Sarcopenia: A clinical review

Reviews in Clinical Gerontology

Volumn 23, Issue 4, 2013, Pages 267-274

  Cruz Jentoft, A J ^a  

^a HOSPITAL RAMÓN Y CAJAL   (Spain)

Author keywords

frail elderly; muscle; sarcopenia; skeletal

Indexed keywords

ADVERSE OUTCOME; CLINICAL PRACTICE; DIFFERENTIAL DIAGNOSIS; DUAL ENERGY X RAY ABSORPTIOMETRY; EXERCISE; FRAIL ELDERLY; GERIATRIC ASSESSMENT; HUMAN; LEAN BODY WEIGHT; MUSCLE FUNCTION; MUSCLE MASS; MUSCLE STRENGTH; NEUROMUSCULAR SYNAPSE; NUCLEAR MAGNETIC RESONANCE IMAGING; PHYSICAL ACTIVITY; PHYSICAL DISABILITY; PHYSICAL PERFORMANCE; QUALITY OF LIFE; REVIEW; SARCOPENIA; SKELETAL MUSCLE;

EID: 84887423380     PISSN: 09592598     EISSN: 14699036     Source Type: Journal    
DOI: 10.1017/S0959259813000154     Document Type: Review

References (67)

1. Rosenberg IH. Sarcopenia: Origins and clinical relevance. J Nutr 1997; 127 (suppl 5): 990-91S.
2. Vandewoude MF, Cederholm T, Cruz-Jentoft AJ. Relevant outcomes in intervention trials for sarcopenia. J Am Geriatr Soc 2011; 59: 1566-67
3. Cruz-Jentoft AJ, Morley JE. Sarcopenia. Chichester, West Sussex; Hoboken, NJ: Wiley-Blackwell; 2012
4. Janssen I. The epidemiology of sarcopenia. Clin Geriatr Med 2011; 27: 355-63
5. Manini TM, Clark BC. Dynapenia and aging: An update. J Gerontol A Biol Sci Med Sci 2012; 67: 28-40
6. Mijnarends DM, Meijers JMM, Halfens RJG et al. Validity and reliability of tools to measure muscle mass, strength, and physical performance in community-dwelling older people: A systematic review. J Am Med Dir Assoc 2013; 14: 170-78
7. Bijlsma AY, Meskers CG, Ling CH et al. Defining sarcopenia: The impact of different diagnostic criteria on the prevalence of sarcopenia in a large middle aged cohort. Age (Dordr) 2013; 35: 871-81
8. Papanicolaou DA, Ather SN, Zhu H et al. A phase IIA randomized, placebo-controlled clinical trial to study the efficacy and safety of the selective androgen receptor modulator (SARM), MK-0773 in female participants with sarcopenia. J Nutr Health Aging 2013; 17: 533-43
9. Muscaritoli M, Anker SD, Argiles J et al. Consensus definition of sarcopenia, cachexia and pre-cachexia: Joint document elaborated by Special Interest Groups (SIG) 'cachexia-anorexia in chronic wasting diseases' and 'nutrition in geriatrics'. Clin Nutr 2010; 29: 154-59
10. Fielding RA, Vellas B, Evans WJ et al. Sarcopenia: An undiagnosed condition in older adults. Current consensus definition: Prevalence, etiology, and consequences. International working group on sarcopenia. J Am Med Dir Assoc 2011; 12: 249-56
11. Morley JE, Abbatecola AM, Argiles JM et al. Sarcopenia with limited mobility: An international consensus. J Am Med Dir Assoc 2011; 12: 403-9
12. Cruz-Jentoft AJ, Baeyens JP, Bauer JM et al. Sarcopenia: European consensus on definition and diagnosis: Report of the European Working Group on Sarcopenia in Older People. Age Ageing 2010; 39: 412-23
13. Patel HP, Syddall HE, Jameson K et al. Prevalence of sarcopenia in community-dwelling older people in the UK using the European Working Group on Sarcopenia in Older People (EWGSOP) definition: Findings from the Hertfordshire Cohort Study (HCS). Age Ageing 2013; 42: 378-84
