메뉴 건너뛰기




Volumn 122, Issue 4, 2012, Pages 1529-1540

β 1 Integrin/FAK/cortactin signaling is essential for human head and neck cancer resistance to radiotherapy

Author keywords

[No Author keywords available]

Indexed keywords

BETA1 INTEGRIN; CORTACTIN; FOCAL ADHESION KINASE 1; STRESS ACTIVATED PROTEIN KINASE;

EID: 84859598676     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI61350     Document Type: Article
Times cited : (187)

References (57)
  • 1
    • 45849089879 scopus 로고    scopus 로고
    • Exploring the role of cancer stem cells in radioresistance
    • DOI 10.1038/nrc2419, PII NRC2419
    • Baumann M, Krause M, Hill R. Exploring the role of cancer stem cells in radioresistance. Nat Rev Cancer. 2008;8(7):545-554. (Pubitemid 351881850)
    • (2008) Nature Reviews Cancer , vol.8 , Issue.7 , pp. 545-554
    • Baumann, M.1    Krause, M.2    Hill, R.3
  • 2
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2010;144(5):646-674.
    • (2010) Cell , vol.144 , Issue.5 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 4
    • 78650026375 scopus 로고    scopus 로고
    • ALK inhibition for nonsmall cell lung cancer: From discovery to therapy in record time
    • Gerber DE, Minna JD. ALK inhibition for nonsmall cell lung cancer: from discovery to therapy in record time. Cancer Cell. 2011;18(6):548-551.
    • (2011) Cancer Cell , vol.18 , Issue.6 , pp. 548-551
    • Gerber, D.E.1    Minna, J.D.2
  • 5
    • 70449509655 scopus 로고    scopus 로고
    • Heterogeneity of tumour response to combined radiotherapy and EGFR inhibitors: Differences between antibodies and TK inhibitors
    • Krause M, Gurtner K, Deuse Y, Baumann M. Heterogeneity of tumour response to combined radiotherapy and EGFR inhibitors: differences between antibodies and TK inhibitors. Int J Radiat Biol. 2009; 85(11):943-954.
    • (2009) Int J Radiat Biol , vol.85 , Issue.11 , pp. 943-954
    • Krause, M.1    Gurtner, K.2    Deuse, Y.3    Baumann, M.4
  • 6
    • 9244222261 scopus 로고    scopus 로고
    • Targeted cancer therapy
    • DOI 10.1038/nature03095
    • Sawyers C. Targeted cancer therapy. Nature. 2004; 432(7015):294-297. (Pubitemid 39551656)
    • (2004) Nature , vol.432 , Issue.7015 , pp. 294-297
    • Sawyers, C.1
  • 8
    • 0036280046 scopus 로고    scopus 로고
    • Integrins as novel drug targets for overcoming innate drug resistance
    • DOI 10.2174/1568009023334033
    • Damiano JS. Integrins as novel drug targets for overcoming innate drug resistance. Curr Cancer Drug Targets. 2002;2(1):37-43. (Pubitemid 34627377)
    • (2002) Current Cancer Drug Targets , vol.2 , Issue.1 , pp. 37-43
    • Damiano, J.S.1
  • 9
    • 72949119124 scopus 로고    scopus 로고
    • Integrins in cancer: Biological implications and therapeutic opportunities
    • Desgrosellier JS, Cheresh DA. Integrins in cancer: biological implications and therapeutic opportunities. Nat Rev Cancer. 2010;10(1):9-22.
