-
1
-
-
84871993429
-
The impact of molecular targets in cancer drug development: Major hurdles and future strategies
-
Hebar A, Valent P, Selzer E. The impact of molecular targets in cancer drug development: major hurdles and future strategies. Expert Rev. Clin. Pharmacol. 6(1), 23-34 (2013).
-
(2013)
Expert Rev. Clin. Pharmacol.
, vol.6
, Issue.1
, pp. 23-34
-
-
Hebar, A.1
Valent, P.2
Selzer, E.3
-
2
-
-
61549117795
-
Targeted therapies in solid tumours: Pinpointing the tumour's Achilles heel
-
Review
-
Kornek G, Selzer E. Targeted therapies in solid tumours: pinpointing the tumour's Achilles heel. Curr. Pharm. 15(2), 207-42 Review (2009).
-
(2009)
Curr. Pharm.
, vol.15
, Issue.2
, pp. 207-42
-
-
Kornek, G.1
Selzer, E.2
-
3
-
-
0027319521
-
P53 is required for radiation-induced apoptosis in mouse thymocytes
-
Lowe SW, Schmitt EM, Smith SW, Osborne BA, Jacks T. p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature 362, 847-849 (1993).
-
(1993)
Nature
, vol.362
, pp. 847-849
-
-
Lowe, S.W.1
Schmitt, E.M.2
Smith, S.W.3
Osborne, B.A.4
Jacks, T.5
-
4
-
-
0141869078
-
The RAS signal transduction pathway and its role in radiation sensitivity
-
Review
-
McKenna WG, Muschel RJ, Gupta AK, Hahn SM, Bernhard EJ. The RAS signal transduction pathway and its role in radiation sensitivity. Oncogene 22(37), 5866-5875 Review (2003).
-
(2003)
Oncogene
, vol.22
, Issue.37
, pp. 5866-5875
-
-
McKenna, W.G.1
Muschel, R.J.2
Gupta, A.K.3
Hahn, S.M.4
Bernhard, E.J.5
-
5
-
-
4444351073
-
Angiogenesis inhibitors: A rational strategy for radiosensitization in the treatment of non-small-cell lung cancer? Clin
-
Review
-
Raben D, Helfrich B. Angiogenesis inhibitors: a rational strategy for radiosensitization in the treatment of non-small-cell lung cancer? Clin. Lung Cancer 6(1), 48-57 Review (2004).
-
(2004)
Lung Cancer
, vol.6
, Issue.1
, pp. 48-57
-
-
Raben, D.1
Helfrich, B.2
-
6
-
-
2342557044
-
Targeted therapies for non-small-cell lung cancer: Biology, rationale, and preclinical results from a radiation oncology perspective
-
Review
-
Raben D, Helfrich B, Bunn PA Jr. Targeted therapies for non-small-cell lung cancer: biology, rationale, and preclinical results from a radiation oncology perspective. Int. J. Radiat. Oncol. Biol. Phys. 59(2 Suppl.), 27-38 Review (2004).
-
(2004)
Int. J. Radiat. Oncol. Biol. Phys.
, vol.59
, Issue.2 SUPPL.
, pp. 27-38
-
-
Raben, D.1
Helfrich, B.2
Bunn Jr., P.A.3
-
7
-
-
0036684517
-
Interference with EGFR signaling: Paradigm for improving radiation response in cancer treatment
-
Review
-
Raben D, Bianco C, Helfrich B, Weng E, Ciardiello F, Harari P. Interference with EGFR signaling: paradigm for improving radiation response in cancer treatment. Expert Rev. Anticancer Ther. 2(4), 461-471 Review (2002).
-
(2002)
Expert Rev. Anticancer Ther.
, vol.2
, Issue.4
, pp. 461-471
-
-
Raben, D.1
Bianco, C.2
Helfrich, B.3
Weng, E.4
Ciardiello, F.5
Harari, P.6
-
8
-
-
84857556316
-
Human papillomavirus as a marker of the natural history and response to therapy of head and neck squamous cell carcinoma
-
Review
-
Ang KK, Sturgis EM. Human papillomavirus as a marker of the natural history and response to therapy of head and neck squamous cell carcinoma. Semin. Radiat. Oncol. 22(2), 128-142 Review (2012).
-
(2012)
Semin. Radiat. Oncol.
, vol.22
, Issue.2
, pp. 128-142
-
-
Ang, K.K.1
Sturgis, E.M.2
-
9
-
-
77955282693
-
HPV-associated head and neck cancer: A virus-related cancer epidemic
-
Marur S, D'Souza G, Westra WH, Forastiere AA. HPV-associated head and neck cancer: a virus-related cancer epidemic. Lancet Oncol. 11(8), 781-789 (2010).
-
(2010)
Lancet Oncol.
, vol.11
, Issue.8
, pp. 781-789
-
-
Marur, S.1
D'Souza, G.2
Westra, W.H.3
Forastiere, A.A.4
-
10
-
-
84880738343
-
Predictive and prognostic biomarkers with therapeutic targets in breast, colorectal, and non-small cell lung cancers: A systemic review of current development, evidence, and recommendation
-
(Epub ahead of print)
-
Chung C, Christianson M. Predictive and prognostic biomarkers with therapeutic targets in breast, colorectal, and non-small cell lung cancers: A systemic review of current development, evidence, and recommendation. J. Oncol. Pharm. Pract. (2013) (Epub ahead of print).
-
(2013)
J. Oncol. Pharm. Pract.
-
-
Chung, C.1
Christianson, M.2
-
11
-
-
84879412482
-
Oncogenic RAS simultaneously protects against anti-EGFR antibody-dependent cellular cytotoxicity and EGFR signaling blockade
-
Kasper S, Breitenbuecher F, Reis H et al. Oncogenic RAS simultaneously protects against anti-EGFR antibody-dependent cellular cytotoxicity and EGFR signaling blockade. Oncogene 32(23), 2873-2881 (2013).
