Physiological effects beyond the significant gain in muscle mass in sarcopenic elderly men: Evidence from a randomized clinical trial using a protein-rich food

Clinical Interventions in Aging

Volumn 7, Issue , 2012, Pages 225-234

  Alemán Mateo, Heliodoro ^a   Macías, Liliana ^a   Esparza Romero, Julián ^a   Astiazaran García, Humberto ^a   Blancas, Ana Luz ^b  

^a CENTRO DE INVESTIGACIÓN EN ALIMENTACIÓN Y DESARROLLO   (Mexico)

^b Servicios de Salud a la Persona   (Mexico)

Author keywords

Elderly; Nutritional intervention; Protein rich food; Ricotta cheese; Sarcopenia

Indexed keywords

INSULIN; SOMATOMEDIN C; AMINO ACID;

AGED; ARTICLE; BODY MASS; CONTROLLED STUDY; FEMALE; FOOD; GERIATRIC NUTRITION; HUMAN; HUMAN EXPERIMENT; INSULIN BLOOD LEVEL; INTERVENTION STUDY; LEAN BODY WEIGHT; MALE; MICROALBUMINURIA; MUSCLE ATROPHY; MUSCLE MASS; MUSCLE STRENGTH; NUTRITIONAL ASSESSMENT; PROTEIN INTAKE; RANDOMIZED CONTROLLED TRIAL; RICOTTA CHEESE; SKELETAL MUSCLE; WEIGHT GAIN; WEIGHT REDUCTION; CHEESE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; DIET SUPPLEMENTATION; DIET THERAPY; METABOLISM; MEXICO; PATHOPHYSIOLOGY; PHYSIOLOGY; SEX DIFFERENCE;

AGED; AMINO ACIDS; CHEESE; DIETARY PROTEINS; DIETARY SUPPLEMENTS; FEMALE; HUMANS; MALE; MEXICO; MUSCLE STRENGTH; MUSCLE, SKELETAL; SARCOPENIA; SEX FACTORS;

EID: 84871690337     PISSN: 11769092     EISSN: 11781998     Source Type: Journal    
DOI: 10.2147/CIA.S32356     Document Type: Article

References (39)

