Brain endogenous estrogen levels determine responses to estrogen replacement therapy via regulation of BACE1 and NEP in female Alzheimer's transgenic mice

Molecular Neurobiology

Volumn 47, Issue 3, 2013, Pages 857-867

  Li, Rena ^a   He, Ping ^a   Cui, Jie ^a   Staufenbiel, Matthias ^b   Harada, Nobuhiro ^c   Shen, Yong ^a  

^a ROSKAMP INSTITUTE   (United States)

^b NOVARTIS PHARMA AG   (Switzerland)

^c FUJITA HEALTH UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Alzheimer's disease; A deposition; BACE1; Brain estrogen; Hormone therapy

Indexed keywords

17ALPHA ESTRADIOL; AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; BETA SECRETASE 1; BRAIN PROTEIN; ESTROGEN; GENISTEIN; MEMBRANE METALLOENDOPEPTIDASE; AMYLOID BETA PROTEIN; AROMATASE; ASPARTIC PROTEINASE; BACE1 PROTEIN, MOUSE; ESTRADIOL; MESSENGER RNA; SECRETASE;

ACTAEA RACEMOSA; ALZHEIMER DISEASE; AMYLOID PLAQUE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN LEVEL; CONTROLLED STUDY; DOWN REGULATION; ESTRADIOL BLOOD LEVEL; ESTROGEN BRAIN LEVEL; ESTROGEN DEFICIENCY; ESTROGEN THERAPY; FEMALE; HIPPOCAMPAL CA3 REGION; IN VITRO STUDY; MOUSE; NONHUMAN; PROTEIN DEGRADATION; PROTEIN EXPRESSION; RISK FACTOR; TRANSGENIC MOUSE; TREATMENT RESPONSE; ANIMAL; BRAIN; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; HUMAN; METABOLISM; OVARIECTOMY; PATHOLOGY;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; AROMATASE; ASPARTIC ACID ENDOPEPTIDASES; BRAIN; ESTRADIOL; ESTROGEN REPLACEMENT THERAPY; ESTROGENS; FEMALE; GENE EXPRESSION REGULATION; GENISTEIN; HUMANS; MICE; MICE, TRANSGENIC; NEPRILYSIN; OVARIECTOMY; PLAQUE, AMYLOID; PROTEOLYSIS; RNA, MESSENGER;

EID: 84887282073     PISSN: 08937648     EISSN: 15591182     Source Type: Journal    
DOI: 10.1007/s12035-012-8377-3     Document Type: Article

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