Histological changes in the colonic mucosa following irrigation with short-chain fatty acids

European Journal of Gastroenterology and Hepatology

Volumn 9, Issue 2, 1997, Pages 163-168

  Scheppach, Wolfgang ^a   Müller, Justus Gottfreid ^a   Boxberger, Frank ^a   Dusel, Gerda ^a   Richter, Frank ^a   Bartram, Hans Peter ^a   Christl, Stefan Ulrich ^a   Dempfle, Carl Erik ^b   Kasper, Heinrich ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Butyrate; Factor XIII; Histology; Proliferating cell nuclear antigen; Short chain fatty acids; Ulcerative colitis

Indexed keywords

BLOOD CLOTTING FACTOR 13; BUTYRIC ACID; CYCLINE; ENEMA; SHORT CHAIN FATTY ACID;

ADULT; ARTICLE; CLINICAL ARTICLE; COLON BIOPSY; COLON MUCOSA; CONTROLLED STUDY; FEMALE; HISTOLOGY; HUMAN; HUMAN TISSUE; LAMINA PROPRIA; MALE; NEUTROPHIL; PATHOGENESIS; PRIORITY JOURNAL; ULCERATIVE COLITIS;

EID: 0031054973     PISSN: 0954691X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00042737-199702000-00010     Document Type: Article

References (37)