    • (2010) Nat Rev Cancer , vol.10 , Issue.1 , pp. 9-22
    • Desgrosellier, J.S.1    Cheresh, D.A.2
  • 10
    • 33845329178 scopus 로고    scopus 로고
    • Signalling via integrins: Implications for cell survival and anticancer strategies
    • DOI 10.1016/j.bbcan.2006.09.001, PII S0304419X06000588
    • Hehlgans S, Haase M, Cordes N. Signalling via integrins: implications for cell survival and anticancer strategies. Biochim Biophys Acta. 2007; 1775(1):163-180. (Pubitemid 44881199)
    • (2007) Biochimica et Biophysica Acta - Reviews on Cancer , vol.1775 , Issue.1 , pp. 163-180
    • Hehlgans, S.1    Haase, M.2    Cordes, N.3
  • 11
    • 77953658108 scopus 로고    scopus 로고
    • Vascular integrins: Therapeutic and imaging targets of tumor angiogenesis
    • Ruegg C, Alghisi GC. Vascular integrins: therapeutic and imaging targets of tumor angiogenesis. Recent Results Cancer Res. 2010;180:83-101.
    • (2010) Recent Results Cancer Res , vol.180 , pp. 83-101
    • Ruegg, C.1    Alghisi, G.C.2
  • 12
    • 0036726312 scopus 로고    scopus 로고
    • beta4 integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium
    • DOI 10.1016/S1535-6108(02)00125-3
    • Weaver VM, et al. beta4 integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium. Cancer Cell. 2002; 2(3):205-216. (Pubitemid 41043976)
    • (2002) Cancer Cell , vol.2 , Issue.3 , pp. 205-216
    • Weaver, V.M.1    Lelievre, S.2    Lakins, J.N.3    Chrenek, M.A.4    Jones, J.C.R.5    Giancotti, F.6    Werb, Z.7    Bissell, M.J.8
  • 13
    • 11144322013 scopus 로고    scopus 로고
    • Expression of integrins and E-cadherin in squamous cell carcinomas of the head and neck
    • DOI 10.1111/j.1600-0463.2004.apm1120902.x
    • Eriksen JG, Steiniche T, Sogaard H, Overgaard J. Expression of integrins and E-cadherin in squamous cell carcinomas of the head and neck. Apmis. 2004; 112(9):560-568. (Pubitemid 40040183)
    • (2004) APMIS , vol.112 , Issue.9 , pp. 560-568
    • Eriksen, J.G.1    Steiniche, T.2    Sogaard, H.3    Overgaard, J.4
  • 14
    • 33846653542 scopus 로고    scopus 로고
    • 1 integrin is associated with decreased survival in invasive breast cancer
    • DOI 10.1158/0008-5472.CAN-06-2768
    • Yao ES, et al. Increased beta1 integrin is associated with decreased survival in invasive breast cancer. Cancer Res. 2007;67(2):659-664. (Pubitemid 46192205)
    • (2007) Cancer Research , vol.67 , Issue.2 , pp. 659-664
    • Yao, E.S.1    Zhang, H.2    Chen, Y.-Y.3    Lee, B.4    Chew, K.5    Moore, D.6    Park, C.7
  • 15
    • 33644522372 scopus 로고    scopus 로고
    • New roles for integrins in squamous-cell carcinoma
    • DOI 10.1038/nrc1817, PII N1817
    • Janes SM, Watt FM. New roles for integrins in squamous-cell carcinoma. Nat Rev Cancer. 2006; 6(3):175-183. (Pubitemid 43292561)
    • (2006) Nature Reviews Cancer , vol.6 , Issue.3 , pp. 175-183
    • Janes, S.M.1    Watt, F.M.2
  • 16
    • 33644778551 scopus 로고    scopus 로고
    • beta1-integrin-mediated signaling essentially contributes to cell survival after radiation-induced genotoxic injury
    • DOI 10.1038/sj.onc.1209164, PII 1209164
    • Cordes N, Seidler J, Durzok R, Geinitz H, Brakebusch C. beta1-integrin-mediated signaling essentially contributes to cell survival after radiation- induced genotoxic injury. Oncogene. 2006; 25(9):1378-1390. (Pubitemid 43336466)
    • (2006) Oncogene , vol.25 , Issue.9 , pp. 1378-1390
    • Cordes, N.1    Seidler, J.2    Durzok, R.3    Geinitz, H.4    Brakebusch, C.5
  • 17
    • 0037145037 scopus 로고    scopus 로고
    • Integrins: Bidirectional, allosteric signaling machines
    • DOI 10.1016/S0092-8674(02)00971-6
    • Hynes RO. Integrins: bidirectional, allosteric signaling machines. Cell. 2002;110(6):673-687. (Pubitemid 35283958)
    • (2002) Cell , vol.110 , Issue.6 , pp. 673-687
    • Hynes, R.O.1
  • 18
    • 66149128873 scopus 로고    scopus 로고
    • The tail of integrins, talin, and kindlins
    • Moser M, Legate KR, Zent R, Fassler R. The tail of integrins, talin, and kindlins. Science. 2009; 324(5929):895-899.
