Dynapenia and aging: An update

Journals of Gerontology - Series A Biological Sciences and Medical Sciences

Volumn 67 A, Issue 1, 2012, Pages 28-40

  Manini, Todd M ^a   Clark, Brian C ^b  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^b OHIO UNIVERSITY   (United States)

Author keywords

Atrophy; Disability; Function; Strength; Weakness

Indexed keywords

AGED; AGING; ALGORITHM; ANIMAL; ARTICLE; CLASSIFICATION; DISABLED PERSON; FEMALE; GERIATRIC ASSESSMENT; HAND STRENGTH; HUMAN; INNERVATION; KNEE; MALE; MUSCLE ATROPHY; MUSCLE STRENGTH; MUSCLE WEAKNESS; PATHOPHYSIOLOGY; PHYSIOLOGY; RAT; RISK FACTOR; SKELETAL MUSCLE; TRANSLATIONAL RESEARCH;

AGED; AGED, 80 AND OVER; AGING; ALGORITHMS; ANIMALS; DISABLED PERSONS; FEMALE; GERIATRIC ASSESSMENT; HAND STRENGTH; HUMANS; KNEE; MALE; MUSCLE STRENGTH; MUSCLE WEAKNESS; MUSCLE, SKELETAL; RATS; RISK FACTORS; SARCOPENIA; TRANSLATIONAL MEDICAL RESEARCH;

EID: 84856178558     PISSN: 10795006     EISSN: 1758535X     Source Type: Journal    
DOI: 10.1093/gerona/glr010     Document Type: Article

References (141)

1. Clark BC, Manini TM. Sarcopenia r/f dynapenia. J Gerontol A Biol Sci Med Sci. 2008;63:829-834.
2. Statistics FIFoA-R. Older Americans 2008: Key Indicators of Well-being; Washington, DC: U.S. Government Printing Office; 2008.
3. Committee on the Future Health Care Workforce for Older Americans IoM. Retooling for an Aging America: Building the Health Care Workforce; Washington, DC: National Academies Press; 2008.
4. Cesari M, Pahor M, Lauretani F, Zamboni V, Bandinelli S, Bernabei R, et al. Skeletal muscle and mortality results from the InCHIANTI Study. J Gerontol A Biol Sci Med Sci. 2009;64:377-384.
5. Manini TM, Visser M, Won-Park S, Patel KV, Strotmeyer ES, Chen H, et al. Knee extension strength cutpoints for maintaining mobility. J Am Geriatr Soc. 2007;55:451-457. (Pubitemid 46328122)
6. Newman AB, Kupelian V, Visser M, Simonsick EM, Goodpaster BH, Kritchevsky SB, et al. Strength, but not muscle mass, is associated with mortality in the health, aging and body composition study cohort. J Gerontol A Biol Sci Med Sci. 2006;61:72-77. (Pubitemid 43227803)
7. Visser M, Newman AB, Nevitt MC, Kritchevsky SB, Stamm EB, Goodpaster BH, et al. Reexamining the sarcopenia hypothesis. Muscle mass versus muscle strength. Health, Aging, and Body Composition Study Research Group. Ann N Y Acad Sci. 2000;904:456-461. (Pubitemid 30389237)
8. Visser M, Simonsick EM, Colbert LH, Brach J, Rubin SM, Kritchevsky SB, et al. Type and intensity of activity and risk of mobility limitation: the mediating role of muscle parameters. J Am Geriatr Soc. 2005;53:762-770. (Pubitemid 41656920)
9. Lainscak M, Podbregar M, Anker SD. How does cachexia influence survival in cancer, heart failure and other chronic diseases? Curr Opin Support Palliat Care. 2007;1:299-305.
10. Muscaritoli M, Bossola M, Bellantone R, Rossi Fanelli F. Therapy of muscle wasting in cancer: what is the future? Curr Opin Clin Nutr Metab Care. 2004;7:459-466. (Pubitemid 40340654)
11. Tan BH, Fearon KC. Cachexia: prevalence and impact in medicine. Curr Opin Clin Nutr Metab Care. 2008;11:400-407.
12. Cruz-Jentoft AJ, Baeyens JP, Bauer JM, Boirie Y, Cederholm T, Landi F, et al. Sarcopenia: European consensus on definition and diagnosis: Report of the European Working Group on Sarcopenia in Older People. Age Ageing. 2010;39:412-423.
