Lactobacillus GG and tributyrin supplementation reduce antibiotic-induced intestinal injury

Journal of Parenteral and Enteral Nutrition

Volumn 37, Issue 6, 2013, Pages 763-774

  Cresci, Gail ^a   Nagy, Laura E ^a   Ganapathy, Vadivel ^b  

^a LERNER RESEARCH INSTITUTE   (United States)

^b MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

antibiotics; diarrhea; intestine; probiotics; tributyrin

Indexed keywords

ANTIBIOTIC AGENT; ELECTROLYTE; MESSENGER RNA; METRONIDAZOLE; NEOMYCIN; OCCLUDIN; PROBIOTIC AGENT; TIGHT JUNCTION PROTEIN; TRIBUTYRIN; VANCOMYCIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANION EXCHANGE; ANTIBIOTIC ASSOCIATED DIARRHEA; ANTIBIOTIC THERAPY; ARTICLE; CONTROLLED STUDY; DIET SUPPLEMENTATION; FECES; FLUID INTAKE; IMMUNOHISTOCHEMISTRY; INOCULATION; INTESTINE FLORA; LACTOBACILLUS; LACTOBACILLUS GG; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; TIGHT JUNCTION;

ANTIBIOTICS; DIARRHEA; INTESTINE; PROBIOTICS; TRIBUTYRIN;

ANIMALS; ANTI-BACTERIAL AGENTS; BUTYRATES; DYSBIOSIS; FEMALE; GENE EXPRESSION; INTESTINAL DISEASES; INTESTINAL MUCOSA; INTESTINES; LACTOBACILLUS; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MICROBIOTA; PROBIOTICS; RNA, MESSENGER; TIGHT JUNCTION PROTEINS; TRIGLYCERIDES;

EID: 84887227527     PISSN: 01486071     EISSN: None     Source Type: Journal    
DOI: 10.1177/0148607113486809     Document Type: Article

References (50)

