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Volumn 19, Issue 7, 2009, Pages 1214-1223

Genome sequencing of linezolid-resistant Streptococcus pneumoniae mutants reveals novel mechanisms of resistance

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER; CHLORAMPHENICOL; ERYTHROMYCIN; FLORFENICOL; LINEZOLID; RIBOSOME RNA; RNA 23S; RNA METHYLTRANSFERASE; VANCOMYCIN;

EID: 67650087598     PISSN: 10889051     EISSN: 15495469     Source Type: Journal    
DOI: 10.1101/gr.089342.108     Document Type: Article
Times cited : (82)

References (67)
  • 3
    • 42049096982 scopus 로고    scopus 로고
    • Linezolid resistance in Staphylococcus aureus: Gene dosage effect, stability, fitness costs, and cross-resistances
    • Besier S, Ludwig A, Zander J, Brade V, Wichelhaus TA. 2008. Linezolid resistance in Staphylococcus aureus: Gene dosage effect, stability, fitness costs, and cross-resistances. Antimicrob Agents Chemother 52: 1570-1572.
    • (2008) Antimicrob Agents Chemother , vol.52 , pp. 1570-1572
    • Besier, S.1    Ludwig, A.2    Zander, J.3    Brade, V.4    Wichelhaus, T.A.5
  • 4
    • 43449093704 scopus 로고    scopus 로고
    • Mutations outside the anisomycin-binding site can make ribosomes drug-resistant
    • Blaha G, Gurel G, Schroeder SJ, Moore PB, Steitz TA. 2008. Mutations outside the anisomycin-binding site can make ribosomes drug-resistant. J Mol Biol 379: 505-519.
    • (2008) J Mol Biol , vol.379 , pp. 505-519
    • Blaha, G.1    Gurel, G.2    Schroeder, S.J.3    Moore, P.B.4    Steitz, T.A.5
  • 6
    • 0029116529 scopus 로고
    • Use of a novel mobilizable vector to inactivate the scrA gene of Streptococcus sobrinus by allelic replacement
    • Buckley ND, Lee LN, LeBlanc DJ. 1995. Use of a novel mobilizable vector to inactivate the scrA gene of Streptococcus sobrinus by allelic replacement. J Bacteriol 177: 5028-5034.
    • (1995) J Bacteriol , vol.177 , pp. 5028-5034
    • Buckley, N.D.1    Lee, L.N.2    LeBlanc, D.J.3
  • 8
    • 38049042725 scopus 로고    scopus 로고
    • Comparative proteomics analyses reveal a potential biomarker for the detection of vancomycin-intermediate Staphylococcus aureus strains
    • Drummelsmith J, Winstall E, Bergeron MG, Poirier GG, Ouellette M. 2007. Comparative proteomics analyses reveal a potential biomarker for the detection of vancomycin-intermediate Staphylococcus aureus strains. J Proteome Res 6: 4690-4702.
    • (2007) J Proteome Res , vol.6 , pp. 4690-4702
    • Drummelsmith, J.1    Winstall, E.2    Bergeron, M.G.3    Poirier, G.G.4    Ouellette, M.5
  • 9
    • 33144490023 scopus 로고    scopus 로고
    • Fournier PE, Vallenet D, Barbe V, Audic S, Ogata H, Poirel L, Richet H, Robert C, Mangenot S, Abergel C, et al. 2006. Comparative genomics of multidrug resistance in Acinetobacter baumannii. PLoS Genet 2: e7. doi: 10.1371/journal.pgen.0020007.
    • Fournier PE, Vallenet D, Barbe V, Audic S, Ogata H, Poirel L, Richet H, Robert C, Mangenot S, Abergel C, et al. 2006. Comparative genomics of multidrug resistance in Acinetobacter baumannii. PLoS Genet 2: e7. doi: 10.1371/journal.pgen.0020007.
  • 10
    • 35349014651 scopus 로고    scopus 로고
    • Bacterial genome sequencing and its use in infectious diseases
    • Fournier PE, Drancourt M, Raoult D. 2007. Bacterial genome sequencing and its use in infectious diseases. Lancet Infect Dis 7: 711-723.