-
(2013)
Oncogene
, vol.32
, Issue.23
, pp. 2873-2881
-
-
Kasper, S.1
Breitenbuecher, F.2
Reis, H.3
-
12
-
-
77955437259
-
Targeting epidermal growth factor receptor-associated signaling pathways in non-small cell lung cancer cells: Implication in radiation response
-
Choi EJ, Ryu YK, Kim SY et al. Targeting epidermal growth factor receptor-associated signaling pathways in non-small cell lung cancer cells: implication in radiation response. Mol. Cancer Res. 8(7), 1027-1036 (2010).
-
(2010)
Mol. Cancer Res.
, vol.8
, Issue.7
, pp. 1027-1036
-
-
Choi, E.J.1
Ryu, Y.K.2
Kim, S.Y.3
-
13
-
-
33746088022
-
Blockage of epidermal growth factor receptor-phosphatidylinositol 3-kinase-AKT signaling increases radiosensitivity of K-RAS mutated human tumor cells in vitro by affecting DNA repair
-
Toulany M, Kasten-Pisula U, Brammer I et al. Blockage of epidermal growth factor receptor-phosphatidylinositol 3-kinase-AKT signaling increases radiosensitivity of K-RAS mutated human tumor cells in vitro by affecting DNA repair. Clin. Cancer Res. 12(13), 4119-4126 (2006).
-
(2006)
Clin. Cancer Res.
, vol.12
, Issue.13
, pp. 4119-4126
-
-
Toulany, M.1
Kasten-Pisula, U.2
Brammer, I.3
-
14
-
-
84861694666
-
Targeted agents in non-small cell lung cancer (NSCLC): Clinical developments and rationale for the combination with thoracic radiotherapy
-
Koh PK, Faivre-Finn C, Blackhall FH, De Ruysscher D. Targeted agents in non-small cell lung cancer (NSCLC): clinical developments and rationale for the combination with thoracic radiotherapy. Cancer Treat. Rev. 38(6), 626-640 (2012).
-
(2012)
Cancer Treat. Rev.
, vol.38
, Issue.6
, pp. 626-640
-
-
Koh, P.K.1
Faivre-Finn, C.2
Blackhall, F.H.3
De Ruysscher, D.4
-
15
-
-
77954216798
-
Cetuximab in the management of locoregionally advanced head and neck cancer: Expanding the treatment options? Eur
-
Bourhis J, Lefebvre JL, Vermorken JB. Cetuximab in the management of locoregionally advanced head and neck cancer: expanding the treatment options? Eur. J. Cancer 46, 1979-1989 (2010).
-
(2010)
J. Cancer
, vol.46
, pp. 1979-1989
-
-
Bourhis, J.1
Lefebvre, J.L.2
Vermorken, J.B.3
-
16
-
-
84876232194
-
Cetuximab: Its unique place in head and neck cancer treatment
-
Specenier P, Vermorken JB. Cetuximab: its unique place in head and neck cancer treatment. Biologics 7, 77-90 (2013).
-
(2013)
Biologics
, vol.7
, pp. 77-90
-
-
Specenier, P.1
Vermorken, J.B.2
-
17
-
-
53049109473
-
The efficacy and toxicity of EGFR in the settings of radiotherapy: Focus on published clinical trials
-
Magné N, Chargari C, Castadot P et al. The efficacy and toxicity of EGFR in the settings of radiotherapy: Focus on published clinical trials. Eur. J. Cancer. 44(15), 2133-2143 (2008).
-
(2008)
Eur. J. Cancer.
, vol.44
, Issue.15
, pp. 2133-2143
-
-
Magné, N.1
Chargari, C.2
Castadot, P.3
-
18
-
-
84876079071
-
Cisplatin and radiotherapy with or without erlotinib in locally advanced squamous cell carcinoma of the head and neck: A randomized phase II trial
-
Martins RG, Parvathaneni U, Bauman JE et al. Cisplatin and radiotherapy with or without erlotinib in locally advanced squamous cell carcinoma of the head and neck: a randomized phase II trial. J. Clin. Oncol. 31(11), 1415-1421 (2013).
-
(2013)
J. Clin. Oncol.
, vol.31
, Issue.11
, pp. 1415-1421
-
-
Martins, R.G.1
Parvathaneni, U.2
Bauman, J.E.3
-
19
-
-
73249143536
-
Radiotherapy plus cetuximab for locoregionally advanced head and neck cancer: 5-year survival data from a phase 3 randomised trial, and relation between cetuximab-induced rash and survival
-
Bonner JA, Harari PM, Giralt J et al. Radiotherapy plus cetuximab for locoregionally advanced head and neck cancer: 5-year survival data from a phase 3 randomised trial, and relation between cetuximab-induced rash and survival. Lancet Oncol. 11, 21-28 (2010).
-
(2010)
Lancet Oncol.
, vol.11
, pp. 21-28
-
-
Bonner, J.A.1
Harari, P.M.2
Giralt, J.3
-
20
-
-
32144433159
-
Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck
-
Bonner JA, Harari PM, Giralt J et al. Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck. N. Engl. J. Med. 354, 567-578 (2006).
-
(2006)
N. Engl. J. Med.
, vol.354
, pp. 567-578
-
-
Bonner, J.A.1
Harari, P.M.2
Giralt, J.3
-
21
-
-
51649085865
-
Platinum-based chemotherapy plus cetuximab in head and neck cancer
-
Vermorken JB, Mesia R, Rivera F et al. Platinum-based chemotherapy plus cetuximab in head and neck cancer. N. Engl. J. Med. 359(11), 1116-1127 (2008).
