The Moribund State as an Experimental Endpoint

Contemporary Topics in Laboratory Animal Science

Volumn 36, Issue 3, 1997, Pages 44-48

  Toth, Linda A ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0008457303     PISSN: 10600558     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (45)

1. Parkes, C. M. 1972. Accuracy of predictions of survival in later stages of cancer. Brit. Med. J. 2:29-31.
2. Yates, J. W., B. Chalmers, and P. McKegney. 1980. Evaluation of patients with advanced cancer using the Karnovsky performance status. Cancer 45:2220-2224.
3. Evans, C. and M. McCarthy. 1985. Prognostic uncertainty in terminal care: can the Karnovsky index help? Lancet i:1204-1206.
4. Mor, V., L. Laliberte, J. N. Morris, et al. 1984. The Karnovsky performance status scale: an examination of its reliability and validity in a research setting. Cancer 53:2002-2007.
5. Reuben, D. B., V. Mor, and J. Hiris. 1988. Clinical symptoms and length of survival in patients with terminal cancer. Arch. Intern. Med. 148:1586-1591.
6. Coyle, N., J. Adelhardt, K. M. Foley, et al. 1990. Character of terminal illness in the advanced cancer patient: pain and other symptoms during the last four weeks of life. J. Pain Symptom Manage. 5:83-93.
7. Higginson, I. and M. McCarthy. 1989. Measuring symptoms in terminal cancer: are pain and dyspnoea controlled? J. R. Soc. Med. 82:264-267.
8. Reuben, D. B. and V. Mor. 1986. Dyspnea in terminally ill cancer patients. Chest 89:234-236.
9. Ventafridda, V., C. Ripamonti, F. De Conno, et al. 1990. Symptom prevalence and control during cancer patients' last days of life. J. Palliative Care 6:7-11.
10. Marsh, K., D. Forster, C. Waruiru, et al. 1995. Indicators of life-threatening malaria in African children. N. Engl. J. Med. 332:1399-1404.
11. Waller, D., S. Krishna, J. Crawley, et al. 1996. Clinical features and outcome of severe malaria in Gambian children. Clin. Infect. Dis. 21:577-587.
12. Krishna, S., D. W. Waller, F. ter Kuile, et al. 1994. Lactic acidosis and hypoglycaemia in children with severe malaria: pathophysiological and prognostic significance. Trans. R. Soc. Trop. Med. Hyg. 88:67-73.
13. Phu, N. H., N. Day, P. T. Diep, et al. 1995. Intraleucocytic malaria pigment and prognosis in severe malaria. Trans. R. Soc. Trop. Med. Hyg. 89:200-204.
14. Marano, M. A., Y. Fong, L. L. Moldawer, et al. 1990. Serum cachectin/tumor necrosis factor in critically ill patients with burns correlates with infection and mortality. Surg. Gynecol. Obstet. 170:32-38.
15. Girardin, E., G. E. Grau, J. M. Dayer, et al. 1988. Tumor necrosis factor and interleukin-1 in the serum of children with severe infectious purpura. N. Engl. J. Med. 319:397-400.
16. Debets, J. M. P., R. Kampmeijer, M. P. M. H. van der Linden, et al. 1989. Plasma tumor necrosis factor and mortality in critically ill septic patients. Crit. Care Med. 17:489-494.
17. Meduri, G. U., S. Headley, G. Kohler, et al. 1995. Persistent elevation of inflammatory cytokines predicts a poor outcome in ARDS. Chest 107:1062-1073.
18. Acred, P., T. D. Hennessey, J. A. MacArthur-Clark, et al. 1993. Guidelines for the welfare of animals in rodent protection tests: a report from the rodent protection test working party. Lab. Anim. 28:13-18.
19. Morton, D. B. and P. H. M. Griffiths. 1985. Guidelines on the recognition of pain, distress and discomfort in experimental animals and an hypothesis for assessment. Vet. Rec. 116:431-436.
20. Montgomery, C. A. 1990. Oncologic and toxicologic research: alleviation and control of pain and distress in laboratory animals. Cancer Bull. 42:230-237.
