N-benzylcinnamide protects rat cultured cortical neurons from β-amyloid peptide-induced neurotoxicity

Neuroscience Letters

Volumn 556, Issue , 2013, Pages 20-25

  Thangnipon, Wipawan ^a   Puangmalai, Nicha ^a   Chinchalongporn, Vorapin ^a   Jantrachotechatchawan, Chanati ^a   Kitiyanant, Narisorn ^a   Soi ampornkul, Rungtip ^b   Tuchinda, Patoomratana ^c   Nobsathian, Saksit ^a  

^a MAHIDOL UNIVERSITY   (Thailand)

^b MAHIDOL UNIVERSITY   (Thailand)

^c Mahidol University   (Thailand)

Author keywords

Alzheimer's disease; Amyloid peptide; Anti inflammation; Antioxidant; Apoptosis; Mechanism; N benzylcinnamide

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; CASPASE 3; INTERLEUKIN 1BETA; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; N BENZYLCINNAMIDE; NEUROPROTECTIVE AGENT; PLANT EXTRACT; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; BRAIN CELL CULTURE; CELL DEATH; CELL STRESS; CELL STRUCTURE; CELL VIABILITY; DRUG PURIFICATION; ENZYME PHOSPHORYLATION; NERVOUS SYSTEM INFLAMMATION; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PATHOGENESIS; PIPER (PLANT); PIPER SUBMULTINERVE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

ALZHEIMER'S DISEASE; AMYLOID Β-PEPTIDE; ANTI-INFLAMMATION; ANTIOXIDANT; APOPTOSIS; MECHANISM; N-BENZYLCINNAMIDE;

AMYLOID BETA-PEPTIDES; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTIOXIDANTS; APOPTOSIS; CELLS, CULTURED; CEREBRAL CORTEX; CINNAMATES; JNK MITOGEN-ACTIVATED PROTEIN KINASES; NEURONS; NEUROPROTECTIVE AGENTS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PEPTIDE FRAGMENTS; PHOSPHORYLATION; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES;

EID: 84887362386     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2013.09.071     Document Type: Article

References (28)

