Selective potentiation of (α4)3(β2)2 nicotinic acetylcholine receptors augments amplitudes of prefrontal acetylcholine- and nicotine-evoked glutamatergic transients in rats

Biochemical Pharmacology

Volumn 86, Issue 10, 2013, Pages 1487-1496

  Grupe, Morten ^a,b,c,d   Paolone, Giovanna ^a   Jensen, Anders A ^b   Sandager Nielsen, Karin ^c   Sarter, Martin ^a   Grunnet, Morten ^c  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c NEUROSEARCH A S   (Denmark)

^d H LUNDBECK A S   (Denmark)

Author keywords

4 2; Nicotinic acetylcholine receptor; NS9283; Positive allosteric modulator; Prefrontal glutamate release

Indexed keywords

ACETYLCHOLINE; CHOLINERGIC RECEPTOR STIMULATING AGENT; GLUTAMIC ACID; NICOTINE; NICOTINIC RECEPTOR ALPHA4BETA2; NS 9283; UNCLASSIFIED DRUG; URETHAN;

ALLOSTERISM; AMPLITUDE MODULATION; ANESTHESIA; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN DEPTH RECORDING; CELL STRAIN HEK293; CONTROLLED STUDY; DRUG POTENTIATION; EMBRYO; EVOKED RESPONSE; HUMAN; HUMAN CELL; INTRACRANIAL PRESSURE; MALE; MICRODIALYSIS; MICROELECTRODE; NEUROTRANSMISSION; NEUROTRANSMITTER RELEASE; NONHUMAN; PREFRONTAL CORTEX; PRIORITY JOURNAL; RAT; STOICHIOMETRY;

Α4Β2; 192-IGG SAPORIN; 192-SAP; 2-HYDROXYPROPYL-Β-CYCLODEXTRIN; ACETYLCHOLINE; ACH; ACSF; ARTIFICIAL CEREBROSPINAL FLUID; BOVINE SERUM ALBUMIN; BSA; CENTRAL NERVOUS SYSTEM; CHAT; CHOLINE ACETYLTRANSFERASE; CNS; ECD; ELECTROCHEMICAL DETECTION; GLUT; GLUTAMATE; GLUTAMATE OXIDASE; GO; HBC; HEK293 CELLS STABLY EXPRESSING HUMAN Α4Β2 NACHR; HEK293-HΑ4Β2; HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY; HPLC; LIMIT OF DETECTION; LOD; LOW SENSITIVITY; LS; M-PD; MEDIAL PREFRONTAL CORTEX; META-PHENYLENEDIAMINE; MPFC; NACHR; NICOTINIC ACETYLCHOLINE RECEPTOR; NS9283; PAM; POSITIVE ALLOSTERIC MODULATOR; PREFRONTAL GLUTAMATE RELEASE;

ACETYLCHOLINE; ALLOSTERIC REGULATION; ANIMALS; GLUTAMIC ACID; HEK293 CELLS; HUMANS; MICROELECTRODES; NICOTINE; NICOTINIC AGONISTS; OXADIAZOLES; PREFRONTAL CORTEX; PYRIDINES; RATS; RECEPTORS, NICOTINIC;

EID: 84887093851     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2013.09.005     Document Type: Article

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