    • (2009) Science , vol.324 , Issue.5929 , pp. 895-899
    • Moser, M.1    Legate, K.R.2    Zent, R.3    Fassler, R.4
  • 19
    • 67649849871 scopus 로고    scopus 로고
    • Integrin beta1-focal adhesion kinase signaling directs the proliferation of metastatic cancer cells disseminated in the lungs
    • Shibue T, Weinberg RA. Integrin beta1-focal adhesion kinase signaling directs the proliferation of metastatic cancer cells disseminated in the lungs. Proc Natl Acad Sci U S A. 2009;106(25):10290-10295.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , Issue.25 , pp. 10290-10295
    • Shibue, T.1    Weinberg, R.A.2
  • 20
    • 78650940402 scopus 로고    scopus 로고
    • The alphabeta integrin is a metastasis suppressor in mouse models and human cancer
    • Ramirez NE, et al. The alphabeta integrin is a metastasis suppressor in mouse models and human cancer. J Clin Invest. 2010;121(1):226-237.
    • (2010) J Clin Invest , vol.121 , Issue.1 , pp. 226-237
    • Ramirez, N.E.1
  • 21
    • 49249107671 scopus 로고    scopus 로고
    • Beta1 integrin inhibition dramatically enhances radiotherapy efficacy in human breast cancer xenografts
    • Park CC, Zhang HJ, Yao ES, Park CJ, Bissell MJ. Beta1 integrin inhibition dramatically enhances radiotherapy efficacy in human breast cancer xenografts. Cancer Res. 2008;68(11):4398-4405.
    • (2008) Cancer Res , vol.68 , Issue.11 , pp. 4398-4405
    • Park, C.C.1    Zhang, H.J.2    Yao, E.S.3    Park, C.J.4    Bissell, M.J.5
  • 22
    • 69249087671 scopus 로고    scopus 로고
    • Environment-mediated drug resistance: A major contributor to minimal residual disease
    • Meads MB, Gatenby RA, Dalton WS. Environment-mediated drug resistance: a major contributor to minimal residual disease. Nat Rev Cancer. 2009; 9(9):665-674.
    • (2009) Nat Rev Cancer , vol.9 , Issue.9 , pp. 665-674
    • Meads, M.B.1    Gatenby, R.A.2    Dalton, W.S.3
  • 23
    • 77954994889 scopus 로고    scopus 로고
    • PINCH1 regulates Akt1 activation and enhances radioresistance by inhibiting PP1alpha
    • Eke I, et al. PINCH1 regulates Akt1 activation and enhances radioresistance by inhibiting PP1alpha. J Clin Invest. 2010;120(7):2516-2527.
    • (2010) J Clin Invest , vol.120 , Issue.7 , pp. 2516-2527
    • Eke, I.1
  • 24
    • 61449213806 scopus 로고    scopus 로고
    • Mechanisms that regulate adaptor binding to beta-integrin cytoplasmic tails
    • Legate KR, Fassler R. Mechanisms that regulate adaptor binding to beta-integrin cytoplasmic tails. J Cell Sci. 2009;122(pt 2):187-198.
    • (2009) J Cell Sci , vol.122 , Issue.PART 2 , pp. 187-198
    • Legate, K.R.1    Fassler, R.2
  • 26
    • 48849089827 scopus 로고    scopus 로고
    • FERM control of FAK function: Implications for cancer therapy
    • Lim ST, Mikolon D, Stupack DG, Schlaepfer DD. FERM control of FAK function: implications for cancer therapy. Cell Cycle. 2008;7(15):2306-2314.