13. The Biomarkers Consortium: Sarcopenia Project. Foundation for the National Institutes of Health; 2010. www.thebiomarkersconsortium.org/index.php? option=com-content&;task=view&id=138&Itemid=61. Accessed November 15, 2010.
14. Rosenberg IH. Summary comments. Am J Clin Nutr. 1989;50:1231-1233. (Pubitemid 19282798)
15. Janssen I. Evolution of sarcopenia research. Appl Physiol Nutr Metab. 2010;35:707-712.
16. Bouchard DR, Janssen I. Dynapenic-obesity and physical function in older adults. J Gerontol A Biol Sci Med Sci. 65:71-77.
17. Glover EI, Phillips SM. Resistance exercise and appropriate nutrition to counteract muscle wasting and promote muscle hypertrophy. Curr Opin Clin Nutr Metab Care. 13:630-634.
18. Barbat-Artigas S, Dupontgand S, Fex A, Karelis AD, Aubertin-Leheudre M. Relationship between dynapenia and cardio-respiratory functions in healthy postmenopausal women: a novel clinical criteria. Menopause. In press.
19. Evans WJ. What is sarcopenia? J Gerontol A Biol Sci Med Sci. 1995;50:5-8.
20. Moritani T, deVries HA. Neural factors versus hypertrophy in the time course of muscle strength gain. Am J Phys Med. 1979;58:115-130. (Pubitemid 9210010)
21. Delmonico MJ, Harris TB, Visser M, Park SW, Conroy MB, Velasquez-Mieyer P, et al. Longitudinal study of muscle strength, quality, and adipose tissue infiltration. Am J Clin Nutr. 2009;90:1579-1585.
22. Clark BC, Fernhall B, Ploutz-Snyder LL. Adaptations in human neuromuscular function following prolonged unweighting: I. Skeletal muscle contractile properties and applied ischemia efficacy. J Appl Physiol. 2006;101:256-263. (Pubitemid 44035372)
23. Clark BC, Manini TM, Bolanowski SJ, Ploutz-Snyder LL. Adaptations in human neuromuscular function following prolonged unweighting: II. Neurological properties and motor imagery efficacy. J Appl Physiol. 2006;101:264-272. (Pubitemid 44035373)
24. Clark BC, Taylor JL. Age-related changes in motor cortical properties and voluntary activation of skeletal muscle. Curr Aging Sci. In press.
25. Delbono O. Expression and regulation of excitation-contraction coupling proteins in aging skeletal muscle. Curr Aging Sci. In press.
26. Kostek MC. Delmonico MJ. Age-related changes in adult muscle morphology. Curr Aging Sci. In press.
27. Buchman AS, Boyle PA, Leurgans SE, Evans DA, Bennett DA. Pulmonary function, muscle strength, and incident mobility disability in elders. Proc Am Thorac Soc. 2009;6:581-587.
28. Davis JW, Ross PD, Preston SD, Nevitt MC, Wasnich RD. Strength, physical activity, and body mass index: relationship to performance-based measures and activities of daily living among older Japanese women in Hawaii. J Am Geriatr Soc. 1998;46:274-279. (Pubitemid 28117521)
29. Hairi NN, Cumming RG, Naganathan V, Handelsman DJ, Le Couteur DG, Creasey H, et al. Loss of muscle strength, mass (sarcopenia), and quality (specific force) and its relationship with functional limitation and physical disability: the concord health and ageing in men project. J Am Geriatr Soc. 2010;58:2055-2062.
