Probing the role of CXC motif in chemokine CXCL8 for high affinity binding and activation of CXCR1 and CXCR2 receptors

Journal of Biological Chemistry

Volumn 285, Issue 38, 2010, Pages 29262-29269

  Joseph, Prem Raj B ^a   Sarmiento, Jose M ^b   Mishra, Anurag K ^a   Das, Sandhya T ^a   Garofalo, Roberto P ^a   Navarro, Javier ^a,b   Rajarathnam, Krishna ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

^b UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; PEPTIDES;

CHEMOKINES; CONFORMATIONAL SWITCHES; CXCR2 RECEPTORS; HIGH AFFINITY BINDING; HL-60 CELLS; IMMUNE SURVEILLANCE; MOUSE LUNG; N-TERMINALS; QUATERNARY STRUCTURE; RECEPTOR ACTIVATION; WEAK BINDING;

CALCIUM ION SENSORS;

CALCIUM ION; CHEMOKINE RECEPTOR CXCR1; CHEMOKINE RECEPTOR CXCR2; INTERLEUKIN 8; CALCIUM; PROTEIN BINDING;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; CALCIUM MOBILIZATION; CELL STRAIN HL 60; CONTROLLED STUDY; ENZYME ACTIVATION; FEMALE; HUMAN; HUMAN CELL; MOLECULAR PROBE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN ENGINEERING; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; PROTEIN VARIANT; REGULATORY MECHANISM; WILD TYPE; ANIMAL; BAGG ALBINO MOUSE; CELL CULTURE; CHEMISTRY; GENETICS; HL 60 CELL LINE; METABOLISM; MOLECULAR DYNAMICS; NEUTROPHIL; PHYSIOLOGY; PROTEIN SECONDARY STRUCTURE;

AMINO ACID MOTIFS; ANIMALS; CALCIUM; CELLS, CULTURED; FEMALE; HL-60 CELLS; HUMANS; INTERLEUKIN-8; MICE; MICE, INBRED BALB C; MOLECULAR DYNAMICS SIMULATION; NEUTROPHILS; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; RECEPTORS, INTERLEUKIN-8A; RECEPTORS, INTERLEUKIN-8B;

EID: 77956530120     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.146555     Document Type: Article

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