14. Landi F, Liperoti R, Fusco D et al. Prevalence and risk factors of sarcopenia among nursing home older residents. J Gerontol A Biol Sci Med Sci 2012; 67: 48-55
15. Landi F, Liperoti R, Fusco D et al. Sarcopenia and mortality among older nursing home residents. J Am Med Dir Assoc 2012; 13: 121-26
16. Landi F, Liperoti R, Russo A et al. Sarcopenia as a risk factor for falls in elderly individuals: Results from the ilSIRENTE study. Clin Nutr 2012; 31: 652-58
17. Arango-Lopera VE, Arroyo P, Gutiérrez-Robledo LM, Pérez-Zepeda MU, Cesari M. Mortality as an adverse outcome of sarcopenia. J Nutr Health Aging 2013; 17: 259-62
18. Lee W-J, Liu L-K, Peng L-N, Lin M-H, Chen L-K. Comparisons of sarcopenia defined by IWGS and EWGSOP criteria among older people: Results from the I-Lan Longitudinal Aging Study. J AmMed Dir Assoc 2013; 14: 528. e1-7
19. Fried LP, Tangen CM, Walston J et al. Frailty in older adults: Evidence for a phenotype. J Gerontol Biol Sci Med Sci 2001; 56: M146-56
20. Rodriguez-Mañas L, Feart C, Mann G et al. Searching for an operational definition of frailty: A Delphi Method Based Consensus Statement. The Frailty Operative Definition-Consensus Conference Project. J Gerontol A Biol Sci Med Sci 2013; 68: 62-67
21. Rockwood K, Bergman H. FRAILTY: A Report from the 3rd Joint Workshop of IAGG/WHO/SFGG, Athens, January 2012. Can Geriatr J 2012; 15: 31-36
22. Deane AJB, Jaafar AF. An update on frailty diagnosis and management. Rev Clin Gerontol 2013; Epub ahead of print
23. Bouillon K, Kivimaki M, Hamer M et al. Measures of frailty in population-based studies: An overview. BMC Geriatr 2013; 13: 64-75
24. Michel JP, Cruz-Jentoft AJ. Sarcopenia: A useful paradigm for physical frailty. Eur Geriatr Med 2013; 4: 102-5
25. Jeejeebhoy KN. Malnutrition, fatigue, frailty, vulnerability, sarcopenia and cachexia: Overlap of clinical features. Curr Opin Clin Nutr Metab Care 2012; 15: 213-19
26. Cooper C, Dere W, Evans W et al. Frailty and sarcopenia: Definitions and outcome parameters. Osteoporosis Int 2012; 23: 1839-48
27. Rizzoli R, Reginster J-Y, Arnal J-F et al. Quality of life in sarcopenia and frailty. Calcif Tissue Int 2013; 93: 101-20
28. Drey M, Sieber CC, Bauer JM, Uter W, Dahinden P, Fariello RG et al. C-terminal Agrin Fragment as a potential marker for sarcopenia caused by degeneration of the neuromuscular junction. Exp Gerontol 2013; 48: 76-80
29. Cruz-Jentoft AJ, Landi F, Topinkova E, Michel JP. Understanding sarcopenia as a geriatric syndrome. Curr Opin Clin Nutr Metab Care 2010; 13: 1-7
30. Olde Rikkert MG, Rigaud AS, Van Hoeyweghen RJ, De Graaf J. Geriatric syndromes: Medical misnomer or progress in geriatrics? Neth J Med 2003; 61: 83-87
31. Inouye SK, Studenski S, Tinetti ME, Kuchel GA. Geriatric syndromes: Clinical, research, and policy implications of a core geriatric concept. J Am Geriatr Soc 2007; 55: 780-91
32. Sjöoblom S, Suuronen J, Rikkonen T, Honkanen R, Kröger H, Sirola J. Relationship between postmenopausal osteoporosis and the components of clinical sarcopenia. Maturitas 2013; 75: 175-80
33. Cederholm T, Cruz-Jentoft AJ, Maggi S. Sarcopenia and fragility fractures. Eur J Phys Rehabil Med 2013; 49: 111-17