30. Lauretani F, Russo CR, Bandinelli S, Bartali B, Cavazzini C, Di Iorio A, et al. Age-associated changes in skeletal muscles and their effect on mobility: an operational diagnosis of sarcopenia. J Appl Physiol. 2003;95:1851-1860. (Pubitemid 37310367)
31. Rantanen T, Guralnik JM, Foley D, Masaki K, Leveille S, Curb JD, et al. Midlife hand grip strength as a predictor of old age disability. J Am Med Assoc. 1999;281:558-560. (Pubitemid 29081310)
32. Visser M, Goodpaster BH, Kritchevsky SB, Newman AB, Nevitt M, Rubin SM, et al. Muscle mass, muscle strength, and muscle fat infiltration as predictors of incident mobility limitations in well-functioning older persons. J Gerontol A Biol Sci Med Sci. 2005;60:324-333. (Pubitemid 40628797)
33. Baumgartner RN, Koehler KM, Gallagher D, Romero L, Heymsfield SB, Ross RR, et al. Epidemiology of sarcopenia among the elderly in New Mexico. Am J Epidemiol. 1998;147:755-763. (Pubitemid 28183275)
34. Cesari M, Leeuwenburgh C, Lauretani F, Onder G, Bandinelli S, Maraldi C, et al. Frailty syndrome and skeletal muscle: results from the Invecchiare in Chianti study. Am J Clin Nutr. 2006;83:1142-1148. (Pubitemid 44713116)
35. Delmonico MJ, Harris TB, Lee JS, Visser M, Nevitt M, Kritchevsky SB, et al. Alternative definitions of sarcopenia, lower extremity performance, and functional impairment with aging in older men and women. J Am Geriatr Soc. 2007;55:769-774. (Pubitemid 46668965)
36. Janssen I. Influence of sarcopenia on the development of physical disability: the Cardiovascular Health Study. J Am Geriatr Soc. 2006;54:56-62.
37. Janssen I, Heymsfield SB, Ross R. Low relative skeletal muscle mass (sarcopenia) in older persons is associated with functional impairment and physical disability. J Am Geriatr Soc. 2002;50:889-896. (Pubitemid 34496687)
38. Newman AB, Kupelian V, Visser M, Simonsick E, Goodpaster B, Nevitt M, et al. Sarcopenia: alternative definitions and associations with lower extremity function. J Am Geriatr Soc. 2003;51:1602-1609. (Pubitemid 37409595)
39. Visser M, Harris TB, Langlois J, Hannan MT, Roubenoff R, Felson DT, et al. Body fat and skeletal muscle mass in relation to physical disability in very old men and women of the Framingham Heart Study. J Gerontol A Biol Sci Med Sci. 1998;53:M214-M221. (Pubitemid 28232604)
40. Bassey EJ, Short AH. A new method for measuring power output in a single leg extension: feasibility, reliability and validity. Eur J Appl Physiol Occup Physiol. 1990;60:385-390. (Pubitemid 20197282)
41. Buchner DM, Larson EB, Wagner EH, Koepsell TD, de Lateur BJ. Evidence for a non-linear relationship between leg strength and gait speed. Age Ageing. 1996;25:386-391. (Pubitemid 26381771)
42. Ferrucci L, Guralnik JM, Buchner D, Kasper J, Lamb SE, Simonsick EM, et al. Departures from linearity in the relationship between measures of muscular strength and physical performance of the lower extremities: the Women's Health and Aging Study. J Gerontol A Biol Sci Med Sci. 1997;52:M275-M285. (Pubitemid 27413628)
43. Young A. Exercise physiology in geriatric practice. Acta Med Scand Suppl. 1986;711:227-232. (Pubitemid 16008743)
44. Begg CB, Berlin JA. Publication bias and dissemination of clinical research. J Natl Cancer Inst. 1989;81:107-115. (Pubitemid 19031327)
45. Holtzer R, Verghese J, Xue X, Lipton RB. Cognitive processes related to gait velocity: results from the Einstein Aging Study. Neuropsychology. 2006;20:215-223.
46. Paterson DH, Govindasamy D, Vidmar M, Cunningham DA, Koval JJ. Longitudinal study of determinants of dependence in an elderly population. J Am Geriatr Soc. 2004;52:1632-1638. (Pubitemid 41709915)
47. Clark BC, Manini TM. Functional consequences of sarcopenia and dynapenia in the elderly. Curr Opin Clin Nutr Metab Care. 2010;13:271-276.
48. Gandevia SC. Spinal and supraspinal factors in human muscle fatigue. Physiol Rev. 2001;81:1725-1789. (Pubitemid 32951808)
49. Ashe J. Force and the motor cortex. Behav Brain Res. 1997;87:255-269.
50. Taylor JL. Point: the interpolated twitch does/does not provide a valid measure of the voluntary activation of muscle. J Appl Physiol. 2009;107:354-355.
