Essential role of estrogen for improvements in vascular endothelial function with endurance exercise in postmenopausal women

Journal of Clinical Endocrinology and Metabolism

Volumn 98, Issue 11, 2013, Pages 4507-4515

  Moreau, Kerrie L ^a,b   Stauffer, Brian L ^a,b   Kohrt, Wendy M ^a   Seals, Douglas R ^a,b  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASCORBIC ACID; ESTRADIOL; ESTROGEN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PLACEBO;

ADULT; AGED; ARTERY DILATATION; ARTICLE; BODY FAT; BODY MASS; BRACHIAL ARTERY; CONTROLLED STUDY; ENDURANCE TRAINING; ESTROGEN DEFICIENCY; FEMALE; FLOW MEDIATED DILATION; HUMAN; HUMAN EXPERIMENT; NORMAL HUMAN; OXIDATIVE STRESS; OXYGEN CONSUMPTION; PHYSICAL ACTIVITY; POSTMENOPAUSE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; VASCULAR ENDOTHELIUM;

ADMINISTRATION, CUTANEOUS; ADMINISTRATION, ORAL; ADULT; AGED; BRACHIAL ARTERY; ENDOTHELIUM, VASCULAR; ESTRADIOL; ESTROGEN REPLACEMENT THERAPY; EXERCISE; FEMALE; HUMANS; OXIDATIVE STRESS; PHYSICAL ENDURANCE; POSTMENOPAUSE; SEDENTARY LIFESTYLE;

EID: 84887435060     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2013-2183     Document Type: Article

References (40)