34. Kaji H. Linkage between muscle and bone: Common catabolic signals resulting in osteoporosis and sarcopenia. Curr Opin Clin Nutr Metab Care 2013; 16: 272-77
35. Thomas DR. Loss of skeletal muscle mass in aging: Examining the relationship of starvation, sarcopenia and cachexia. Clin Nutr 2007; 26: 389-99
36. Evans WJ, Morley JE, Argiles J et al. Cachexia: A new definition. Clin Nutr 2008; 27: 793-99
37. Dodds R, Denison HJ, Ntani G et al. Birth weight and muscle strength: A systematic review and meta-analysis. J Nutr Health Aging 2012; 16: 609-15
38. Candow DG, Forbes SC, Little JP, Cornish SM, Pinkoski C, Chilibeck PD. Effect of nutritional interventions and resistance exercise on aging muscle mass and strength. Biogerontology 2012; 13: 345-58
39. Caspersen CJ, Powell KE, Christenson GM. Physical activity, exercise, and physical fitness: Definitions and distinctions for health-related research. Public Health Reports Wash 1985; 100: 126-31
40. Chastin SF, Ferriolli E, Stephens NA, Fearon KC, Greig C. Relationship between sedentary behaviour, physical activity, muscle quality and body composition in healthy older adults. Age Ageing 2012; 41: 111-14
41. Ryu M, Jo J, Lee Y, Chung Y-S, Kim K-M, Baek W-C. Association of physical activity with sarcopenia and sarcopenic obesity in community-dwelling older adults: The Fourth Korea National Health and Nutrition Examination Survey. Age Ageing 2013 (Epub ahead of print: 11 June
42. Kim S-H, Kim T-H, Hwang H-J. The relationship of physical activity (PA) and walking with sarcopenia in Korean males aged 60 years and older using the Fourth Korean National Health and Nutrition Examination Survey (KNHANES IV-2, 3), 2008-2009. Arch Gerontol Geriatr 2013; 56: 472-77
43. Hamer M, Stamatakis E. Screen-based sedentary behavior, physical activity, and muscle strength in the English longitudinal study of ageing. PloS One 2013; 8: E66222
44. Timmerman KL, Dhanani S, Glynn EL et al. A moderate acute increase in physical activity enhances nutritive flow and the muscle protein anabolic response to mixed nutrient intake in older adults. Am J Clin Nutr 2012; 95: 1403-12
45. Scanlon TC, Fragala MS, Stout JR et al. Muscle architecture and strength: Adaptations to short term resistance training. Muscle Nerve 2013 (Epub ahead of print: 28 July
46. Fry CS, Drummond MJ, Glynn EL et al. Skeletal muscle autophagy and protein breakdown following resistance exercise are similar in younger and older adults. J Gerontol A Biol Sci Med Sci 2013; 68: 599-607
47. Forbes SC, Little JP, Candow DG. Exercise and nutritional interventions for improving aging muscle health. Endocrine 2012; 42: 29-38
48. Peterson MD, Sen A, Gordon PM. Influence of resistance exercise on lean body mass in aging adults: A meta-analysis. Med Sci Sports Exerc 2011; 43: 249-58
49. Serra-Rexach JA, Bustamante-Ara N, Hierro VM et al. Short-term, light- to moderate-intensity exercise training improves leg muscle strength in the oldest old: A randomized controlled trial. J Am Geriatr Soc 2011; 59: 594-602
