메뉴 건너뛰기




Volumn , Issue , 2012, Pages 25-50

DNA Methylation and Toxicogenomics

Author keywords

DNA methylation and toxicogenomics, dose as basic principle; DNA methylation, an epigenetic modification of DNA; Functional genomics, in phenotype measure, linking to specific gene; Novel methods, using cDNA microarray and genome wide methylation; Toxicogenomic or functional genomic map, identification of early signs; Toxicogenomics, toxicant action and targeted cellular assays; Toxicological analysis, critical in pharmacologics of drug efficacy

Indexed keywords


EID: 84887209586     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9781118349045.ch3     Document Type: Chapter
Times cited : (3)

References (100)
  • 1
    • 0037192320 scopus 로고    scopus 로고
    • Toxicology and genetic toxicology in the new era of toxicogenomics: impact of "-omics" technologies
    • Aardema, M.J. and MacGregor, J.T. (2002) Toxicology and genetic toxicology in the new era of toxicogenomics: impact of "-omics" technologies. Mutat. Res. Fund. Mol. Mech. Mutagen., 499 (1), 13-25.
    • (2002) Mutat. Res. Fund. Mol. Mech. Mutagen. , vol.499 , Issue.1 , pp. 13-25
    • Aardema, M.J.1    MacGregor, J.T.2
  • 2
    • 0000179727 scopus 로고
    • Carcinogens are mutagens: a simple test system combining liver homogenates for activation and bacteria for detection
    • Ames, B.N., Durston, W.E., Yamasaki, E. and Lee, F.D. (1973) Carcinogens are mutagens: a simple test system combining liver homogenates for activation and bacteria for detection. Proc. Natl. Acad. Sci. U.S.A., 70 (8), 2281.
    • (1973) Proc. Natl. Acad. Sci. U.S.A. , vol.70 , Issue.8 , pp. 2281
    • Ames, B.N.1    Durston, W.E.2    Yamasaki, E.3    Lee, F.D.4
  • 3
    • 0015591140 scopus 로고
    • An improved bacterial test system for the detection and classification of mutagens and carcinogens
    • Ames, B.N., Lee, F.D. and Durston, W.E. (1973) An improved bacterial test system for the detection and classification of mutagens and carcinogens. Proc. Natl. Acad. Sci. U.S.A., 70 (3), 782.
    • (1973) Proc. Natl. Acad. Sci. U.S.A. , vol.70 , Issue.3 , pp. 782
    • Ames, B.N.1    Lee, F.D.2    Durston, W.E.3
  • 4
    • 59149106151 scopus 로고    scopus 로고
    • Toxicity testing in the 21st century: bringing the vision to life
    • Andersen, M.E. and Krewski, D. (2009) Toxicity testing in the 21st century: bringing the vision to life. Toxicol. Sci., 107 (2), 324.
    • (2009) Toxicol. Sci. , vol.107 , Issue.2 , pp. 324
    • Andersen, M.E.1    Krewski, D.2
  • 5
    • 20344385787 scopus 로고    scopus 로고
    • Epigenetic transgenerational actions of endocrine disruptors and male fertility
    • Anway, M.D., Cupp, A.S., Uzumcu, M. and Skinner, M.K. (2005) Epigenetic transgenerational actions of endocrine disruptors and male fertility. Science, 308 (5727), 1466.
    • (2005) Science , vol.308 , Issue.5727 , pp. 1466
    • Anway, M.D.1    Cupp, A.S.2    Uzumcu, M.3    Skinner, M.K.4
  • 6
    • 0034069495 scopus 로고    scopus 로고
    • Gene ontology: tool for the unification of biology
    • Ashburner, M., Ball, C.A., Blake, J.A. et al. (2000) Gene ontology: tool for the unification of biology. Nat. Genet., 25 (1), 25.
    • (2000) Nat. Genet. , vol.25 , Issue.1 , pp. 25
    • Ashburner, M.1    Ball, C.A.2    Blake, J.A.3
  • 7
    • 67749129297 scopus 로고    scopus 로고
    • Epigenetics and environmental chemicals
    • Baccarelli, A. and Bollati, V. (2009) Epigenetics and environmental chemicals. Curr. Opin. Pediatr., 21 (2), 243.
    • (2009) Curr. Opin. Pediatr. , vol.21 , Issue.2 , pp. 243
    • Baccarelli, A.1    Bollati, V.2
  • 8
    • 0027326933 scopus 로고
    • DNA methylation in folate deficiency: use of CpG methylase
    • Balaghi, M. and Wagner, C. (1993) DNA methylation in folate deficiency: use of CpG methylase. Biochem. Biophys. Res. Commun., 193 (3), 1184-1190.
    • (1993) Biochem. Biophys. Res. Commun. , vol.193 , Issue.3 , pp. 1184-1190
    • Balaghi, M.1    Wagner, C.2
  • 9
    • 79952202310 scopus 로고    scopus 로고
    • Epigenomic disruption: the effects of early developmental exposures
    • Bernal, A.J. and Jirtle, R.L. (2010) Epigenomic disruption: the effects of early developmental exposures. Birth Defects Res., A Clin. Mol. Teratol., 88 (10), 938-944.
    • (2010) Birth Defects Res., A Clin. Mol. Teratol , vol.88 , Issue.10 , pp. 938-944
    • Bernal, A.J.1    Jirtle, R.L.2
  • 10
    • 0036144048 scopus 로고    scopus 로고
    • DNA methylation patterns and epigenetic memory
    • Bird, A. (2002) DNA methylation patterns and epigenetic memory. Genes Dev., 16 (1), 6.
    • (2002) Genes Dev. , vol.16 , Issue.1 , pp. 6
    • Bird, A.1
  • 11
    • 33847026146 scopus 로고    scopus 로고
    • Changes in DNA methylation patterns in subjects exposed to low-dose benzene
    • Bollati, V., Baccarelli, A., Hou, L. et al. (2007) Changes in DNA methylation patterns in subjects exposed to low-dose benzene. Cancer Res., 67 (3), 876.
    • (2007) Cancer Res. , vol.67 , Issue.3 , pp. 876
    • Bollati, V.1    Baccarelli, A.2    Hou, L.3
  • 12
    • 77953281055 scopus 로고    scopus 로고
    • Biomarkers of lead exposure and DNA methylation within retrotransposons
    • Bollati, V., Tarantini, L. and Baccarelli, A. (2010) Biomarkers of lead exposure and DNA methylation within retrotransposons. Environ. Health Perspect., 118 (6), 790-795.
