메뉴 건너뛰기




Volumn 17, Issue 1, 2011, Pages 12-18

p27: A barometer of signaling deregulation and potential predictor of response to targeted therapies

Author keywords

[No Author keywords available]

Indexed keywords

ANASTROZOLE; BCR ABL PROTEIN; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE 2; CYCLIN E; ESTROGEN RECEPTOR; FULVESTRANT; IMATINIB; LAPATINIB; MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN P27; PROTEIN TYROSINE KINASE; RAPAMYCIN; RAS PROTEIN; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; SARACATINIB; SOMATOMEDIN C; TAMOXIFEN;

EID: 78751505998     PISSN: 10780432     EISSN: 15573265     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-10-0752     Document Type: Article
Times cited : (146)

References (93)
  • 1
    • 0027318843 scopus 로고
    • Negative regulation of G1 in mammalian cells: Inhibition of cyclin E-dependent kinase by TGF-beta
    • Koff A, Ohtsuki M, Polyak K, Roberts JM, Massague J. Negative regulation of G1 in mammalian cells: inhibition of cyclin E-dependent kinase by TGF-beta. Science 1993;260:536-9.
    • (1993) Science , vol.260 , pp. 536-539
    • Koff, A.1    Ohtsuki, M.2    Polyak, K.3    Roberts, J.M.4    Massague, J.5
  • 2
    • 0028179669 scopus 로고
    • p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factorbeta and contact inhibition to cell cycle arrest
    • Polyak K, Kato JY, Solomon MJ, Sherr CJ, Massague J, Roberts JM, et al. p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factorbeta and contact inhibition to cell cycle arrest. Genes Dev 1994;8:9-22.
    • (1994) Genes Dev , vol.8 , pp. 9-22
    • Polyak, K.1    Kato, J.Y.2    Solomon, M.J.3    Sherr, C.J.4    Massague, J.5    Roberts, J.M.6
  • 3
    • 0028227197 scopus 로고
    • A novel inhibitor of cyclin-Cdk activity detected in transforming growth factor beta-arrested epithelial cells
    • Slingerland JM, Hengst L, Pan CH, Alexander D, Stampfer MR, Reed SI. A novel inhibitor of cyclin-Cdk activity detected in transforming growth factor beta-arrested epithelial cells. Mol Cell Biol 1994;14:3683-94.
    • (1994) Mol Cell Biol , vol.14 , pp. 3683-3694
    • Slingerland, J.M.1    Hengst, L.2    Pan, C.H.3    Alexander, D.4    Stampfer, M.R.5    Reed, S.I.6
  • 4
    • 70449710913 scopus 로고    scopus 로고
    • p27 as Jekyll and Hyde: Regulation of cell cycle and cell motility
    • Larrea MD, Wander SA, Slingerland JM. p27 as Jekyll and Hyde: regulation of cell cycle and cell motility. Cell Cycle 2009;8:3455-61.
    • (2009) Cell Cycle , vol.8 , pp. 3455-3461
    • Larrea, M.D.1    Wander, S.A.2    Slingerland, J.M.3
  • 6
    • 41149150219 scopus 로고    scopus 로고
    • The Cdk inhibitor p27 in human cancer: Prognostic potential and relevance to anticancer therapy
    • Chu IM, Hengst L, Slingerland JM. The Cdk inhibitor p27 in human cancer: prognostic potential and relevance to anticancer therapy. Nat Rev Cancer 2008;8:253-67.
    • (2008) Nat Rev Cancer , vol.8 , pp. 253-267
    • Chu, I.M.1    Hengst, L.2    Slingerland, J.M.3
  • 7
    • 15844415946 scopus 로고    scopus 로고
    • Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27Kip1
    • Kiyokawa H, Kineman RD, Manova-Todorova KO, Soares VC, Hoffman ES, Ono M, et al. Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27Kip1. Cell 1996;85:721-32.
    • (1996) Cell , vol.85 , pp. 721-732
    • Kiyokawa, H.1    Kineman, R.D.2    Manova-Todorova, K.O.3    Soares, V.C.4    Hoffman, E.S.5    Ono, M.6
  • 8
    • 0030010591 scopus 로고    scopus 로고
    • Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors
    • Nakayama K, Ishida N, Shirane M, Inomata A, Inoue T, Shishido N, et al. Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors. Cell 1996;85:707-20.