    • (2008) Cell Cycle , vol.7 , Issue.15 , pp. 2306-2314
    • Lim, S.T.1    Mikolon, D.2    Stupack, D.G.3    Schlaepfer, D.D.4
  • 27
    • 77951863320 scopus 로고    scopus 로고
    • Adrenergic modulation of focal adhesion kinase protects human ovarian cancer cells from anoikis
    • Sood AK, et al. Adrenergic modulation of focal adhesion kinase protects human ovarian cancer cells from anoikis. J Clin Invest. 2010;120(5):1515-1523.
    • (2010) J Clin Invest , vol.120 , Issue.5 , pp. 1515-1523
    • Sood, A.K.1
  • 28
    • 77956062542 scopus 로고    scopus 로고
    • Expression and prognostic significance of focal adhesion kinase in hepatocellular carcinoma
    • Yuan Z, Zheng Q, Fan J, Ai KX, Chen J, Huang XY. Expression and prognostic significance of focal adhesion kinase in hepatocellular carcinoma. J Cancer Res Clin Oncol. 2010;136(10):1489-1496.
    • (2010) J Cancer Res Clin Oncol , vol.136 , Issue.10 , pp. 1489-1496
    • Yuan, Z.1    Zheng, Q.2    Fan, J.3    Ai, K.X.4    Chen, J.5    Huang, X.Y.6
  • 29
    • 0034044795 scopus 로고    scopus 로고
    • Immunohistochemical analyses of focal adhesion kinase expression in benign and malignant human breast and colon tissues: Correlation with preinvasive and invasive phenotypes
    • Cance WG, et al. Immunohistochemical analyses of focal adhesion kinase expression in benign and malignant human breast and colon tissues: correlation with preinvasive and invasive phenotypes. Clin Cancer Res. 2000;6(6):2417-2423. (Pubitemid 30399210)
    • (2000) Clinical Cancer Research , vol.6 , Issue.6 , pp. 2417-2423
    • Cance, W.G.1    Harris, J.E.2    Iacocca, M.V.3    Roche, E.4    Yang, X.H.5    Chang, J.6    Simkins, S.7    Xu, L.H.8
  • 30
    • 0029039421 scopus 로고
    • Overexpression of the focal adhesion kinase (p125FAK) in invasive human tumors
    • Owens LV, et al. Overexpression of the focal adhesion kinase (p125FAK) in invasive human tumors. Cancer Res. 1995;55(13):2752-2755.
    • (1995) Cancer Res , vol.55 , Issue.13 , pp. 2752-2755
    • Owens, L.V.1
  • 31
    • 0028350859 scopus 로고
    • Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2- dependent binding of pp60src
    • Schaller MD, Hildebrand JD, Shannon JD, Fox JW, Vines RR, Parsons JT. Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2- dependent binding of pp60src. Mol Cell Biol. 1994; 14(3):1680-1688.
    • (1994) Mol Cell Biol , vol.14 , Issue.3 , pp. 1680-1688
    • Schaller, M.D.1    Hildebrand, J.D.2    Shannon, J.D.3    Fox, J.W.4    Vines, R.R.5    Parsons, J.T.6
  • 32
    • 7244231301 scopus 로고    scopus 로고
    • MAP kinases and cell migration
    • DOI 10.1242/jcs.01481
    • Huang C, Jacobson K, Schaller MD. MAP kinases and cell migration. J Cell Sci. 2004;117(pt 20):4619-4628. (Pubitemid 39433429)
    • (2004) Journal of Cell Science , vol.117 , Issue.20 , pp. 4619-4628
    • Huang, C.1    Jacobson, K.2    Schaller, M.D.3
  • 33
    • 9644276865 scopus 로고    scopus 로고
    • Rho GTPases regulate axon growth through convergent and divergent signaling pathways
    • DOI 10.1016/j.neuron.2004.11.014, PII S0896627304007524
    • Ng J, Luo L. Rho GTPases regulate axon growth through convergent and divergent signaling pathways. Neuron. 2004;44(5):779-793. (Pubitemid 39575632)
    • (2004) Neuron , vol.44 , Issue.5 , pp. 779-793
    • Ng, J.1    Luo, L.2
  • 34
    • 0033731119 scopus 로고    scopus 로고
    • Integrin cytoplasmic domain-binding proteins
    • Liu S, Calderwood DA, Ginsberg MH. Integrin cytoplasmic domain-binding proteins. J Cell Sci. 2000; 113(pt 20):3563-3571.