-
(2008)
N. Engl. J. Med.
, vol.359
, Issue.11
, pp. 1116-1127
-
-
Vermorken, J.B.1
Mesia, R.2
Rivera, F.3
-
22
-
-
79957851698
-
Head and neck cancers
-
National Comprehensive Concer Network
-
Pfister DG, Ang KK, Brizel DM et al.; National Comprehensive Concer Network. Head and neck cancers. J. Natl. Compr. Canc. Netw. 9(6), 596-650 (2011).
-
(2011)
J. Natl. Compr. Canc. Netw.
, vol.9
, Issue.6
, pp. 596-650
-
-
Pfister, D.G.1
Ang, K.K.2
Brizel, D.M.3
-
23
-
-
77950399100
-
Cetuximab: From bench to bedside
-
Vincenzi B, Zoccoli A, Pantano F, Venditti O, Galluzzo S. Cetuximab: from bench to bedside. Curr. Cancer Drug Targets 10(1), 80-95 (2010).
-
(2010)
Curr. Cancer Drug Targets
, vol.10
, Issue.1
, pp. 80-95
-
-
Vincenzi, B.1
Zoccoli, A.2
Pantano, F.3
Venditti, O.4
Galluzzo, S.5
-
24
-
-
84887267306
-
A Phase 2, randomized trial (CONCERT-1) of chemoradiotherapy (CRT) with or without panitumumab in patients (pts) with unresected, locally advanced squamous cell carcinoma of the head and neck (LASCCHN)
-
abstract 5502
-
Giralt J, Fortin A, Mesia R et al. A Phase 2, randomized trial (CONCERT-1) of chemoradiotherapy (CRT) with or without panitumumab in patients (pts) with unresected, locally advanced squamous cell carcinoma of the head and neck (LASCCHN). J. Clin. Oncol. 30(Suppl.), abstract 5502 (2007).
-
(2007)
J. Clin. Oncol.
, vol.30
, Issue.SUPPL.
-
-
Giralt, J.1
Fortin, A.2
Mesia, R.3
-
25
-
-
34249933404
-
Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: A phase III trial of the national cancer institute of Canada clinical trials group
-
Moore MJ, Goldstein D, Hamm J et al. Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase III trial of the national cancer institute of Canada clinical trials group. J. Clin. Oncol. 25, 1960-1966 (2007).
-
(2007)
J. Clin. Oncol.
, vol.25
, pp. 1960-1966
-
-
Moore, M.J.1
Goldstein, D.2
Hamm, J.3
-
26
-
-
22044445517
-
Erlotinib in previously treated non-small-cell lung cancer
-
National Cancer Institute of Canada Clinical Trials Group
-
Shepherd FA, Rodrigues Pereira J, Ciuleanu T et al.; National Cancer Institute of Canada Clinical Trials Group. Erlotinib in previously treated non-small-cell lung cancer. N. Engl. J. Med. 353(2):123-132 (2005).
-
(2005)
N. Engl. J. Med.
, vol.353
, Issue.2
, pp. 123-132
-
-
Shepherd, F.A.1
Rodrigues Pereira, J.2
Ciuleanu, T.3
-
27
-
-
84876079071
-
Cisplatin and radiotherapy with or without erlotinib in locally advanced squamous cell carcinoma of the head and neck: A randomized phase II trial
-
Martins RG, Parvathaneni U, Bauman JE et al. Cisplatin and radiotherapy with or without erlotinib in locally advanced squamous cell carcinoma of the head and neck: a randomized phase II trial. J. Clin. Oncol. 31(11), 1415-1421 (2013).
-
(2013)
J. Clin. Oncol.
, vol.31
, Issue.11
, pp. 1415-1421
-
-
Martins, R.G.1
Parvathaneni, U.2
Bauman, J.E.3
-
28
-
-
79952284127
-
Hallmarks of cancer: The next generation
-
Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 144(5), 646-674 (2011).
-
(2011)
Cell
, vol.144
, Issue.5
, pp. 646-674
-
-
Hanahan, D.1
Weinberg, R.A.2
-
29
-
-
85013312416
-
Tumor angiogenesis: Therapeutic implications
-
Folkman J. Tumor angiogenesis: Therapeutic implications. N. Engl. J. Med. 285(21), 1182-1186 (1971).
-
(1971)
N. Engl. J. Med.
, vol.285
, Issue.21
, pp. 1182-1186
-
-
Folkman, J.1
-
30
-
-
0036782278
-
VEGF and the quest for tumour angiogenesis factors
-
Ferrara N. VEGF and the quest for tumour angiogenesis factors. Nat. Rev. Cancer 2(10), 795-803 (2002).
-
(2002)
Nat. Rev. Cancer
, vol.2
, Issue.10
, pp. 795-803
-
-
Ferrara, N.1
-
31
-
-
81255188940
-
Tumor angiogenesis: Molecular pathways and therapeutic targets
-
Weis SM, Cheresh DA. Tumor angiogenesis: molecular pathways and therapeutic targets. Nat. Med. 17(11), 1359-1370 (2011).
-
(2011)
Nat. Med.
, vol.17
, Issue.11
, pp. 1359-1370
-
-
Weis, S.M.1
Cheresh, D.A.2
-
32
-
-
84884755163
-
The relationship between tumor blood flow, angiogenesis, tumor hypoxia, and aerobic glycolysis
-
doi:10.1158/0008-5472. CAN-13-0964 (Epub ahead of print)
-
Ostergaard L, Tietze A, Nielsen T et al. The relationship between tumor blood flow, angiogenesis, tumor hypoxia, and aerobic glycolysis. Cancer Res. doi:10.1158/0008-5472. CAN-13-0964 (2013) (Epub ahead of print).
