Optimizing a chromatographic three component separation: A comparison of mechanistic and empiric modeling approaches

Journal of Chromatography A

Volumn 1237, Issue , 2012, Pages 86-95

  Osberghaus, A ^a   Hepbildikler, S ^b   Nath, S ^b   Haindl, M ^b   von Lieres, E ^c   Hubbuch, J ^a  

^a KARLSRUHE INSTITUTE OF TECHNOLOGY   (Germany)

^b ROCHE DIAGNOSTICS GMBH   (Germany)

^c FORSCHUNGSZENTRUM JÜLICH   (Germany)

Author keywords

Design of experiments; Ion exchange chromatography; Mechanistic modeling; Response surface modeling; Separation optimization; Steric mass action (SMA)

Indexed keywords

ION EXCHANGE CHROMATOGRAPHY; MECHANISTIC MODELING; RESPONSE SURFACE MODELING; SEPARATION OPTIMIZATIONS; STERIC MASS ACTION;

CHROMATOGRAPHIC ANALYSIS; CHROMATOGRAPHY; DESIGN OF EXPERIMENTS; FORECASTING; GEL PERMEATION CHROMATOGRAPHY; SEPARATION; SURFACE PROPERTIES;

OPTIMIZATION;

CYTOCHROME C; RIBONUCLEASE A;

ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; HIGH THROUGHPUT SCREENING; ION EXCHANGE CHROMATOGRAPHY; LYSOSOME; PRIORITY JOURNAL; PROCESS OPTIMIZATION; RESPONSE SURFACE METHOD;

CHROMATOGRAPHY, ION EXCHANGE; MODELS, THEORETICAL; PROTEINS;

EID: 84859652583     PISSN: 00219673     EISSN: 18733778     Source Type: Journal    
DOI: 10.1016/j.chroma.2012.03.029     Document Type: Article

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