunit. Characterization in vitro. J. Pharmacol. Exp. Ther. 283, 1285-1292 (1997).
    • (1997) J. Pharmacol. Exp. Ther. , vol.283 , pp. 1285-1292
    • Fischer, G.1
  • 28
    • 0031985248 scopus 로고    scopus 로고
    • State-dependent NMDa receptor antagonism by Ro 8-4304, a novel NR2B selective, non-competitive, voltage-independent antagonist
    • Kew, J. N. C., Trube, G. & Kemp, J. A. State-dependent NMDA receptor antagonism by Ro 8-4304, a novel NR2B selective, non-competitive, voltage-independent antagonist. Brit. J. Pharmacol. 123, 463-472 (1998).
    • (1998) Brit. J. Pharmacol. , vol.123 , pp. 463-472
    • Kew, J.N.C.1    Trube, G.2    Kemp, J.A.3
  • 29
    • 0029100602 scopus 로고
    • (1S,2S)-1-(4-hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidino)-1-propanol: A potent new neuroprotectant which blocks N-methyl-D-aspartate responses
    • Chenard, B. L. et al. (1S,2S)-1-(4-hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidino)-1-propanol: a potent new neuroprotectant which blocks N-methyl-D-aspartate responses. J. Med. Chem. 38, 3138-3145 (1995).
    • (1995) J. Med. Chem. , vol.38 , pp. 3138-3145
    • Chenard, B.L.1
  • 30
    • 0027405347 scopus 로고
    • Developmental switch in the expression of NMDA receptors occurs in vivo and in vitro
    • Williams, K., Russell, S. L., Shen, Y. M. & Molinoff, P. B. Developmental switch in the expression of NMDA receptors occurs in vivo and in vitro. Neuron 10, 267-278 (1993).
    • (1993) Neuron , vol.10 , pp. 267-278
    • Williams, K.1    Russell, S.L.2    Shen, Y.M.3    Molinoff, P.B.4
  • 31
    • 0030839993 scopus 로고    scopus 로고
    • CP-101,606, a potent neuroprotectant selective for forebrain neurons
    • Menniti, F. et al. CP-101,606, a potent neuroprotectant selective for forebrain neurons. Eur. J. Pharmacol. 331, 117-126 (1997).
    • (1997) Eur. J. Pharmacol. , vol.331 , pp. 117-126
    • Menniti, F.1
  • 32
    • 0023754192 scopus 로고
    • Requirement for glycine in activation of NMDA receptors expressed in Xenopus oocytes
    • Kleckner, N. W. & Dingledine, R. Requirement for glycine in activation of NMDA receptors expressed in Xenopus oocytes. Science 241, 835-837 (1988).
    • (1988) Science , vol.241 , pp. 835-837
    • Kleckner, N.W.1    Dingledine, R.2
  • 33
    • 0032529588 scopus 로고    scopus 로고
    • Control of voltage-independent zinc inhibition of NMDA receptors by the NR1 subunit
    • Traynelis, S. F., Burgess, M. F., Zheng, F., Lyuboslavsky, P. & Powers, J. L. Control of voltage-independent zinc inhibition of NMDA receptors by the NR1 subunit. J. Neurosci. 18, 6163-6175 (1998).
    • (1998) J. Neurosci. , vol.18 , pp. 6163-6175
    • Traynelis, S.F.1    Burgess, M.F.2    Zheng, F.3    Lyuboslavsky, P.4    Powers, J.L.5
  • 34
    • 0029021010 scopus 로고
    • Control of proton sensitivity of the NMDA receptor by RNA splicing and polyamines
    • Traynelis, S. F., Hartley, M. & Heinemann, S. F. Control of proton sensitivity of the NMDA receptor by RNA splicing and polyamines. Science 268, 873-876 (1995).
    • (1995) Science , vol.268 , pp. 873-876
    • Traynelis, S.F.1    Hartley, M.2    Heinemann, S.F.3
  • 35
    • 0028034803 scopus 로고
    • Identification of two cysteine residues that are required for redox modulation of the NMDA subtype of glutamate receptor
    • Sullivan, J. M. et al. Identification of two cysteine residues that are required for redox modulation of the NMDA subtype of glutamate receptor. Neuron 13, 929-936 (1994).
    • (1994) Neuron , vol.13 , pp. 929-936
    • Sullivan, J.M.1
  • 36
    • 0029561009 scopus 로고
    • An acidic amino acid in the N-methyl-D aspartate receptor that is important for spermine stimulation
    • Williams, K., Kashiwagi, K., Fukuchi, J. & Igarashi, K. An acidic amino acid in the N-methyl-D aspartate receptor that is important for spermine stimulation. Mol. Pharmacol. 48, 1087-1097 (1995).
    • (1995) Mol. Pharmacol. , vol.48 , pp. 1087-1097
    • Williams, K.1    Kashiwagi, K.2    Fukuchi, J.3    Igarashi, K.4
  • 37
    • 0029945013 scopus 로고    scopus 로고
    • An aspartate residue in the extracellular loop of the N-methyl-D-aspartate receptor controls sensitivity to spermine and protons
    • Kashiwagi, K., Fukuchi, J.-I., Chao, J., Igarashi, K. & Williams, K. An aspartate residue in the extracellular loop of the N-methyl-D-aspartate receptor controls sensitivity to spermine and protons. Mol. Pharmacol. 49, 1131-1141 (1996).
