Diversity of PspA: Mosaic genes and evidence for past recombination in Streptococcus pneumoniae

Infection and Immunity

Volumn 68, Issue 10, 2000, Pages 5889-5900

  Hollingshead, S K ^a   Becker, R ^a   Briles, D E ^a  

^a University of Alabama at Birmingham   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; PNEUMOCOCCUS SURFACE PROTEIN A; UNCLASSIFIED DRUG;

ALLELISM; ARTICLE; GENE LOCUS; GENE STRUCTURE; GENETIC RECOMBINATION; GENETIC VARIABILITY; MOSAICISM; NATURAL SELECTION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SEQUENCE ANALYSIS; STREPTOCOCCUS PNEUMONIAE; VACCINATION;

ALLELES; AMINO ACID SEQUENCE; BACTERIAL PROTEINS; HUMAN; MOLECULAR SEQUENCE DATA; PNEUMOCOCCAL INFECTIONS; RECOMBINATION, GENETIC; SELECTION (GENETICS); SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS, DNA; STREPTOCOCCUS PNEUMONIAE; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; VARIATION (GENETICS);

STREPTOCOCCUS PNEUMONIAE;

EID: 0033801656     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.68.10.5889-5900.2000     Document Type: Article

References (66)

1. Mosaicism in vacuolating cytotoxin alleles of Helicobacter pylori. Association of specific vacA types with cytotoxin production and peptic ulceration
2. Vacuolating cytotoxin (vacA) alleles of Helicobacter pylori comprise two geographically widespread types, m1 and m2, and have evolved through limited recombination
3. Emergence of drug-resistant pneumococcal infections in the United States
4. The potential to use PspA and other pneumococcal proteins to elicit protection against pneumococcal infection
5. Immunization of humans with rPspA elicits antibodies which passively protect mice from fatal infection with Streptococcus pneumoniae expressing heterologous PspA molecules
6. PspA and PspC: Their potential for use as pneumococcal vaccines
7. Vaccine strategies for S. pneumoniae
8. Pneumococcal diversity: Considerations for new vaccine strategies with emphasis on pneumococcal surface protein A (PspA)
9. Systemic and mucosal protective immunity to pneumococcal surface protein A
10. The pspC gene of Streptococcus pneumoniae encodes a polymorphic protein, PspC, which elicits cross-reactive antibodies to PspA and provides immunity to pneumococcal bacteremia
11. Horizontal spread of an altered penicillin-binding protein 2B gene between Streptococcus pneumoniae and Streptococcus oralis
12. Horizontal transfer of multiple penicillin-binding protein genes, and capsule biosynthetic genes, in natural populations of Streptococcus pneumoniae
13. Recombinational exchanges at the capsular polysaccharide biosynthetic locus lead to frequent serotype changes among natural isolates of Streptococcus pneumoniae
14. Pneumococcal polysaccharide immunization in infants and children
15. Pneumococcal surface protein A (PspA) is serologically highly variable and is expressed by all clinically important capsular serotypes of Streptococcus pneumoniae
16. Characterization of the cassette containing genes for type 3 capsular polysaccharide biosynthesis in Streptococcus pneumoniae
17. Penicillin-resistant viridans streptococci have obtained altered penicillin- binding protein genes from penicillin-resistant strains of Streptococcus pneumoniae
18. Horizontal transfer of penicillin-binding protein genes in penicillin-resistant clinical isolates of Streptococcus pneumoniae
19. Transformation competence and type-4 pilus biogenesis in Neisseria gonorrhoeae - A review
20. Pneumococcal infections in an era of multiple antibiotic resistance
21. Epidemiologic studies of Streptococcus pneumoniae in infants: Acquisition, carriage, and infection during the first 24 months of life
22. The epidemiology of pneumococcal infection in children in the developing world
23. Acquisition of five high-M(r) penicillin-binding protein variants during transfer of high-level β-lactam resistance from Streptococcus mitis to Streptococcus pneumoniae
24. Identification of pneumococcal surface protein A as a lactoferrin-binding protein of Streptococcus pneumoniae
25. Direct DNA sequencing of PCR-amplified vector inserts following enzymatic degradation of primer and dNTPs
26. The contribution of specific pneumococcal serogroups to different disease manifestations: Implications for conjugate vaccine formulation and use, part II
27. Which pneumococcal serogroups cause the most invasive disease: Implications for conjugate vaccine formulation and use, part I