    • (2000) J Cell Sci , vol.113 , Issue.PART 20 , pp. 3563-3571
    • Liu, S.1    Calderwood, D.A.2    Ginsberg, M.H.3
  • 35
    • 0034911925 scopus 로고    scopus 로고
    • Regulation of actin filament network formation through Arp2/3 complex: Activation by a diverse array of proteins
    • DOI 10.1146/annurev.biochem.70.1.649
    • Higgs HN, Pollard TD. Regulation of actin filament network formation through ARP2/3 complex: activation by a diverse array of proteins. Annu Rev Biochem. 2001;70:649-676. (Pubitemid 32662221)
    • (2001) Annual Review of Biochemistry , vol.70 , pp. 649-676
    • Higgs, H.N.1    Pollard, T.D.2
  • 36
    • 0035475450 scopus 로고    scopus 로고
    • Cortactin: Coupling membrane dynamics to cortical actin assembly
    • DOI 10.1038/sj.onc.1204783
    • Weed SA, Parsons JT. Cortactin: coupling membrane dynamics to cortical actin assembly. Oncogene. 2001;20(44):6418-6434. (Pubitemid 32977848)
    • (2001) Oncogene , vol.20 , Issue.44 REV. ISS. 5 , pp. 6418-6434
    • Weed, S.A.1    Parsons, J.T.2
  • 37
    • 34249320529 scopus 로고    scopus 로고
    • Cortactin is an essential regulator of matrix metalloproteinase secretion and extracellular matrix degradation in invadopodia
    • DOI 10.1158/0008-5472.CAN-06-3928
    • Clark ES, Whigham AS, Yarbrough WG, Weaver AM. Cortactin is an essential regulator of matrix metalloproteinase secretion and extracellular matrix degradation in invadopodia. Cancer Res. 2007; 67(9):4227-4235. (Pubitemid 46815069)
    • (2007) Cancer Research , vol.67 , Issue.9 , pp. 4227-4235
    • Clark, E.S.1    Whigham, A.S.2    Yarbrough, W.G.3    Weaver, A.M.4
  • 38
    • 2442676727 scopus 로고    scopus 로고
    • Cytoplasmic p120ctn regulates the invasive phenotypes of E-cadherin-deficient breast cancer
    • Shibata T, Kokubu A, Sekine S, Kanai Y, Hirohashi S. Cytoplasmic p120ctn regulates the invasive phenotypes of E-cadherin-deficient breast cancer. Am J Pathol. 2004;164(6):2269-2278. (Pubitemid 38669372)
    • (2004) American Journal of Pathology , vol.164 , Issue.6 , pp. 2269-2278
    • Shibata, T.1    Kokubu, A.2    Sekine, S.3    Kanai, Y.4    Hirohashi, S.5
  • 39
    • 33846974037 scopus 로고    scopus 로고
    • Transmitting on actin: Synaptic control of dendritic architecture
    • Schubert V, Dotti CG. Transmitting on actin: synaptic control of dendritic architecture. J Cell Sci. 2007; 120(pt 2):205-212.
