The molecular mechanisms of allosteric mutations impairing MepR repressor function in multidrug-resistant strains of Staphylococcus aureus

mBio

Volumn 4, Issue 5, 2013, Pages

  Birukou, Ivan ^a   Tonthat, Nam K ^a   Seo, Susan M ^b   Schindler, Bryan D ^b   Kaatz, Glenn W ^b,c   Brennan, Richard G ^a  

^a DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOSTERISM; AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DIMERIZATION; DNA BINDING; DNA CONFORMATION; GENE FUNCTION; GENE MUTATION; GENETIC COMPATIBILITY; GENETIC VARIABILITY; MEPR GENE; MOLECULAR MECHANICS; MULTIDRUG RESISTANT STAPHYLOCOCCUS AUREUS; NONHUMAN; OPERATOR GENE; PRIORITY JOURNAL; PROTEIN UNFOLDING; REPRESSOR GENE; STAPHYLOCOCCUS AUREUS; THERMODYNAMICS;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BINDING SITES; DRUG RESISTANCE, MULTIPLE, BACTERIAL; GENE EXPRESSION REGULATION, BACTERIAL; HUMANS; MODELS, MOLECULAR; MUTATION, MISSENSE; PROTEIN BINDING; REPRESSOR PROTEINS; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS;

EID: 84887142118     PISSN: 21612129     EISSN: 21507511     Source Type: Journal    
DOI: 10.1128/mBio.00528-13     Document Type: Article

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