-
(2013)
Cancer Res.
-
-
Ostergaard, L.1
Tietze, A.2
Nielsen, T.3
-
33
-
-
0038626211
-
Tumor response to radiotherapy regulated by endothelial cell apoptosis
-
Garcia-Barros M, Paris F, Cordon-Cardo C et al. Tumor response to radiotherapy regulated by endothelial cell apoptosis. Science 300(5622), 1155-1159 (2003).
-
(2003)
Science
, vol.300
, Issue.5622
, pp. 1155-1159
-
-
Garcia-Barros, M.1
Paris, F.2
Cordon-Cardo, C.3
-
36
-
-
0038176480
-
Tumor response to ionizing radiation combined with antiangiogenesis or vascular targeting agents: Exploring mechanisms of interaction
-
Review
-
Wachsberger P, Burd R, Dicker AP. Tumor response to ionizing radiation combined with antiangiogenesis or vascular targeting agents: exploring mechanisms of interaction. Clin. Cancer Res. 9, 1957-1971 Review (2003).
-
(2003)
Clin. Cancer Res.
, vol.9
, pp. 1957-1971
-
-
Wachsberger, P.1
Burd, R.2
Dicker, A.P.3
-
37
-
-
33748869678
-
Pathophysiologic effects of vascular-targeting agents and the implications for combination with conventional therapies
-
Horsman MR, Siemann DW. Pathophysiologic effects of vascular-targeting agents and the implications for combination with conventional therapies. Cancer Res. 66, 11520-11539 (2006).
-
(2006)
Cancer Res.
, vol.66
, pp. 11520-11539
-
-
Horsman, M.R.1
Siemann, D.W.2
-
38
-
-
77949655884
-
Growth factors protect intestinal stem cells from radiation-induced apoptosis by suppressing PUMA through the PI3K/AKT/ p53 axis
-
Qiu W, Leibowitz B, Zhang L, Yu J. Growth factors protect intestinal stem cells from radiation-induced apoptosis by suppressing PUMA through the PI3K/AKT/ p53 axis. Oncogene 29(11), 1622-1632 (2010).
-
(2010)
Oncogene
, vol.29
, Issue.11
, pp. 1622-1632
-
-
Qiu, W.1
Leibowitz, B.2
Zhang, L.3
Yu, J.4
-
39
-
-
0035854479
-
Endothelial apoptosis as the primary lesion initiating intestinal radiation damage in mice
-
Paris F, Fuks Z, Kang A et al. Endothelial apoptosis as the primary lesion initiating intestinal radiation damage in mice. Science 293, 293-297 (2001).
-
(2001)
Science
, vol.293
, pp. 293-297
-
-
Paris, F.1
Fuks, Z.2
Kang, A.3
-
40
-
-
84879498361
-
Dose-dependent response of tumor vasculature to radiation therapy in combination with Sunitinib depicted by three-dimensional high-frequency power Doppler ultrasound
-
El Kaffas A, Giles A, Czarnota GJ. Dose-dependent response of tumor vasculature to radiation therapy in combination with Sunitinib depicted by three-dimensional high-frequency power Doppler ultrasound. Angiogenesis 16, 443-454 (2013).
-
(2013)
Angiogenesis
, vol.16
, pp. 443-454
-
-
El Kaffas, A.1
Giles, A.2
Czarnota, G.J.3
-
41
-
-
84872343720
-
Tumor angiogenesis and lymphangiogenesis: Tumor/endothelial crosstalk and cellular/microenvironmental signaling mechanisms
-
Gomes FG, Nedel F, Alves AM, Nör JE, Tarquinio SB. Tumor angiogenesis and lymphangiogenesis: tumor/endothelial crosstalk and cellular/microenvironmental signaling mechanisms. Life Sci. 92, 101-107 (2013).
-
(2013)
Life Sci.
, vol.92
, pp. 101-107
-
-
Gomes, F.G.1
Nedel, F.2
Alves, A.M.3
Nör, J.E.4
Tarquinio, S.B.5
-
43
-
-
60649087564
-
Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis
-
Ebos JM, Lee CR, Cruz-Munoz W, Bjarnason GA, Christensen JG, Kerbel RS. Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis. Cancer Cell. 15, 232-239 (2009).
-
(2009)
Cancer Cell.
, vol.15
, pp. 232-239
-
-
Ebos, J.M.1
Lee, C.R.2
Cruz-Munoz, W.3
Bjarnason, G.A.4
Christensen, J.G.5
Kerbel, R.S.6
-
44
-
-
79953244361
-
Antiangiogenic therapy: Impact on invasion, disease progression, and metastasis
-
Ebos JM, Kerbel RS. Antiangiogenic therapy: impact on invasion, disease progression, and metastasis. Nat. Rev. Clin. Oncol. 8, 210-221 (2011).
-
(2011)
Nat. Rev. Clin. Oncol.
, vol.8
, pp. 210-221
-
-
Ebos, J.M.1
Kerbel, R.S.2
-
45
-
-
84857407549
-
Antiangiogenic agents increase breast cancer stem cells via the generation of tumor hypoxia
-
Conley SJ, Gheordunescu E, Kakarala P et al. Antiangiogenic agents increase breast cancer stem cells via the generation of tumor hypoxia. Proc. Natl. Acad. Sci. U.S.A. 109, 2784-2789 (2012).
-
(2012)
Proc. Natl. Acad. Sci. U.S.A.
