Malnutrition, fatigue, frailty, vulnerability, sarcopenia and cachexia: Overlap of clinical features

Current Opinion in Clinical Nutrition and Metabolic Care

Volumn 15, Issue 3, 2012, Pages 213-219

  Jeejeebhoy, Khursheed N ^a  

^a ST MICHAEL'S HOSPITAL   (Canada)

Author keywords

Ageing; Cachexia; Cancer; Malnutrition; Sarcopenia; Sepsis; Trauma

Indexed keywords

ALPHA INTERMEDIN; CATECHOLAMINE; CORTICOSTEROID; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INSULIN; INTERLEUKIN 3; TESTOSTERONE; TUMOR NECROSIS FACTOR ALPHA;

ACCIDENTAL INJURY; AGING; ANOREXIA; BODY COMPOSITION; CACHEXIA; CALORIC INTAKE; CATECHOLAMINE BLOOD LEVEL; CLINICAL EFFECTIVENESS; CORTICOSTEROID BLOOD LEVEL; DIET THERAPY; DIGESTIVE SYSTEM FUNCTION DISORDER; DISEASE ASSOCIATION; EXERCISE; FATIGUE; FOOD INTAKE; FRAILTY SYNDROME; GASTROINTESTINAL OBSTRUCTION; HIP FRACTURE; HORMONE ACTION; HORMONE DEFICIENCY; HUMAN; IMMOBILIZATION; INSULIN BLOOD LEVEL; MALABSORPTION; MALNUTRITION; MUSCLE ATROPHY; MUSCLE METABOLISM; NUTRITIONAL SUPPORT; PHENOTYPE; PNEUMONIA; PROTEIN CALORIE MALNUTRITION; REVIEW; SEDENTARY LIFESTYLE; SEPSIS; TESTOSTERONE BLOOD LEVEL; TREATMENT RESPONSE; WEIGHT REDUCTION;

CACHEXIA; CLINICAL TRIALS AS TOPIC; CYTOKINES; ENERGY INTAKE; EXERCISE; FATIGUE; HORMONES; HUMANS; NUTRITIONAL SUPPORT; PHENOTYPE; PROTEIN-ENERGY MALNUTRITION; SARCOPENIA; SEDENTARY LIFESTYLE;

EID: 84863627587     PISSN: 13631950     EISSN: 14736519     Source Type: Journal    
DOI: 10.1097/MCO.0b013e328352694f     Document Type: Review

References (27)

1. Appel LJ, Clark JM, Yeh H-C, et al. Comparative Effectiveness of Weight-Loss Interventions in Clinical Practice. N Engl J Med 2011;365:1959-1968. This article is an excellent reference for the effect of diets on weight loss.
2. William J, Evans WJ, Morley JE, et al. Cachexia: a new definition. Clin Nutr 2008;27:793-799.
3. Fearon K, Strasser F, Anker SD, et al. Definition and classification of cancer cachexia: an international consensus. Lancet Oncol 2011;12:489-495. The specific features of cancer related cachexia is discussed in this review.
4. Papersack T. An operational definition of cachexia. Lancet Oncol 2011;12:423-424.
5. Fielding RA, Vellas B, Evans WJ, et al. Sarcopenia: an undiagnosed condition in older adults. Current consensus definition: prevalence, etiology, and consequences. International working group on sarcopenia. J Am Med Dir Assoc 2011;12:249-256. Important recent consensus about sarcopenia.
6. Alfonso JC-J, Baeyens JP, Baeuer JM, et al. Sarcopenia: European consensus on definition and diagnosis. Age and Ageing 2010;39:412-423. European view about sarcopenia.
7. Rosenberg IH. Sarcopenia: origins and clinical relevance. J Nutr 1997;127:990S-991S.
8. Rosenberg IH. Sarcopenia: origins and clinical relevance. Clin Geriatr Med 2011;27:337-339.
9. Buehring B, Belavy DL, Michaelis I, et al. Changes in lower extremity muscle function after 56 days of bed rest. J Appl Physiol 2011;111:87-94. Important article about the effects of inactivity on muscle.
10. Glover EL, Phillips SM, Oates BR, et al. Immobilization induces anabolic resistance in human myofibrillar protein synthesis with low and high dose amino acid infusion. J Physiol 2008;586:6049-6061.
11. Leiter LA, Marliss EB. Survival during fasting may depend on fat as well as protein stores. JAMA 1982;248:2306-2307.
12. Blum D, Omlin A, Baracos VE, et al. Cancer cachexia: A systematic literature review of items and domains associated with involuntary weight loss in cancer. Crit Rev Oncol Hematol 2011;80:114-144.
13. Mitch WE, Price SR. Transcription factors and muscle cachexia: is there a therapeutic target? Lancet 2001;337:734-735.
14. Zoico E, Roubenoff R. The role of cytokines in regulating protein metabolism and muscle function. Nutr Rev 2002;60:39-51.
15. Grossberg AJ, Scarlett JM, Marks DL. Hypothalamic mechanisms in cachexia. Physiol Behav 2010;100:478-489.
16. Hughes VA, Frontera WR, Roubenoff R, et al. Longitudinal changes in body composition in older men and women: role of body weight change and physical activity. Am J Clin Nutr 2002;76:473-481.
17. Fielding RA, Vellas B, Evans WJ, et al. Sarcopenia: An Undiagnosed Condition in Older Adults. Current Consensus Definition: Prevalence, Etiology, and Consequences. International Working Group on Sarcopenia. J Am Med Dir Assoc 2011;12:249-256.
18. Baumgartner RN, Waters DL, Gallagher D, et al. Predictors of skeletal muscle mass in elderly men and women. Mech Ageing Dev 1999;107:123-136.
19. Heuberger R. The frailty syndrome: a comprehensive review. J Nutr Gerontol Geriatr 2011;30:315-368. Important article about the causes, diagnosis and treatment of frailty.
20. Chioléro R, Revelly JP, Tappy L. Energy metabolism in sepsis and injury. Nutrition 1997;13(9 Suppl):45S-51S.
21. Hart DW, Wolf SE, Herndon DN, et al. Energy expenditure and calorie balance after burns: Increased feeding leads to fat rather than lean mass accretion. Ann Surg 2002;235:152-161.
22. Fiatarone MA, O'Neill EF, Ryan ND, et al. Exercise training and nutritional supplementation for physical frailty in very elderly people. N Engl J Med 1994;330:1769-1775.
23. Lynch NA, Ryan AS, Evans J, et al. Older Elite Football Players Have Reduced Cardiac and Osteoporosis Risk Factors. Med Sci Sports Exerc 2007;39:1124-1130.
24. Vogiatzis I, Simoes DCM, Stratakos G, et al. Effect of pulmonary rehabilitation on muscle remodelling in cachectic patients with COPD. Eur Respir J 2010;36:301-310.
25. Temel JS, Greer JA, Goldberg S, et al. A structured exercise program for patients with advanced nonsmall cell lung cancer. J Thorac Oncol 2009;4:595-601.
26. Burd NA, West DW, Staples AW, et al. Low-load high volume resistance exercise stimulates muscle protein synthesis more than high-load low volume resistance exercise in young men. PLoS One 2010;5:e12033.
27. Sillen MJH, Speksnijer CM, Eterman R-MA, et al. Effects of neuromuscular electrical stimulation of muscles of ambulation in patients with chronic heart failure or COPD: a systematic review of the English-language literature. Chest 2009;136:44-61.