1. Acarin L., González B., Castellano B., Neuronal astroglial and microglial cytokine expression after an excitotoxic lesion in the immature rat brain Eur. J. Neurosci. 2000, 12:3505-3520.
2. Cecchi C., Fiorillo C., Baglioni S., Pensalfini A., Bagnoli S., Nacmias B., Sorbi S., Nosi D., Relini A., Liguri G. Increased susceptibility to amyloid toxicity in familial Alzheimer's fibroblasts. Neurobiol. Aging 2007, 28:863-876.
3. Clayden J., Greeves N., Warren S. Organic Chemistry 2012, Oxford University Press, Oxford. Second ed.
4. Couturier J., Paccalin M., Morel M., Terro F., Milin S., Pontcharraud R., Fauconneau B., Page G. Prevention of the β-amyloid peptide-induced inflammatory process by inhibition of double-stranded RNA-dependent protein kinase in primary murine mixed co-cultures. J. Neuroinflammation 2011, 8:72.
5. Curtis N.R., Diggle H.J., Kulagowski J.J., London C., Grimwood S., Hutson P.H., Murray F., Richards P., Macaulay A., Wafford K.A. Novel N1-(benzyl)cinnamamidine derived NR2B subtype-selective NMDA receptor antagonists. Bioorg. Med. Chem. Lett. 2003, 13:693-696.
6. Dahlgren K.N., Manelli A.M., Stine W.B., Baker L.K., Krafft G.A., LaDu M.J. Oligomeric and fibrillar species of amyloid-β peptides differentially affect neuronal viability. J. Biol. Chem. 2002, 277:32046-32053.
7. Gu L., Guo Z. Alzheimer's Aβ42 and Aβ40 peptides form interlaced amyloid fibrils. J. Neurochem. 2013, 126:305-311.
8. Hill M.M., Adrain C., Duriez P.J., Creagh E.M., Martin S.J. Analysis of the composition, assembly kinetics and activity of native Apaf-1 apoptosomes. EMBO J. 2004, 23:2134-2145.
9. Ivins K.J., Ivins J.K., Sharp J.P., Cotman C.W. Multiple pathways of apoptosis in PC12 cells. CrmA inhibits apoptosis induced by beta-amyloid. J. Biol. Chem. 1999, 274:2107-2112.
10. 1-42 inhibition of LTP is mediated by a signaling pathway involving caspase-3, Akt1, and GSK-3β. Nat. Neurosci. 2011, 14:545-547.
11. Junttila M.R., Li S.P., Westermarck J. Phosphatase-mediated crosstalk between MAPK signaling pathways in the regulation of cell survival. FASEB J. 2008, 22:954-965.
12. Kamada H., Nito C., Endo H., Chan P.H. Bad as a converging signaling molecule between survival PI3-K/Akt and death JNK in neurons after transient focal cerebral ischemia in rats. J. Cereb. Blood Flow Metab. 2007, 27:521-533.
13. Karuppagounder S.S., Pinto J.T., Xu H., Chen H.L., Beal M.F., Gibson G.E. Dietary supplementation with resveratrol reduces plaque pathology in a transgenic model of Alzheimer's disease. Neurochem. Int. 2009, 54:111-118.
14. LaFerla F.M., Green K.N., Oddo S. Intracellular amyloid-β in Alzheimer's disease. Nat. Rev. Neurosci. 2007, 8:499-509.
15. Li S., Jin M., Koeglsperger T., Shepardson N.E., Shankar G.M., Selkoe D.J. Soluble Aβ oligomers inhibit long-term potentiation through a mechanism involving excessive activation of extrasynaptic NR2B-containing NMDA receptors. J. Neurosci. 2011, 31:6627-6638.
16. Lin J.K., Chen P.C., Ho C.T., Lin-Shiau S.Y. Inhibition of xanthine oxidase and suppression of intracellular reactive oxygen species in HL-60 cells by theaflavin-3,3'-digallate, (-)-epigallocatechin-3-gallate, and propyl gallate. J. Agric. Food Chem. 2000, 48:2736-2743.
17. Liu Y., Guyton K.Z., Gorospe M., Xu Q., Lee J.C., Holbrook N.J. Differential activation of ERK JNK/SAPK and P38/CSBP/RK map kinase family members during the cellular response to arsenite. Free. Radic. Biol. Med. 1996, 21:771-781.
18. Ma T., Du X., Pick J.E., Sui G., Brownlee M., Klann E. Glucagon-like peptide-1 cleavage product GLP-1(9-36) amide rescues synaptic plasticity and memory deficits in Alzheimer's disease model mice. J. Neurosci. 2012, 32:13701-13708.
19. Ma T., Tzavaras N., Tsokas P., Landau E.M., Blitzer R.D. Synaptic stimulation of mTOR is mediated by Wnt signaling and regulation of glycogen synthetase kinase-3. J. Neurosci. 2011, 31:17537-17546.
20. Miranda S., Opazo C., Larrondo L.F., Muñoz F.J., Ruiz F., Leighton F., Inestrosa N.C. The role of oxidative stress in the toxicity induced by amyloid β-peptide in Alzheimer's disease. Prog. Neurobiol. 2000, 62:633-648.
21. Nobsathian S., Tuchinda P., Soorukram D., Pohmakotr M., Reutrakul V., Yoosook C., Kasisit J., Napaswad C. A new conjugated amide-dimer from the aerial parts of Piper submultinerve. Nat. Prod. Res. 2012, 26:1824-1830.
22. Querfurth H.W., LaFerla F.M. Alzheimer's disease. N. Engl. J. Med. 2010, 362:329-344.
23. Saelens X., Festjens N., Vande Walle L., van Gurp M., van Loo G., Vandenabeele P. Toxic proteins released from mitochondria in cell death. Oncogene 2004, 12:2861-2874.
24. Salminen A., Ojala J., Kauppinen A., Kaarniranta K., Suuronen T. Inflammation in Alzheimer's disease: amyloid-β oligomers trigger innate immunity defence via pattern recognition receptors. Prog. Neurobiol. 2009, 87:181-194.
25. Tan Z.W., Zhong H.Y., Chen X. Effect of qingxin kaiqiao recipe saponin on the expressions of Bax, Bcl-2, Aβ, and βAPP in the cortex and hippocampus of Alzheimer's disease rats. Zhongguo Zhong Xi Yi Jie He Za Zhi 2012, 32:1258-1263.
26. Thangnipon W., Suwanna N., Kitiyanant N., Soi-ampornkul R., Tuchinda P., Munyoo B., Nobsathian S. Protective role of N-trans-feruloyltyramine against β-amyloid peptide-induced neurotoxicity in rat cultured cortical neurons. Neurosci. Lett. 2012, 513:229-232.
27. Tong L., Balazs R., Thornton P.L., Cotman C.W. β-amyloid peptide at sublethal concentrations downregulates brain-derived neurotrophic factor functions in cultured cortical neurons. J. Neurosci. 2004, 24:6799-6809.
28. Zhang L., Yu H., Zhao X., Lin X., Tan C., Cao G., Wang Z. Neuroprotective effects of salidroside against β-amyloid-induced oxidative stress in SH-SY5Y human neuroblastoma cells. Neurochem. Int. 2010, 57:547-555.