, vol.109
, pp. 2784-2789
-
-
Conley, S.J.1
Gheordunescu, E.2
Kakarala, P.3
-
46
-
-
0031038068
-
Expression of the angiogenic factors vascular endothelial cell growth factor, acidic and basic fibroblast growth factor, tumor growth factor beta-1, platelet-derived endothelial cell growth factor, placenta growth factor, and pleiotrophin in human primary breast cancer and its relation to angiogenesis
-
Relf M, LeJeune S, Scott PA et al. Expression of the angiogenic factors vascular endothelial cell growth factor, acidic and basic fibroblast growth factor, tumor growth factor beta-1, platelet-derived endothelial cell growth factor, placenta growth factor, and pleiotrophin in human primary breast cancer and its relation to angiogenesis. Cancer Res. 57(5), 963-969 (1997).
-
(1997)
Cancer Res.
, vol.57
, Issue.5
, pp. 963-969
-
-
Relf, M.1
Lejeune, S.2
Scott, P.A.3
-
47
-
-
0035865450
-
Clinical implications of circulating angiogenic factors in cancer patients
-
Poon RT, Fan ST, Wong J. Clinical implications of circulating angiogenic factors in cancer patients. J. Clin. Oncol. 19(4), 1207-1225 (2001).
-
(2001)
J. Clin. Oncol.
, vol.19
, Issue.4
, pp. 1207-1225
-
-
Poon, R.T.1
Fan, S.T.2
Wong, J.3
-
48
-
-
77956268839
-
Understanding resistance to EGFR inhibitors - Impact on future treatment strategies
-
Wheeler DL, Dunn EF, Harari PM. Understanding resistance to EGFR inhibitors - impact on future treatment strategies. Nat. Rev. Clin. Oncol. 7(9), 493-507 (2010).
-
(2010)
Nat. Rev. Clin. Oncol.
, vol.7
, Issue.9
, pp. 493-507
-
-
Wheeler, D.L.1
Dunn, E.F.2
Harari, P.M.3
-
49
-
-
34147130694
-
The role of VEGF and EGFR inhibition: Implications for combining anti-VEGF and anti-EGFR agents
-
Tabernero J. The role of VEGF and EGFR inhibition: implications for combining anti-VEGF and anti-EGFR agents. Mol. Cancer Res. 5(3), 203-220 (2007).
-
(2007)
Mol. Cancer Res.
, vol.5
, Issue.3
, pp. 203-220
-
-
Tabernero, J.1
-
50
-
-
33644546368
-
Tumor endothelial cells express epidermal growth factor receptor (EGFR) but not ErbB3 and are responsive to EGF and to EGFR kinase inhibitors
-
Amin DN, Hida K, Bielenberg DR, Klagsbrun M. Tumor endothelial cells express epidermal growth factor receptor (EGFR) but not ErbB3 and are responsive to EGF and to EGFR kinase inhibitors. Cancer Res. 66(4), 2173-2180 (2006).
-
(2006)
Cancer Res.
, vol.66
, Issue.4
, pp. 2173-2180
-
-
Amin, D.N.1
Hida, K.2
Bielenberg, D.R.3
Klagsbrun, M.4
-
51
-
-
0032972944
-
Anti-epidermal growth factor receptor antibody C225 inhibits angiogenesis in human transitional cell carcinoma growing orthotopically in nude mice
-
Perrotte P, Matsumoto T, Inoue K et al. Anti-epidermal growth factor receptor antibody C225 inhibits angiogenesis in human transitional cell carcinoma growing orthotopically in nude mice. Clin. Cancer Res. 5(2), 257-265 (1999).
-
(1999)
Clin. Cancer Res.
, vol.5
, Issue.2
, pp. 257-265
-
-
Perrotte, P.1
Matsumoto, T.2
Inoue, K.3
-
52
-
-
77957769325
-
Cetuximab may inhibit tumor growth and angiogenesis induced by ionizing radiation: A preclinical rationale for maintenance treatment after radiotherapy
-
Pueyo G, Mesia R, Figueras A et al. Cetuximab may inhibit tumor growth and angiogenesis induced by ionizing radiation: a preclinical rationale for maintenance treatment after radiotherapy. Oncologist 15(9), 976-986 (2010).
-
(2010)
Oncologist
, vol.15
, Issue.9
, pp. 976-986
-
-
Pueyo, G.1
Mesia, R.2
Figueras, A.3
-
53
-
-
45449113946
-
Targeting EGFR activity in blood vessels is sufficient to inhibit tumor growth and is accompanied by an increase in VEGFR-2 dependence in tumor endothelial cells
-
Amin DN, Bielenberg DR, Lifshits E, Heymach JV, Klagsbrun M. Targeting EGFR activity in blood vessels is sufficient to inhibit tumor growth and is accompanied by an increase in VEGFR-2 dependence in tumor endothelial cells. Microvasc. Res. 76(1), 15-22 (2008).
-
(2008)
Microvasc. Res.
, vol.76
, Issue.1
, pp. 15-22
-
-
Amin, D.N.1
Bielenberg, D.R.2
Lifshits, E.3
Heymach, J.V.4
Klagsbrun, M.5
-
54
-
-
72949119124
-
Integrins in cancer: Biological implications and therapeutic opportunities
-
Desgrosellier JS, Cheresh DA. Integrins in cancer: biological implications and therapeutic opportunities. Nat. Rev. Cancer 9, 9-22 (2010).
-
(2010)
Nat. Rev. Cancer
, vol.9
, pp. 9-22
-
-
Desgrosellier, J.S.1
Cheresh, D.A.2
-
55
-
-
1542269303
-
Integrins: Roles in cancer development and as treatment agents
-
Jin H, Varner J. Integrins: Roles in cancer development and as treatment agents. Br. J. Cancer 90, 561-565 (2004).