    • (2010) Environ. Health Perspect. , vol.118 , Issue.6 , pp. 790-795
    • Bollati, V.1    Tarantini, L.2    Baccarelli, A.3
  • 13
    • 0034650743 scopus 로고    scopus 로고
    • Nickel compounds are novel inhibitors of histone H4 acetylation
    • Broday, L., Peng, W., Kuo, M.H. et al. (2000) Nickel compounds are novel inhibitors of histone H4 acetylation. Cancer Res., 60 (2), 238.
    • (2000) Cancer Res. , vol.60 , Issue.2 , pp. 238
    • Broday, L.1    Peng, W.2    Kuo, M.H.3
  • 14
    • 2642540057 scopus 로고    scopus 로고
    • Air pollution and cardiovascular disease: a statement for healthcare professionals from the expert panel on population and prevention science of the American heart association
    • Brook, R.D., Franklin, B., Cascio, W. et al. (2004) Air pollution and cardiovascular disease: a statement for healthcare professionals from the expert panel on population and prevention science of the American heart association. Circulation, 109 (21), 2655.
    • (2004) Circulation , vol.109 , Issue.21 , pp. 2655
    • Brook, R.D.1    Franklin, B.2    Cascio, W.3
  • 15
    • 0041866794 scopus 로고    scopus 로고
    • Increased homocysteine and S-adenosylhomocysteine concentrations and DNA hypomethylation in vascular disease
    • Castro, R., Rivera, I., Struys, E.A. et al. (2003) Increased homocysteine and S-adenosylhomocysteine concentrations and DNA hypomethylation in vascular disease. Clin. Chem., 49 (8), 1292.
    • (2003) Clin. Chem. , vol.49 , Issue.8 , pp. 1292
    • Castro, R.1    Rivera, I.2    Struys, E.A.3
  • 16
    • 31144434402 scopus 로고    scopus 로고
    • DNA hypermethylation of promoter of gene p53 and p16 in arsenic-exposed people with and without malignancy
    • Chanda, S., Dasgupta, U.B., GuhaMazumder, D. et al. (2006) DNA hypermethylation of promoter of gene p53 and p16 in arsenic-exposed people with and without malignancy. Toxicol. Sci., 89 (2), 431.
    • (2006) Toxicol. Sci. , vol.89 , Issue.2 , pp. 431
    • Chanda, S.1    Dasgupta, U.B.2    GuhaMazumder, D.3
  • 17
    • 0031474509 scopus 로고    scopus 로고
    • Ambient particulate matter and respiratory and cardiovascular illness in adults: particle-borne transition metals and the heart-lung axis1, 2
    • Chapman, R.S., Watkinson, W.P., Dreher, K.L. and Costa, D.L. (1997) Ambient particulate matter and respiratory and cardiovascular illness in adults: particle-borne transition metals and the heart-lung axis1, 2. Environ. Toxicol. Pharmacol., 4 (3-4), 331-338.
    • (1997) Environ. Toxicol. Pharmacol. , vol.4 , Issue.3-4 , pp. 331-338
    • Chapman, R.S.1    Watkinson, W.P.2    Dreher, K.L.3    Costa, D.L.4
  • 18
    • 33646576501 scopus 로고    scopus 로고
    • Nickel ions increase histone H3 lysine 9 dimethylation and induce transgene silencing
    • Chen, H., Ke, Q., Kluz, T. et al. (2006) Nickel ions increase histone H3 lysine 9 dimethylation and induce transgene silencing. Mol. Cell. Biol., 26 (10), 3728.
    • (2006) Mol. Cell. Biol. , vol.26 , Issue.10 , pp. 3728
    • Chen, H.1    Ke, Q.2    Kluz, T.3
  • 19
    • 79961093766 scopus 로고    scopus 로고
    • DNA methylation of tumor suppressor and metastasis suppressor genes in circulating tumor cells
    • 2011165902 v1.
    • Chimonidou, M., Strati, A., Tzitzira, A. et al. (2011) DNA methylation of tumor suppressor and metastasis suppressor genes in circulating tumor cells. Clin. Chem., 57 (8), 1169-1177, 2011.165902 v1.
    • (2011) Clin. Chem. , vol.57 , Issue.8 , pp. 1169-1177
    • Chimonidou, M.1    Strati, A.2    Tzitzira, A.3
  • 20
    • 0031951062 scopus 로고    scopus 로고
    • Transgenerational effect of a single neonatal benzpyrene treatment on the glucocorticoid receptor of the rat thymus
    • Csaba, G. and Inczefi-Gonda, A. (1998) Transgenerational effect of a single neonatal benzpyrene treatment on the glucocorticoid receptor of the rat thymus. Hum. Exp. Toxicol., 17 (2), 88.
    • (1998) Hum. Exp. Toxicol. , vol.17 , Issue.2 , pp. 88
    • Csaba, G.1    Inczefi-Gonda, A.2
  • 21
    • 3242791873 scopus 로고    scopus 로고
    • Discrimination of genotoxic from non-genotoxic carcinogens by gene expression profiling
    • van Delft, J., van Agen, E., van Breda, S. et al. (2004) Discrimination of genotoxic from non-genotoxic carcinogens by gene expression profiling. Carcinogenesis, 25 (7), 1265.
    • (2004) Carcinogenesis , vol.25 , Issue.7 , pp. 1265
    • van Delft, J.1    van Agen, E.2    van Breda, S.3
  • 22
    • 84858437434 scopus 로고    scopus 로고
    • An immunochemical method for detection and analysis of changes in methylome
    • Deobagkar, D.D., Panikar, C., Rajpathak, S.N. et al. (2012) An immunochemical method for detection and analysis of changes in methylome. Methods, 56, 260-267.
    • (2012) Methods , vol.56 , pp. 260-267
    • Deobagkar, D.D.1    Panikar, C.2    Rajpathak, S.N.3
  • 23
    • 79959652668 scopus 로고    scopus 로고
    • Epigenetic markers for chemosensitivity and chemoresistance in pancreatic cancer--a review
    • Dhayat, S., Mardin, W.A., Mees, S.T. and Haier, J. (2011) Epigenetic markers for chemosensitivity and chemoresistance in pancreatic cancer--a review. Int. J. Cancer, 129 (5), 1031-1041.
