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Volumn 129, Issue 5, 2011, Pages 1031-1041

Epigenetic markers for chemosensitivity and chemoresistance in pancreatic cancer-A review

Author keywords

chemoresistance; gemcitabine; miRNA; pancreatic cancer

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; ALPHA5 INTEGRIN; BIOLOGICAL MARKER; CALVASCULIN; CARCINOEMBRYONIC ANTIGEN RELATED CELL ADHESION MOLECULE; CURCUMIN; EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 1; FOCAL ADHESION KINASE; GEMCITABINE; GENISTEIN; GLYCOPROTEIN; HIGH MOBILITY GROUP A1A PROTEIN; INTEGRIN LINKED KINASE; ISOFLAVONE; JAGGED1; LAMININ; LUPEOL; MICRORNA; NOTCH2 RECEPTOR; OMEGA 3 FATTY ACID; PROTEIN BNIP3; PROTEIN KINASE; RIBONUCLEOTIDE REDUCTASE; RIBONUCLEOTIDE REDUCTASE M1; RIBONUCLEOTIDE REDUCTASE M2; SALAZOSULFAPYRIDINE; TELOMERASE REVERSE TRANSCRIPTASE; THYMIDYLATE SYNTHASE; UNCLASSIFIED DRUG;

EID: 79959652668     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.26078     Document Type: Review
Times cited : (28)

References (108)
  • 2
    • 1642588228 scopus 로고    scopus 로고
    • Pancreatic cancer
    • DOI 10.1016/S0140-6736(04)15841-8, PII S0140673604158418
    • Li D, Xie K, Wolff R, Abbruzzese JL,. Pancreatic cancer. Lancet 2004; 363: 1049-57. (Pubitemid 38410779)
    • (2004) Lancet , vol.363 , Issue.9414 , pp. 1049-1057
    • Li, D.1    Xie, K.2    Wolff, R.3    Abbruzzese, J.L.4
  • 4
    • 67349117952 scopus 로고    scopus 로고
    • Treatment of advanced pancreatic cancer: From gemcitabine single agent to combinations and targeted therapy
    • Rivera F, Lopez-Tarruella S, Vega-Villegas ME, Salcedo M,. Treatment of advanced pancreatic cancer: from gemcitabine single agent to combinations and targeted therapy. Cancer Treat Rev 2009; 35: 335-9.
    • (2009) Cancer Treat Rev , vol.35 , pp. 335-339
    • Rivera, F.1    Lopez-Tarruella, S.2    Vega-Villegas, M.E.3    Salcedo, M.4
  • 7
    • 60149088848 scopus 로고    scopus 로고
    • Origins and mechanisms of miRNAs and siRNAs
    • Carthew RW, Sontheimer EJ,. Origins and mechanisms of miRNAs and siRNAs. Cell 2009; 136: 642-55.
    • (2009) Cell , vol.136 , pp. 642-655
    • Carthew, R.W.1    Sontheimer, E.J.2
  • 11
    • 0036057585 scopus 로고    scopus 로고
    • Acquired resistance of pancreatic cancer cells towards 5-fluorouracil and gemcitabine is associated with altered expression of apoptosis-regulating genes
    • DOI 10.1159/000065068
    • Shi X, Liu S, Kleeff J, Friess H, Buchler MW,. Acquired resistance of pancreatic cancer cells towards 5-fluorouracil and gemcitabine is associated with altered expression of apoptosis-regulating genes. Oncology 2002; 62: 354-62. (Pubitemid 34914105)
    • (2002) Oncology , vol.62 , Issue.4 , pp. 354-362
    • Shi, X.1    Liu, S.2    Kleeff, J.3    Friess, H.4    Buchler, M.W.5
  • 12
    • 34547120221 scopus 로고    scopus 로고
    • S100A4 contributes to the suppression of BNIP3 expression, chemoresistance, and inhibition of apoptosis in pancreatic cancer
    • DOI 10.1158/0008-5472.CAN-07-0440
    • Mahon PC, Baril P, Bhakta V, Chelala C, Caulee K, Harada T, Lemoine NR,. S100A4 contributes to the suppression of BNIP3 expression, chemoresistance, and inhibition of apoptosis in pancreatic cancer. Cancer Res 2007; 67: 6786-95. (Pubitemid 47105526)
    • (2007) Cancer Research , vol.67 , Issue.14 , pp. 6786-6795
    • Mahon, P.C.1    Baril, P.2    Bhakta, V.3    Chelala, C.4    Caulee, K.5    Harada, T.6    Lemoine, N.R.7
  • 13
    • 0038621384 scopus 로고    scopus 로고
    • Role of NF-κB and Akt/PI3K in the resistance of pancreatic carcinoma cell lines against gemcitabine-induced cell death
    • DOI 10.1038/sj.onc.1206390
    • Arlt A, Gehrz A, Muerkoster S, Vorndamm J, Kruse ML, Folsch UR, Schafer H,. Role of NF-kappaB and Akt/PI3K in the resistance of pancreatic carcinoma cell lines against gemcitabine-induced cell death. Oncogene 2003; 22: 3243-51. (Pubitemid 36712936)
    • (2003) Oncogene , vol.22 , Issue.21 , pp. 3243-3251
    • Arlt, A.1    Gehrz, A.2    Muerkoster, S.3    Vorndamm, J.4    Kruse, M.-L.5    Folsch, U.R.6    Schafer, H.7
  • 14
    • 74549213069 scopus 로고    scopus 로고
    • Intrinsic chemoresistance to gemcitabine is associated with constitutive and laminin-induced phosphorylation of FAK in pancreatic cancer cell lines
    • Huanwen W, Zhiyong L, Xiaohua S, Xinyu R, Kai W, Tonghua L,. Intrinsic chemoresistance to gemcitabine is associated with constitutive and laminin-induced phosphorylation of FAK in pancreatic cancer cell lines. Mol Cancer 2009; 8: 125.