    • (2007) Lancet Infect Dis , vol.7 , pp. 711-723
    • Fournier, P.E.1    Drancourt, M.2    Raoult, D.3
  • 12
    • 34248641680 scopus 로고    scopus 로고
    • Genome content determination in methicillin-resistant Staphylococcus aureus
    • Francois P, Hernandez D, Schrenzel J. 2007. Genome content determination in methicillin-resistant Staphylococcus aureus. Future Microbiol 2: 187-198.
    • (2007) Future Microbiol , vol.2 , pp. 187-198
    • Francois, P.1    Hernandez, D.2    Schrenzel, J.3
  • 13
    • 0032907704 scopus 로고    scopus 로고
    • Identification of an efflux pump gene, pmrA, associated with fluoroquinolone resistance in Streptococcus pneumoniae
    • Gill MJ, Brenwald NP, Wise R. 1999. Identification of an efflux pump gene, pmrA, associated with fluoroquinolone resistance in Streptococcus pneumoniae. Antimicrob Agents Chemother 43: 187-189.
    • (1999) Antimicrob Agents Chemother , vol.43 , pp. 187-189
    • Gill, M.J.1    Brenwald, N.P.2    Wise, R.3
  • 14
    • 20144372744 scopus 로고    scopus 로고
    • Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain
    • Gill SR, Fouts DE, Archer GL, Mongodin EF, Deboy RT, Ravel J, Paulsen IT, Kolonay JF, Brinkac L, Beanan M, et al. 2005. Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain. J Bacteriol 187: 2426-2438.
    • (2005) J Bacteriol , vol.187 , pp. 2426-2438
    • Gill, S.R.1    Fouts, D.E.2    Archer, G.L.3    Mongodin, E.F.4    Deboy, R.T.5    Ravel, J.6    Paulsen, I.T.7    Kolonay, J.F.8    Brinkac, L.9    Beanan, M.10
  • 16
    • 21844446585 scopus 로고    scopus 로고
    • Mutational analysis of 16S and 23S rRNA genes of Thermus thermophilus
    • Gregory ST, Carr JF, Rodriguez-Correa D, Dahlberg AE. 2005. Mutational analysis of 16S and 23S rRNA genes of Thermus thermophilus. J Bacteriol 187: 4804-4812.
    • (2005) J Bacteriol , vol.187 , pp. 4804-4812
    • Gregory, S.T.1    Carr, J.F.2    Rodriguez-Correa, D.3    Dahlberg, A.E.4
  • 17
    • 43149085041 scopus 로고    scopus 로고
    • De novo bacterial genome sequencing: Millions of very short reads assembled on a desktop computer
    • Hernandez D, Francois P, Farinelli L, Osteras M, Schrenzel J. 2008. De novo bacterial genome sequencing: Millions of very short reads assembled on a desktop computer. Genome Res 18: 802-809.
    • (2008) Genome Res , vol.18 , pp. 802-809
    • Hernandez, D.1    Francois, P.2    Farinelli, L.3    Osteras, M.4    Schrenzel, J.5
  • 19
  • 21
    • 35348861448 scopus 로고    scopus 로고
    • Sequential linezolid-resistant Staphylococcus epidermidis isolates with G2576T mutation
    • Hong T, Li X, Wang J, Sloan C, Cicogna C. 2007. Sequential linezolid-resistant Staphylococcus epidermidis isolates with G2576T mutation. J Clin Microbiol 45: 3277-3280.
    • (2007) J Clin Microbiol , vol.45 , pp. 3277-3280
    • Hong, T.1    Li, X.2    Wang, J.3    Sloan, C.4    Cicogna, C.5
  • 23
    • 54049146958 scopus 로고    scopus 로고
    • Genomic analysis reveals a point mutation in the two-component sensor gene graS that leads to intermediate vancomycin resistance in clinical Staphylococcus aureus
    • Howden BP, Stinear TP, Allen DL, Johnson PD, Ward PB, Davies JK. 2008. Genomic analysis reveals a point mutation in the two-component sensor gene graS that leads to intermediate vancomycin resistance in clinical Staphylococcus aureus. Antimicrob Agents Chemother 52: 3755-3762.