1. Fielding RA, Vellas B, Evans W, etal. Sarcopenia: an undiagnosed condition in older adults. Current consensus definition: prevalence, etiology, and consequences. International working group on sarcopenia. J Am Med Dir Assoc. 2011;12:249-256.
2. Boirie Y. Physiopathological mechanism of sarcopenia. J Nutr Health Aging. 2009;13:717-723.
3. Morley JE. Sarcopenia in the elderly. Fam Pract. 2012;29:i44-i48.
4. Marcell TJ. Sarcopenia: causes, consequences, and preventions. J Gerontol A Biol Sci Med Sci. 2003;58:M911-M916.
5. Rolland Y, Czerwinski S, Abellan Van Kan G, etal. Sarcopenia: its assessment, etiology, pathogenesis, consequences and future perspectives. J Nutr Health Aging. 2008;12:433-450.
6. Roubenoff R, Hughes VA. Sarcopenia: current concepts. J Gerontol A Biol Sci Med Sci. 2000;55:M716-M724.
7. Houston DK, Nicklas BJ, Ding J, etal. Dietary protein intake is associated with lean mass change in older, community-dwelling adults: the Health, Aging, and Body Composition (Health ABC) Study. Am J Clin Nutr. 2008;87:150-155.
8. Solerte SB, Gazzaruso C, Bonacasa R, etal. Nutritional supplements with oral amino acid mixtures increases whole-body lean mass and insulin sensitivity in elderly subjects with sarcopenia. Am J Cardiol. 2008;101:69E-77E.
9. Dillon E, Sheffield-Moore M, Paddon-Jones D, etal. Amino acid supplementation increases lean body mass, basal muscle protein synthesis, and insulin-like growth factor-I expression in older women. J Clin Endocrinol Metab. 2009;94:1630-1637.
10. Paddon-Jones D, Sheffield-Moore M, Katsanos CS, Zhang XJ, Wolfe RR. Differential stimulation of muscle protein synthesis in elderly humans following isocaloric ingestion of amino acids or whey protein. Exp Gerontol. 2006;41:215-219.
11. Morley JE. Sarcopenia: diagnosis and treatment. J Nutr Health Aging. 2008;12:452-456.
12. Stout JR. Nutrition intervention in sarcopenia. Sarcopenia Proceedings Book. Available from: http://search-ebooks.eu/nutrition-intervention-in-sarcopenia-25868874. Accessed 2 January, 2010.
13. Symons TB, Sheffield-Moore M, Wolfe RR, Paddon-Jones D. A moderate serving of high-quality protein maximally stimulates skeletal muscle protein synthesis in young and elderly subjects. J Am Diet Assoc. 2009;109:1582-1586.
14. Symons TB, Schutzler SE, Cocke TL, Chinkes DL, Wolfe RR, Paddon-Jones D. Aging does not impair the anabolic response to a protein-rich meal. Am J Clin Nutr. 2007;86:451-456.
15. Wilkinson SB, Tarnopolsky MA, Macdonald MJ, Macdonald JR, Armstrong D, Phillips SM. Consumption of fluid skim milk promotes greater muscle protein accretion after resistance exercise than does consumption of an isonitrogenous and isoenergetic soy-protein beverage. Am J Clin Nutr. 2007;85:1031-1040.
16. Phillips SM, Tang JE, Moore DR. The role of milk-and soy-based protein in support of muscle protein synthesis and muscle protein accretion in young and elderly persons. J Am Coll Nutr. 2009;28:343-354.
17. Phillips SM, Hartman JW, Wilkinson SB. Dietary protein to support anabolism with resistance exercise in young men. J Am Coll Nutr. 2005;24(Suppl 2):134S-139S.
18. Iglay HB, Apolzan JW, Gerrard DE, Eash JK, Anderson JC, Campbell WW. Moderately increased protein intake predominantly from egg sources does not influence whole body, regional, or muscle composition responses to resistance training in older people. J Nutr Health Aging. 2009;13:108-114.
19. Björkman MP, Pilvi TK, Kekkonen RA, Korpela R, Tilvis RS. Similar effects of leucine rich and regular dairy products on muscle mass and functions of older polymyalgia rheumatica patients: a randomized crossover trial. J Nutr Health Aging. 2011;15:462-467.
20. Delmonico MJ, Harris TB, Lee JS, etal. Alternative definitions of sarcopenia, lower extremity performance, and functional impairment with aging in older men and women. J Am Geriatr Soc. 2007;55:769-774.
21. Cockcroft DW, Gault MH. Prediction of creatinine clearance from serum creatinine. Nephron. 1976;16:31-41.
22. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetología. 1985;28:412-419.
23. Norton K, Whittingham N, Carter L, Kerr D, Gore C, Marfell-Jones M. Measurement techniques in anthropometry. In: Norton K, Olds T, editors. Antropométrica: A Textbook of Body Measurement for Sports and Health Courses. Sydney: University of New South Wales Press; 1996:25-75.
24. Aleman-Mateo H, Lee SY, Javed F, etal. Elderly Mexicans have less muscle and greater total and truncal fat compared to African-Americans and Caucasians with the same BMI. J Nutr Health Aging. 2009;13:919-923.
25. Katsanos CS, Chinkes DL, Paddon-Jones D, Zhang XJ, Aarsland A, Wolfe RR. Whey protein ingestion in elderly results in greater muscle protein accrual than ingestion of its constituent essential amino acid content. Nutr Res. 2008;28:651-658.
26. Schaap LA, Pluijm SM, Deeg DJ, Visser M. Inflammatory markers and loss of muscle mass (sarcopenia) and strength. Am J Med. 2006;119:526. e9-e17.
27. Carlsson M, Littbrand H, Gustafson Y, etal. Effects of high-intensity exercise and protein supplement on muscle mass in ADL dependent older people with and without malnutrition: a randomized controlled trial. J Nutr Health Aging. 2011;15:554-560.
28. Bos C, Benamouzig R, Bruhat A, etal. Nutritional status after short-term dietary supplementation in hospitalized malnourished geriatric patients. Clin Nutr. 2001;20:225-233.
29. Chevalier S, Gougeon R, Nayar K, etal. Frailty amplifies the effects of aging on protein metabolism: Role of protein intake. Am J Clin Nutr. 2003;78:422-429.
30. Goodpaster BH, Park SW, Harris TB, etal. The loss of skeletal muscle strength, mass, and quality in older adults: the health, aging and body composition study. J Gerontol A Biol Sci Med Sci. 2006;61:1059-1064.
31. Janssen I, Baumgartner RN, Ross R, Rosenberg IH, Roubenoff R. Skeletal muscle cutpoints associated with elevated physical disability risk in older men and women. Am J Epidemiol. 2004;159:413-421.
32. Lord SR, Menz HB, Tiedemann A. A physiological profile approach to falls risk assessment and prevention. Phys Ther. 2003;83:237-252.
33. de Rekeneire N, Visser M, Peila R, etal. Is a fall just a fall: correlates of falling in healthy older persons. The health, aging and body composition study. J Am Geriatr Soc. 2003;51:841-846.
34. Moreland JD, Richardson JA, Goldsmith CH, Clase CM. Muscle weakness and falls in older adults: a systematic review and meta-analysis. J Am Ger Soc. 2004;52:1121-1129.
35. Rao SS. Prevention of falls in older patients. Am Fam Physician. 2005;72:81-88.
36. Rubenstein LZ. Falls in older people: epidemiology, risk factors and strategies for prevention. Age Ageing. 2006;35(Suppl 2):ii37-ii41.
37. Skelton DA, Kennedy J, Rutherford OM. Explosive power and asymmetry in leg muscle function in frequent fallers and non-fallers aged over 65. Age Ageing. 2002;31:119-125.
38. Børsheim E, Bui QU, Tissier S, Kobayashi H, Ferrando AA, Wolfe RR. Effect of amino acid supplementation on muscle mass, strength and physical function in elderly. Clin Nutr. 2008;27:189-195.
39. Alemán H, Esparza J, Ramirez FA, Astiazaran H, Payette H. Longitudinal evidence on the association between interleukin-6 and c-reactive protein with the loss of total appendicular skeletal muscle in free-living older men and women. Age Ageing. 2011;40:469-475.