    • (2009) Mol Cancer , vol.8 , pp. 125
    • Huanwen, W.1    Zhiyong, L.2    Xiaohua, S.3    Xinyu, R.4    Kai, W.5    Tonghua, L.6
  • 15
    • 0842329842 scopus 로고    scopus 로고
    • CEACAM6 gene silencing impairs anoikis resistance and in vivo metastatic ability of pancreatic adenocarcinoma cells
    • DOI 10.1038/sj.onc.1207036
    • Duxbury MS, Ito H, Zinner MJ, Ashley SW, Whang EE,. CEACAM6 gene silencing impairs anoikis resistance and in vivo metastatic ability of pancreatic adenocarcinoma cells. Oncogene 2004; 23: 465-73. (Pubitemid 38175001)
    • (2004) Oncogene , vol.23 , Issue.2 , pp. 465-473
    • Duxbury, M.S.1    Ito, H.2    Zinner, M.J.3    Ashley, S.W.4    Whang, E.E.5
  • 17
    • 40949087142 scopus 로고    scopus 로고
    • HMGA1 is a molecular determinant of chemoresistance to gemcitabine in pancreatic adenocarcinoma
    • DOI 10.1158/1078-0432.CCR-07-1450
    • Liau SS, Whang E,. HMGA1 is a molecular determinant of chemoresistance to gemcitabine in pancreatic adenocarcinoma. Clin Cancer Res 2008; 14: 1470-7. (Pubitemid 351413931)
    • (2008) Clinical Cancer Research , vol.14 , Issue.5 , pp. 1470-1477
    • Liau, S.-S.1    Whang, E.E.2
  • 18
    • 18244381555 scopus 로고    scopus 로고
    • RNA interference demonstrates a novel role for integrin-linked kinase as a determinant of pancreatic adenocarcinoma cell gemcitabine chemoresistance
    • DOI 10.1158/1078-0432.CCR-04-1510
    • Duxbury MS, Ito H, Benoit E, Waseem T, Ashley SW, Whang EE,. RNA interference demonstrates a novel role for integrin-linked kinase as a determinant of pancreatic adenocarcinoma cell gemcitabine chemoresistance. Clin Cancer Res 2005; 11: 3433-8. (Pubitemid 40627897)
    • (2005) Clinical Cancer Research , vol.11 , Issue.9 , pp. 3433-3438
    • Duxbury, M.S.1    Ito, H.2    Benoit, E.3    Waseem, T.4    Ashley, S.W.5    Whang, E.E.6
  • 19
    • 36349006961 scopus 로고    scopus 로고
    • Development and characterization of gemcitabine-resistant pancreatic tumor cells
    • DOI 10.1245/s10434-007-9583-5
    • Shah AN, Summy JM, Zhang J, Park SI, Parikh NU, Gallick GE,. Development and characterization of gemcitabine-resistant pancreatic tumor cells. Ann Surg Oncol 2007; 14: 3629-37. (Pubitemid 350160137)
    • (2007) Annals of Surgical Oncology , vol.14 , Issue.12 , pp. 3629-3637
    • Shah, A.N.1    Summy, J.M.2    Zhang, J.3    Park, S.I.4    Parikh, N.U.5    Gallick, G.E.6
  • 20
    • 65549141305 scopus 로고    scopus 로고
    • Acquisition of epithelial-mesenchymal transition phenotype of gemcitabine-resistant pancreatic cancer cells is linked with activation of the notch signaling pathway
    • Wang Z, Li Y, Kong D, Banerjee S, Ahmad A, Azmi AS, Ali S, Abbruzzese JL, Gallick GE, Sarkar FH,. Acquisition of epithelial-mesenchymal transition phenotype of gemcitabine-resistant pancreatic cancer cells is linked with activation of the notch signaling pathway. Cancer Res 2009; 69: 2400-7.