    • (2011) Int. J. Cancer , vol.129 , Issue.5 , pp. 1031-1041
    • Dhayat, S.1    Mardin, W.A.2    Mees, S.T.3    Haier, J.4
  • 24
    • 47749117212 scopus 로고    scopus 로고
    • Distinctive patterns of microRNA expression associated with karyotype in acute myeloid leukaemia
    • Dixon-McIver, A., East, P., Mein, C.A. et al. (2008) Distinctive patterns of microRNA expression associated with karyotype in acute myeloid leukaemia. PLoS ONE, 3 (5), e2141.
    • (2008) PLoS ONE , vol.3 , Issue.5
    • Dixon-McIver, A.1    East, P.2    Mein, C.A.3
  • 25
    • 0024402152 scopus 로고
    • Erythromycin resistant propionibacteria in antibiotic treated acne patients: association with therapeutic failure
    • Eady, E.A., Cove, J.H., Holland, K.T. and Cunliffe, W.J. (1989) Erythromycin resistant propionibacteria in antibiotic treated acne patients: association with therapeutic failure. Br. J. Dermatol., 121 (1), 51-57.
    • (1989) Br. J. Dermatol. , vol.121 , Issue.1 , pp. 51-57
    • Eady, E.A.1    Cove, J.H.2    Holland, K.T.3    Cunliffe, W.J.4
  • 26
    • 0037068353 scopus 로고    scopus 로고
    • DNA methylation in cancer: too much, but also too little
    • Ehrlich, M. (2002) DNA methylation in cancer: too much, but also too little. Oncogene, 21 (35), 5400-5413.
    • (2002) Oncogene , vol.21 , Issue.35 , pp. 5400-5413
    • Ehrlich, M.1
  • 27
    • 1642481241 scopus 로고    scopus 로고
    • Mutagenicity of cadmium in mammalian cells: implication of oxidative DNA damage
    • Filipic, M. and Hei, T.K. (2004) Mutagenicity of cadmium in mammalian cells: implication of oxidative DNA damage. Mutat. Res. Fund. Mol. Mech. Mutagen., 546 (1-2), 81-91.
    • (2004) Mutat. Res. Fund. Mol. Mech. Mutagen. , vol.546 , Issue.1-2 , pp. 81-91
    • Filipic, M.1    Hei, T.K.2
  • 28
    • 79954523767 scopus 로고    scopus 로고
    • Epigenetic mechanisms in metal toxicity
    • Fragou, D., Fragou, A., Kouidou, S. et al. (2011) Epigenetic mechanisms in metal toxicity. Toxicol. Mech. Methods, 21 (4), 343-352.
    • (2011) Toxicol. Mech. Methods , vol.21 , Issue.4 , pp. 343-352
    • Fragou, D.1    Fragou, A.2    Kouidou, S.3
  • 29
    • 0025129780 scopus 로고
    • Recent developments in replacing, reducing, and refining animal use in toxicologic research and testing* 1
    • Gad, S.C. (1990) Recent developments in replacing, reducing, and refining animal use in toxicologic research and testing* 1. Fundam. Appl. Toxicol., 15 (1), 8-16.
    • (1990) Fundam. Appl. Toxicol. , vol.15 , Issue.1 , pp. 8-16
    • Gad, S.C.1
  • 30
    • 34447517134 scopus 로고    scopus 로고
    • Toxicogenomics: a pivotal piece in the puzzle of toxicological research
    • Gatzidou, E.T., Zira, A.N. and Theocharis, S.E. (2007) Toxicogenomics: a pivotal piece in the puzzle of toxicological research. J. Appl. Toxicol., 27 (4), 302-309.
    • (2007) J. Appl. Toxicol. , vol.27 , Issue.4 , pp. 302-309
    • Gatzidou, E.T.1    Zira, A.N.2    Theocharis, S.E.3
  • 31
    • 67149086996 scopus 로고    scopus 로고
    • Extensive demethylation of repetitive elements during seed development underlies gene imprinting
    • Gehring, M., Bubb, K.L. and Henikoff, S. (2009) Extensive demethylation of repetitive elements during seed development underlies gene imprinting. Science, 324 (5933), 1447.
    • (2009) Science , vol.324 , Issue.5933 , pp. 1447
    • Gehring, M.1    Bubb, K.L.2    Henikoff, S.3
  • 32
    • 46449087037 scopus 로고    scopus 로고
    • Effect of in utero and early-life conditions on adult health and disease
    • Gluckman, P.D., Hanson, M.A., Cooper, C. and Thornburg, K.L. (2008) Effect of in utero and early-life conditions on adult health and disease. N. Engl. J. Med., 359 (1), 61-73.
    • (2008) N. Engl. J. Med. , vol.359 , Issue.1 , pp. 61-73
    • Gluckman, P.D.1    Hanson, M.A.2    Cooper, C.3    Thornburg, K.L.4
  • 33
    • 15744401773 scopus 로고    scopus 로고
    • Eukaryotic cytosine methyltransferases
    • Goll, M.G. and Bestor, T.H. (2005) Eukaryotic cytosine methyltransferases. Annu. Rev. Biochem., 74, 481-514.
    • (2005) Annu. Rev. Biochem. , vol.74 , pp. 481-514
    • Goll, M.G.1    Bestor, T.H.2
  • 34
    • 0026770308 scopus 로고
    • Increased postimplantation loss and malformations among the F2 progeny of male rats chronically treated with cyclophosphamide
    • Hales, B.F., Crosman, K. and Robaire, B. (1992) Increased postimplantation loss and malformations among the F2 progeny of male rats chronically treated with cyclophosphamide. Teratology, 45 (6), 671-678.
    • (1992) Teratology , vol.45 , Issue.6 , pp. 671-678
    • Hales, B.F.1    Crosman, K.2    Robaire, B.3
  • 36
    • 15344347753 scopus 로고    scopus 로고
    • Advances in toxicogenomics
    • Hayes, K.R. and Bradfield, C.A. (2005) Advances in toxicogenomics. Chem. Res. Toxicol., 18 (3), 403-414.
    • (2005) Chem. Res. Toxicol. , vol.18 , Issue.3 , pp. 403-414
    • Hayes, K.R.1    Bradfield, C.A.2
  • 37
    • 0030725715 scopus 로고    scopus 로고
    • Functional genomics: it's all how you read it
    • Hieter, P. and Boguski, M. (1997) Functional genomics: it's all how you read it. Science, 278 (5338), 601.
    • (1997) Science , vol.278 , Issue.5338 , pp. 601
    • Hieter, P.1    Boguski, M.2
  • 38
    • 79955594736 scopus 로고    scopus 로고
    • Child health, developmental plasticity, and epigenetic programming
    • Hochberg Z., Feil R., Constancia M. et al. (2011) Child health, developmental plasticity, and epigenetic programming. Endocr. Rev., 32 (2), 159-224.