1. Bugaut M, Bentejac M: Biological effects of short-chain fatty acids in nonruminant mammals. Annu Rev Nutr 1993, 13:217-241.
2. Roediger WEW: The starved colon - diminished mucosal nutrition, diminished absorption, and colitis. Dis Colon Rectum 1990, 33:858-862.
3. Breuer RI, Buto SK, Christ ML, Bean J, Vernia P, Paoluzi P, et al.: Rectal irrigation with short-chain fatty acids for distal ulcerative colitis. Preliminary report. Dig Dis Sci 1991, 36:185-187.
4. Senagore AJ, MacKeigan JM, Scheider M, Ebrom JS: Short-chain fatty acid enemas: a cost-effective alternative in the treatment of nonspecific proctosigmoiditis. Dis Colon Rectum 1992, 35:923-927.
5. Scheppach W, Sommer H, Kirchner T, Paganelli G-M, Bartram P, Christl S, et al.: Effect of butyrate enemas on the colonic mucosa in distal ulcerative colitis. Gastroenterology 1992, 103:51-56.
6. Steinhart AH, Brzezinski A, Baker JP: Treatment of refractory ulcerative proctosigmoiditis with butyrate enemas. Am J Gastroenterol 1994, 89:179-183.
7. Vernia P, Cittadini M, Caprilli R, Torsoli A: Topical treatment of refractory distal ulcerative colitis with 5-ASA and sodium butyrate. Dig Dis Sci 1995, 40:305-307.
8. Vernia P, Marcheggiano A, Caprilli R, Frieri G, Corrao G, Valpiani D, et al.: Short-chain fatty acid topical treatment in distal ulcerative colitis. Aliment Pharmacol Ther 1995, 9:309-313.
9. Frankel W, Zhang W, Singh A, Klurfeld DM, Don S, Sakata T, et al.: Mediation of the trophic effects of short-chain fatty acids on the rat jejunum and colon. Gastroenterology 1994, 106:375-380.
10. Scheppach W, Bartram P, Richter A, Richter F, Liepold H, Dusel G, et al.: Effect of short-chain fatty acids on the human colonic mucosa in vitro. J Parenter Enteral Nutr 1992, 16:43-48.
11. Stadnicki A, Kloczko J, Nowak A, Sierka E, Sliwinski Z: Factor XIII subunits in relation to some other hemostatic parameters in ulcerative colitis. Am J Gastroenterol 1991, 86:690-693.
12. Scheppach W and the German-Austrian SCFA Study Group: Treatment of distal ulcerative colitis with short-chain fatty acid enemas: a placebo-controlled trial. Dig Dis Sci 1996 (in press).
13. Sutherland LR, Martin F, Greer S, Robinson M, Greenberger N, Saibil F, et al.: 5-Aminosalicylic acid enema in the treatment of distal ulcerative colitis, proctosigmoiditis, and proctitis. Gastroenterology 1987, 92:1894-1898.
14. 3H]thymidine. Cancer Epidemiol Biomarkers Prev 1992, 1:561-566.
15. Lipkin M, Blattner WE, Fraumeni JF, Lynch HT, Deschner E, Winawer S: Tritiated thymidine (φ p, φ h) labeling distribution as a marker for hereditary predisposition to colon cancer. Cancer Res 1983, 43:1899-1904.
16. Dempfle CE, Harenberg J, Hochreuter K, Heene DL: Microtiter assay for measurement of factor XIII activity in plasma. J Lab Clin Med 1992, 119:522-528.
17. Dempfle CE, Hensler C, Gladisch R, Heene DL: Lokale Faktor XIII-Bestimmung in der Dickdarmmukosa. Hämostaseologie 1994, 14:33-36.
18. Bernard C, Barbich M, Spinedi E, Vega G, Malbran A, De Paula JA: Butyrate modulates polymorphonuclear leukocyte functions. Gastroenterology 1993, 104:A667.
19. Brisseau GF, Rotstein OD: The effects of short-chain fatty acids on phagocytic cell function. In Physiological and Clinical Aspects of Short-chain Fatty Acids. Edited by Cummings JH, Rombeau JL, Sakata T. Cambridge: Cambridge University Press; 1995:361-372.
20. Carpaneto EM, Mariani MR, Ferrini S, Boffa LC, Lipkin M, Newmark H: Stimulation of DNA synthesis in primary culture of human lymphocytes by sodium butyrate. Proc Am Assoc Cancer Res 1992, 32:331.
21. D'Argenio G, Cosenza V, Sorrentini I, De Ritis F, Gatto A, Delle Cave M, et al.: Butyrate, mesalamine, and factor XIII in experimental colitis in the rat: effects of transglutaminase activity. Gastroenterohgy 1994, 106:399-404.
22. Breuer RI, Christ ML, Lashner BA, Soergel KH, Hanauer SB, Harig JM, et al.: Short chain fatty acid rectal irrigation therapy for left-sided ulcerative colitis: a randomized, placebo-controlled clinical trial. Interim report. In Short Chain Fatty Acids. Edited by Binder HJ, Cummings JH, Soergel KH. Dordrecht: Kluwer; 1994:214-220.
23. Lipkin M: Biomarkers of increased susceptibility to gastrointestinal cancer: new application to studies of cancer prevention in human subjects. Cancer Res 1988, 48:235-245.
24. Terpstra OT, Van Blankenstein M, Dees J, Eilers GAM: Abnormal pattern of cell proliferation in the entire colonic mucosa of patients with colon adenoma or cancer. Gastroenterology 1987, 92:704-708.
25. Risio M, Lipkin M, Candelaresi GL, Bertone A, Coverlizza S, Rossini FP: Correlations between rectal mucosa cell proliferation and the clinical and pathological features of nonfamilial neoplasia of the large intestine. Cancer Res 1991, 51:1917-1921.
26. Lightdale C, Lipkin M, Deschner E: In vivo measurements in familial polyposis: kinetics and location of proliferating cells in colonic adenomas. Cancer Res 1982, 42:4280-4283.
27. Lynch HT, Schuelke GS, Kimberling WJ, Albano WA, Lynch JF, Biscone KA, et al.: Hereditary nonpolyposis colorectal cancer (Lynch syndromes I and II). II. Biomarker studies. Cancer 1985, 56:939-951.
28. Biasco G, Lipkin M, Minarini A, Higgins P, Miglioli M, Barbara L: Proliferative and antigenic properties of rectal cells in patients with chronic ulcerative colitis. Cancer Res 1984, 44:5450-5454.
29. Biasco G, Paganelli GM, Miglioli M, Brillanti S, Di Febo G, Gizzi G, et al.: Rectal cell proliferation and colon cancer risk in ulcerative colitis. Cancer Res 1990, 50:1156-1159.
30. Paganelli GM, Higgins P, Biasco G, Lipkin M, Brandi G, Santucci R, et al.: Abnormal rectal cell proliferation and p52/p53 protein expression in patients with ulcerative colitis. Cancer Lett 1993, 73:23-28.
31. Scheppach W, Bartram HP, Richter F: Role of short-chain fatty acids in the prevention of colorectal cancer. Eur J Cancer 1995, 31A:1077-1080.
32. Tonelli F, Dolara P, Batignani G, Monaci I, Caderni G, Spagnesi MT, et al.: Effects of short chain fatty acids on mucosal proliferation of ileal pouches in patients with ulcerative colitis and familial polyposis. Dis Colon Rectum 1995, 38:974-978.
33. McDonagh J, Seitz R, Egbring R: factor XIII. Stuttgart: Schattauer; 1993.
34. Wisen O, Gardlund B: Hemostasis in Crohn's disease: low factor XIII levels in active disease. Scand J Gastroenterol 1988, 23:961-966.
35. Lorenz R, Born P, Classen M: Substitution von Faktor-XIII-Konzentrat bei therapieresistenter Colitis ulcerosa. Med Klin 1994, 89:534-537.
36. Schmidt R, Cathelineau C, Cavey MT, Dionisius V, Michel S, Shroot B, et al.: Sodium butyrate selectively antagonizes the inhibitory effect of retinoids on cornified envelope formation in cultured human keratinocytes. J Cell Physiol 1989, 140:281-287.
37. Birckbichler PJ, Orr JR, Patterson MK, Conway E, Carter HA, Maxwel MD: Enhanced transglutaminase activity in transformed human lung fibroblast cells after exposure to sodium butyrate. Biochim Biophys Acta 1983, 723:27-34.