    • (2009) Cancer Res , vol.69 , pp. 2400-2407
    • Wang, Z.1    Li, Y.2    Kong, D.3    Banerjee, S.4    Ahmad, A.5    Azmi, A.S.6    Ali, S.7    Abbruzzese, J.L.8    Gallick, G.E.9    Sarkar, F.H.10
  • 23
    • 77951705674 scopus 로고    scopus 로고
    • Identifying molecular markers for chemosensitivity to gemcitabine in pancreatic cancer: Increased expression of interferon-stimulated gene 15 kD is associated with intrinsic chemoresistance
    • Ina S, Hirono S, Noda T, Yamaue H,. Identifying molecular markers for chemosensitivity to gemcitabine in pancreatic cancer: increased expression of interferon-stimulated gene 15 kD is associated with intrinsic chemoresistance. Pancreas 2010; 39: 473-85.
    • (2010) Pancreas , vol.39 , pp. 473-485
    • Ina, S.1    Hirono, S.2    Noda, T.3    Yamaue, H.4
  • 24
    • 1542742114 scopus 로고    scopus 로고
    • RNA interference targeting the M2 subunit of ribonucleotide reductase enhances pancreatic adenocarcinoma chemosensitivity to gemcitabine
    • DOI 10.1038/sj.onc.1207272
    • Duxbury MS, Ito H, Zinner MJ, Ashley SW, Whang EE,. RNA interference targeting the M2 subunit of ribonucleotide reductase enhances pancreatic adenocarcinoma chemosensitivity to gemcitabine. Oncogene 2004; 23: 1539-48. (Pubitemid 38406516)
    • (2004) Oncogene , vol.23 , Issue.8 , pp. 1539-1548
    • Duxbury, M.S.1    Ito, H.2    Zinner, M.J.3    Ashley, S.W.4    Whang, E.E.5
  • 25
    • 1642551021 scopus 로고    scopus 로고
    • Inhibition of Src Tyrosine Kinase Impairs Inherent and Acquired Gemcitabine Resistance in Human Pancreatic Adenocarcinoma Cells
    • DOI 10.1158/1078-0432.CCR-1183-3
    • Duxbury MS, Ito H, Zinner MJ, Ashley SW, Whang EE,. Inhibition of SRC tyrosine kinase impairs inherent and acquired gemcitabine resistance in human pancreatic adenocarcinoma cells. Clin Cancer Res 2004; 10: 2307-18. (Pubitemid 38445688)
    • (2004) Clinical Cancer Research , vol.10 , Issue.7 , pp. 2307-2318
    • Duxbury, M.S.1    Ito, H.2    Zinner, M.J.3    Ashley, S.W.4    Whang, E.E.5
  • 26
    • 50249152822 scopus 로고    scopus 로고
    • Ex vivo chemosensitivity testing and gene expression profiling predict response towards adjuvant gemcitabine treatment in pancreatic cancer
    • Michalski CW, Erkan M, Sauliunaite D, Giese T, Stratmann R, Sartori C, Giese NA, Friess H, Kleeff J,. Ex vivo chemosensitivity testing and gene expression profiling predict response towards adjuvant gemcitabine treatment in pancreatic cancer. Br J Cancer 2008; 99: 760-7.