    • (2011) Endocr. Rev. , vol.32 , Issue.2 , pp. 159-224
    • Hochberg, Z.1    Feil, R.2    Constancia, M.3
  • 39
    • 44149105575 scopus 로고    scopus 로고
    • Global DNA hypomethylation, rather than reactive oxygen species (ROS), a potential facilitator of cadmium-stimulated K562 cell proliferation
    • Huang, D., Zhang, Y., Qi, Y. et al. (2008) Global DNA hypomethylation, rather than reactive oxygen species (ROS), a potential facilitator of cadmium-stimulated K562 cell proliferation. Toxicol. Lett., 179 (1), 43-47.
    • (2008) Toxicol. Lett. , vol.179 , Issue.1 , pp. 43-47
    • Huang, D.1    Zhang, Y.2    Qi, Y.3
  • 40
    • 78649328673 scopus 로고    scopus 로고
    • State-of-the-art genomics approaches in toxicology
    • van Hummelen, P. and Sasaki, J. (2010) State-of-the-art genomics approaches in toxicology. Mutat. Res., 705 (3), 165-171.
    • (2010) Mutat. Res. , vol.705 , Issue.3 , pp. 165-171
    • van Hummelen, P.1    Sasaki, J.2
  • 41
    • 0041837642 scopus 로고    scopus 로고
    • Aberrant p16 promoter methylation in smokers and former smokers with nonsmall cell lung cancer
    • Jarmalaite, S., Kannio, A., Anttila, S. et al. (2003) Aberrant p16 promoter methylation in smokers and former smokers with nonsmall cell lung cancer. Int. J. Cancer, 106 (6), 913-918.
    • (2003) Int. J. Cancer , vol.106 , Issue.6 , pp. 913-918
    • Jarmalaite, S.1    Kannio, A.2    Anttila, S.3
  • 42
    • 73749086794 scopus 로고    scopus 로고
    • Environmental toxicogenomics: a postgenomic approach to analysing biological responses to environmental toxins
    • Jayapal, M., Bhattacharjee, R.N., Melendez, A.J. and Hande, M.P. (2010) Environmental toxicogenomics: a postgenomic approach to analysing biological responses to environmental toxins. Int. J. Biochem. Cell Biol., 42 (2), 230-240.
    • (2010) Int. J. Biochem. Cell Biol. , vol.42 , Issue.2 , pp. 230-240
    • Jayapal, M.1    Bhattacharjee, R.N.2    Melendez, A.J.3    Hande, M.P.4
  • 44
    • 66349120133 scopus 로고    scopus 로고
    • The toxicity data landscape for environmental chemicals
    • Judson, R., Richard, A., Dix, D.J. et al. (2009) The toxicity data landscape for environmental chemicals. Environ. Health Perspect., 117 (5), 685.
    • (2009) Environ. Health Perspect. , vol.117 , Issue.5 , pp. 685
    • Judson, R.1    Richard, A.2    Dix, D.J.3
  • 45
    • 38549126643 scopus 로고    scopus 로고
    • KEGG for linking genomes to life and the environment
    • Kanehisa, M., Araki, M., Goto, S. et al. (2008) KEGG for linking genomes to life and the environment. Nucleic Acids Res., 36 (Suppl 1), D480.
    • (2008) Nucleic Acids Res. , vol.36 , Issue.SUPPL 1
    • Kanehisa, M.1    Araki, M.2    Goto, S.3
  • 46
    • 33745603983 scopus 로고    scopus 로고
    • Alterations of histone modifications and transgene silencing by nickel chloride
    • Ke, Q., Davidson, T., Chen, H. et al. (2006) Alterations of histone modifications and transgene silencing by nickel chloride. Carcinogenesis, 27 (7), 1481.
    • (2006) Carcinogenesis , vol.27 , Issue.7 , pp. 1481
    • Ke, Q.1    Davidson, T.2    Chen, H.3
  • 47
    • 73449091851 scopus 로고    scopus 로고
    • A novel method to assess the full genome methylation profile using monoclonal antibody combined with the high throughput based microarray approach
    • Kelkar, A. and Deobagkar, D. (2009) A novel method to assess the full genome methylation profile using monoclonal antibody combined with the high throughput based microarray approach. Epigenetics, 4 (6), 415-420.
    • (2009) Epigenetics , vol.4 , Issue.6 , pp. 415-420
    • Kelkar, A.1    Deobagkar, D.2
  • 48
    • 70349876562 scopus 로고    scopus 로고
    • Identification of genomic biomarkers for concurrent diagnosis of drug-induced renal tubular injury using a large-scale toxicogenomics database
    • Kondo, C., Minowa, Y., Uehara, T. et al. (2009) Identification of genomic biomarkers for concurrent diagnosis of drug-induced renal tubular injury using a large-scale toxicogenomics database. Toxicology. 265 (1-2), 15-26.
    • (2009) Toxicology , vol.265 , Issue.1-2 , pp. 5-26
    • Kondo, C.1    Minowa, Y.2    Uehara, T.3
  • 49
    • 80051675851 scopus 로고    scopus 로고
    • Epigenetic mechanisms of mouse inter-strain variability in genotoxicity of the environmental toxicant 1, 3-butadiene
    • Koturbash, I., Scherhag, A., Sorrentino, J. et al. (2011) Epigenetic mechanisms of mouse inter-strain variability in genotoxicity of the environmental toxicant 1, 3-butadiene. Toxicol. Sci., 122 (2), 448-456.
    • (2011) Toxicol. Sci. , vol.122 , Issue.2 , pp. 448-456
    • Koturbash, I.1    Scherhag, A.2    Sorrentino, J.3
  • 51
    • 0028966572 scopus 로고
    • Carcinogenic nickel silences gene expression by chromatin condensation and DNA methylation: a new model for epigenetic carcinogens
    • Lee, Y., Klein, C., Kargacin, B. et al. (1995) Carcinogenic nickel silences gene expression by chromatin condensation and DNA methylation: a new model for epigenetic carcinogens. Mol. Cell. Biol., 15 (5), 2547.
    • (1995) Mol. Cell. Biol. , vol.15 , Issue.5 , pp. 2547
    • Lee, Y.1    Klein, C.2    Kargacin, B.3
  • 52
    • 77955433253 scopus 로고    scopus 로고
    • Whole genome DNA methylation analysis based on high throughput sequencing technology
    • Li, N., Ye, M., Li, Y. et al. (2010) Whole genome DNA methylation analysis based on high throughput sequencing technology. Methods, 52 (3), 203-212.