    • (2008) Antimicrob Agents Chemother , vol.52 , pp. 3755-3762
    • Howden, B.P.1    Stinear, T.P.2    Allen, D.L.3    Johnson, P.D.4    Ward, P.B.5    Davies, J.K.6
  • 25
    • 34748921084 scopus 로고    scopus 로고
    • Zyvox annual appraisal of potency and spectrum program results for 2006: An activity and spectrum analysis of linezolid using clinical isolates from 16 countries
    • Jones RN, Fritsche TR, Sader HS, Ross JE. 2007. Zyvox annual appraisal of potency and spectrum program results for 2006: An activity and spectrum analysis of linezolid using clinical isolates from 16 countries. Diagn Microbiol Infect Dis 59: 199-209.
    • (2007) Diagn Microbiol Infect Dis , vol.59 , pp. 199-209
    • Jones, R.N.1    Fritsche, T.R.2    Sader, H.S.3    Ross, J.E.4
  • 26
    • 0036274888 scopus 로고    scopus 로고
    • Redefining bacterial populations: A post-genomic reformation
    • Joyce EA, Chan K, Salama NR, Falkow S. 2002. Redefining bacterial populations: A post-genomic reformation. Nat Rev Genet 3: 462-473.
    • (2002) Nat Rev Genet , vol.3 , pp. 462-473
    • Joyce, E.A.1    Chan, K.2    Salama, N.R.3    Falkow, S.4
  • 27
    • 53649101617 scopus 로고    scopus 로고
    • What would you do if you could sequence everything?
    • Kahvejian A, Quackenbush J, Thompson JF. 2008. What would you do if you could sequence everything? Nat Biotechnol 26: 1125-1133.
    • (2008) Nat Biotechnol , vol.26 , pp. 1125-1133
    • Kahvejian, A.1    Quackenbush, J.2    Thompson, J.F.3
  • 32
    • 33750290824 scopus 로고    scopus 로고
    • Identification of Escherichia coli m2G methyltransferases: I. The ycbY gene encodes a methyltransferase specific for G2445 of the 23 S rRNA
    • Lesnyak DV, Sergiev PV, Bogdanov AA, Dontsova OA. 2006. Identification of Escherichia coli m2G methyltransferases: I. The ycbY gene encodes a methyltransferase specific for G2445 of the 23 S rRNA. J Mol Biol 364: 20-25.
    • (2006) J Mol Biol , vol.364 , pp. 20-25
    • Lesnyak, D.V.1    Sergiev, P.V.2    Bogdanov, A.A.3    Dontsova, O.A.4
  • 33
    • 34548724460 scopus 로고    scopus 로고
    • Distribution and physiology of ABC-type transporters contributing to multidrug resistance in bacteria
    • Lubelski J, Konings WN, Driessen AJ. 2007. Distribution and physiology of ABC-type transporters contributing to multidrug resistance in bacteria. Microbiol Mol Biol Rev 71: 463-476.
    • (2007) Microbiol Mol Biol Rev , vol.71 , pp. 463-476
    • Lubelski, J.1    Konings, W.N.2    Driessen, A.J.3
  • 35
    • 29944443917 scopus 로고    scopus 로고
    • Global transcriptome analysis of the responses of a fluoroquinolone-resistant Streptococcus pneumoniae mutant and its parent to ciprofloxacin
    • Marrer E, Satoh AT, Johnson MM, Piddock LJ, Page MG. 2006a. Global transcriptome analysis of the responses of a fluoroquinolone-resistant Streptococcus pneumoniae mutant and its parent to ciprofloxacin. Antimicrob Agents Chemother 50: 269-278.
    • (2006) Antimicrob Agents Chemother , vol.50 , pp. 269-278
    • Marrer, E.1    Satoh, A.T.2    Johnson, M.M.3    Piddock, L.J.4    Page, M.G.5
  • 36
    • 31944438999 scopus 로고    scopus 로고
    • Involvement of the putative ATP-dependent efflux proteins PatA and PatB in fluoroquinolone resistance of a multidrug-resistant mutant of Streptococcus pneumoniae
    • Marrer E, Schad K, Satoh AT, Page MG, Johnson MM, Piddock LJ. 2006b. Involvement of the putative ATP-dependent efflux proteins PatA and PatB in fluoroquinolone resistance of a multidrug-resistant mutant of Streptococcus pneumoniae. Antimicrob Agents Chemother 50: 685-693.