    • (2008) Br J Cancer , vol.99 , pp. 760-767
    • Michalski, C.W.1    Erkan, M.2    Sauliunaite, D.3    Giese, T.4    Stratmann, R.5    Sartori, C.6    Giese, N.A.7    Friess, H.8    Kleeff, J.9
  • 27
    • 25444493107 scopus 로고    scopus 로고
    • Molecular evidence for increased antitumor activity of gemcitabine by genistein in vitro and in vivo using an orthotopic model of pancreatic cancer
    • DOI 10.1158/0008-5472.CAN-05-1330
    • Banerjee S, Zhang Y, Ali S, Bhuiyan M, Wang Z, Chiao PJ, Philip PA, Abbruzzese J, Sarkar FH,. Molecular evidence for increased antitumor activity of gemcitabine by genistein in vitro and in vivo using an orthotopic model of pancreatic cancer. Cancer Res 2005; 65: 9064-72. (Pubitemid 41377399)
    • (2005) Cancer Research , vol.65 , Issue.19 , pp. 9064-9072
    • Banerjee, S.1    Zhang, Y.2    Ali, S.3    Bhuiyan, M.4    Wang, Z.5    Chiao, P.J.6    Philip, P.A.7    Abbruzzese, J.8    Sarkar, F.H.9
  • 28
    • 34248573808 scopus 로고    scopus 로고
    • Curcumin potentiates antitumor activity of gemcitabine in an orthotopic model of pancreatic cancer through suppression of proliferation, angiogenesis, and inhibition of nuclear factor-κB-regulated gene products
    • DOI 10.1158/0008-5472.CAN-06-4257
    • Kunnumakkara AB, Guha S, Krishnan S, Diagaradjane P, Gelovani J, Aggarwal BB,. Curcumin potentiates antitumor activity of gemcitabine in an orthotopic model of pancreatic cancer through suppression of proliferation, angiogenesis, and inhibition of nuclear factor-kappaB-regulated gene products. Cancer Res 2007; 67: 3853-61. (Pubitemid 46762173)
    • (2007) Cancer Research , vol.67 , Issue.8 , pp. 3853-3861
    • Kunnumakkara, A.B.1    Guha, S.2    Krishnan, S.3    Diagaradjane, P.4    Gelovani, J.5    Aggarwal, B.B.6
  • 29
    • 21744434389 scopus 로고    scopus 로고
    • Loss of BNIP3 expression is a late event in pancreatic cancer contributing to chemoresistance and worsened prognosis
    • DOI 10.1038/sj.onc.1208642
    • Erkan M, Kleeff J, Esposito I, Giese T, Ketterer K, Buchler MW, Giese NA, Friess H,. Loss of BNIP3 expression is a late event in pancreatic cancer contributing to chemoresistance and worsened prognosis. Oncogene 2005; 24: 4421-32. (Pubitemid 40961765)
    • (2005) Oncogene , vol.24 , Issue.27 , pp. 4421-4432
    • Erkan, M.1    Kleeff, J.2    Esposito, I.3    Giese, T.4    Ketterer, K.5    Buchler, M.W.6    Giese, N.A.7    Friess, H.8
  • 31
    • 38649085043 scopus 로고    scopus 로고
    • Telomerase transcriptional targeting of inducible bax/TRAIL gene therapy improves gemcitabine treatment of pancreatic cancer
    • DOI 10.1038/sj.mt.6300340, PII 6300340
    • Wack S, Rejiba S, Parmentier C, Aprahamian M, Hajri A,. Telomerase transcriptional targeting of inducible Bax/TRAIL gene therapy improves gemcitabine treatment of pancreatic cancer. Mol Ther 2008; 16: 252-60. (Pubitemid 351168033)
    • (2008) Molecular Therapy , vol.16 , Issue.2 , pp. 252-260
    • Wack, S.1    Rejiba, S.2    Parmentier, C.3    Aprahamian, M.4    Hajri, A.5
  • 32
    • 59149087882 scopus 로고    scopus 로고
    • Suppression of cFLIP by lupeol, a dietary triterpene, is sufficient to overcome resistance to TRAIL-mediated apoptosis in chemoresistant human pancreatic cancer cells
    • Murtaza I, Saleem M, Adhami VM, Hafeez BB, Mukhtar H,. Suppression of cFLIP by lupeol, a dietary triterpene, is sufficient to overcome resistance to TRAIL-mediated apoptosis in chemoresistant human pancreatic cancer cells. Cancer Res 2009; 69: 1156-65.
    • (2009) Cancer Res , vol.69 , pp. 1156-1165
    • Murtaza, I.1    Saleem, M.2    Adhami, V.M.3    Hafeez, B.B.4    Mukhtar, H.5
  • 33
    • 67650496175 scopus 로고    scopus 로고
    • 3,3′-Diindolylmethane enhances chemosensitivity of multiple chemotherapeutic agents in pancreatic cancer
    • Banerjee S, Wang Z, Kong D, Sarkar FH,. 3,3′-Diindolylmethane enhances chemosensitivity of multiple chemotherapeutic agents in pancreatic cancer. Cancer Res 2009; 69: 5592-600.
    • (2009) Cancer Res , vol.69 , pp. 5592-5600
    • Banerjee, S.1    Wang, Z.2    Kong, D.3    Sarkar, F.H.4
  • 37
  • 38
    • 67650485895 scopus 로고    scopus 로고
    • Gemcitabine-based chemogene therapy for pancreatic cancer using Ad-dCK::UMK GDEPT and TS/RR siRNA strategies
    • Rejiba S, Bigand C, Parmentier C, Hajri A,. Gemcitabine-based chemogene therapy for pancreatic cancer using Ad-dCK::UMK GDEPT and TS/RR siRNA strategies. Neoplasia 2009; 11: 637-50.