    • (1996) Cell , vol.85 , pp. 707-720
    • Nakayama, K.1    Ishida, N.2    Shirane, M.3    Inomata, A.4    Inoue, T.5    Shishido, N.6
  • 9
    • 15844384256 scopus 로고    scopus 로고
    • A syndrome of multi-organ hyperplasia with features of gigantism, tumorigenesis and female sterility in p27Kip1-deficient mice
    • Fero ML, Rivkin M, Tasch M, Porter P, Carow CE, Firpo E, et al. A syndrome of multi-organ hyperplasia with features of gigantism, tumorigenesis and female sterility in p27Kip1-deficient mice. Cell 1996;85:733-44.
    • (1996) Cell , vol.85 , pp. 733-744
    • Fero, M.L.1    Rivkin, M.2    Tasch, M.3    Porter, P.4    Carow, C.E.5    Firpo, E.6
  • 10
    • 0029670477 scopus 로고    scopus 로고
    • Translational control of p27Kip1 accumulation during the cell cycle
    • Hengst L, Reed SI. Translational control of p27Kip1 accumulation during the cell cycle. Science 1996;271:1861-4.
    • (1996) Science , vol.271 , pp. 1861-1864
    • Hengst, L.1    Reed, S.I.2
  • 11
    • 0034643331 scopus 로고    scopus 로고
    • AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1
    • Medema RH, Kops GJ, Bos JL, Burgering BM. AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1. Nature 2000;404:782-7.
    • (2000) Nature , vol.404 , pp. 782-787
    • Medema, R.H.1    Kops, G.J.2    Bos, J.L.3    Burgering, B.M.4
  • 12
    • 0036645678 scopus 로고    scopus 로고
    • A growth factor-dependent nuclear kinase phosphorylates p27(Kip1) and regulates cell cycle progression
    • Boehm M, Yoshimoto T, Crook MF, Nallamshetty S, True A, Nabel GJ, et al. A growth factor-dependent nuclear kinase phosphorylates p27(Kip1) and regulates cell cycle progression. EMBO J 2002;21:3390-401.
    • (2002) EMBO J , vol.21 , pp. 3390-3401
    • Boehm, M.1    Yoshimoto, T.2    Crook, M.F.3    Nallamshetty, S.4    True, A.5    Nabel, G.J.6
  • 13
    • 0037242575 scopus 로고    scopus 로고
    • CRM1/Ran-Mediated Nuclear Export of p27(Kip1) Involves a Nuclear Export Signal and Links p27 Export and Proteolysis
    • Connor MK, Kotchetkov R, Cariou S, Resch A, Lupetti R, Beniston RG, et al. CRM1/Ran-Mediated Nuclear Export of p27(Kip1) Involves a Nuclear Export Signal and Links p27 Export and Proteolysis. Mol Biol Cell 2003;14:201-13.
    • (2003) Mol Biol Cell , vol.14 , pp. 201-213
    • Connor, M.K.1    Kotchetkov, R.2    Cariou, S.3    Resch, A.4    Lupetti, R.5    Beniston, R.G.6
  • 14
  • 15
    • 33846268807 scopus 로고    scopus 로고
    • p27 phosphorylation by Src regulates inhibition of cyclin E-Cdk2
    • Chu I, Sun J, Arnaout A, Kahn H, Hanna W, Narod S, et al. p27 phosphorylation by Src regulates inhibition of cyclin E-Cdk2. Cell 2007;128:281-94.
    • (2007) Cell , vol.128 , pp. 281-294
    • Chu, I.1    Sun, J.2    Arnaout, A.3    Kahn, H.4    Hanna, W.5    Narod, S.6
  • 16
    • 33846321913 scopus 로고    scopus 로고
    • Cdk-inhibitory activity and stability of p27Kip1 are directly regulated by oncogenic tyrosine kinases
    • Grimmler M, Wang Y, Mund T, Cilensek Z, Keidel EM, Waddell MB, et al. Cdk-inhibitory activity and stability of p27Kip1 are directly regulated by oncogenic tyrosine kinases. Cell 2007;128:269-80.
