Efflux-mediated bis-indole resistance in Staphylococcus aureus reveals differential substrate specificities for MepA and MepR

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 6, 2010, Pages 2123-2130

  Opperman, Timothy J ^a   Williams, John D ^a   Houseweart, Chad ^a   Panchal, Rekha G ^b   Bavari, Sina ^b   Peet, Norton P ^a   Moir, Donald T ^a   Bowlin, Terry L ^a  

^a MICROBIOTIX INC   (United States)

^b UNITED STATES ARMY MEDICAL RESEARCH INSTITUTE OF INFECTIOUS DISEASES   (United States)

Author keywords

Bis indole antibiotics; Efflux; MepA; MepR; Resistance; Staphylococcus aureus

Indexed keywords

ANTIBIOTIC AGENT; BACTERIAL PROTEIN; CARBENICILLIN; CIPROFLOXACIN; DISTAMYCIN A; ENROFLOXACIN; INDOLE DERIVATIVE; MBX 1066; MBX 1090; MBX 1113; MBX 1128; MBX 1162; PROTEIN MEPA; PROTEIN MEPR; PSEUDOMONIC ACID; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GENE; BACTERIUM MUTANT; CONTROLLED STUDY; DRUG SPECIFICITY; ENZYME SPECIFICITY; GENE LOCUS; MEPA GENE; MEPR GENE; NONHUMAN; NUCLEOTIDE SEQUENCE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STAPHYLOCOCCUS AUREUS;

BACTERIAL PROTEINS; DRUG RESISTANCE, BACTERIAL; INDOLES; MICROBIAL SENSITIVITY TESTS; MUTATION; REPRESSOR PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STAPHYLOCOCCUS AUREUS; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

NEGIBACTERIA; POSIBACTERIA; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS AUREUS SUBSP. AUREUS NCTC 8325;

EID: 77649234521     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.02.005     Document Type: Article

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