    • (2007) J Cell Sci , vol.120 , Issue.PART 2 , pp. 205-212
    • Schubert, V.1    Dotti, C.G.2
  • 40
    • 33947140891 scopus 로고    scopus 로고
    • Dissecting the functional domain requirements of cortactin in invadopodia formation
    • DOI 10.1016/j.ejcb.2007.01.003, PII S0171933507000155
    • Webb BA, Jia L, Eves R, Mak AS. Dissecting the functional domain requirements of cortactin in invadopodia formation. Eur J Cell Biol. 2007; 86(4):189-206. (Pubitemid 46404601)
    • (2007) European Journal of Cell Biology , vol.86 , Issue.4 , pp. 189-206
    • Webb, B.A.1    Jia, L.2    Eves, R.3    Mak, A.S.4
  • 41
    • 0026778133 scopus 로고
    • The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors
    • Ridley AJ, Hall A. The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. Cell. 1992;70(3):389-399.
    • (1992) Cell , vol.70 , Issue.3 , pp. 389-399
    • Ridley, A.J.1    Hall, A.2
  • 44
    • 0036682924 scopus 로고    scopus 로고
    • Characterization of an activated mutant of focal adhesion kinase: 'SuperFAK'
    • DOI 10.1042/BJ20020065
    • Gabarra-Niecko V, Keely PJ, Schaller MD. Characterization of an activated mutant of focal adhesion kinase: 'SuperFAK'. Biochem J. 2002; 365(pt 3):591-603. (Pubitemid 34864441)
    • (2002) Biochemical Journal , vol.365 , Issue.3 , pp. 591-603
    • Gabarra-Niecko, V.1    Keely, P.J.2    Schaller, M.D.3
  • 45
    • 2542435885 scopus 로고    scopus 로고
    • BPGAP1 interacts with cortactin and facilitates its translocation to cell periphery for enhanced cell migration
    • DOI 10.1091/mbc.E04-02-0141
    • Lua BL, Low BC. BPGAP1 interacts with cortactin and facilitates its translocation to cell periphery for enhanced cell migration. Mol Biol Cell. 2004; 15(6):2873-2883. (Pubitemid 38691875)
    • (2004) Molecular Biology of the Cell , vol.15 , Issue.6 , pp. 2873-2883
    • Lua, B.L.1    Low, B.C.2
  • 47
    • 36849053853 scopus 로고    scopus 로고
    • beta1 integrin as a molecular therapeutic target
    • DOI 10.1080/09553000701639694, PII 787788695
    • Cordes N, Park CC. beta1 integrin as a molecular therapeutic target. Int J Radiat Biol. 2007; 83(11-12):753-760. (Pubitemid 350219108)
    • (2007) International Journal of Radiation Biology , vol.83 , Issue.11-12 , pp. 753-760
    • Cordes, N.1    Park, C.C.2
  • 48
    • 70749103751 scopus 로고    scopus 로고
    • Tissue-penetrating delivery of compounds and nanoparticles into tumors
    • Sugahara KN, et al. Tissue-penetrating delivery of compounds and nanoparticles into tumors. Cancer Cell. 2009;16(6):510-520.
    • (2009) Cancer Cell , vol.16 , Issue.6 , pp. 510-520
    • Sugahara, K.N.1
  • 49
    • 67649528138 scopus 로고    scopus 로고
    • Collective cell migration in morphogenesis, regeneration and cancer
    • Friedl P, Gilmour D. Collective cell migration in morphogenesis, regeneration and cancer. Nat Rev Mol Cell Biol. 2009;10(7):445-457.
    • (2009) Nat Rev Mol Cell Biol , vol.10 , Issue.7 , pp. 445-457
    • Friedl, P.1    Gilmour, D.2
  • 50
    • 79955469358 scopus 로고    scopus 로고
    • 5?-Nitro-indirubinoxime, an indirubin derivative, suppresses metastatic ability of human head and neck cancer cells through the inhibition of Integrin beta1/FAK/Akt signaling
    • Kim SA, Kwon SM, Kim JA, Kang KW, Yoon JH, Ahn SG. 5?-Nitro- indirubinoxime, an indirubin derivative, suppresses metastatic ability of human head and neck cancer cells through the inhibition of Integrin beta1/FAK/Akt signaling. Cancer Lett. 2011; 306(2):197-204.