    • (2007) Cell , vol.128 , pp. 269-280
    • Grimmler, M.1    Wang, Y.2    Mund, T.3    Cilensek, Z.4    Keidel, E.M.5    Waddell, M.B.6
  • 17
    • 53549126089 scopus 로고    scopus 로고
    • Phosphorylation of p27Kip1 regulates assembly and activation of cyclin D1-Cdk4
    • Larrea MD, Liang J, Da ST, Hong F, Shao SH, Han K, et al. Phosphorylation of p27Kip1 regulates assembly and activation of cyclin D1-Cdk4. Mol Cell Biol 2008;28:6462-72.
    • (2008) Mol Cell Biol , vol.28 , pp. 6462-6472
    • Larrea, M.D.1    Liang, J.2    Da, S.T.3    Hong, F.4    Shao, S.H.5    Han, K.6
  • 18
    • 37549061066 scopus 로고    scopus 로고
    • Differential modification of p27Kip1 controls its cyclin D-cdk4 inhibitory activity
    • James MK, Ray A, Leznova D, Blain SW. Differential modification of p27Kip1 controls its cyclin D-cdk4 inhibitory activity. Mol Cell Biol 2008;28:498-510.
    • (2008) Mol Cell Biol , vol.28 , pp. 498-510
    • James, M.K.1    Ray, A.2    Leznova, D.3    Blain, S.W.4
  • 19
    • 0034092911 scopus 로고    scopus 로고
    • Regulation of the cdk inhibitor p27 and its deregulation in cancer
    • Slingerland J, Pagano M. Regulation of the cdk inhibitor p27 and its deregulation in cancer. J Cell Physiol 2000;183:10-7.
    • (2000) J Cell Physiol , vol.183 , pp. 10-17
    • Slingerland, J.1    Pagano, M.2
  • 20
    • 0031759170 scopus 로고    scopus 로고
    • Transduction of full-length TAT fusion proteins into mammalian cells: TAT-p27Kip1 induces cell migration
    • Nagahara H, Vocero-Akbani AM, Synder EL, Ho A, Latham DG, Lissy NA, et al. Transduction of full-length TAT fusion proteins into mammalian cells: TAT-p27Kip1 induces cell migration. Nat Med 1998;4:1449-52.
    • (1998) Nat Med , vol.4 , pp. 1449-1452
    • Nagahara, H.1    Vocero-Akbani, A.M.2    Synder, E.L.3    Ho, A.4    Latham, D.G.5    Lissy, N.A.6
  • 21
    • 1942466518 scopus 로고    scopus 로고
    • p27Kip1 modulates cell migration through the regulation of RhoA activation
    • Besson A, Gurian-West M, Schmidt A, Hall A, Roberts JM. p27Kip1 modulates cell migration through the regulation of RhoA activation. Genes Dev 2004;18:862-76.
    • (2004) Genes Dev , vol.18 , pp. 862-876
    • Besson, A.1    Gurian-West, M.2    Schmidt, A.3    Hall, A.4    Roberts, J.M.5
  • 22
    • 34447544650 scopus 로고    scopus 로고
    • Discovery of an oncogenic activity in p27Kip1 that causes stem cell expansion and a multiple tumor phenotype
    • Besson A, Hwang HC, Cicero S, Donovan SL, Gurian-West M, Johnson D, et al. Discovery of an oncogenic activity in p27Kip1 that causes stem cell expansion and a multiple tumor phenotype. Genes Dev 2007;21:1731-46.
    • (2007) Genes Dev , vol.21 , pp. 1731-1746
    • Besson, A.1    Hwang, H.C.2    Cicero, S.3    Donovan, S.L.4    Gurian-West, M.5    Johnson, D.6
  • 23
    • 1942434712 scopus 로고    scopus 로고
    • Cip/Kip proteins: More than just CDKs inhibitors
    • Denicourt C, Dowdy SF. Cip/Kip proteins: more than just CDKs inhibitors. Genes Dev 2004;18:851-5.