-
(2004)
Br. J. Cancer
, vol.90
, pp. 561-565
-
-
Jin, H.1
Varner, J.2
-
56
-
-
77957363101
-
Integrins as therapeutic targets: Lessons and opportunities
-
Cox D, Brennan M, Moran N. Integrins as therapeutic targets: lessons and opportunities. Nat. Rev. Drug Discov. 9, 804-820 (2010).
-
(2010)
Nat. Rev. Drug Discov.
, vol.9
, pp. 804-820
-
-
Cox, D.1
Brennan, M.2
Moran, N.3
-
57
-
-
84879414338
-
Cell adhesion: Integrating the integrin response
-
Minton K. Cell adhesion: Integrating the integrin response. Nat. Rev. Mol. Cell Biol. 14(7), 401 (2013).
-
(2013)
Nat. Rev. Mol. Cell Biol.
, vol.14
, Issue.7
, pp. 401
-
-
Minton, K.1
-
58
-
-
0028911765
-
Comparison of cell adhesion molecule expression between glioblastoma multiforme and autologous normal brain tissue
-
Gingras MC, Roussel E, Bruner JM, Branch CD, Moser RP. Comparison of cell adhesion molecule expression between glioblastoma multiforme and autologous normal brain tissue. J. Neuroimmunol. 57, 143-153 (1995).
-
(1995)
J. Neuroimmunol.
, vol.57
, pp. 143-153
-
-
Gingras, M.C.1
Roussel, E.2
Bruner, J.M.3
Branch, C.D.4
Moser, R.P.5
-
59
-
-
0029846478
-
Expression of integrin alpha v beta 3 in small blood vessels of glioblastoma tumors
-
Gladson CL Expression of integrin alpha v beta 3 in small blood vessels of glioblastoma tumors. J. Neuropathol. Exp. Neurol. 55, 1143-1149, (1996).
-
(1996)
J. Neuropathol. Exp. Neurol.
, vol.55
, pp. 1143-1149
-
-
Gladson, C.L.1
-
60
-
-
79952741178
-
Cilengitide: The first anti-angiogenic small molecule drug candidate design, synthesis and clinical evaluation
-
Mas-Moruno C, Rechenmacher F, Kessler H. Cilengitide: the first anti-angiogenic small molecule drug candidate design, synthesis and clinical evaluation. Anticancer Agents Med. Chem. 10(10), 753-768 (2010).
-
(2010)
Anticancer Agents Med. Chem.
, vol.10
, Issue.10
, pp. 753-768
-
-
Mas-Moruno, C.1
Rechenmacher, F.2
Kessler, H.3
-
61
-
-
79953144790
-
Cilengitide: An RGD pentapeptide anb3 and anb5 integrin inhibitor in development for glioblastoma and other malignancies
-
Reardon DA, Neyns B,Weller M, Tonn JC, Nabors LB, Stupp R. Cilengitide: an RGD pentapeptide anb3 and anb5 integrin inhibitor in development for glioblastoma and other malignancies. Future Oncol. 7(3), 339-354 (2011).
-
(2011)
Future Oncol.
, vol.7
, Issue.3
, pp. 339-354
-
-
Reardon, D.A.1
Neyns, B.2
Weller, M.3
Tonn, J.C.4
Nabors, L.B.5
Stupp, R.6
-
62
-
-
84868621665
-
Cilengitide: A prototypic integrin inhibitor for the treatment of glioblastoma and other malignancies
-
Reardon DA, Cheresh D. Cilengitide: a prototypic integrin inhibitor for the treatment of glioblastoma and other malignancies. Genes Cancer 2(12), 1159-1165 (2011).
-
(2011)
Genes Cancer
, vol.2
, Issue.12
, pp. 1159-1165
-
-
Reardon, D.A.1
Cheresh, D.2
-
63
-
-
84866510711
-
Mechanisms of glioma-associated neovascularization
-
Review
-
Hardee ME, Zagzag D. Mechanisms of glioma-associated neovascularization. Am. J. Pathol. 181(4), 1126-1141 Review (2012).
-
(2012)
Am. J. Pathol.
, vol.181
, Issue.4
, pp. 1126-1141
-
-
Hardee, M.E.1
Zagzag, D.2
-
64
-
-
84859598676
-
B1Integrin/FAK/cortactin signaling is essential for human head and neck cancer resistance to radiotherapy
-
Eke I, Deuse Y, Hehlgans S et al. b1Integrin/FAK/cortactin signaling is essential for human head and neck cancer resistance to radiotherapy. J. Clin. Invest. 122(4), 1529-1540 (2012).
-
(2012)
J. Clin. Invest.
, vol.122
, Issue.4
, pp. 1529-1540
-
-
Eke, I.1
Deuse, Y.2
Hehlgans, S.3
-
65
-
-
36849089031
-
Cell adhesion-mediated radioresistance revisited
-
Sandfort V, Koch U, Cordes N. Cell adhesion-mediated radioresistance revisited. Int. J. Radiat. Biol. 83(11-12), 727-732 (2007).
-
(2007)
Int. J. Radiat. Biol.
, vol.83
, Issue.11-12
, pp. 727-732
-
-
Sandfort, V.1
Koch, U.2
Cordes, N.3
-
66
-
-
73249136703
-
Cilengitide modulates attachment and viability of human glioma cells, but not sensitivity to irradiation or temozolomide in vitro
-
Maurer GD, Tritschler I, Adams B, Tabatabai G, Wick W, Stupp R, Weller M. Cilengitide modulates attachment and viability of human glioma cells, but not sensitivity to irradiation or temozolomide in vitro. Neuro Oncol. 11(6), 747-756 (2009).
-
(2009)
Neuro Oncol.