    • (2010) Methods , vol.52 , Issue.3 , pp. 203-212
    • Li, N.1    Ye, M.2    Li, Y.3
  • 53
    • 33845312687 scopus 로고    scopus 로고
    • MicroRNA responses to cellular stress
    • Marsit, C.J., Eddy, K. and Kelsey, K.T. (2006) MicroRNA responses to cellular stress. Cancer Res., 66 (22), 10843.
    • (2006) Cancer Res. , vol.66 , Issue.22 , pp. 10843
    • Marsit, C.J.1    Eddy, K.2    Kelsey, K.T.3
  • 54
    • 0030742792 scopus 로고    scopus 로고
    • Arsenic alters cytosine methylation patterns of the promoter of the tumor suppressor gene p53 in human lung cells: a model for a mechanism of carcinogenesis
    • Mass, M.J. and Wang, L. (1997) Arsenic alters cytosine methylation patterns of the promoter of the tumor suppressor gene p53 in human lung cells: a model for a mechanism of carcinogenesis. Mutat. Res., 386 (3), 263-277.
    • (1997) Mutat. Res. , vol.386 , Issue.3 , pp. 263-277
    • Mass, M.J.1    Wang, L.2
  • 55
    • 33748502967 scopus 로고    scopus 로고
    • The Comparative Toxicogenomics Database (CTD): a resource for comparative toxicological studies
    • Mattingly, C.J. Rosenstein, M.C., Colby, G.T. et al. (2006) The Comparative Toxicogenomics Database (CTD): a resource for comparative toxicological studies. J. Exp. Zool. A. Comp. Exp. Biol., 305 (9), 689-692.
    • (2006) J. Exp. Zool. A. Comp. Exp. Biol. , vol.305 , Issue.9 , pp. 689-692
    • Mattingly, C.J.1    Rosenstein, M.C.2    Colby, G.T.3
  • 56
    • 61349100097 scopus 로고    scopus 로고
    • Chemical databases for environmental health and clinical research
    • Mattingly, C.J. (2009) Chemical databases for environmental health and clinical research. Toxicol. Lett., 186 (1), 62-65.
    • (2009) Toxicol. Lett. , vol.186 , Issue.1 , pp. 62-65
    • Mattingly, C.J.1
  • 57
    • 21844434219 scopus 로고    scopus 로고
    • Environmental programming of stress responses through DNA methylation: life at the interface between a dynamic environment and a fixed genome
    • Meaney, M.J. and Szyf, M. (2005a) Environmental programming of stress responses through DNA methylation: life at the interface between a dynamic environment and a fixed genome. Dialogues Clin. Neurosc., 7 (2), 103-123.
    • (2005) Dialogues Clin. Neurosc. , vol.7 , Issue.2 , pp. 103-123
    • Meaney, M.J.1    Szyf, M.2
  • 58
    • 23944441386 scopus 로고    scopus 로고
    • Maternal care as a model for experience-dependent chromatin plasticity?
    • Meaney, M.J. and Szyf, M. (2005b) Maternal care as a model for experience-dependent chromatin plasticity? Trends Neurosci., 28 (9), 456-463.
    • (2005) Trends Neurosci , vol.28 , Issue.9 , pp. 456-463
    • Meaney, M.J.1    Szyf, M.2
  • 59
    • 79961106763 scopus 로고    scopus 로고
    • Identification of methylated genes in BALB/c mice liver using monoclonal antibody combined with the high throughput cDNA microarray approach
    • Mukherjee, S., Sainis, K.B. and Deobagkar, D. (2011) Identification of methylated genes in BALB/c mice liver using monoclonal antibody combined with the high throughput cDNA microarray approach. Curr. Sci., 101 (1), 66.
    • (2011) Curr. Sci. , vol.101 , Issue.1 , pp. 66
    • Mukherjee, S.1    Sainis, K.B.2    Deobagkar, D.3
  • 60
    • 33646821720 scopus 로고    scopus 로고
    • Adverse effects of the model environmental estrogen diethylstilbestrol are transmitted to subsequent generations
    • Newbold, R.R., Padilla-Banks, E. and Jefferson, W.N. (2006) Adverse effects of the model environmental estrogen diethylstilbestrol are transmitted to subsequent generations. Endocrinology, 147 (6), s11.
    • (2006) Endocrinology , vol.147 , Issue.6
    • Newbold, R.R.1    Padilla-Banks, E.2    Jefferson, W.N.3
  • 61
    • 78650987056 scopus 로고    scopus 로고
    • Functional toxicogenomics: mechanism-centered toxicology
    • North, M. and Vulpe, C.D. (2010) Functional toxicogenomics: mechanism-centered toxicology. Int. J. Mol. Sci., 11 (12), 4796-4813.
    • (2010) Int. J. Mol. Sci. , vol.11 , Issue.12 , pp. 4796-4813
    • North, M.1    Vulpe, C.D.2
  • 62
    • 0032901303 scopus 로고    scopus 로고
    • Microarrays and toxicology: the advent of toxicogenomics
    • Nuwaysir, E.F., Bittner, M., Trent, J. et al. (1999) Microarrays and toxicology: the advent of toxicogenomics. Mol. Carcinog., 24 (3), 153-159.
    • (1999) Mol. Carcinog. , vol.24 , Issue.3 , pp. 153-159
    • Nuwaysir, E.F.1    Bittner, M.2    Trent, J.3
  • 63
    • 48249105104 scopus 로고    scopus 로고
    • Long lasting depression like behavior and epigenetic changes of BDNF gene expression induced by perinatal exposure to methylmercury
    • Onishchenko, N., Karpova, N., Sabri, F. et al. (2008) Long lasting depression like behavior and epigenetic changes of BDNF gene expression induced by perinatal exposure to methylmercury. J. Neurochem., 106 (3), 1378-1387.
    • (2008) J. Neurochem. , vol.106 , Issue.3 , pp. 1378-1387
    • Onishchenko, N.1    Karpova, N.2    Sabri, F.3
  • 64
    • 77951840730 scopus 로고    scopus 로고
    • Predicting environmental chemical factors associated with disease-related gene expression data
    • Patel, C. and Butte, A. (2010) Predicting environmental chemical factors associated with disease-related gene expression data. BMC Med. Genomics, 3 (1), 17.
    • (2010) BMC Med. Genomics , vol.3 , Issue.1 , pp. 17
    • Patel, C.1    Butte, A.2
  • 65
    • 24644501346 scopus 로고    scopus 로고
    • Particulate matter and heart disease: evidence from epidemiological studies
    • Peters, A. (2005) Particulate matter and heart disease: evidence from epidemiological studies. Toxicol. Appl. Pharmacol., 207 (2), 477-482.