51. de Haan A, Gerrits KH, de Ruiter CJ. Counterpoint: the interpolated twitch does not provide a valid measure of the voluntary activation of muscle. J Appl Physiol. 2009;107:355-357; discussion 357-358.
52. Klass M, Baudry S, Duchateau J. Voluntary activation during maximal contraction with advancing age: a brief review. Eur J Appl Physiol. 2007;100:543-551. (Pubitemid 47023749)
53. Bilodeau M, Erb MD, Nichols JM, Joiner KL, Weeks JB. Fatigue of elbow flexor muscles in younger and older adults. Muscle Nerve. 2001;24:98-106. (Pubitemid 32038032)
54. De Serres SJ, Enoka RM. Older adults can maximally activate the biceps brachii muscle by voluntary command. J Appl Physiol. 1998;84:284-291. (Pubitemid 28065141)
55. Hunter SK, Todd G, Butler JE, Gandevia SC, Taylor JL. Recovery from supraspinal fatigue is slowed in old adults after fatiguing maximal isometric contractions. J Appl Physiol. 2008;105:1199-1209.
56. Jakobi JM, Rice CL. Voluntary muscle activation varies with age and muscle group. J Appl Physiol. 2002;93:457-462. (Pubitemid 34810204)
57. Yoon T, De-Lap BS, Griffith EE, Hunter SK. Age-related muscle fatigue after a low-force fatiguing contraction is explained by central fatigue. Muscle Nerve. 2008;37:457-466. (Pubitemid 351501971)
58. Yue GH, Ranganathan VK, Siemionow V, Liu JZ, Sahgal V. Older adults exhibit a reduced ability to fully activate their biceps brachii muscle. J Gerontol A Biol Sci Med Sci. 1999;54:M249-M253. (Pubitemid 29252713)
59. Cannon J, Kay D, Tarpenning KM, Marino FE. Comparative effects of resistance training on peak isometric torque, muscle hypertrophy, voluntary activation and surface EMG between young and elderly women. Clin Physiol Funct Imaging. 2007;27:91-100.
60. Knight CA, Kamen G. Adaptations in muscular activation of the knee extensor muscles with strength training in young and older adults. J Electromyogr Kinesiol. 2001;11:405-412. (Pubitemid 33101136)
61. Roos MR, Rice CL, Connelly DM, Vandervoort AA. Quadriceps muscle strength, contractile properties, and motor unit firing rates in young and old men. Muscle Nerve. 1999;22:1094-1103. (Pubitemid 29360256)
62. Wilder MR, Cannon J. Effect of age on muscle activation and twitch properties during static and dynamic actions. Muscle Nerve. 2009;39:683-691.
63. Harridge SD, Kryger A, Stensgaard A. Knee extensor strength, activation, and size in very elderly people following strength training. Muscle Nerve. 1999;22:831-839. (Pubitemid 29330029)
64. Stevens JE, Stackhouse SK, Binder-Macleod SA, Snyder-Mackler L. Are voluntary muscle activation deficits in older adults meaningful? Muscle Nerve. 2003;27:99-101. (Pubitemid 36083450)
65. Hortobagyi T, Mizelle C, Beam S, DeVita P. Old adults perform activities of daily living near their maximal capabilities. J Gerontol A Biol Sci Med Sci. 2003;58:M453-M460.
66. Haug H, Eggers R. Morphometry of the human cortex cerebri and corpus striatum during aging. Neurobiol Aging. 1991;12:336-338; discussion 352-355.