    • (2011) Cancer Lett , vol.306 , Issue.2 , pp. 197-204
    • Kim, S.A.1    Kwon, S.M.2    Kim, J.A.3    Kang, K.W.4    Yoon, J.H.5    Ahn, S.G.6
  • 51
    • 79952741178 scopus 로고    scopus 로고
    • Cilengitide: The first anti-angiogenic small molecule drug candidate design, synthesis and clinical evaluation
    • Mas-Moruno C, Rechenmacher F, Kessler H. Cilengitide: the first anti-angiogenic small molecule drug candidate design, synthesis and clinical evaluation. Anticancer Agents Med Chem. 2010;10(10):753-768.
    • (2010) Anticancer Agents Med Chem , vol.10 , Issue.10 , pp. 753-768
    • Mas-Moruno, C.1    Rechenmacher, F.2    Kessler, H.3
  • 52
    • 59449094255 scopus 로고    scopus 로고
    • Volociximab, a chimeric monoclonal antibody that specifically binds alpha5beta1 integrin: A phase I, pharmacokinetic, and biological correlative study
    • Ricart AD, et al. Volociximab, a chimeric monoclonal antibody that specifically binds alpha5beta1 integrin: a phase I, pharmacokinetic, and biological correlative study. Clin Cancer Res. 2008;14(23):7924-7929.
    • (2008) Clin Cancer Res , vol.14 , Issue.23 , pp. 7924-7929
    • Ricart, A.D.1
  • 53
    • 35348995145 scopus 로고    scopus 로고
    • Ligand bound beta1 integrins inhibit procaspase-8 for mediating cell adhesion-mediated drug and radiation resistance in human leukemia cells
    • Estrugo D, Fischer A, Hess F, Scherthan H, Belka C, Cordes N. Ligand bound beta1 integrins inhibit procaspase-8 for mediating cell adhesion-mediated drug and radiation resistance in human leukemia cells. PLoS One. 2007;2(3):e269.
    • (2007) PLoS One , vol.2 , Issue.3
    • Estrugo, D.1    Fischer, A.2    Hess, F.3    Scherthan, H.4    Belka, C.5    Cordes, N.6
  • 55
    • 80053320001 scopus 로고    scopus 로고
    • β1 integrin controls EGFR signaling and tumorigenic properties of lung cancer cells
    • Morello V, et al. β1 integrin controls EGFR signaling and tumorigenic properties of lung cancer cells. Oncogene. 2011;30(39):4087-4096.
    • (2011) Oncogene , vol.30 , Issue.39 , pp. 4087-4096
    • Morello, V.1
  • 56
    • 0024335963 scopus 로고
    • Signal transduction through the fibronectin receptor induces collagenase and stromelysin gene expression
    • Werb Z, Tremble PM, Behrendtsen O, Crowley E, Damsky CH. Signal transduction through the fibronectin receptor induces collagenase and stromelysin gene expression. J Cell Biol. 1989; 109(2):877-889. (Pubitemid 19197045)
    • (1989) Journal of Cell Biology , vol.109 , Issue.2 , pp. 877-889
    • Werb, Z.1    Tremble, P.M.2    Behrendtsen, O.3    Crowley, E.4    Damsky, C.H.5
  • 57
    • 4143144444 scopus 로고    scopus 로고
    • B23/nucleophosmin serine 4 phosphorylation mediates mitotic functions of Polo-like kinase 1
    • DOI 10.1074/jbc.M403264200
    • Zhang H, Shi X, Paddon H, Hampong M, Dai W, Pelech S. B23/nucleophosmin serine 4 phosphorylation mediates mitotic functions of polo-like kinase 1. J Biol Chem. 2004;279(34):35726-35734. (Pubitemid 39100577)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.34 , pp. 35726-35734
    • Zhang, H.1    Shi, X.2    Paddon, H.3    Hampong, M.4    Dai, W.5    Pelech, S.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.