1. Roger VL, Go AS, Lloyd-Jones DM, et al. Heart disease and stroke statistics - 2011 update: a report from the American Heart Association. Circulation. 2011;123:e18-e209.
2. Mosca L, Benjamin EJ, Berra K, et al. Effectiveness-based guidelines for the prevention of cardiovascular disease in women - 2011 update: a guideline from the American Heart Association. Circulation. 2011;123: 1243-1262.
3. Manson JE, Hsia J, Johnson KC, et al. Estrogen plus progestin and the risk of coronary heart disease. N Engl J Med. 2003;349: 523-534.
4. Anderson GL, Limacher M, Assaf AR, et al. Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: the Women's Health Initiative randomized controlled trial. JAMA. 2004;291: 1701-1712.
5. Parker BA, Kalasky MJ, Proctor DN. Evidence for sex differences in cardiovascular aging and adaptive responses to physical activity. Eur J Appl Physiol. 2010;110: 235-246.
6. Deanfield JE, Halcox JP, Rabelink TJ. Endothelial function and dysfunction: testing and clinical relevance. Circulation. 2007;115: 1285-1295.
7. Celermajer DS, Sorensen KE, Spiegelhalter DJ, Georgakopoulos D, Robinson J, Deanfield JE. Aging is associated with endothelial dysfunction in healthy men years before the age-related decline in women. J Am Coll Cardiol. 1994;24: 471-476.
8. Moreau KL, Hildreth KL, Meditz AL, Deane KD, Kohrt WM. Endothelial function is impaired across the stages of the menopause transition in healthy women. J Clin Endocrinol Metab. 2012;97: 4692-4700.
9. Seals DR, Walker AE, Pierce GL, Lesniewski LA. Habitual exercise and vascular ageing. J Physiol. 2009;587: 5541-5549.
10. Eskurza I, Monahan KD, Robinson JA, Seals DR. Effect of acute and chronic ascorbic acid on flow-mediated dilatation with sedentary and physically active human ageing. J Physiol. 2004;556: 315-324.
11. Pierce GL, Eskurza I, Walker AE, Fay TN, Seals DR. Sex-specific effects of habitual aerobic exercise on brachial artery flow-mediated dilation in middle-aged and older adults. Clin Sci (Lond). 2011; 120: 13-23.
12. Casey DP, Pierce GL, Howe KS, Mering MC, Braith RW. Effect of resistance training on arterial wave reflection and brachial artery reactivity in normotensive postmenopausal women. Eur J Appl Physiol. 2007;100: 403-408.
13. Moreau KL, Meditz A, Deane KD, KohrtWM.Tetrahydrobiopterin improves endothelial function and decreases arterial stiffness in estrogen- deficient postmenopausal women. Am J Physiol Heart Circ Physiol. 2012;302:H1211-H1218.
14. Virdis A, Ghiadoni L, Pinto S, et al. Mechanisms responsible for endothelial dysfunction associated with acute estrogen deprivation in normotensive women. Circulation. 2000;101: 2258-2263.
15. Pereira MA, FitzerGerald SJ, Gregg EW, et al. A collection of Physical Activity Questionnaires for health-related research. Med Sci Sports Exerc. 1997;29:S1-S205.
16. Rosano GMC, Vitale C, Silvestri A, Fini M. Metabolic and vascular effect of progestins in post-menopausal women: implications for cardioprotection. Maturitas. 2003;46: 17-29.
17. DeSouza CA, Shapiro LF, Clevenger CM, et al. Regular aerobic exercise prevents and restores age-related declines in endotheliumdependent vasodilation in healthy men. Circulation. 2000;102: 1351-1357.
18. Eskurza I, Myerburgh LA, Kahn ZD, Seals DR. Tetrahydrobiopterin augments endothelium-dependent dilatation in sedentary but not in habitually exercising older adults. J Physiol. 2005;568:1057- 1065.
19. Harman SM, Metter EJ, Tobin JD, Pearson J, Blackman MR. Longitudinal effects of aging on serum total and free testosterone levels in healthy men. Baltimore Longitudinal Study of Aging. J Clin Endocrinol Metab. 2001;86: 724-731.
20. Yoshida N, Ikeda H, Sugi K, Imaizumi T. Impaired endotheliumdependent and -independent vasodilation in young female athletes with exercise-associated amenorrhea. Arterioscler Thromb Vasc Biol. 2006;26: 231-232.
21. Rickenlund A, Eriksson MJ, Schenck-Gustafsson K, Hirschberg AL. Oral contraceptives improve endothelial function in amenorrheic athletes. J Clin Endocrinol Metab. 2005;90: 3162-3167.
22. Hagmar M, Eriksson MJ, Lindholm C, Schenck-Gustafsson K, Hirschberg AL. Endothelial function in post-menopausal former elite athletes. Clin J Sport Med. 2006;16: 247-252.
23. Harvey PJ, Picton PE, Su WS, Morris BL, Notarius CF, Floras JS. Exercise as an alternative to oral estrogen for amelioration of endothelial dysfunction in postmenopausal women.AmHeart J. 2005; 149: 291-297.
24. O'Donnell E, Goodman JM, Harvey PJ. Clinical review: cardiovascular consequences of ovarian disruption: a focus on functional hypothalamic amenorrhea in physically active women. J Clin Endocrinol Metab. 2011;96: 3638-3648.
25. Kojda G, Harrison D. Interactions betweenNOand reactive oxygen species: pathophysiological importance in atherosclerosis, hypertension, diabetes and heart failure. Cardiovasc Res. 1999;43: 562-571.
26. Wagner AH, Schroeter MR, Hecker M. 17β-estradiol inhibition of NADPH oxidase expression in human endothelial cells. FASEB J. 2001;15: 2121-2130.
27. Pierce GL, Donato AJ, LaRocca TJ, Eskurza I, Silver AE, Seals DR. Habitually exercising older men do not demonstrate age-associated vascular endothelial oxidative stress. Aging Cell. 2011;10:1032- 1037.
28. Zhang QJ, McMillin SL, Tanner JM, PalionyteM,Abel ED, Symons JD. Endothelial nitric oxide synthase phosphorylation in treadmillrunning mice: role of vascular signalling kinases. J Physiol. 2009; 587: 3911-3920.
29. Traub O, Berk BC. Laminar shear stress: mechanisms by which endothelial cells transduce an atheroprotective force. Arterioscler Thromb Vasc Biol. 1998;18: 677-685.
30. Kim KH, Moriarty K, Bender Jr. Vascular cell signaling by membrane estrogen receptors. Steroids. 2008;73: 864-869.
31. Tan E, Gurjar MV, Sharma RV, Bhalla RC. Estrogen receptor-α gene transfer into bovine aortic endothelial cells induces eNOS gene expression and inhibits cell migration. Cardiovasc Res. 1999;43: 788-797.
32. Chambliss KL, Shaul PW. Estrogen modulation of endothelial nitric oxide synthase. Endocr Rev. 2002;23: 665-686.
33. Huang A, Sun D, Koller A, Kaley G. 17β-Estradiol restores endothelial nitric oxide release to shear stress in arterioles of male hypertensive rats. Circulation. 2000;101: 94-100.
34. Pinna C, Cignarella A, Sanvito P, Pelosi V, Bolego C. Prolonged ovarian hormone deprivation impairs the protective vascular actions of estrogen receptorα agonists. Hypertension. 2008;51:1210- 1217.
35. Gavin KM, Seals DR, Silver AE, Moreau KL. Vascular endothelial estrogen receptor α is modulated by estrogen status and related to endothelial function and endothelial nitric oxide synthase in healthy women. J Clin Endocrinol Metab. 2009;94: 3513-3520.
36. Vitale C, Mercuro G, Cerquetani E, et al. Time since menopause influences the acute and chronic effect of estrogens on endothelial function. Arterioscler Thromb Vasc Biol. 2008;28: 348-352.
37. Black MA, Cable NT, Thijssen DH, Green DJ. Impact of age, sex, and exercise on brachial artery flow-mediated dilatation. Am J Physiol Heart Circ Physiol. 2009;297:H1109-H1116.
38. Powers MS, Schenkel L, Darley PE, Good WR, Balestra JC, Place VA. Pharmacokinetics and pharmacodynamics of transdermal dosage forms of 17 β-estradiol: comparison with conventional oral estrogens used for hormone replacement. Am J Obstet Gynecol. 1985;152: 1099-1106.
39. Vehkavaara S, Hakala-Ala-Pietilä T, Virkamaki A, et al. Differential effects of oral and transdermal estrogen replacement therapy on endothelial function in postmenopausal women. Circulation. 2000; 102: 2687-2693.
40. Vehkavaara S, Silveira A, Hakala-Ala-Pietilä T, et al. Effects of oral and transdermal estrogen replacement therapy on markers of coagulation, fibrinolysis, inflammation and serum lipids and lipoproteins in postmenopausal women. Thromb Haemost. 2001;85: 619-625.