50. Tieland M, Dirks ML, Van Der Zwaluw N et al. Protein supplementation increases muscle mass gain during prolonged resistance-type exercise training in frail elderly people: A randomized, double-blind, placebo-controlled trial. J AmMed Dir Assoc 2012; 13: 713-19
51. Vandewoude MFJ, Alish CJ, Sauer AC, Hegazi RA. Malnutrition-sarcopenia syndrome: Is this the future of nutrition screening and assessment for older adults? J Aging Res 2012; article ID 651570
52. Bauer J, Biolo G, Cederholm T et al. Evidence-based Recommendations for Optimal Dietary Protein Intake in Older People: A Position Paper From the PROT-AGE Study Group. J Am Med Dir Assoc 2013 (Epub ahead of print: 15 July
53. Aleman-Mateo H, Macias L, Esparza-Romero J, Astiazaran-Garcia H, Blancas AL. Physiological effects beyond the significant gain in muscle mass in sarcopenic elderly men: Evidence from a randomized clinical trial using a protein-rich food. Clin Interv Aging 2012; 7: 225-34
54. Leenders M, Van Loon LJC. Leucine as a pharmaconutrient to prevent and treat sarcopenia and type 2 diabetes. Nutr Rev 2011; 69: 675-89
55. Deutz NE, Pereira SL, Hays NP et al. Effect of ß-hydroxy-ß- methylbutyrate (HMB) on lean body mass during 10 days of bed rest in older adults. Clin Nutr 2013 (Epub ahead of print: 4 March
56. Candow DG. Sarcopenia: Current theories and the potential beneficial effect of creatine application strategies. Biogerontology 2011; 12: 273-81
57. Burd NA, Yang Y, Moore DR, Tang JE, Tarnopolsky MA, Phillips SM. Greater stimulation of myofibrillar protein synthesis with ingestion of whey protein isolate v. micellar casein at rest and after resistance exercise in elderly men. Br J Nutr 2012; 108: 958-62
58. Björkman MP, Pilvi TK, Kekkonen RA, Korpela R, Tilvis RS. Similar effects of leucine-rich and regular dairy products on muscle mass and functions of older polymyalgia rheumatica patients: A randomized crossover trial. J Nutr Health Aging 2011; 15: 462-67
59. Brotto M, Abreu EL. Sarcopenia: Pharmacology of today and tomorrow. J Pharmacol Exp Ther 2012; 343: 540-46
60. Rolland Y, Onder G, Morley JE, Gillette-Guyonet S, Abellan Van Kan G, Vellas B. Current and future pharmacologic treatment of sarcopenia. Clin Geriatr Med 2011; 27: 423-47
61. Maggio M, Lauretani F, Ceda GP. Sex hormones and sarcopenia in older persons. Curr Opin Clin Nutr Metab Care 2013; 16: 3-13
62. Gumucio JP, Mendias CL. Atrogin-1, MuRF-1 and sarcopenia. Endocrine 2013; 43: 12-21
63. MacDonald EM, Cohn RD. TGFß signaling: Its role in fibrosis formation and myopathies. Curr Opin Rheumatol 2012; 24: 628-34
64. Marzetti E, Calvani R, Bernabei R, Leeuwenburgh C. Apoptosis in skeletal myocytes: A potential target for interventions against sarcopenia and physical frailty - A mini-review. Gerontology 2012; 58: 99-106
65. Elliott B, Renshaw D, Getting S, Mackenzie R. The central role of myostatin in skeletal muscle and whole body homeostasis. Acta Physiol Oxf 2012; 205: 324-40
66. Clark DJ, Fielding RA. Neuromuscular contributions to age-related weakness. J Gerontol A Biol Sci Med Sci 2012; 67: 41-47
67. Brass EP, Sietsema KE. Considerations in the development of drugs to treat sarcopenia. J Am Geriatr Soc 2011; 59: 530-35