    • (2004) Genes Dev , vol.18 , pp. 851-855
    • Denicourt, C.1    Dowdy, S.F.2
  • 24
    • 33644509197 scopus 로고    scopus 로고
    • Reduction of cytosolic p27(Kip1) inhibits cancer cell motility, survival, and tumorigenicity
    • Wu FY, Wang SE, Sanders ME, Shin I, Rojo F, Baselga J, et al. Reduction of cytosolic p27(Kip1) inhibits cancer cell motility, survival, and tumorigenicity. Cancer Res 2006;66:2162-72.
    • (2006) Cancer Res , vol.66 , pp. 2162-2172
    • Wu, F.Y.1    Wang, S.E.2    Sanders, M.E.3    Shin, I.4    Rojo, F.5    Baselga, J.6
  • 25
    • 77953578555 scopus 로고    scopus 로고
    • p27 deficiency is associated with migration defects in PDGF-expressing gliomas in vivo
    • Epub 2010 Apr 19
    • See WL, Heinberg AR, Holland EC, Resh MD. p27 deficiency is associated with migration defects in PDGF-expressing gliomas in vivo. Cell Cycle 2010;9. Epub 2010 Apr 19.
    • (2010) Cell Cycle , pp. 9
    • See, W.L.1    Heinberg, A.R.2    Holland, E.C.3    Resh, M.D.4
  • 26
    • 77953724897 scopus 로고    scopus 로고
    • Inhibition of the PI3K pathway: Hope we can believe in?
    • Van Der Heijden MS, Bernards R. Inhibition of the PI3K pathway: hope we can believe in? Clin Cancer Res 2010;16:3094-9.
    • (2010) Clin Cancer Res , vol.16 , pp. 3094-3099
    • Van Der Heijden, M.S.1    Bernards, R.2
  • 27
    • 2342618936 scopus 로고    scopus 로고
    • Multiple roles of the PI3K/PKB (Akt) pathway in cell cycle progression
    • Liang J, Slingerland JM. Multiple roles of the PI3K/PKB (Akt) pathway in cell cycle progression. Cell Cycle 2003;2:339-45.
    • (2003) Cell Cycle , vol.2 , pp. 339-345
    • Liang, J.1    Slingerland, J.M.2
  • 28
    • 0030916209 scopus 로고    scopus 로고
    • Inhibition of cyclin D1 phosphorylation on threonine-286 prevents its rapid degradation via the ubiquitin-proteasome pathway
    • Diehl JA, Zindy F, Sherr CJ. Inhibition of cyclin D1 phosphorylation on threonine-286 prevents its rapid degradation via the ubiquitin-proteasome pathway. Genes Dev 1997;11:957-72.
    • (1997) Genes Dev , vol.11 , pp. 957-972
    • Diehl, J.A.1    Zindy, F.2    Sherr, C.J.3
  • 29
    • 18644376449 scopus 로고    scopus 로고
    • PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest
    • Liang J, Zubovitz J, Petrocelli T, Kotchetkov R, Connor MK, Han K, et al. PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest. Nat Med 2002;8:1153-60.
    • (2002) Nat Med , vol.8 , pp. 1153-1160
    • Liang, J.1    Zubovitz, J.2    Petrocelli, T.3    Kotchetkov, R.4    Connor, M.K.5    Han, K.6
  • 30
    • 0036799377 scopus 로고    scopus 로고
    • PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization
    • Shin I, Yakes FM, Rojo F, Shin NY, Bakin AV, Baselga J, et al. PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization. Nat Med 2002;8:1145-52.
    • (2002) Nat Med , vol.8 , pp. 1145-1152
    • Shin, I.1    Yakes, F.M.2    Rojo, F.3    Shin, N.Y.4    Bakin, A.V.5    Baselga, J.6
  • 31
    • 18644370396 scopus 로고    scopus 로고
    • Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer
    • Viglietto G, Motti ML, Bruni P, Melillo RM, D'Alessio A, Califano D, et al. Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer. Nat Med 2002;8:1136-44.
    • (2002) Nat Med , vol.8 , pp. 1136-1144
    • Viglietto, G.1    Motti, M.L.2    Bruni, P.3    Melillo, R.M.4    D'Alessio, A.5    Califano, D.6
  • 32
    • 33947250696 scopus 로고    scopus 로고
    • The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis
    • Liang J, Shao SH, Xu Z, Hennessy B, Ding Z, Larrea M, et al. The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis. Nat Cell Biol 2007;9:218-24.