67. Salat DH, Buckner RL, Snyder AZ, Greve DN, Desikan RS, Busa E, et al. Thinning of the cerebral cortex in aging. Cereb Cortex. 2004;14:721-730. (Pubitemid 38856947)
68. Marner L, Nyengaard JR, Tang Y, Pakkenberg B. Marked loss of myelinated nerve fibers in the human brain with age. J Comp Neurol. 2003;462:144-152. (Pubitemid 36723664)
69. Madden DJ, Whiting WL, Huettel SA, White LE, MacFall JR, Provenzale JM. Diffusion tensor imaging of adult age differences in cerebral white matter: relation to response time. Neuroimage. 2004;21:1174-1181. (Pubitemid 38314979)
70. Morgan DG, May PC, Finch CE. Dopamine and serotonin systems in human and rodent brain: effects of age and neurodegenerative disease. J Am Geriatr Soc. 1987;35:334-345. (Pubitemid 17044849)
71. Bigham MH, Lidow MS. Adrenergic and serotonergic receptors in aged monkey neocortex. Neurobiol Aging. 1995;16:91-104.
72. Bartus RT, Dean RL III, Beer B, Lippa AS. The cholinergic hypothesis of geriatric memory dysfunction. Science. 1982;217:408-414.
73. Segovia G, Porras A, Del Arco A, Mora F. Glutamatergic neurotransmission in aging: a critical perspective. Mech Ageing Dev. 2001;122:1-29. (Pubitemid 32332958)
74. Roth GS. Age changes in signal transduction and gene expression. Mech Ageing Dev. 1997;98:231-238. (Pubitemid 27464113)
75. Mora F, Segovia G, Del Arco A. Glutamate-dopamine-GABA interactions in the aging basal ganglia. Brain Res Rev. 2008;58:340-353.
76. Roth GS, Joseph JA. Cellular and molecular mechanisms of impaired dopaminergic function during aging. Ann N Y Acad Sci. 1994;719:129-135. (Pubitemid 24199970)
77. Hayashi M, Yamashita A, Shimizu K. Somatostatin and brain-derived neurotrophic factor mRNA expression in the primate brain: decreased levels of mRNAs during aging. Brain Res. 1997;749:283-289. (Pubitemid 27104209)
78. Kossev AR, Schrader C, Dauper J, Dengler R, Rollnik JD. Increased intracortical inhibition in middle-aged humans; a study using paired-pulse transcranial magnetic stimulation. Neurosci Lett. 2002;333:83-86. (Pubitemid 35284890)
79. Sale MV, Semmler JG. Age-related differences in corticospinal control during functional isometric contractions in left and right hands. J Appl Physiol. 2005;99:1483-1493. (Pubitemid 43014358)
80. Smith AE, Ridding MC, Higgins RD, Wittert GA, Pitcher JB. Age-related changes in short-latency motor cortex inhibition. Exp Brain Res. 2009;198(4):489-500.
81. McGinley M, Hoffman RL, Russ DW, Thomas JS, Clark BC. Older adults exhibit more intracortical inhibition and less intracortical facilitation than young adults. Exp Gerontol. 2010;45(9):671-678.
82. Heuninckx S, Wenderoth N, Debaere F, Peeters R, Swinnen SP. Neural basis of aging: the penetration of cognition into action control. J Neurosci. 2005;25:6787-6796. (Pubitemid 41023146)
83. Naccarato M, Calautti C, Jones PS, Day DJ, Carpenter TA, Baron JC. Does healthy aging affect the hemispheric activation balance during paced index-to-thumb opposition task? An fMRI study. Neuroimage. 2006;32:1250-1256. (Pubitemid 44278683)
84. Rowe JB, Siebner H, Filipovic SR, Cordivari C, Gerschlager W, Rothwell J, et al. Aging is associated with contrasting changes in local and distant cortical connectivity in the human motor system. Neuroimage. 2006;32:747-760. (Pubitemid 44149138)
85. Fathi D, Ueki Y, Mima T, Koganemaru S, Nagamine T, Tawfik A, et al. Effects of aging on the human motor cortical plasticity studied by paired associative stimulation. Clin Neurophysiol. 2009;121:90-93.
86. Sawaki L, Yaseen Z, Kopylev L, Cohen LG. Age-dependent changes in the ability to encode a novel elementary motor memory. Ann Neurol. 2003;53:521-524. (Pubitemid 36373264)
87. Clark BC, McGinley MP, Hoffman RL, Thomas JS, Russ DW. Age-related differences in cortical excitability. Med Sci Sports Exerc. 2010;42(5):S10.