    • (2006) Antimicrob Agents Chemother , vol.50 , pp. 685-693
    • Marrer, E.1    Schad, K.2    Satoh, A.T.3    Page, M.G.4    Johnson, M.M.5    Piddock, L.J.6
  • 38
    • 0033954578 scopus 로고    scopus 로고
    • Correlation between the resistance genotype determined by multiplex PCR assays and the antibiotic susceptibility patterns of Staphylococcus aureus and Staphylococcus epidermidis
    • Martineau F, Picard FJ, Lansac N, Menard C, Roy PH, Ouellette M, Bergeron MG. 2000. Correlation between the resistance genotype determined by multiplex PCR assays and the antibiotic susceptibility patterns of Staphylococcus aureus and Staphylococcus epidermidis. Antimicrob Agents Chemother 44: 231-238.
    • (2000) Antimicrob Agents Chemother , vol.44 , pp. 231-238
    • Martineau, F.1    Picard, F.J.2    Lansac, N.3    Menard, C.4    Roy, P.H.5    Ouellette, M.6    Bergeron, M.G.7
  • 39
    • 4744364598 scopus 로고    scopus 로고
    • Antimicrobial resistance to linezolid
    • Meka VG, Gold HS. 2004. Antimicrobial resistance to linezolid. Clin Infect Dis 39: 1010-1015.
    • (2004) Clin Infect Dis , vol.39 , pp. 1010-1015
    • Meka, V.G.1    Gold, H.S.2
  • 41
    • 44449125584 scopus 로고    scopus 로고
    • First report of cfr-mediated resistance to linezolid in human staphylococcal clinical isolates recovered in the United States
    • Mendes RE, Deshpande LM, Castanheira M, Dipersio J, Saubolle M, Jones RN. 2008. First report of cfr-mediated resistance to linezolid in human staphylococcal clinical isolates recovered in the United States. Antimicrob Agents Chemother 52: 2244-2246.
    • (2008) Antimicrob Agents Chemother , vol.52 , pp. 2244-2246
    • Mendes, R.E.1    Deshpande, L.M.2    Castanheira, M.3    Dipersio, J.4    Saubolle, M.5    Jones, R.N.6
  • 42
    • 0026787870 scopus 로고
    • Genetics of resistance to third-generation cephalosporins in clinical isolates of Streptococcus pneumoniae
    • Munoz R, Dowson CG, Daniels M, Coffey TJ, Martin C, Hakenbeck R, Spratt BG. 1992. Genetics of resistance to third-generation cephalosporins in clinical isolates of Streptococcus pneumoniae. Mol Microbiol 6: 2461-2465.
    • (1992) Mol Microbiol , vol.6 , pp. 2461-2465
    • Munoz, R.1    Dowson, C.G.2    Daniels, M.3    Coffey, T.J.4    Martin, C.5    Hakenbeck, R.6    Spratt, B.G.7
  • 43
    • 0037561936 scopus 로고    scopus 로고
    • Linezolid resistance since 2001: SENTRY Antimicrobial Surveillance Program
    • Mutnick AH, Enne V, Jones RN. 2003. Linezolid resistance since 2001: SENTRY Antimicrobial Surveillance Program. Ann Pharmacother 37: 769-774.
    • (2003) Ann Pharmacother , vol.37 , pp. 769-774
    • Mutnick, A.H.1    Enne, V.2    Jones, R.N.3
  • 45
    • 72849132992 scopus 로고    scopus 로고
    • Clinical relevance of drug resistance mediated by ABC-transporters in parasites of humans
    • eds. B. Holland et al, pp, Academic Press, New York
    • Ouellette M, Légaré D. 2002. Clinical relevance of drug resistance mediated by ABC-transporters in parasites of humans. In ABC transporters (eds. B. Holland et al.), pp. 317-333. Academic Press, New York.
    • (2002) ABC transporters , pp. 317-333
    • Ouellette, M.1    Légaré, D.2
  • 47
    • 9644301282 scopus 로고    scopus 로고
    • Mutations in ribosomal protein L3 and 23S ribosomal RNA at the peptidyl transferase centre are associated with reduced susceptibility to tiamulin in Brachyspira spp. isolates
    • Pringle M, Poehlsgaard J, Vester B, Long KS. 2004. Mutations in ribosomal protein L3 and 23S ribosomal RNA at the peptidyl transferase centre are associated with reduced susceptibility to tiamulin in Brachyspira spp. isolates. Mol Microbiol 54: 1295-1306.
