Effect of estrogen-depletion and 17β-estradiol replacement therapy upon rat hippocampus β-amyloid generation

National Medical Journal of China

Volumn 89, Issue 37, 2009, Pages 2658-2661

  Yang, Hong Qi ^a   Sun, Zhi Kun ^a   Jiang, Qiu Huan ^a   Shang, Qian ^a   Xu, Jun ^a  

^a HENAN PROVINCIAL PEOPLE'S HOSPITAL   (China)

Author keywords

secretase; amyloid; secretase; Alzheimer's disease; Estrogens; Neprilysin

Indexed keywords

AMYLASE; AMYLOID BETA PROTEIN; ASPARTIC PROTEINASE; BACE PROTEIN, RAT; BETA AMYLASE; ESTRADIOL; ESTROGEN; MEMBRANE METALLOENDOPEPTIDASE; SECRETASE;

ANIMAL; ARTICLE; BIOSYNTHESIS; ESTROGEN THERAPY; FEMALE; HIPPOCAMPUS; METABOLISM; OVARIECTOMY; RAT; SPRAGUE DAWLEY RAT;

ALPHA-AMYLASES; AMYLOID BETA-PROTEIN; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ACID ENDOPEPTIDASES; BETA-AMYLASE; ESTRADIOL; ESTROGEN REPLACEMENT THERAPY; ESTROGENS; FEMALE; HIPPOCAMPUS; NEPRILYSIN; OVARIECTOMY; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84871420455     PISSN: 03762491     EISSN: None     Source Type: Journal    
DOI: 10.3760/cma.j.issn.0376-2491.2009.37.016     Document Type: Article

References (18)

1. Panza F, Solfrizzi V, Frisardi V, et al. Disease-modifying approach to the treatment of Alzheimer's disease: from alpha-secretase activators to gamma-secretase inhibitors and modulators. Drugs Aging, 2009, 26: 537-555.
2. Kasuga K, Shimohata T, Nishimura A, et al. Identification of independent APP locus duplication in Japanese patients with early-onset Alzheimer disease. J Neurol Neurosurg Psychiatry, 2009, 80: 1050-1052.
3. Mulnard RA, Corrada MM, Kawas CH. Estrogen replacement therapy, Alzheimer's disease, and mild cognitive impairment. Curr Neurol Neurosci Rep, 2004, 4: 368-373.
4. Sano M, Jacobs D, Andrews H, et al. A multi-center, randomized, double blind placebo-controlled trial of estrogens to prevent Alzheimer's disease and loss of memory in women: design and baseline characteristics. Clin Trials, 2008, 5: 523-533.
5. Pike CJ, Carroll JC, Rosario ER, et al. Protective actions of sex steroid hormones in Alzheimer's disease. Front Neuroendocrinol, 2009, 30: 239-258.
6. Zhang S, Huang Y, Zhu YC, et al. Estrogen stimulates release of secreted amyloid precursor protein from primary rat cortical neurons via protein kinase C pathway. Acta Pharmacol Sin, 2005, 26: 171-176.
7. Manthey D, Heck S, Engert S, et al. Estrogen induces a rapid secretion of amyloid beta precursor protein via the mitogen- activated protein kinase pathway. Eur J Biochem, 2001, 268: 4285-4291.
8. Pardossi-Piquard R, Yang SP, Kanemoto S, et al. APH1 polar transmembrane residues regulate the assembly and activity of presenilin complexes. J Biol Chem, 2009, 284: 16298-16307.
9. Suzuki Y, Ohta K, Itoh M, et al. An alternative spliced mouse presenilin-2 mRNA encodes a novel gamma-secretase inhibitor. FEBS Lett, 2009, 583: 1403-1408.
10. Petanceska SS, Nagy V, Frail D, et al. Ovariectomy and 17beta-estradiol modulate the levels of Alzheimer's amyloid beta peptides in brain. Exp Gerontol, 2000, 35: 1317-1325.
11. Yue X, Lu M, Lancaster T, et al. Brain estrogen deficiency accelerates Abeta plaque formation in an Alzheimer's disease animal model. Proc Natl Acad Sci USA, 2005, 102: 19198-19203.
12. Morinaga A, Hirohata M, Ono K, et al. Estrogen has anti- amyloidogenic effects on Alzheimer's beta-amyloid fibrils in vitro. Biochem Biophys Res Commun, 2007, 359: 697-702.
13. Aguado-Llera D, Arilla-Ferreiro E, Chowen JA, et al. 17Beta-estradiol protects depletion of rat temporal cortex somatostatinergic system by beta-amyloid. Neurobiol Aging, 2007, 28: 1396-1409.
14. Liu Y, Studzinski C, Beckett T, et al. Expression of neprilysin in skeletal muscle reduces amyloid burden in a transgenic mouse model of Alzheimer disease. Mol Ther, 2009, 17: 1381-1386.
15. El-Amouri SS, Zhu H, Yu J, et al. Neprilysin: an enzyme candidate to slow the progression of Alzheimer's disease. Am J Pathol, 2008, 172: 1342-1354.
16. Rose JB, Crews L, Rockenstein E, et al. Neuropeptide Y fragments derived from neprilysin processing are neuroprotective in a transgenic model of Alzheimer's disease. J Neurosci, 2009, 29: 1115-1125.
17. Nalivaeva NN, Fisk LR, Belyaev ND, et al. Amyloid-degrading enzymes as therapeutic targets in Alzheimer's disease. Curr Alzheimer Res, 2008, 5: 212-224.
18. 2004, 20: 2291-2293.