88. Scaglioni G, Ferri A, Minetti AE, Martin A, Van Hoecke J, Capodaglio P, et al. Plantar flexor activation capacity and H reflex in older adults: adaptations to strength training. J Appl Physiol. 2002;92:2292-2302. (Pubitemid 34666350)
89. Kido A, Tanaka N, Stein RB. Spinal excitation and inhibition decrease as humans age. Can J Physiol Pharmacol. 2004;82:238-248. (Pubitemid 38859594)
90. Christie A, Kamen G. Doublet discharges in motoneurons of young and older adults. J Neurophysiol. 2006;95:2787-2795.
91. Kamen G, Sison SV, Du CC, Patten C. Motor unit discharge behavior in older adults during maximal-effort contractions. J Appl Physiol. 1995;79:1908-1913. (Pubitemid 26010558)
92. Klass M, Baudry S, Duchateau J. Age-related decline in rate of torque development is accompanied by lower maximal motor unit discharge frequency during fast contractions. J Appl Physiol. 2008;104:739-746. (Pubitemid 351468803)
93. Nelson RM, Soderberg GL, Urbscheit NL. Comparison of skeletal muscle motor unit discharge characteristics in young and aged humans. Arch Gerontol Geriatr. 1983;2:255-264. (Pubitemid 14202116)
94. Doherty TJ, Brown WF. The estimated numbers and relative sizes of thenar motor units as selected by multiple point stimulation in young and older adults. Muscle Nerve. 1993;16:355-366. (Pubitemid 23094099)
95. McNeil CJ, Doherty TJ, Stashuk DW, Rice CL. Motor unit number estimates in the tibialis anterior muscle of young, old, and very old men. Muscle Nerve. 2005;31:461-467. (Pubitemid 40393090)
96. Auyeung TW, Kwok T, Lee J, Leung PC, Leung J, Woo J. Functional decline in cognitive impairment-the relationship between physical and cognitive function. Neuroepidemiology. 2008;31:167-173.
97. Boyle PA, Buchman AS, Wilson RS, Leurgans SE, Bennett DA. Association of muscle strength with the risk of Alzheimer disease and the rate of cognitive decline in community-dwelling older persons. Arch Neurol. 2009;66:1339-1344.
98. Goodpaster BH, Park SW, Harris TB, Kritchevsky SB, Nevitt M, Schwartz AV, et al. The loss of skeletal muscle strength, mass, and quality in older adults: the health, aging and body composition study. J Gerontol A Biol Sci Med Sci. 2006;61:1059-1064. (Pubitemid 44727214)
99. Kawakami Y, Akima H, Kubo K, Muraoka Y, Hasegawa H, Kouzaki M, et al. Changes in muscle size, architecture, and neural activation after 20 days of bed rest with and without resistance exercise. Eur J Appl Physiol. 2001;84:7-12. (Pubitemid 32177864)
100. D'Antona G, Pellegrino MA, Adami R, Rossi R, Carlizzi CN, Canepari M, et al. The effect of ageing and immobilization on structure and function of human skeletal muscle fibres. J Physiol. 2003;552:499-511. (Pubitemid 37321847)
101. Ochala J, Frontera WR, Dorer DJ, Van Hoecke J, Krivickas LS. Single skeletal muscle fiber elastic and contractile characteristics in young and older men. J Gerontol A Biol Sci Med Sci. 2007;62:375-381. (Pubitemid 47065704)
102. Russ DW, Grandy JS, Toma K, Ward CW. Aging, but not yet senescent, rats exhibit reduced muscle quality and sarcoplasmic reticulum function. Acta Physiol (Oxf). 2011;201:391-403.
103. Yu F, Hedstrom M, Cristea A, Dalen N, Larsson L. Effects of ageing and gender on contractile properties in human skeletal muscle and single fibres. Acta Physiol (Oxf). 2007;190:229-241. (Pubitemid 46934661)
104. D'Antona G, Pellegrino MA, Carlizzi CN, Bottinelli R. Deterioration of contractile properties of muscle fibres in elderly subjects is modulated by the level of physical activity. Eur J Appl Physiol. 2007;100:603-611. (Pubitemid 47023755)
105. Delbono O. Regulation of excitation contraction coupling by insulin-like growth factor-1 in aging skeletal muscle. J Nutr Health Aging. 2000;4:162-164.