    • (1996) Mol. Pharmacol. , vol.49 , pp. 1131-1141
    • Kashiwagi, K.1    Fukuchi, J.-I.2    Chao, J.3    Igarashi, K.4    Williams, K.5
  • 38
    • 0030899137 scopus 로고    scopus 로고
    • Influence of extracellular pH on inhibition by ifenprodil at N-methyl-D-aspartate receptors in Xenopus oocytes
    • Pahk, A. J. & Williams, K. Influence of extracellular pH on inhibition by ifenprodil at N-methyl-D-aspartate receptors in Xenopus oocytes. Neurosci. Lett. 225, 29-32 (1997).
    • (1997) Neurosci. Lett. , vol.225 , pp. 29-32
    • Pahk, A.J.1    Williams, K.2
  • 39
    • 0029871365 scopus 로고    scopus 로고
    • Interactions between ifenprodil and the NR2B subunit of the N-methyl-D-aspartate receptor
    • Gallagher, M. J., Huang, H., Pritchett, D. R. & Lynch, D. R. Interactions between ifenprodil and the NR2B subunit of the N-methyl-D-aspartate receptor. J. Biol. Chem. 271, 9603-9611 (1996).
    • (1996) J. Biol. Chem. , vol.271 , pp. 9603-9611
    • Gallagher, M.J.1    Huang, H.2    Pritchett, D.R.3    Lynch, D.R.4
  • 40
    • 0028077663 scopus 로고
    • Two identical noninteracting sites in an ion channel revealed by proton transfer
    • Root, M. J. & MacKinnon, R. Two identical noninteracting sites in an ion channel revealed by proton transfer. Science 265, 1852-1856 (1994).
    • (1994) Science , vol.265 , pp. 1852-1856
    • Root, M.J.1    MacKinnon, R.2
  • 41
    • 0343472092 scopus 로고    scopus 로고
    • Termination of acute stroke studies involving selfotel treatment
    • Davis, S. M., Albers, G. W., Diener, H.-C., Lees, K. R. & Norris, J. Termination of acute stroke studies involving selfotel treatment. Lancet 349, 32 (1997).
    • (1997) Lancet , vol.349 , pp. 32
    • Davis, S.M.1    Albers, G.W.2    Diener, H.-C.3    Lees, K.R.4    Norris, J.5
  • 42
    • 0030666876 scopus 로고    scopus 로고
    • Cerestat and other NMDA antagonists in ischemic stroke
    • Lees, K. R. Cerestat and other NMDA antagonists in ischemic stroke. Neurology 49, S66-S69 (1997).
    • (1997) Neurology , vol.49
    • Lees, K.R.1
  • 43
    • 0029901314 scopus 로고    scopus 로고
    • 2+ channels and in gerbil global cerebral ischemia
    • 2+ channels and in gerbil global cerebral ischemia. Eur. J. Pharmacol. 299, 103-112 (1996).
    • (1996) Eur. J. Pharmacol. , vol.299 , pp. 103-112
    • Bath, C.P.1
  • 44
    • 0031000863 scopus 로고    scopus 로고
    • 2+ channels are insensitive to eliprodil in rat cultured cerebellar neurons
    • 2+ channels are insensitive to eliprodil in rat cultured cerebellar neurons. Eur J. Pharmacol. 323, 277-281 (1997).
    • (1997) Eur J. Pharmacol. , vol.323 , pp. 277-281
    • Biton, B.1    Godet, D.2    Granger, P.3    Avenet, P.4
  • 45
    • 0030456734 scopus 로고    scopus 로고
    • A receptors in acutely isolated pyramidal neurons of rat hippocampus
    • A receptors in acutely isolated pyramidal neurons of rat hippocampus. Neuropharmacology 35, 1279-1288 (1996).
    • (1996) Neuropharmacology , vol.35 , pp. 1279-1288
    • Pasternack, M.1    Smirnov, S.2    Kaila, K.3
  • 46
    • 0003013349 scopus 로고    scopus 로고
    • eds Kaila, K. & Ransom, B. R. Wiley-Liss, New York
    • Traynelis, S. F. in pH and Brain Function (eds Kaila, K. & Ransom, B. R.) 407-437 (Wiley-Liss, New York, 1998).
    • (1998) pH and Brain Function , pp. 407-437
    • Traynelis, S.F.1
  • 47
    • 0026675738 scopus 로고
    • Structural determinants of barium permeation and rectification in non-NMDA glutamate receptor channels
    • Dingledine, R., Hume, R. I. & Heinemann, S. F. Structural determinants of barium permeation and rectification in non-NMDA glutamate receptor channels. J. Neurosci. 12, 4080-4087 (1992).
    • (1992) J. Neurosci. , vol.12 , pp. 4080-4087
    • Dingledine, R.1    Hume, R.I.2    Heinemann, S.F.3
  • 48
    • 0022670078 scopus 로고
    • GABAergic neurons in rat hippocampal culture
    • Hoch, D. B. & Dingledine, R. GABAergic neurons in rat hippocampal culture. Dev. Brain Res. 25, 53-64 (1986).
    • (1986) Dev. Brain Res. , vol.25 , pp. 53-64
    • Hoch, D.B.1    Dingledine, R.2


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