    • (2004) Mol Microbiol , vol.54 , pp. 1295-1306
    • Pringle, M.1    Poehlsgaard, J.2    Vester, B.3    Long, K.S.4
  • 49
    • 34247165180 scopus 로고    scopus 로고
    • First linezolid-resistant clinical isolates of Mycobacterium tuberculosis
    • Richter E, Rusch-Gerdes S, Hillemann D. 2007. First linezolid-resistant clinical isolates of Mycobacterium tuberculosis. Antimicrob Agents Chemother 51: 1534-1536.
    • (2007) Antimicrob Agents Chemother , vol.51 , pp. 1534-1536
    • Richter, E.1    Rusch-Gerdes, S.2    Hillemann, D.3
  • 50
    • 42449112810 scopus 로고    scopus 로고
    • Update on macrolide-lincosamide-streptogramin, ketolide, and oxazolidinone resistance genes
    • Roberts MC. 2008. Update on macrolide-lincosamide-streptogramin, ketolide, and oxazolidinone resistance genes. FEMS Microbiol Lett 282: 147-159.
    • (2008) FEMS Microbiol Lett , vol.282 , pp. 147-159
    • Roberts, M.C.1
  • 51
    • 27644571508 scopus 로고    scopus 로고
    • Use of an efflux-deficient streptococcus pneumoniae strain panel to identify ABC-class multidrug transporters involved in intrinsic resistance to antimicrobial agents
    • Robertson GT, Doyle TB, Lynch AS. 2005. Use of an efflux-deficient streptococcus pneumoniae strain panel to identify ABC-class multidrug transporters involved in intrinsic resistance to antimicrobial agents. Antimicrob Agents Chemother 49: 4781-4783.
    • (2005) Antimicrob Agents Chemother , vol.49 , pp. 4781-4783
    • Robertson, G.T.1    Doyle, T.B.2    Lynch, A.S.3
  • 52
    • 0242365629 scopus 로고    scopus 로고
    • Nosocomial superinfections due to linezolid-resistant Enterococcus faecalis: Evidence for a gene dosage effect on linezolid MICs
    • Ruggero KA, Schroeder LK, Schreckenberger PC, Mankin AS, Quinn JP. 2003. Nosocomial superinfections due to linezolid-resistant Enterococcus faecalis: Evidence for a gene dosage effect on linezolid MICs. Diagn Microbiol Infect Dis 47: 511-513.
    • (2003) Diagn Microbiol Infect Dis , vol.47 , pp. 511-513
    • Ruggero, K.A.1    Schroeder, L.K.2    Schreckenberger, P.C.3    Mankin, A.S.4    Quinn, J.P.5
  • 53
    • 0036886952 scopus 로고    scopus 로고
    • Ribosomal and non-ribosomal resistance to oxazolidinones: Species-specific idiosyncrasy of ribosomal alterations
    • Sander P, Belova L, Kidan YG, Pfister P, Mankin AS, Bottger EC. 2002. Ribosomal and non-ribosomal resistance to oxazolidinones: Species-specific idiosyncrasy of ribosomal alterations. Mol Microbiol 46: 1295-1304.
    • (2002) Mol Microbiol , vol.46 , pp. 1295-1304
    • Sander, P.1    Belova, L.2    Kidan, Y.G.3    Pfister, P.4    Mankin, A.S.5    Bottger, E.C.6
  • 55
    • 0242322580 scopus 로고    scopus 로고
    • Rapid detection and estimation by pyrosequencing of 23S rRNA genes with a single nucleotide polymorphism conferring linezolid resistance in Enterococci
    • Sinclair A, Arnold C, Woodford N. 2003. Rapid detection and estimation by pyrosequencing of 23S rRNA genes with a single nucleotide polymorphism conferring linezolid resistance in Enterococci. Antimicrob Agents Chemother 47: 3620-3622.
