Dominant Role of Nucleotide Substitution in the Diversification of Serotype 3 Pneumococci over Decades and during a Single Infection

PLoS Genetics

Volumn 9, Issue 10, 2013, Pages

  Croucher, Nicholas J ^a,b   Mitchell, Andrea M ^c   Gould, Katherine A ^d   Inverarity, Donald ^e   Barquist, Lars ^a   Feltwell, Theresa ^a   Fookes, Maria C ^a   Harris, Simon R ^a   Dordel, Janina ^a   Salter, Susannah J ^a   Browall, Sarah ^f,g   Zemlickova, Helena ^h   Parkhill, Julian ^a   Normark, Staffan ^f,g   Henriques Normark, Birgitta ^f,g   Hinds, Jason ^d   Mitchell, Tim J ^c   Bentley, Stephen D ^a,i  

^a WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^b HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^c UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^d ST GEORGE S HOSPITAL   (United Kingdom)

^e UNIVERSITY OF GLASGOW   (United Kingdom)

^f KAROLINSKA INSTITUTE   (Sweden)

^g KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^h NATIONAL INSTITUTE OF PUBLIC HEALTH   (Czech Republic)

ⁱ UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

NUCLEOTIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL GENE; BACTERIAL GENOME; BACTERIAL STRAIN; BACTERIUM ISOLATE; CELL DENSITY; COLONY FORMING UNIT; COMPARATIVE GENOMIC HYBRIDIZATION; CONTROLLED STUDY; FEMALE; GENETIC VARIABILITY; HOMOLOGOUS RECOMBINATION; MOUSE; NONHUMAN; PATAB GENE; PHENOTYPE; PHYLOGENY; PLASMID; POLYMERASE CHAIN REACTION; RNA CONFORMATION; SEQUENCE ALIGNMENT; SINGLE NUCLEOTIDE POLYMORPHISM; STOP CODON; STREPTOCOCCUS PNEUMONIA; STREPTOCOCCUS PNEUMONIAE; STREPTOCOCCUS PNEUMONIAE SEROTYPE 3; UPREGULATION;

ANIMALS; GENETIC VARIATION; GENOME, BACTERIAL; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HUMANS; MENINGITIS; MICE; MUTATION; PHYLOGENY; SEROTYPING; STREPTOCOCCUS PNEUMONIAE;

EID: 84887295186     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1003868     Document Type: Article

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