    • (2009) Neoplasia , vol.11 , pp. 637-650
    • Rejiba, S.1    Bigand, C.2    Parmentier, C.3    Hajri, A.4
  • 39
    • 33846666657 scopus 로고    scopus 로고
    • Activation of integrin-linked kinase is a critical prosurvival pathway induced in leukemic cells by bone marrow-derived stromal cells
    • DOI 10.1158/0008-5472.CAN-06-3166
    • Tabe Y, Jin L, Tsutsumi-Ishii Y, Xu Y, McQueen T, Priebe W, Mills GB, Ohsaka A, Nagaoka I, Andreeff M, Konopleva M,. Activation of integrin-linked kinase is a critical prosurvival pathway induced in leukemic cells by bone marrow-derived stromal cells. Cancer Res 2007; 67: 684-94. (Pubitemid 46192208)
    • (2007) Cancer Research , vol.67 , Issue.2 , pp. 684-694
    • Tabe, Y.1    Jin, L.2    Tsutsumi-Ishii, Y.3    Xu, Y.4    McQueen, T.5    Priebe, W.6    Mills, G.B.7    Ohsaka, A.8    Nagaoka, I.9    Andreeff, M.10    Konopleva, M.11
  • 40
    • 27544505676 scopus 로고    scopus 로고
    • Chromatin modifier enzymes, the histone code and cancer
    • DOI 10.1016/j.ejca.2005.08.010, PII S0959804905007100, Transcription Factors in Cancer
    • Santos-Rosa H, Caldas C,. Chromatin modifier enzymes, the histone code and cancer. Eur J Cancer 2005; 41: 2381-402. (Pubitemid 41540617)
    • (2005) European Journal of Cancer , vol.41 , Issue.16 , pp. 2381-2402
    • Santos-Rosa, H.1    Caldas, C.2
  • 41
    • 0036830642 scopus 로고    scopus 로고
    • Role of histone H3 lysine 27 methylation in polycomb-group silencing
    • DOI 10.1126/science.1076997
    • Cao R, Wang L, Wang H, Xia L, Erdjument-Bromage H, Tempst P, Jones RS, Zhang Y,. Role of histone H3 lysine 27 methylation in Polycomb-group silencing. Science 2002; 298: 1039-43. (Pubitemid 35247314)
    • (2002) Science , vol.298 , Issue.5595 , pp. 1039-1043
    • Cao, R.1    Wang, L.2    Wang, H.3    Xia, L.4    Erdjument-Bromage, H.5    Tempst, P.6    Jones, R.S.7    Zhang, Y.8
  • 43
    • 0242539836 scopus 로고    scopus 로고
    • Cancer epigenetics
    • Momparler RL,. Cancer epigenetics. Oncogene 2003; 22: 6479-83. (Pubitemid 37372327)
    • (2003) Oncogene , vol.22 , Issue.43 , pp. 6479-6483
    • Momparler, R.L.1
  • 45
    • 58149214373 scopus 로고    scopus 로고
    • Regulation of pancreatic tumor cell proliferation and chemoresistance by the histone methyltransferase enhancer of zeste homologue 2
    • Ougolkov AV, Bilim VN, Billadeau DD,. Regulation of pancreatic tumor cell proliferation and chemoresistance by the histone methyltransferase enhancer of zeste homologue 2. Clin Cancer Res 2008; 14: 6790-6.
    • (2008) Clin Cancer Res , vol.14 , pp. 6790-6796
    • Ougolkov, A.V.1    Bilim, V.N.2    Billadeau, D.D.3
  • 46
    • 25844465921 scopus 로고    scopus 로고
    • Epigenetic therapy of cancer with 5-aza-2′-deoxycytidine (decitabine)
    • DOI 10.1053/j.seminoncol.2005.07.008, PII S0093775405002770, Cancer Epigenetics
    • Momparler RL,. Epigenetic therapy of cancer with 5-aza-2′- deoxycytidine (decitabine). Semin Oncol 2005; 32: 443-51. (Pubitemid 41396420)
    • (2005) Seminars in Oncology , vol.32 , Issue.5 , pp. 443-451
    • Momparler, R.L.1
  • 48
    • 67349285731 scopus 로고    scopus 로고
    • Enhancing the apoptotic and therapeutic effects of HDAC inhibitors
    • Frew AJ, Johnstone RW, Bolden JE,. Enhancing the apoptotic and therapeutic effects of HDAC inhibitors. Cancer Lett 2009; 280: 125-33.
    • (2009) Cancer Lett , vol.280 , pp. 125-133
    • Frew, A.J.1    Johnstone, R.W.2    Bolden, J.E.3
  • 50
    • 78650723028 scopus 로고    scopus 로고
    • Rationale for possible targeting of histone deacetylase signaling in cancer diseases with a special reference to pancreatic cancer
    • Ouaissi M, Giger U, Sielezneff I, Pirro N, Sastre B, Ouaissi A,. Rationale for possible targeting of histone deacetylase signaling in cancer diseases with a special reference to pancreatic cancer. J Biomed Biotechnol 2011; 2011: 315939.