21. Olfert, E. D. 1996. Considerations for defining an acceptable endpoint in toxicological experiments. Lab. Anim. 25:38-43.
22. Tomasovic, S. P., L. G. Coghlan, K. N. Gray, et al. 1988. IACUC evaluation of experiments requiring death as an end point a cancer center's recommendations. Lab. Anim. 17:31-34.
23. Beynen, A. C., V. Baumans, A. P. M. G. Bertens, et al. 1988. Assessment of discomfort in rats with hepatomegaly. Lab. Anim. 22:320-325.
24. Redgate, E. S., M. Deutsch, and S. S. Boggs. 1991. Time of death of CNS tumor-bearing rats can be reliably predicted by body weight-loss patterns. Lab. Anim. Sci. 41:269-273.
25. 50 for measurement of bacterial virulence. Int. J. Exp. Path. 73:9q5-98.
26. Toth, L. A., J. E. Rehg, and R. G. Webster. 1995. Strain differences in sleep and other pathophysiological sequelae of influenza virus infection in naive and immunized mice. J. Neuroimmunol. 58:89-99.
27. Toth, L. A., E. A. Tolley, and J. M. Krueger. 1993. Sleep as a prognostic indicator during infectious disease in rabbits. Proc. Soc. Exp. Biol. Med. 203:179-192.
28. Huang, Y., J. A. Richardson, A. W. Tong, et al. 1993. Disseminated growth of a human multiple myeloma cell line in mice with severe combined immunodeficiency disease. Cancer Res. 53:1392-1396.
29. Huang, Y., J. A. Richardson, and E. S. Vitetta. 1995. Anti-CD54 (ICAM-1) has antitumor activity in SCID mice with human myeloma cells. Cancer Res. 55:610-616.
30. Schnaper, N. 1975. The psychological implications of severe trauma: emotional sequelae to unconsciousness. J. Trauma 15:9q4-98.
31. Tosch, P. 1988. Patients' recollections of their posttraumatic coma. J. Neurosci. Nurs. 20:223-228.
32. Lawrence, M. 1995. The unconscious experience. Am. J. Crit. Care 4:227-232.
33. Klein, M. S., C. A. Conn, and M. J. Kluger. 1992. Behavioral thermoregulation in mice inoculated with influenza virus. Physiol. Behav. 52:1133-1139.
34. Andrews, M. R. and A. M. Levine. 1989. Dehydration in the terminal patient: perception of hospice nurses. Am. J. Hospice Care 6:31-34.
35. McCann, R. M., W. J. Hall, and A. Groth-Juncker. 1994. Comfort care for terminally ill patients: the appropriate use of nutrition and hydration. J. Am. Med. Assoc. 272:1263-1266.
36. Hart, B. L. 1988. Biological basis of the behavior of sick animals. Neurosci. Biobehav. Rev. 12:123-137.
37. Dantzer, R. 1993. Cytokines and sickness behavior, pp-1-16. In: A. J. Husband (ed.), Psychoimmunology: CNS-Immune Interactions. CRC Press, Ann Arbor, Mich.
38. Sullivan, R. J. 1993. Accepting death without artificial nutrition or hydration. J. Gen. Intern. Med. 8:220-224.
39. Grieger, T. A. and M. J. Kluger. 1978. Fever and survival: the role of serum iron. J. Physiol. 279:187-196.
40. Kluger, M. J. and B. A. Rothenburg. 1979. Fever and reduced iron: their interaction in host defense response to bacterial infection. Science 203:374-376.
41. Holbein, B. E. 1980. Iron-controlled infection with Neis-seria meningitidis in mice. Infect. Immun. 29:886-891.
42. Holbien, B. E. 1981. Enhancement of Neisseria meningitidis infection in mice by addition of iron bound to transferrin. Infect. Immun. 34:120-125.
43. Murray, M. J. and A. B. Murray. 1979. Anorexia of infection as a mechanism of host defense. Am. J. Clin. Nutr. 32:593-596.
44. Clamon, G. H., R. Feld, W. K. Evans, et al. 1985. Effect of adjuvant central IV hyperalimentation on the survival and response to treatment of patients with small cell lung cancer: a randomized trial. Cancer Treat. Rep. 69:167-177.
45. Koretz, R. L. 1984. Parenteral nutrition: is it oncologically logical? J. Clin. Oncol. 2:534-538.