    • (2007) Nat Cell Biol , vol.9 , pp. 218-224
    • Liang, J.1    Shao, S.H.2    Xu, Z.3    Hennessy, B.4    Ding, Z.5    Larrea, M.6
  • 34
  • 35
    • 58849158826 scopus 로고    scopus 로고
    • Cytoplasmic sequestration of p27 via AKT phosphorylation in renal cell carcinoma
    • Kim J, Jonasch E, Alexander A, Short JD, Cai S, Wen S, et al. Cytoplasmic sequestration of p27 via AKT phosphorylation in renal cell carcinoma. Clin Cancer Res 2009;15:81-90.
    • (2009) Clin Cancer Res , vol.15 , pp. 81-90
    • Kim, J.1    Jonasch, E.2    Alexander, A.3    Short, J.D.4    Cai, S.5    Wen, S.6
  • 36
    • 20044380158 scopus 로고    scopus 로고
    • Complex regulation of the cyclin-dependent kinase inhibitor p27kip1 in thyroid cancer cells by the PI3K/AKT pathway: Regulation of p27kip1 expression and localization
    • Motti ML, Califano D, Troncone G, De Marco C, Migliaccio I, Palmieri E, et al. Complex regulation of the cyclin-dependent kinase inhibitor p27kip1 in thyroid cancer cells by the PI3K/AKT pathway: regulation of p27kip1 expression and localization. Am J Pathol 2005;166:737-49.
    • (2005) Am J Pathol , vol.166 , pp. 737-749
    • Motti, M.L.1    Califano, D.2    Troncone, G.3    De Marco, C.4    Migliaccio, I.5    Palmieri, E.6
  • 37
    • 3442890875 scopus 로고    scopus 로고
    • Cytoplasmic mislocalization of p27Kip1 protein is associated with constitutive phosphorylation of Akt or protein kinase B and poor prognosis in acute myelogenous leukemia
    • Min YH, Cheong JW, Kim JY, Eom JI, Lee ST, Hahn JS, et al. Cytoplasmic mislocalization of p27Kip1 protein is associated with constitutive phosphorylation of Akt or protein kinase B and poor prognosis in acute myelogenous leukemia. Cancer Res 2004;64:5225-31.
    • (2004) Cancer Res , vol.64 , pp. 5225-5231
    • Min, Y.H.1    Cheong, J.W.2    Kim, J.Y.3    Eom, J.I.4    Lee, S.T.5    Hahn, J.S.6
  • 38
    • 33747819801 scopus 로고    scopus 로고
    • mTOR and cancer: Insights into a complex relationship
    • Sabatini DM. mTOR and cancer: insights into a complex relationship. Nat Rev Cancer 2006;6:729-34.
    • (2006) Nat Rev Cancer , vol.6 , pp. 729-734
    • Sabatini, D.M.1
  • 40
    • 58649092475 scopus 로고    scopus 로고
    • mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)
    • Garcia-Martinez JM, Alessi DR. mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1). Biochem J 2008;416:375-85.
    • (2008) Biochem J , vol.416 , pp. 375-385
    • Garcia-Martinez, J.M.1    Alessi, D.R.2
  • 41
    • 50649090571 scopus 로고    scopus 로고
    • Advances in the development of cancer therapeutics directed against the RAS-mitogen-activated protein kinase pathway
    • Sebolt-Leopold JS. Advances in the development of cancer therapeutics directed against the RAS-mitogen-activated protein kinase pathway. Clin Cancer Res 2008;14:3651-6.
    • (2008) Clin Cancer Res , vol.14 , pp. 3651-3656
    • Sebolt-Leopold, J.S.1
  • 42
    • 0034637527 scopus 로고    scopus 로고
    • Oncogenic signals of HER-2/neu in regulating the stability of the cyclin-dependent kinase inhibitor p27
    • Yang HY, Zhou BP, Hung MC, Lee MH. Oncogenic signals of HER-2/neu in regulating the stability of the cyclin-dependent kinase inhibitor p27. J Biol Chem 2000;275:24735-9.