    • (2011) J Biomed Biotechnol , vol.2011 , pp. 315939
    • Ouaissi, M.1    Giger, U.2    Sielezneff, I.3    Pirro, N.4    Sastre, B.5    Ouaissi, A.6
  • 51
    • 0038343499 scopus 로고    scopus 로고
    • MicroRNA pathways in flies and worms: Growth, death, fat, stress, and timing
    • DOI 10.1016/S0092-8674(03)00428-8
    • Ambros V,. MicroRNA pathways in flies and worms: growth, death, fat, stress, and timing. Cell 2003; 113: 673-6. (Pubitemid 36724931)
    • (2003) Cell , vol.113 , Issue.6 , pp. 673-676
    • Ambros, V.1
  • 52
    • 28044455435 scopus 로고    scopus 로고
    • microPrimer: The biogenesis and function of microRNA
    • DOI 10.1242/dev.02070
    • Du T, Zamore PD,. microPrimer: the biogenesis and function of microRNA. Development 2005; 132: 4645-52. (Pubitemid 41685275)
    • (2005) Development , vol.132 , Issue.21 , pp. 4645-4652
    • Du, T.1    Zamore, P.D.2
  • 53
    • 10744225153 scopus 로고    scopus 로고
    • Asymmetry in the assembly of the RNAi enzyme complex
    • DOI 10.1016/S0092-8674(03)00759-1
    • Schwarz DS, Hutvagner G, Du T, Xu Z, Aronin N, Zamore PD,. Asymmetry in the assembly of the RNAi enzyme complex. Cell 2003; 115: 199-208. (Pubitemid 37329583)
    • (2003) Cell , vol.115 , Issue.2 , pp. 199-208
    • Schwarz, D.S.1    Hutvagner, G.2    Du, T.3    Xu, Z.4    Aronin, N.5    Zamore, P.D.6
  • 54
    • 0037144546 scopus 로고    scopus 로고
    • A microRNA in a multiple-turnover RNAi enzyme complex
    • Hutvagner G, Zamore PD,. A microRNA in a multiple-turnover RNAi enzyme complex. Science 2002; 297: 2056-60.
    • (2002) Science , vol.297 , pp. 2056-2060
    • Hutvagner, G.1    Zamore, P.D.2
  • 55
    • 2442495329 scopus 로고    scopus 로고
    • RISC is a 5′ phosphomonoester-producing RNA endonuclease
    • Martinez J, Tuschl T,. RISC is a 5′ phosphomonoester-producing RNA endonuclease. Genes Dev 2004; 18: 975-80.
    • (2004) Genes Dev , vol.18 , pp. 975-980
    • Martinez, J.1    Tuschl, T.2
  • 56
    • 33749059160 scopus 로고    scopus 로고
    • MiRBase: The microRNA sequence database
    • Griffiths-Jones S,. miRBase: the microRNA sequence database. Methods Mol Biol 2006; 342: 129-38.
    • (2006) Methods Mol Biol , vol.342 , pp. 129-138
    • Griffiths-Jones, S.1
  • 58
    • 34247540446 scopus 로고    scopus 로고
    • Epigenetics and microRNAs
    • DOI 10.1203/pdr.0b013e3180457684
    • Chuang JC, Jones PA,. Epigenetics and microRNAs. Pediatr Res 2007; 61 (Part 2): 24R-29R. (Pubitemid 46653064)
    • (2007) Pediatric Research , vol.61 , Issue.5 PART 2 SUPPL.
    • Chuang, J.C.1    Jones, P.A.2
  • 60
    • 55549120234 scopus 로고    scopus 로고
    • MicroRNA miR-21 overexpression in human breast cancer is associated with advanced clinical stage, lymph node metastasis and patient poor prognosis
    • Yan LX, Huang XF, Shao Q, Huang MY, Deng L, Wu QL, Zeng YX, Shao JY,. MicroRNA miR-21 overexpression in human breast cancer is associated with advanced clinical stage, lymph node metastasis and patient poor prognosis. RNA 2008; 14: 2348-60.