    • (2003) Antimicrob Agents Chemother , vol.47 , pp. 3620-3622
    • Sinclair, A.1    Arnold, C.2    Woodford, N.3
  • 56
    • 28244497055 scopus 로고    scopus 로고
    • A proteomic analysis of penicillin resistance in Streptococcus pneumoniae reveals a novel role for PstS, a subunit of the phosphate ABC transporter
    • Soualhine H, Brochu V, Menard F, Papadopoulou B, Weiss K, Bergeron MG, Legare D, Drummelsmith J, Ouellette M. 2005. A proteomic analysis of penicillin resistance in Streptococcus pneumoniae reveals a novel role for PstS, a subunit of the phosphate ABC transporter. Mol Microbiol 58: 1430-1440.
    • (2005) Mol Microbiol , vol.58 , pp. 1430-1440
    • Soualhine, H.1    Brochu, V.2    Menard, F.3    Papadopoulou, B.4    Weiss, K.5    Bergeron, M.G.6    Legare, D.7    Drummelsmith, J.8    Ouellette, M.9
  • 58
    • 66849140758 scopus 로고    scopus 로고
    • Antimicrobial activity among multidrug-resistant Streptococcus pneumoniae isolated in the United States, 2001-2005
    • Thornsberry C, Brown NP, Draghi DC, Evangelista AT, Yee YC, Sahm DF. 2008. Antimicrobial activity among multidrug-resistant Streptococcus pneumoniae isolated in the United States, 2001-2005. Postgrad Med 120: 32-38.
    • (2008) Postgrad Med , vol.120 , pp. 32-38
    • Thornsberry, C.1    Brown, N.P.2    Draghi, D.C.3    Evangelista, A.T.4    Yee, Y.C.5    Sahm, D.F.6
  • 59
    • 45649083395 scopus 로고    scopus 로고
    • An indigenous posttranscriptional modification in the ribosomal peptidyl transferase center confers resistance to an array of protein synthesis inhibitors
    • Toh SM, Mankin AS. 2008. An indigenous posttranscriptional modification in the ribosomal peptidyl transferase center confers resistance to an array of protein synthesis inhibitors. J Mol Biol 380: 593-597.
    • (2008) J Mol Biol , vol.380 , pp. 593-597
    • Toh, S.M.1    Mankin, A.S.2
  • 60
    • 34250028674 scopus 로고    scopus 로고
    • Acquisition of a natural resistance gene renders a clinical strain of methicillin-resistant Staphylococcus aureus resistant to the synthetic antibiotic linezolid
    • Toh SM, Xiong L, Arias CA, Villegas MV, Lolans K, Quinn J, Mankin AS. 2007. Acquisition of a natural resistance gene renders a clinical strain of methicillin-resistant Staphylococcus aureus resistant to the synthetic antibiotic linezolid. Mol Microbiol 64: 1506-1514.
    • (2007) Mol Microbiol , vol.64 , pp. 1506-1514
    • Toh, S.M.1    Xiong, L.2    Arias, C.A.3    Villegas, M.V.4    Lolans, K.5    Quinn, J.6    Mankin, A.S.7
  • 64
    • 51649117099 scopus 로고    scopus 로고
    • The oxazolidinone antibiotics perturb the ribosomal peptidyltransferase center and effect tRNA positioning
    • Wilson DN, Schluenzen F, Harms JM, Starosta AL, Connell SR, Fucini P. 2008. The oxazolidinone antibiotics perturb the ribosomal peptidyltransferase center and effect tRNA positioning. Proc Natl Acad Sci 105: 13339-13344.
    • (2008) Proc Natl Acad Sci , vol.105 , pp. 13339-13344
    • Wilson, D.N.1    Schluenzen, F.2    Harms, J.M.3    Starosta, A.L.4    Connell, S.R.5    Fucini, P.6
  • 67
    • 0033797686 scopus 로고    scopus 로고
    • Oxazolidinone resistance mutations in 23S rRNA of Escherichia coli reveal the central region of domain V as the primary site of drug action
    • Xiong L, Kloss P, Douthwaite S, Andersen NM, Swaney S, Shinabarger DL, Mankin AS. 2000. Oxazolidinone resistance mutations in 23S rRNA of Escherichia coli reveal the central region of domain V as the primary site of drug action. J Bacteriol 182: 5325-5331.
    • (2000) J Bacteriol , vol.182 , pp. 5325-5331
    • Xiong, L.1    Kloss, P.2    Douthwaite, S.3    Andersen, N.M.4    Swaney, S.5    Shinabarger, D.L.6    Mankin, A.S.7


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