1. Backhed F, Ley RE, Sonnenburg JL, Peterson D, Gordon J. Host-bacterial mutualism in the human intestine. Science. 2005 ; 307: 1915-1920 (Pubitemid 40404694)
2. Hooper L, Midtvedt T, Gordon J. How host-microbial interactions shape the nutrient environment of the mammalian intestine. Annu Rev Nutr. 2002 ; 22: 283-307 (Pubitemid 35221463)
3. Turnbaugh P, Ley R, Mahowald M, Magrini V, Mardis E, Gordon J. An obesity-associated gut microbiome with increased capacity for energy harvest. Nature. 2006 ; 444: 1027-1031 (Pubitemid 46018515)
4. Bartlett JG. Clinical practice: antibiotic-associated diarrhea. N Engl J Med. 2002 ; 346: 334-339
5. Bergogne-Berezin E. Treatment and prevention of antibiotic associated diarrhea. Int J Antimicrob Agents. 2000 ; 16: 521-526
6. Mylonakis E, Ryan ET, Calderwood SB. Clostridium difficile-associated diarrhea: a review. Arch Intern Med. 2001 ; 161: 525-533 (Pubitemid 32167517)
7. Yap IK, Li JV, Saric J, et al. Metabolomic and microbiological analysis of the dynamic effect of vancomycin-induced gut microbiota modification in the mouse. J Proteome Res. 2008 ; 7: 3718-3728
8. Pryde SE, Duncan SH, Hold GL, Stewart CS, Flint HJ. The microbiology of butyrate formation in the human colon. FEMS Microbiol Lett. 2002 ; 217: 133-139 (Pubitemid 35441298)
9. Young VB, Schmidt TM. Antibiotic-associated diarrhea accompanied by large-scale alterations in the composition of the fecal microbiota. J Clin Microbiol. 2004 ; 42: 1203-1206 (Pubitemid 38332848)
10. Wachtershauser A, Stein J. Rationale for the luminal provision of butyrate in intestinal diseases. Eur J Nutr. 2000 ; 39: 164-171
11. Velazquez OC, Lederer HM, Rombeau JL. Butyrate and the colonocyte. Dig Dis Sci. 1996 ; 41: 727-739
12. Cummings JH, Pomare EW, Brnach WJ, Naylor CP, Macfarlane GT. Short chain fatty acids in human large intestine, portal, hepatic and venous blood. Gut. 1987 ; 28: 1221-1227 (Pubitemid 17156038)
13. Scheppach WJ, Muller G, Boxberger F, et al. Histological changes in the colonic mucosa following irrigation with short-chain fatty acids. Eur J Gastroenterol Hepatol. 1997 ; 9: 163-168 (Pubitemid 27113106)
14. Topping DL, Clifton PM. Short-chain fatty acids and human colonic function: roles of resistant starch and nonstarch polysaccharides. Physiol Rev. 2001 ; 81: 1031-1064 (Pubitemid 32611227)
15. Cummings JH. Short chain fatty acids in the human colon. Gut. 1981 ; 22: 763-779 (Pubitemid 12158885)
16. Newmark HL, Lupton JR, Young CW. Butyrate as a differentiating agent: pharmacokinetics, analogues and current status. Cancer Lett. 1994 ; 78: 1-5 (Pubitemid 24129074)
17. Miyauchi S, Gopal E, Fei YJ, Ganapathy V. Functional identification of SLC5A8, a tumor suppressor down-regulated in colon cancer, as a Na+-coupled transporter for short-chain fatty acids. J Biol Chem. 2004 ; 279: 13293-13296 (Pubitemid 38468849)
18. Thangaraju M, Cresci GA, Itagaki S, et al. Sodium-coupled transport of the short-chain fatty acid butyrate by SLC5A8 and its relevance to colon cancer. J Gastrointest Surg. 2008 ; 12: 1773-1781
19. Cresci G, Thangaraju M, Mellinger J, Liu K, Ganapathy V. Colonic gene expression in conventional and germ-free mice with a focus on the butyrate receptor GPR109A and the butyrate transporter SLC5A8. J Gastrointest Surg. 2010 ; 14: 449-461
20. Gill RK, Saksena S, Alrefai WA, et al. Expression and membrane localization of MCT isoforms along the length of the human intestine. Am J Physiol Cell Physiol. 2005 ; 289: C846 - C852
21. Borthakur A, Priyamvada S, Kumar A, et al. A novel nutrient sensing mechanism underlies substrate-induced regulation of monocarboxylate transporter-1. Am J Physiol Gastrointest Liver Physiol. 2012 ; 303: G1126 - G1133
22. Conley BA, Egorin MJ, Tait N, et al. Phase I study of the orally administered butyrate prodrug, tributyrin, in patients with solid tumors. Clin Canc Res. 1998 ; 4: 629-634 (Pubitemid 28193561)
23. Mullin GE. Probiotics and digestive disease. Nutr Clin Pract. 2012 ; 27: 300-302
24. Rohde CL, Bartolini V, Jones N. The use of probiotics in the prevention and treatment of antibiotic-associated diarrhea with special interest in Clostridium difficile-associated diarrhea. Nutr Clin Pract. 2009 ; 24: 33-40
25. Guarino A, Lo Vecchio A, Berni Canani R. Probiotics as prevention and treatment for diarrhea. Curr Opin Gastroenterol. 2008 ; 25: 18-23
26. Johnston BC, Supina AL, Ospina M, et al. Probiotics for the prevention of pediatric antibiotic-associated diarrhea. Cochrane Database Syst Rev. 2007 ; (2). CD004827