    • (2008) RNA , vol.14 , pp. 2348-2360
    • Yan, L.X.1    Huang, X.F.2    Shao, Q.3    Huang, M.Y.4    Deng, L.5    Wu, Q.L.6    Zeng, Y.X.7    Shao, J.Y.8
  • 64
    • 34547524771 scopus 로고    scopus 로고
    • MicroRNA-21 Regulates Expression of the PTEN Tumor Suppressor Gene in Human Hepatocellular Cancer
    • DOI 10.1053/j.gastro.2007.05.022, PII S0016508507010025
    • Meng F, Henson R, Wehbe-Janek H, Ghoshal K, Jacob ST, Patel T,. MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer. Gastroenterology 2007; 133: 647-58. (Pubitemid 47187346)
    • (2007) Gastroenterology , vol.133 , Issue.2 , pp. 647-658
    • Meng, F.1    Henson, R.2    Wehbe-Janek, H.3    Ghoshal, K.4    Jacob, S.T.5    Patel, T.6
  • 66
    • 70350425809 scopus 로고    scopus 로고
    • MicroRNAs: Novel diagnostic and therapeutic tools for pancreatic ductal adenocarcinoma?
    • Mardin WA, Mees ST,. MicroRNAs: novel diagnostic and therapeutic tools for pancreatic ductal adenocarcinoma? Ann Surg Oncol 2009; 16: 3183-9.
    • (2009) Ann Surg Oncol , vol.16 , pp. 3183-3189
    • Mardin, W.A.1    Mees, S.T.2
  • 78
    • 70349904531 scopus 로고    scopus 로고
    • Antisense inhibition of microRNA-21 or -221 arrests cell cycle, induces apoptosis, and sensitizes the effects of gemcitabine in pancreatic adenocarcinoma
    • Park JK, Lee EJ, Esau C, Schmittgen TD,. Antisense inhibition of microRNA-21 or -221 arrests cell cycle, induces apoptosis, and sensitizes the effects of gemcitabine in pancreatic adenocarcinoma. Pancreas 2009; 38: e190-e199.
    • (2009) Pancreas , vol.38
    • Park, J.K.1    Lee, E.J.2    Esau, C.3    Schmittgen, T.D.4
  • 79
    • 77951745289 scopus 로고    scopus 로고
    • Gemcitabine sensitivity can be induced in pancreatic cancer cells through modulation of miR-200 and miR-21 expression by curcumin or its analogue CDF
    • Ali S, Ahmad A, Banerjee S, Padhye S, Dominiak K, Schaffert JM, Wang Z, Philip PA, Sarkar FH,. Gemcitabine sensitivity can be induced in pancreatic cancer cells through modulation of miR-200 and miR-21 expression by curcumin or its analogue CDF. Cancer Res 2010; 70: 3606-17.
    • (2010) Cancer Res , vol.70 , pp. 3606-3617
    • Ali, S.1    Ahmad, A.2    Banerjee, S.3    Padhye, S.4    Dominiak, K.5    Schaffert, J.M.6    Wang, Z.7    Philip, P.A.8    Sarkar, F.H.9
  • 80
    • 69249096109 scopus 로고    scopus 로고
    • Up-regulation of miR-200 and let-7 by natural agents leads to the reversal of epithelial-to-mesenchymal transition in gemcitabine-resistant pancreatic cancer cells
    • Li Y, VandenBoom TG, II, Kong D, Wang Z, Ali S, Philip PA, Sarkar FH,. Up-regulation of miR-200 and let-7 by natural agents leads to the reversal of epithelial-to-mesenchymal transition in gemcitabine-resistant pancreatic cancer cells. Cancer Res 2009; 69: 6704-12.
    • (2009) Cancer Res , vol.69 , pp. 6704-6712
    • Li, Y.1    Vandenboom, I.I.T.G.2    Kong, D.3    Wang, Z.4    Ali, S.5    Philip, P.A.6    Sarkar, F.H.7
  • 82
    • 77953782181 scopus 로고    scopus 로고
    • MicroRNA-21 is a downstream effector of AKT that mediates its antiapoptotic effects via suppression of Fas ligand
    • Sayed D, He M, Hong C, Gao S, Rane S, Yang Z, Abdellatif M,. MicroRNA-21 is a downstream effector of AKT that mediates its antiapoptotic effects via suppression of Fas ligand. J Biol Chem 2010; 285: 20281-90.
    • (2010) J Biol Chem , vol.285 , pp. 20281-20290
    • Sayed, D.1    He, M.2    Hong, C.3    Gao, S.4    Rane, S.5    Yang, Z.6    Abdellatif, M.7
  • 83
    • 69049087664 scopus 로고    scopus 로고
    • Cellular signaling perturbation by natural products
    • Sarkar FH, Li Y, Wang Z, Kong D,. Cellular signaling perturbation by natural products. Cell Signal 2009; 21: 1541-7.
    • (2009) Cell Signal , vol.21 , pp. 1541-1547
    • Sarkar, F.H.1    Li, Y.2    Wang, Z.3    Kong, D.4
  • 84
    • 70350225860 scopus 로고    scopus 로고
    • Harnessing the fruits of nature for the development of multi-targeted cancer therapeutics
    • Sarkar FH, Li Y,. Harnessing the fruits of nature for the development of multi-targeted cancer therapeutics. Cancer Treat Rev 2009; 35: 597-607.