, vol.11
, Issue.6
, pp. 747-756
-
-
Maurer, G.D.1
Tritschler, I.2
Adams, B.3
Tabatabai, G.4
Wick, W.5
Stupp, R.6
Weller, M.7
-
67
-
-
34249087162
-
Phase i and correlative biology study of cilengitide in patients with recurrent malignant glioma
-
Nabors LB, Mikkelsen T, Rosenfeld SS et al. Phase I and correlative biology study of cilengitide in patients with recurrent malignant glioma. J. Clin. Oncol. 25(13), 1651-1657 (2007).
-
(2007)
J. Clin. Oncol.
, vol.25
, Issue.13
, pp. 1651-1657
-
-
Nabors, L.B.1
Mikkelsen, T.2
Rosenfeld, S.S.3
-
68
-
-
39749191543
-
Phase i clinical trial of cilengitide in children with refractory brain tumors: Pediatric brain tumor consortium study PBTC-012
-
MacDonald TJ, Stewart CF, Kocak M et al. Phase I clinical trial of cilengitide in children with refractory brain tumors: pediatric brain tumor consortium study PBTC-012. J. Clin. Oncol. 26(6), 919-24 (2008).
-
(2008)
J. Clin. Oncol.
, vol.26
, Issue.6
, pp. 919-24
-
-
Macdonald, T.J.1
Stewart, C.F.2
Kocak, M.3
-
69
-
-
84867830537
-
Integrin inhibitor cilengitide for the treatment of glioblastoma: A brief overview of current clinical results
-
Scaringi C, Minniti G, Caporello P, Enrici RM. Integrin inhibitor cilengitide for the treatment of glioblastoma: a brief overview of current clinical results. Anticancer Res. 32(10), 4213-4223 (2012).
-
(2012)
Anticancer Res.
, vol.32
, Issue.10
, pp. 4213-4223
-
-
Scaringi, C.1
Minniti, G.2
Caporello, P.3
Enrici, R.M.4
-
70
-
-
65349121788
-
Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial
-
European Organisation for Research and Treatment of Cancer Brain Tumour and Radiation Oncology Groups; National Cancer Institute of Canada Clinical Trials Group
-
Stupp R, Hegi ME, Mason WP et al; European Organisation for Research and Treatment of Cancer Brain Tumour and Radiation Oncology Groups; National Cancer Institute of Canada Clinical Trials Group. Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial. Lancet Oncol. 10(5), 459-466 (2009).
-
(2009)
Lancet Oncol.
, vol.10
, Issue.5
, pp. 459-466
-
-
Stupp, R.1
Hegi, M.E.2
Mason, W.P.3
-
71
-
-
37449003812
-
Nomograms for predicting survival of patients with newly diagnosed glioblastoma: Prognostic factor analysis of EORTC and NCIC trial 26981-22981/CE.3
-
Gorlia T, van den Bent MJ, Hegi ME et al. Nomograms for predicting survival of patients with newly diagnosed glioblastoma: prognostic factor analysis of EORTC and NCIC trial 26981-22981/CE.3. Lancet Oncol. 9(1), 29-38 (2008).
-
(2008)
Lancet Oncol.
, vol.9
, Issue.1
, pp. 29-38
-
-
Gorlia, T.1
Van Den Bent, M.J.2
Hegi, M.E.3
-
72
-
-
77954924659
-
Phase I/ IIa study of cilengitide and temozolomide with concomitant radiotherapy followed by cilengitide and temozolomide maintenance therapy in patients with newly diagnosed glioblastoma
-
Stupp R, Hegi ME, Neyns B et al. Phase I/ IIa study of cilengitide and temozolomide with concomitant radiotherapy followed by cilengitide and temozolomide maintenance therapy in patients with newly diagnosed glioblastoma. J. Clin. Oncol. 28, 2712-2718 (2010).
-
(2010)
J. Clin. Oncol.
, vol.28
, pp. 2712-2718
-
-
Stupp, R.1
Hegi, M.E.2
Neyns, B.3
-
73
-
-
20044372154
-
MGMT gene silencing and benefit from temozolomide in glioblastoma
-
Hegi ME, Diserens AC, Gorlia T et al. MGMT gene silencing and benefit from temozolomide in glioblastoma. N. Engl. J. Med. 352(10), 997-1003 (2005).
-
(2005)
N. Engl. J. Med.
, vol.352
, Issue.10
, pp. 997-1003
-
-
Hegi, M.E.1
Diserens, A.C.2
Gorlia, T.3
-
74
-
-
76749145918
-
NABTT 0306: A randomized phase II trial of EMD 121974 in conjunction with concomitant and adjuvant temozolomide with radiation therapy in patients with newly diagnosed glioblastoma multiforme (GBM)
-
Abstract 2001
-
Nabors LB, Mikkelsen T, Batchelor T et al. NABTT 0306: A randomized phase II trial of EMD 121974 in conjunction with concomitant and adjuvant temozolomide with radiation therapy in patients with newly diagnosed glioblastoma multiforme (GBM). J. Clin. Oncol. 27, 15s Abstract 2001 (2009).
-
(2009)
J. Clin. Oncol.
, vol.27
-
-
Nabors, L.B.1
Mikkelsen, T.2
Batchelor, T.3
-
76
-
-
84864130994
-
Future directions in research, treatment and prevention of HPV-related squamous cell carcinoma of the head and neck
-
Psyrri A, Sasaki C, Vassilakopoulou M, Dimitriadis G, Rampias T. Future directions in research, treatment and prevention of HPV-related squamous cell carcinoma of the head and neck. Head Neck Pathol. 6(Suppl. 1), S121-S128 (2012).
-
(2012)
Head Neck Pathol.