27. Hooper LV, Wong MH, Thelin A, Hansson L, Falk PG, Gordon JI. Molecular analysis of commensal host-microbial relationships in the intestine. Science. 2001 ; 291: 881-884 (Pubitemid 32120760)
28. Hooper LV, Stappenbeck TS, Hong CV, Gordon JI. Angiogenins: a new class of microbicidal proteins involved in innate immunity. Nat Immunol. 2003 ; 4: 269-273 (Pubitemid 36322137)
29. Brandl K, Plitas G, Mihu C, et al. Vancomycin-resistant enterococci exploit antibiotic-induced innate immune deficits. Nature. 2008 ; 455: 804-808
30. Baqar S, Applebee LA, Bourgeois AL. Immunogenicity and protective efficacy of a prototype Campylobacter killed whole-cell vaccine in mice. Infect Immun. 1995 ; 63: 3731-3735
31. Pei A, Burucoa C, Grignon B, et al. Mutation in the peb1A locus of Campylobacter jejuni reduces interactions with epithelial cells and intestinal colonization of mice. Infect Immun. 1998 ; 66: 938-943 (Pubitemid 28101130)
32. Thangaraju M, Cresci GA, Liu K, et al. GPR109A is a G-protein coupled receptor for the bacterial fermentation product butyrate and functions as a tumor suppressor in colon. Cancer Res. 2009 ; 69: 2826-2832
33. Field M. Intestinal ion transport and the pathophysiology of diarrhea. J Clin Invest. 2003 ; 111: 931-943 (Pubitemid 36397466)
34. Ploger S, Stumpff F, Penner G, et al. Microbial butyrate and its role for barrier function in the gastrointestinal tract. Ann N Y Acad Sci. 2012 ; 1258: 52-59
35. Suzuki T, Yoshida S, Hara H. Physiological concentrations of short-chain fatty acids immediately suppress colonic epithelial permeability. Br J Nutr. 2008 ; 100: 297-305
36. De La, Cochetiere MF, Durand T, Lalande V, et al. Effect of antibiotic therapy on human fecal microbiota and the relation to the development of Clostridium difficile. Microb Ecol. 2008 ; 56: 395-402
37. Robinson CJ, Young VB. Antibiotic administration alters the community structure of gastrointestinal microbiota. Gut Microbes. 2010 ; 1 (4). 279-284
38. Bird AR, Conlon MA, Christophersen CT, Topping DL. Resistant starch, large bowel fermentation and a broader perspective of prebiotics and probiotics. Benef Microbes. 2010 ; 1: 423-431
39. Edelman MJ, Bauer K, Khanwani S, et al. Clinical and pharmacologic study of tributyrin: an oral butyrate prodrug. Cancer Chemother Pharmacol. 2003 ; 51: 439-444 (Pubitemid 36649143)
40. Egorin MJ, Yuan ZM, Sentz DL, Plaisance K, Eiseman JL. Plasma pharmacokinetics of butyrate after intravenous administration of sodium butyrate or oral administration of tributyrin or sodium butyrate to mice and rats. Cancer Chemother Pharmacol. 1999 ; 43: 445-453 (Pubitemid 29187582)
41. Miyoshi M, Sakaki H, Usami M, et al. Oral administration of tributyrin increases concentration of butyrate in the portal vein and prevents lipopolysaccharide-induced liver injury in rats. Clin Nutr. 2011 ; 30 (2). 252-258
42. Ramos MG, Bambirra EA, Cara DC, Vieira EC, Alvarez-Leite JI. Oral administration of short-chain fatty acids reduces the intestinal mucositis caused by treatment with Ara-C in mice fed commercial or elemental diets. Nutr Cancer. 1997 ; 28: 212-217 (Pubitemid 27396212)
43. Frankel WL, Zhang W, Singh A, et al. Mediation of the trophic effects of short-chain fatty acids on the rat jejunum and colon. Gastroenterology. 1994 ; 106: 375-380 (Pubitemid 24041214)
44. Schaedler RW, Dubos R, Costello R. Association of the germ-free mice with bacteria isolated from normal mice. J Exp Med. 1965 ; 122: 77-83
45. Hooper LV. Bacterial contributions to mammalian gut development. Trends Microbiol. 2004 ; 12: 129-134 (Pubitemid 38314756)
46. Dai D, Nanthakumar NN, Newburg DS, Walker WA. Role of oligosaccharides and glycoconjugates in intestinal host defense. J Pediatr Gastroenterol Nutr. 2000 ; 30: S23 - S33
47. Mace OJ, Affleck J, Patel N, Kellett GL. Sweet taste receptors in rat small intestine stimulate glucose absorption through apical GLUT2. J Physiol. 2007 ; 582: 379-392 (Pubitemid 46993582)
48. Ramakrishna S, Mathan VI. Colonic dysfunctions in acute diarrhea: the role of short chain fatty acids. Gut. 1993 ; 34: 1215-1218 (Pubitemid 23274543)
49. Rabbani GH, Albert MJ, Rahman H, Chowdhury AK. Short-chain fatty acids inhibit fluid and electrolyte loss induced by cholera toxin in proximal colon of rabbit in vivo. Dig Dis Sci. 1999 ; 44: 1547-1553 (Pubitemid 29434723)
50. Mariadason JM, Barkla DH, Gibson PR. Effect of short chain-chain fatty acids on paracellular permeability in Caco-2 intestinal epithelium model. Am J Physiol. 1997 ; 272: 705-712