    • (2009) Cancer Treat Rev , vol.35 , pp. 597-607
    • Sarkar, F.H.1    Li, Y.2
  • 85
    • 33645473185 scopus 로고    scopus 로고
    • Down-regulation of Notch-1 contributes to cell growth inhibition and apoptosis in pancreatic cancer cells
    • Wang Z, Zhang Y, Li Y, Banerjee S, Liao J, Sarkar FH,. Down-regulation of Notch-1 contributes to cell growth inhibition and apoptosis in pancreatic cancer cells. Mol Cancer Ther 2006; 5: 483-93.
    • (2006) Mol Cancer Ther , vol.5 , pp. 483-493
    • Wang, Z.1    Zhang, Y.2    Li, Y.3    Banerjee, S.4    Liao, J.5    Sarkar, F.H.6
  • 86
    • 33645064160 scopus 로고    scopus 로고
    • Inhibition of nuclear factor kappab activity by genistein is mediated via Notch-1 signaling pathway in pancreatic cancer cells
    • Wang Z, Zhang Y, Banerjee S, Li Y, Sarkar FH,. Inhibition of nuclear factor kappab activity by genistein is mediated via Notch-1 signaling pathway in pancreatic cancer cells. Int J Cancer 2006; 118: 1930-6.
    • (2006) Int J Cancer , vol.118 , pp. 1930-1936
    • Wang, Z.1    Zhang, Y.2    Banerjee, S.3    Li, Y.4    Sarkar, F.H.5
  • 88
    • 68049097296 scopus 로고    scopus 로고
    • MicroRNAs and parallel stem cell lives
    • Dirks PB,. MicroRNAs and parallel stem cell lives. Cell 2009; 138: 423-4.
    • (2009) Cell , vol.138 , pp. 423-424
    • Dirks, P.B.1
  • 97
    • 1242318826 scopus 로고    scopus 로고
    • Sequence-specific inhibition of microRNA-and siRNA-induced RNA silencing
    • DOI 10.1261/rna.5235104
    • Meister G, Landthaler M, Dorsett Y, Tuschl T,. Sequence-specific inhibition of microRNA- and siRNA-induced RNA silencing. RNA 2004; 10: 544-50. (Pubitemid 38241013)
    • (2004) RNA , vol.10 , Issue.3 , pp. 544-550
    • Meister, G.1    Landthaler, M.2    Dorsett, Y.3    Tuschl, T.4
  • 103
    • 77950602604 scopus 로고    scopus 로고
    • Effects of microRNA-29 on apoptosis, tumorigenicity, and prognosis of hepatocellular carcinoma
    • Xiong Y, Fang JH, Yun JP, Yang J, Zhang Y, Jia WH, Zhuang SM,. Effects of microRNA-29 on apoptosis, tumorigenicity, and prognosis of hepatocellular carcinoma. Hepatology 2010; 51: 836-45.
    • (2010) Hepatology , vol.51 , pp. 836-845
    • Xiong, Y.1    Fang, J.H.2    Yun, J.P.3    Yang, J.4    Zhang, Y.5    Jia, W.H.6    Zhuang, S.M.7
  • 105
    • 77954386183 scopus 로고    scopus 로고
    • The road toward microRNA therapeutics
    • Seto AG,. The road toward microRNA therapeutics. Int J Biochem Cell Biol 2010; 42: 1298-305.
    • (2010) Int J Biochem Cell Biol , vol.42 , pp. 1298-1305
    • Seto, A.G.1
  • 107
    • 77957361864 scopus 로고    scopus 로고
    • Targeting microRNAs in cancer: Rationale, strategies and challenges
    • Garzon R, Marcucci G, Croce CM,. Targeting microRNAs in cancer: rationale, strategies and challenges. Nat Rev Drug Discov 2010; 9: 775-89.
    • (2010) Nat Rev Drug Discov , vol.9 , pp. 775-789
    • Garzon, R.1    Marcucci, G.2    Croce, C.M.3
  • 108
    • 77953022034 scopus 로고    scopus 로고
    • Implication of microRNAs in drug resistance for designing novel cancer therapy
    • Sarkar FH, Li Y, Wang Z, Kong D, Ali S,. Implication of microRNAs in drug resistance for designing novel cancer therapy. Drug Resist Updat 2010; 13: 57-66.
    • (2010) Drug Resist Updat , vol.13 , pp. 57-66
    • Sarkar, F.H.1    Li, Y.2    Wang, Z.3    Kong, D.4    Ali, S.5


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