Prehospital hypertonic saline resuscitation attenuates the activation and promotes apoptosis of neutrophils in patients with severe traumatic brain injury

Shock

Volumn 40, Issue 5, 2013, Pages 366-374

  Junger, Wolfgang G ^a,f   Rhind, Shawn G ^b   Rizoli, Sandro B ^c   Cuschieri, Joseph ^d   Baker, Andrew J ^c   Shek, Pang N ^b   Hoyt, David B ^e   Bulger, Eileen M ^d  

^a HARVARD MEDICAL SCHOOL   (United States)

^b DEFENCE RESEARCH AND DEVELOPMENT CANADA   (Canada)

^c ST MICHAEL'S HOSPITAL   (Canada)

^d UNIVERSITY OF WASHINGTON   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

adhesion molecules; apoptosis; hemorrhage; Hypertonic saline; inflammation; multi organ failure; neutrophils; oxidative burst; resuscitation fluids

Indexed keywords

ANTIGEN; CD11B ANTIGEN; CD63 ANTIGEN; CD64 ANTIGEN; CELL MARKER; CELL SURFACE RECEPTOR; COMPLEMENT COMPONENT C3B RECEPTOR; DEXTRAN 70; HYPERTONIC SOLUTION; INFUSION FLUID; L SELECTIN; SODIUM CHLORIDE;

ADULT; APOPTOSIS; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; DEGRANULATION; EMERGENCY CARE; FEMALE; FLOW CYTOMETRY; FLUID RESUSCITATION; GLASGOW OUTCOME SCALE; HOSPITAL ADMISSION; HUMAN; INJURY SEVERITY; LEUKOCYTE ACTIVATION; LEUKOCYTE ADHERENCE; MAJOR CLINICAL STUDY; MALE; MORTALITY; NEUTROPHIL; NEUTROPHIL COUNT; OUTCOME ASSESSMENT; RESPIRATORY BURST; TRAUMATIC BRAIN INJURY;

ADOLESCENT; ADULT; APOPTOSIS; BIOLOGICAL MARKERS; BRAIN INJURIES; CELL ADHESION MOLECULES; CELL DEGRANULATION; DEXTRANS; DOUBLE-BLIND METHOD; EMERGENCY MEDICAL SERVICES; FEMALE; FLUID THERAPY; HUMANS; LEUKOCYTE COUNT; MALE; MIDDLE AGED; NEUTROPHIL ACTIVATION; NEUTROPHILS; PLASMA SUBSTITUTES; RESPIRATORY BURST; RESUSCITATION; SALINE SOLUTION, HYPERTONIC; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84887109203     PISSN: 10732322     EISSN: 15400514     Source Type: Journal    
DOI: 10.1097/SHK.0000000000000038     Document Type: Article

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