    • (2005) Toxicol. Appl. Pharmacol. , vol.207 , Issue.2 , pp. 477-482
    • Peters, A.1
  • 66
    • 35148901501 scopus 로고    scopus 로고
    • Genomic methylation of peripheral blood leukocyte DNA: influences of arsenic and folate in Bangladeshi adults
    • Pilsner, J.R., Liu, X., Ahsan, H. et al. (2007) Genomic methylation of peripheral blood leukocyte DNA: influences of arsenic and folate in Bangladeshi adults. Am. J. Clin. Nutr., 86 (4), 1179.
    • (2007) Am. J. Clin. Nutr. , vol.86 , Issue.4 , pp. 1179
    • Pilsner, J.R.1    Liu, X.2    Ahsan, H.3
  • 67
    • 60749136375 scopus 로고    scopus 로고
    • Folate deficiency, hyperhomocysteinemia, low urinary creatinine, and hypomethylation of leukocyte DNA are risk factors for arsenic-induced skin lesions
    • Pilsner, J.R., Liu, X., Ahsan, H. et al. (2009) Folate deficiency, hyperhomocysteinemia, low urinary creatinine, and hypomethylation of leukocyte DNA are risk factors for arsenic-induced skin lesions. Environ. Health Perspect., 117 (2), 254.
    • (2009) Environ. Health Perspect. , vol.117 , Issue.2 , pp. 254
    • Pilsner, J.R.1    Liu, X.2    Ahsan, H.3
  • 68
    • 0037029043 scopus 로고    scopus 로고
    • Lung cancer,cardiopulmonary mortality, and long-term exposure to fine particulate air pollution
    • Pope, C.A., Burnett, R.T., Thun, M.J. et al. (2002) Lung cancer,cardiopulmonary mortality, and long-term exposure to fine particulate air pollution. J. Am. Med. Assoc., 287 (9), 1132.
    • (2002) J. Am. Med. Assoc. , vol.287 , Issue.9 , pp. 1132
    • Pope, C.A.1    Burnett, R.T.2    Thun, M.J.3
  • 69
    • 0024436227 scopus 로고
    • Transgenerational effect of orthoaminoasotoluol in mice
    • Popova, N. (1989) Transgenerational effect of orthoaminoasotoluol in mice. Cancer Lett., 46 (3), 203-206.
    • (1989) Cancer Lett. , vol.46 , Issue.3 , pp. 203-206
    • Popova, N.1
  • 70
    • 0033805888 scopus 로고    scopus 로고
    • Genomic DNA methylation decreases in response to moderate folate depletion in elderly women
    • Rampersaud, G.C., Kauwell, G., Hutson, A.D. et al. (2000) Genomic DNA methylation decreases in response to moderate folate depletion in elderly women. Am.J. Clin. Nutr., 72 (4), 998.
    • (2000) Am.J. Clin. Nutr. , vol.72 , Issue.4 , pp. 998
    • Rampersaud, G.C.1    Kauwell, G.2    Hutson, A.D.3
  • 71
    • 33751427435 scopus 로고    scopus 로고
    • Long term low-dose arsenic exposure induces loss of DNA methylation
    • Reichard, J.F., Schnekenburger, M. and Puga, A. (2007) Long term low-dose arsenic exposure induces loss of DNA methylation. Biochem. Biophys. Res. Commun., 352 (1), 188-192.
    • (2007) Biochem. Biophys. Res. Commun. , vol.352 , Issue.1 , pp. 188-192
    • Reichard, J.F.1    Schnekenburger, M.2    Puga, A.3
  • 72
    • 58849158772 scopus 로고    scopus 로고
    • Global DNA hypomethylation is associated with high serumpersistent organic pollutants in Greenlandic Inuit
    • Rusiecki, J.A., Baccarelli, A., Bollati, V. et al. (2008) Global DNA hypomethylation is associated with high serumpersistent organic pollutants in Greenlandic Inuit. Environ. Health Perspect., 116 (11), 1547.
    • (2008) Environ. Health Perspect. , vol.116 , Issue.11 , pp. 1547
    • Rusiecki, J.A.1    Baccarelli, A.2    Bollati, V.3
  • 73
    • 84887169306 scopus 로고    scopus 로고
    • What is toxicology?
    • (accessed December 2011).
    • Schrager, T.F. (2008) What is toxicology? http://www.toxicologysource.com/whatistoxicology.html (accessed December 2011).
    • (2008)
    • Schrager, T.F.1
  • 74
    • 1542399123 scopus 로고    scopus 로고
    • Arsenic-induced DNA hypomethylation affects chromosomal instability in mammalian cells
    • Sciandrello, G., Caradonna, F., Mauro, M. and Barbata, G. (2004) Arsenic-induced DNA hypomethylation affects chromosomal instability in mammalian cells. Carcinogenesis, 25 (3), 413.
    • (2004) Carcinogenesis , vol.25 , Issue.3 , pp. 413
    • Sciandrello, G.1    Caradonna, F.2    Mauro, M.3    Barbata, G.4
  • 75
    • 0028887339 scopus 로고
    • Particulate air pollution and acute health effects
    • Seaton, A., Godden, D., MacNee, W. and Donaldson, K. (1995) Particulate air pollution and acute health effects. Lancet, 345 (8943), 176-178.
    • (1995) Lancet , vol.345 , Issue.8943 , pp. 176-178
    • Seaton, A.1    Godden, D.2    MacNee, W.3    Donaldson, K.4
  • 76
    • 31944444233 scopus 로고    scopus 로고
    • The benzamide MS-275 is a potent, long-lasting brain regionselective inhibitor of histone deacetylases
    • Simonini, M.V., Camargo, L.M., Dong, E. et al. (2006) The benzamide MS-275 is a potent, long-lasting brain regionselective inhibitor of histone deacetylases. Proc. Natl. Acad. Sci. U.S.A., 103 (5), 1587.
    • (2006) Proc. Natl. Acad. Sci. U.S.A. , vol.103 , Issue.5 , pp. 1587
    • Simonini, M.V.1    Camargo, L.M.2    Dong, E.3
  • 77
    • 79953752954 scopus 로고    scopus 로고
    • Epigenetic transgenerational actions of endocrine disruptors
    • Skinner, M.K., Manikkam, M. and Guerrero-Bosagna, C. (2011) Epigenetic transgenerational actions of endocrine disruptors. Reprod. Toxicol., 31 (3), 337-343.