28. Production and characterization of the functional fragment of pneumococcal surface protein A
29. Defining the public health impact of drug resistant Streptococcus pneumoniae: Report of a working group
30. Determination of 16S rRNA sequences of Streptococcus mitis and Streptococcus gordonii and phylogenetic relationships among members of the genus Streptococcus
31. Molecular epidemiology of penicillin-resistant pneumococci isolated in Nairobi
32. Interspecies recombinational events during the evolution of altered PBP 2x genes in penicillin-resistant clinical isolates of Streptococcus pneumoniae
33. Cloning and expression of the gene for group B streptococcal hyaluronate lyase
34. Population genetics: An introduction
35. Localized sex in bacteria
36. Comparison of the PspA sequence from Streptococcus pneumoniae EF5668 to the previously identified PspA sequence from strain Rx1 and ability of PspA from EF5668 to elicit protection against pneumococci of different capsular types
37. Localization of protection-eliciting epitopes on PspA of Streptococcus pneumoniae between amino acid residues 192 and 260
38. PspA, a surface protein of Streptococcus pneumoniae, is capable of eliciting protection against pneumococci of more than one capsular type
39. Molecular evolution and mosaic structure of alpha, beta, and gamma intimins of pathogenic Escherichia coli
40. Recombination and population structure in Escherichia coli
41. Molecular evolution of the Escherichia coli chromosome. II. Clonal segments
42. Molecular mimicry and the generation of host defense protein diversity
43. Immunization of healthy adults with a single recombinant pneumococcal surface protein A (PspA) stimulated cross-reactive antibodies to heterologous PspA molecules
44. Resistance to both complement activation and phagocytosis in type 3 pneumococci is mediated by binding of complement regulatory protein factor H
45. Immunization of mice with combinations of pneumococcal virulence proteins elicits enhanced protection against challenge with Streptococcus pneumoniae
46. A comprehensive genetic study of streptococcal immunoglobulin A1 proteases: Evidence for recombination within and between species
47. Characterization of the Streptococcus pneumoniae immunoglobulin A1 protease gene (iga) and its translation product
48. Competence for genetic transformation in encapsulated strains of Streptococcus pneumoniae: Two allelic variants of the peptide pheromone
49. A high speed, high capacity homology matrix: Zooming through SV40 and polyoma
50. Ubiquitous distribution of the competence related genes coma and comC among isolates of Streptococcus pneumoniae
51. A global gene pool for high-level cephalosporin resistance in commensal Streptococcus species and Streptococcus pneumoniae
52. Safety and immunogenicity of heptavalent pneumococcal CRM197 conjugate vaccine in infants and toddlers
53. Mosaic pbpX genes of major clones of penicillin-resistant Streptococcus pneumoniae have evolved from pbpX genes of a penicillin-sensitive Streptococcus oralis
54. Molecular characterization of pneumococcal nasopharynx isolates collected from children during their first 2 years of life
55. Hybrid penicillin-binding proteins in penicillin-resistant strains of Neisseria gonorrhoeae
56. Resistance to antibiotics mediated by target alterations
57. Determination of 23S rRNA sequences from members of the genus Streptococcus and characterization of genetically distinct organisms previously identified as members of the Streptococcus anginosus group
58. Oligonucleotides identify conserved and variable regions of pspA and pspA-like sequences of Streptococcus pneumoniae
59. Truncated Streptococcus pneumoniae PspA molecules elicit cross-protective immunity against pneumococcal challenge in mice
60. Pneumococcal surface protein A inhibits complement activation by Streptococcus pneumoniae
61. Structural properties und evclutionary relationships of PspA, a surface protein of Streptococcus pneumoniae, as revealed by sequence analysis
62. Truncated forms of PspA that are secreted from Streptococcus pneumoniae and their use in functional studies and cloning of the pspA genel
63. Novel surface attachment mechanism of the Streptococcus pneumoniae protein PspA
64. Interspecies recombination, and phylogenetic distortions, within the glutamine synthetase and shikimate dehydrogenase genes of Neisseria meningitidis and commensal Neisseria species