, vol.6
, Issue.SUPPL. 1
-
-
Psyrri, A.1
Sasaki, C.2
Vassilakopoulou, M.3
Dimitriadis, G.4
Rampias, T.5
-
77
-
-
84881343615
-
New molecular targets in the treatment of NSCLC
-
Schettino C, Bareschino MA, Sacco PC et al. New molecular targets in the treatment of NSCLC. Curr. Pharm. Des. 19(30), 5333-5343 (2013).
-
(2013)
Curr. Pharm. Des.
, vol.19
, Issue.30
, pp. 5333-5343
-
-
Schettino, C.1
Bareschino, M.A.2
Sacco, P.C.3
-
78
-
-
80053130032
-
Monoclonal antibodies against EGFR in non-small cell lung cancer
-
Pirker R, Filipits M. Monoclonal antibodies against EGFR in non-small cell lung cancer. Crit. Rev. Oncol. Hematol. 80(1), 1-9 (2011).
-
(2011)
Crit. Rev. Oncol. Hematol.
, vol.80
, Issue.1
, pp. 1-9
-
-
Pirker, R.1
Filipits, M.2
-
79
-
-
84875917547
-
Role of epidermal growth factor receptor inhibitors in epidermal growth factor receptor wild-type non-small-cell lung cancer
-
Laurie SA, Goss GD. Role of epidermal growth factor receptor inhibitors in epidermal growth factor receptor wild-type non-small-cell lung cancer. J. Clin. Oncol. 31(8), 1061-1069 (2013).
-
(2013)
J. Clin. Oncol.
, vol.31
, Issue.8
, pp. 1061-1069
-
-
Laurie, S.A.1
Goss, G.D.2
-
80
-
-
78650694719
-
First-cycle rash and survival in patients with advanced non-small-cell lung cancer receiving cetuximab in combination with first-line chemotherapy: A subgroup analysis of data from the FLEX phase 3 study
-
Gatzemeier U, von Pawel J, Vynnychenko I et al. First-cycle rash and survival in patients with advanced non-small-cell lung cancer receiving cetuximab in combination with first-line chemotherapy: A subgroup analysis of data from the FLEX phase 3 study. Lancet Oncol. 12, 30-37 (2011).
-
(2011)
Lancet Oncol.
, vol.12
, pp. 30-37
-
-
Gatzemeier, U.1
Von Pawel, J.2
Vynnychenko, I.3
-
81
-
-
84867897974
-
EGFR mutations are associated with favorable intracranial response and progression-free survival following brain irradiation in non-small cell lung cancer patients with brain metastases
-
Lee HL, Chung TS, Ting LL et al. EGFR mutations are associated with favorable intracranial response and progression-free survival following brain irradiation in non-small cell lung cancer patients with brain metastases. Radiat Oncol. 7, 181 (2012).
-
(2012)
Radiat Oncol.
, vol.7
, pp. 181
-
-
Lee, H.L.1
Chung, T.S.2
Ting, L.L.3
-
82
-
-
25844523780
-
Defining risk levels in locally advanced head and neck cancers: A comparative analysis of concurrent postoperative radiation plus chemotherapy trials of the EORTC (#22931) and RTOG (# 9501)
-
Bernier J, Cooper JS, Pajak TF et al. Defining risk levels in locally advanced head and neck cancers: a comparative analysis of concurrent postoperative radiation plus chemotherapy trials of the EORTC (#22931) and RTOG (# 9501). Head Neck 27(10), 843-850 (2005).
-
(2005)
Head Neck
, vol.27
, Issue.10
, pp. 843-850
-
-
Bernier, J.1
Cooper, J.S.2
Pajak, T.F.3
-
83
-
-
84875239644
-
A phase 3 trial of whole brain radiation therapy and stereotactic radiosurgery alone versus WBRT and SRS with temozolomide or erlotinib for non-small cell lung cancer and 1 to 3 brain metastases: Radiation Therapy Oncology Group 0320
-
Sperduto PW, Wang M, Robins HI et al. A phase 3 trial of whole brain radiation therapy and stereotactic radiosurgery alone versus WBRT and SRS with temozolomide or erlotinib for non-small cell lung cancer and 1 to 3 brain metastases: Radiation Therapy Oncology Group 0320. Int. J. Radiat. Oncol. Biol. Phys. 85, 1312-1318 (2013).
-
(2013)
Int. J. Radiat. Oncol. Biol. Phys.
, vol.85
, pp. 1312-1318
-
-
Sperduto, P.W.1
Wang, M.2
Robins, H.I.3
-
84
-
-
84883301484
-
The hallmarks of cancer and the radiation oncologist: Updating the 5rs of radiobiology
-
Good JS, Harrington KJ. The hallmarks of cancer and the radiation oncologist: updating the 5rs of radiobiology. Clin. Oncol. 25(10), 569-577 (2013).
-
(2013)
Clin. Oncol.
, vol.25
, Issue.10
, pp. 569-577
-
-
Good, J.S.1
Harrington, K.J.2
-
85
-
-
84884566959
-
The irradiated tumor microenvironment: Role of tumor-associated macrophages in vascular recovery
-
Russell JS, Brown JM. The irradiated tumor microenvironment: role of tumor-associated macrophages in vascular recovery. Front Physiol. 4, 157 (2013).
-
(2013)
Front Physiol.
, vol.4
, pp. 157
-
-
Russell, J.S.1
Brown, J.M.2
-
86
-
-
79953054421
-
Strategies to improve radiotherapy with targeted drugs
-
Review
-
Begg AC, Stewart FA, Vens C. Strategies to improve radiotherapy with targeted drugs. Nat. Rev. Cancer 11(4), 239-253. Review (2011).
-
(2011)
Nat. Rev. Cancer
, vol.11
, Issue.4
, pp. 239-253
-
-
Begg, A.C.1
Stewart, F.A.2
Vens, C.3
|