    • (2011) Reprod. Toxicol. , vol.31 , Issue.3 , pp. 337-343
    • Skinner, M.K.1    Manikkam, M.2    Guerrero-Bosagna, C.3
  • 78
    • 0015041807 scopus 로고
    • Glucose intolerance in the progeny of rats treated with single subdiabetogenic dose of alloxan
    • Spergel, G., Levy, L.J. and Goldner, M.G. (1971) Glucose intolerance in the progeny of rats treated with single subdiabetogenic dose of alloxan. Metabolism, 20 (4), 401-413.
    • (1971) Metabolism , vol.20 , Issue.4 , pp. 401-413
    • Spergel, G.1    Levy, L.J.2    Goldner, M.G.3
  • 79
    • 75149150268 scopus 로고    scopus 로고
    • Transgenerational effects of the endocrine disruptor vinclozolin on the methylation pattern of imprinted genes in the mouse sperm
    • Stouder, C. and Paoloni-Giacobino, A. (2010) Transgenerational effects of the endocrine disruptor vinclozolin on the methylation pattern of imprinted genes in the mouse sperm. Reproduction, 139 (2), 373.
    • (2010) Reproduction , vol.139 , Issue.2 , pp. 373
    • Stouder, C.1    Paoloni-Giacobino, A.2
  • 80
    • 67349119474 scopus 로고    scopus 로고
    • Chromium has been shown to reduce in vitro H3 phosphorylation and trimethylation, as well as various acetylation marks in H3 and H4
    • Sun, H., Zhou, X., Chen, H. et al. (2009) Chromium has been shown to reduce in vitro H3 phosphorylation and trimethylation, as well as various acetylation marks in H3 and H4. Toxicol. Appl. Pharmacol., 237 (3), 258-266.
    • (2009) Toxicol. Appl. Pharmacol. , vol.237 , Issue.3 , pp. 258-266
    • Sun, H.1    Zhou, X.2    Chen, H.3
  • 81
    • 35448985442 scopus 로고    scopus 로고
    • The dynamic epigenome and its implications in toxicology
    • Szyf, M. (2007) The dynamic epigenome and its implications in toxicology. Toxicol. Sci., 100 (1), 7.
    • (2007) Toxicol. Sci. , vol.100 , Issue.1 , pp. 7
    • Szyf, M.1
  • 82
    • 0037960155 scopus 로고    scopus 로고
    • Effects of cadmium on DNA(Cytosine-5) methyltransferase activity and DNA methylation status during cadmium-induced cellular transformation
    • Takiguchi, M., Achanzar, W.E., Qu, W. et al. (2003) Effects of cadmium on DNA(Cytosine-5) methyltransferase activity and DNA methylation status during cadmium-induced cellular transformation. Exp. Cell Res., 286 (2), 355-365.
    • (2003) Exp. Cell Res. , vol.286 , Issue.2 , pp. 355-365
    • Takiguchi, M.1    Achanzar, W.E.2    Qu, W.3
  • 83
    • 0032616340 scopus 로고    scopus 로고
    • Effect of trichloroethylene on DNA methylation and expression of early intermediate protooncogenes in the liver of B6C3F1 mice
    • Tao, L., Ge, R., Xie, M. et al. (1999) Effect of trichloroethylene on DNA methylation and expression of early intermediate protooncogenes in the liver of B6C3F1 mice. J. Biochem. Mol. Toxicol., 13 (5), 231-237.
    • (1999) J. Biochem. Mol. Toxicol. , vol.13 , Issue.5 , pp. 231-237
    • Tao, L.1    Ge, R.2    Xie, M.3
  • 84
    • 60749124259 scopus 로고    scopus 로고
    • Effects of particulate matter on genomic DNA methylation content and iNOS promoter methylation
    • Tarantini, L., Bonzini, M., Apostoli, P. et al. (2009) Effects of particulate matter on genomic DNA methylation content and iNOS promoter methylation. Environ. Health Perspect., 117 (2), 217.
    • (2009) Environ. Health Perspect. , vol.117 , Issue.2 , pp. 217
    • Tarantini, L.1    Bonzini, M.2    Apostoli, P.3
  • 85
    • 79952088278 scopus 로고    scopus 로고
    • Adult stem cells, the barker hypothesis, epigenetic events, and low-level radiation effects
    • (eds M. Nakashima, N. Takamura, K. Tsukasaki, et al.) Springer
    • Trosko, J.E. and Suzuki, K. (2009) Adult stem cells, the barker hypothesis, epigenetic events, and low-level radiation effects. Radiation Health Risk Sciences, (eds M. Nakashima, N. Takamura, K. Tsukasaki, et al.) Springer, pp. 216-226.
    • (2009) Radiation Health Risk Sciences , pp. 216-226
    • Trosko, J.E.1    Suzuki, K.2
  • 86
    • 78651282659 scopus 로고    scopus 로고
    • DAnCER: disease-annotated chromatin epigenetics resource
    • Turinsky, A.L., Turner, B., Borja, R.C. et al. (2011) DAnCER: disease-annotated chromatin epigenetics resource. Nucleic Acids Res., 39 (Suppl 1), D889.
    • (2011) Nucleic Acids Res. , vol.39 , Issue.SUPPL 1
    • Turinsky, A.L.1    Turner, B.2    Borja, R.C.3
  • 87
    • 0029001483 scopus 로고
    • DNA adduct 8-hydroxyl-2 deoxyguanosine (8- hydroxyguanine) affects function of human DNA methyltransferase
    • Turk, P.W., Laayoun, A., Smith, S.S. and Weitzman, S.A. (1995) DNA adduct 8-hydroxyl-2 deoxyguanosine (8- hydroxyguanine) affects function of human DNA methyltransferase. Carcinogenesis, 16 (5), 1253.
    • (1995) Carcinogenesis , vol.16 , Issue.5 , pp. 1253
    • Turk, P.W.1    Laayoun, A.2    Smith, S.S.3    Weitzman, S.A.4
  • 88
    • 4043112183 scopus 로고    scopus 로고
    • Oxidative damage to methyl-CpG sequences inhibits the binding of the methyl-CpG binding domain (MBD) of methyl-CpG binding protein 2 (MeCP2)
    • Valinluck, V., Tsai, H.H., Rogstad, D.K. et al. (2004) Oxidative damage to methyl-CpG sequences inhibits the binding of the methyl-CpG binding domain (MBD) of methyl-CpG binding protein 2 (MeCP2). Nucleic Acids Res., 32 (14), 4100.