106. Renganathan M, Messi ML, Delbono O. Dihydropyridine receptor-ryanodine receptor uncoupling in aged skeletal muscle. J Membr Biol. 1997;157:247-253. (Pubitemid 27276167)
107. Delbono O, O'Rourke KS, Ettinger WH. Excitation-calcium release uncoupling in aged single human skeletal muscle fibers. J Membr Biol. 1995;148:211-222. (Pubitemid 26017797)
108. Jimenez-Moreno R, Wang ZM, Gerring RC, Delbono O. Sarcoplasmic reticulum Ca2+ release declines in muscle fibers from aging mice. Biophys J. 2008;94:3178-3188.
109. Goodpaster BH, Carlson CL, Visser M, Kelley DE, Scherzinger A, Harris TB, et al. Attenuation of skeletal muscle and strength in the elderly: The Health ABC Study. J Appl Physiol. 2001;90:2157-2165. (Pubitemid 32467407)
110. Goodpaster BH, Kelley DE, Thaete FL, He J, Ross R. Skeletal muscle attenuation determined by computed tomography is associated with skeletal muscle lipid content. J Appl Physiol. 2000;89:104-110. (Pubitemid 30482569)
111. MacIntosh BR, Gardiner PF, McComas AJ. Skeletal Muscle: Form and Function, 2nd ed. Champaign, IL: Human Kinetics; 2006.
112. Anderson AA, Altafaj X, Zheng Z, Wang ZM, Delbono O, Ronjat M, et al. The junctional SR protein JP-45 affects the functional expression of the voltage-dependent Ca2+ channel Cav1.1. J Cell Sci. 2006;119:2145-2155. (Pubitemid 43904969)
113. Anderson AA, Treves S, Biral D, Betto R, Sandona D, Ronjat M, et al. The novel skeletal muscle sarcoplasmic reticulum JP-45 protein. Molecular cloning, tissue distribution, developmental expression, and interaction with alpha 1.1 subunit of the voltage-gated calcium channel. J Biol Chem. 2003;278:39987-39992. (Pubitemid 37248563)
114. Delbono O, Xia J, Treves S, Wang ZM, Jimenez-Moreno R, Payne AM, et al. Loss of skeletal muscle strength by ablation of the sarcoplasmic reticulum protein JP45. Proc Natl Acad Sci USA. 2007;104:20108-20113.
115. O'Connell K, Gannon J, Doran P, Ohlendieck K. Reduced expression of sarcalumenin and related Ca2+-regulatory proteins in aged rat skeletal muscle. Exp Gerontol. 2008;43:958-961.
116. Taylor JR, Zheng Z, Wang ZM, Payne AM, Messi ML, Delbono O. Increased CaVbeta1A expression with aging contributes to skeletal muscle weakness. Aging Cell. 2009;8:584-594.
117. Lowe DA, Thomas DD, Thompson LV. Force generation, but not myosin ATPase activity, declines with age in rat muscle fibers. Am J Physiol Cell Physiol. 2002;283:C187-C192. (Pubitemid 34670562)
118. Song MY, Ruts E, Kim J, Janumala I, Heymsfield S, Gallagher D. Sarcopenia and increased adipose tissue infiltration of muscle in elderly African American women. Am J Clin Nutr. 2004;79:874-880. (Pubitemid 41103890)
119. Zoico E, Rossi A, Di Francesco V, Sepe A, Olioso D, Pizzini F. Adipose tissue infiltration in skeletal muscle of healthy elderly men: relationships with body composition, insulin resistance, and inflammation at the systemic and tissue level. J Gerontol A Biol Sci Med Sci. 65:295-299.
120. Reid MB, Lannergren J, Westerblad H. Respiratory and limb muscle weakness induced by tumor necrosis factor-alpha: involvement of muscle myofilaments. Am J Respir Crit Care Med. 2002;166:479-484.
121. Wilcox P, Osborne S, Bressler B. Monocyte inflammatory mediators impair in vitro hamster diaphragm contractility. Am Rev Respir Dis. 1992;146:462-466.
122. Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C, Gottdiener J, et al. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci. 2001;56:M146-M156. (Pubitemid 32187141)
123. Verbrugge LM, Jette AM. The disablement process. Soc Sci Med. 1994;38:1-14.
124. Marsh AP, Miller ME, Saikin AM, Rejeski WJ, Hu N, Lauretani F, et al. Lower extremity strength and power are associated with 400-meter walk time in older adults: the InCHIANTI study. J Gerontol A Biol Sci Med Sci. 2006;61:1186-1193. (Pubitemid 46034471)
125. Bohannon RW. Internal consistency of manual muscle testing scores. Percept Mot Skills. 1997;85:736-738. (Pubitemid 127734804)
126. Bohannon RW. Intercorrelations and internal consistency of limb muscle-action strengths of patients with renal disease. Percept Mot Skills. 1998;86:1249-1250. (Pubitemid 128701392)
127. Bohannon RW. Is it legitimate to characterize muscle strength using a limited number of measures? J Strength Cond Res. 2008;22:166-173.
128. Bohannon RW. Dynamometer measurements of grip and knee extension strength: are they indicative of overall limb and trunk muscle strength? Percept Mot Skills. 2009;108:339-342.
129. Buchner DM, Larson EB, Wagner EH, Koepsell TD, de Lateur BJ. Evidence for a non-linear relationship between leg strength and gait speed. Age Ageing. 1996;25:386-391. (Pubitemid 26381771)
130. Cress ME, Meyer M. Maximal voluntary and functional performance levels needed for independence in adults aged 65 to 97 years. Phys Ther. 2003;83:37-48. (Pubitemid 36114428)
131. Ferrucci L, Guralnik J, Buchner D, Kasper J, Lamb S, Simonsick E, et al. Departures from linearity in the relationship between measures of muscular strength and physical performance of the lower extremities: The Women's Health and Aging Study. J Gerentol Med Sci. 1997;52A:M275-M285. (Pubitemid 27413628)
132. Ploutz-Snyder LL, Manini T, Ploutz-Snyder RJ, Wolf DA. Functionally relevant thresholds of quadriceps femoris strength. J Gerontol A Biol Sci Med Sci. 2002;57:B144-B152. (Pubitemid 34263291)
133. Sallinen J, Stenholm S, Rantanen T, Heliovaara M, Sainio P, Koskinen S. Hand-grip strength cut points to screen older persons at risk for mobility limitation. J Am Geriatr Soc. 2010;58:1721-1726.
134. Harman E. Strength and power: a definition of terms. J Strength Cond Res. 1993;15:18-20.
135. Cuoco A, Callahan DM, Sayers S, Frontera WR, Bean J, Fielding RA. Impact of muscle power and force on gait speed in disabled older men and women. J Gerontol A Biol Sci Med Sci. 2004;59:1200-1206. (Pubitemid 40024280)
136. Herman S, Kiely DK, Leveille S, O'Neill E, Cyberey S, Bean JF. Upper and lower limb muscle power relationships in mobility-limited older adults. J Gerontol A Biol Sci Med Sci. 2005;60:476-480. (Pubitemid 40712865)
137. Puthoff ML, Nielsen DH. Relationships among impairments in lower-extremity strength and power, functional limitations, and disability in older adults. Phys Ther. 2007;87:1334-1347. (Pubitemid 47584279)
138. Foldvari M, Clark M, Laviolette LC, Bernstein MA, Kaliton D, Castaneda C, et al. Association of muscle power with functional status in community-dwelling elderly women. J Gerontol A Biol Sci Med Sci. 2000;55:M192-M199. (Pubitemid 30257614)
139. Metter EJ, Conwit R, Tobin J, Fozard JL. Age-associated loss of power and strength in the upper extremities in women and men. J Gerontol A Biol Sci Med Sci. 1997;52:B267-B276. (Pubitemid 27413624)
140. Skelton DA, Greig CA, Davies JM, Young A. Strength, power and related functional ability of healthy people aged 65-89 years. Age Ageing. 1994;23:371-377. (Pubitemid 24292161)
141. Bean JF, Kiely DK, LaRose S, O'Neill E, Goldstein R, Frontera WR. Increased velocity exercise specific to task training versus the National Institute on Aging's strength training program: changes in limb power and mobility. J Gerontol A Biol Sci Med Sci. 2009;64:983-991.