    • (2004) Nucleic Acids Res. , vol.32 , Issue.14 , pp. 4100
    • Valinluck, V.1    Tsai, H.H.2    Rogstad, D.K.3
  • 89
    • 18544371009 scopus 로고    scopus 로고
    • Metals, toxicity and oxidative stress
    • Valko, M., Morris, H. and Cronin, M. (2005) Metals, toxicity and oxidative stress. Curr. Med. Chem., 12 (10), 1161-1208.
    • (2005) Curr. Med. Chem. , vol.12 , Issue.10 , pp. 1161-1208
    • Valko, M.1    Morris, H.2    Cronin, M.3
  • 90
    • 77956296566 scopus 로고    scopus 로고
    • Bisulfite patch PCR enables multiplexed sequencing of promoter methylation across cancer samples
    • Varley, K.E. and Mitra, R.D. (2010) Bisulfite patch PCR enables multiplexed sequencing of promoter methylation across cancer samples. Genome Res., 20, 1279.
    • (2010) Genome Res. , vol.20 , pp. 1279
    • Varley, K.E.1    Mitra, R.D.2
  • 91
    • 9444256954 scopus 로고    scopus 로고
    • Toxicogenomics and systems toxicology: aims and prospects
    • Waters, M.D. and Fostel, J.M. (2004) Toxicogenomics and systems toxicology: aims and prospects. Nat. Rev. Genet., 5 (12), 936-948.
    • (2004) Nat. Rev. Genet. , vol.5 , Issue.12 , pp. 936-948
    • Waters, M.D.1    Fostel, J.M.2
  • 92
    • 0033868452 scopus 로고    scopus 로고
    • Inhibition of histone deacetylases: a new strategy to target epigenetic modifications for anticancer treatment
    • Weidle, U.H. and Grossmann, A. (2000) Inhibition of histone deacetylases: a new strategy to target epigenetic modifications for anticancer treatment. AntiCancer Res., 20 (3A), 1471-1485.
    • (2000) AntiCancer Res. , vol.20 , Issue.3 A , pp. 1471-1485
    • Weidle, U.H.1    Grossmann, A.2
  • 94
    • 38649121719 scopus 로고    scopus 로고
    • Germ-line mutations, DNA damage, and global hypermethylation in mice exposed to particulate air pollution in an urban/industrial location
    • Yauk, C., Polyzos, A., Rowan-Carroll, A. et al. (2008) Germ-line mutations, DNA damage, and global hypermethylation in mice exposed to particulate air pollution in an urban/industrial location. Proc. Natl. Acad. Sci. U.S.A., 105 (2), 605.
    • (2008) Proc. Natl. Acad. Sci. U.S.A. , vol.105 , Issue.2 , pp. 605
    • Yauk, C.1    Polyzos, A.2    Rowan-Carroll, A.3
  • 95
    • 55349130961 scopus 로고    scopus 로고
    • DNA hypomethylation arises later in prostate cancer progression than CpG island hypermethylation and contributes to metastatic tumor heterogeneity
    • Yegnasubramanian, S., Haffner, M.C., Zhang, Y. et al. (2008) DNA hypomethylation arises later in prostate cancer progression than CpG island hypermethylation and contributes to metastatic tumor heterogeneity. Cancer Res., 68 (21), 8954.
    • (2008) Cancer Res. , vol.68 , Issue.21 , pp. 8954
    • Yegnasubramanian, S.1    Haffner, M.C.2    Zhang, Y.3
  • 96
    • 33748629119 scopus 로고    scopus 로고
    • Genome-wide high-resolution mapping and functional analysis of DNA methylation in Arabidopsis
    • Zhang, X., Yazaki, J., Sundaresan, A. et al. (2006) Genome-wide high-resolution mapping and functional analysis of DNA methylation in Arabidopsis. Cell, 126 (6), 1189-1201.
    • (2006) Cell , vol.126 , Issue.6 , pp. 1189-1201
    • Zhang, X.1    Yazaki, J.2    Sundaresan, A.3
  • 97
    • 0030885707 scopus 로고    scopus 로고
    • Association of arsenic-induced malignant transformation with DNA hypomethylation and aberrant gene expression
    • Zhao, C.Q., Young, M.R., Diwan, B.A. et al. (1997) Association of arsenic-induced malignant transformation with DNA hypomethylation and aberrant gene expression. Proc. Natl. Acad. Sci. U.S.A., 94 (20), 10907.
    • (1997) Proc. Natl. Acad. Sci. U.S.A. , vol.94 , Issue.20 , pp. 10907
    • Zhao, C.Q.1    Young, M.R.2    Diwan, B.A.3
  • 98
    • 0035816153 scopus 로고    scopus 로고
    • Both hypomethylation and hypermethylation of DNA associated with arsenite exposure in cultures of human cells identified by methylation-sensitive arbitrarily-primed PCR
    • Zhong, C.X. and Mass, M.J. (2001) Both hypomethylation and hypermethylation of DNA associated with arsenite exposure in cultures of human cells identified by methylation-sensitive arbitrarily-primed PCR. Toxicol. Lett., 122 (3), 223-234.
    • (2001) Toxicol. Lett. , vol.122 , Issue.3 , pp. 223-234
    • Zhong, C.X.1    Mass, M.J.2
  • 99
    • 33845880624 scopus 로고    scopus 로고
    • Genome-wide analysis of Arabidopsis thaliana DNA methylation uncovers an interdependence between methylation and transcription
    • Zilberman, D., Gehring, M., Tran, R.K. et al. (2006) Genome-wide analysis of Arabidopsis thaliana DNA methylation uncovers an interdependence between methylation and transcription. Nat. Genet., 39 (1), 61-69.
    • (2006) Nat. Genet. , vol.39 , Issue.1 , pp. 61-69
    • Zilberman, D.1    Gehring, M.2    Tran, R.K.3
  • 100
    • 0036801403 scopus 로고    scopus 로고
    • Molecular mechanisms in nickel carcinogenesis: modeling Ni (II) binding site in histone H4
    • Zoroddu, M.A., Schinocca, L., Kowalik-Jankowska, T. et al. (2002) Molecular mechanisms in nickel carcinogenesis: modeling Ni (II) binding site in histone H4. Environ. Health Perspect., 110 (Suppl 5), 719.
    • (2002) Environ. Health Perspect. , vol.110 , Issue.SUPPL 5 , pp. 719
    • Zoroddu, M.A.1    Schinocca, L.2    Kowalik-Jankowska, T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.