    • (2000) J Biol Chem , vol.275 , pp. 24735-24739
    • Yang, H.Y.1    Zhou, B.P.2    Hung, M.C.3    Lee, M.H.4
  • 43
    • 0035798683 scopus 로고    scopus 로고
    • Constitutive MEK/MAPK activation leads to p27(Kip1) deregulation and antiestrogen resistance in human breast cancer cells
    • Donovan JC, Milic A, Slingerland JM. Constitutive MEK/MAPK activation leads to p27(Kip1) deregulation and antiestrogen resistance in human breast cancer cells. J Biol Chem 2001;276:40888-95.
    • (2001) J Biol Chem , vol.276 , pp. 40888-40895
    • Donovan, J.C.1    Milic, A.2    Slingerland, J.M.3
  • 44
    • 0032477854 scopus 로고    scopus 로고
    • Assembly of cyclin Ddependent kinase and titration of p27Kip1 regulated by mitogenactivated protein kinase kinase (MEK1)
    • Cheng M, Sexl V, Sherr CJ, Roussel MF. Assembly of cyclin Ddependent kinase and titration of p27Kip1 regulated by mitogenactivated protein kinase kinase (MEK1). Proc Natl Acad Sci USA 1998;95:1091-6.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 1091-1096
    • Cheng, M.1    Sexl, V.2    Sherr, C.J.3    Roussel, M.F.4
  • 45
    • 0034735895 scopus 로고    scopus 로고
    • Disruption of TGF-beta growth inhibition by oncogenic ras is linked to p27Kip1 mislocalization
    • Liu X, Sun Y, Ehrlich M, Lu T, Kloog Y, Weinberg RA, et al. Disruption of TGF-beta growth inhibition by oncogenic ras is linked to p27Kip1 mislocalization. Oncogene 2000;19:5926-35.
    • (2000) Oncogene , vol.19 , pp. 5926-5935
    • Liu, X.1    Sun, Y.2    Ehrlich, M.3    Lu, T.4    Kloog, Y.5    Weinberg, R.A.6
  • 46
    • 29944440513 scopus 로고    scopus 로고
    • A pathway in quiescent cells that controls p27Kip1 stability, subcellular localization, and tumor suppression
    • Besson A, Gurian-West M, Chen X, Kelly-Spratt KS, Kemp CJ, Roberts JM. A pathway in quiescent cells that controls p27Kip1 stability, subcellular localization, and tumor suppression. Genes Dev 2006;20:47-64.
    • (2006) Genes Dev , vol.20 , pp. 47-64
    • Besson, A.1    Gurian-West, M.2    Chen, X.3    Kelly-Spratt, K.S.4    Kemp, C.J.5    Roberts, J.M.6
  • 47
    • 24344491428 scopus 로고    scopus 로고
    • Pathway- and expression level-dependent effects of oncogenic N-Ras: p27(Kip1) mislocalization by the Ral-GEF pathway and Erk-mediated interference with Smad signaling
    • Kfir S, Ehrlich M, Goldshmid A, Liu X, Kloog Y, Henis YI. Pathway- and expression level-dependent effects of oncogenic N-Ras: p27(Kip1) mislocalization by the Ral-GEF pathway and Erk-mediated interference with Smad signaling. Mol Cell Biol 2005;25:8239-50.
    • (2005) Mol Cell Biol , vol.25 , pp. 8239-8250
    • Kfir, S.1    Ehrlich, M.2    Goldshmid, A.3    Liu, X.4    Kloog, Y.5    Henis, Y.I.6
  • 48
    • 0035860705 scopus 로고    scopus 로고
    • The p42/p44 mitogen-activated protein kinase activation triggers p27Kip1 degradation independently of CDK2/cyclin E in NIH 3T3 cells
    • Delmas C, Manenti S, Boudjelal A, Peyssonnaux C, Eychene A, Darbon JM. The p42/p44 mitogen-activated protein kinase activation triggers p27Kip1 degradation independently of CDK2/cyclin E in NIH 3T3 cells. J Biol Chem 2001;276:34958-65.
    • (2001) J Biol Chem , vol.276 , pp. 34958-34965
    • Delmas, C.1    Manenti, S.2    Boudjelal, A.3    Peyssonnaux, C.4    Eychene, A.5    Darbon, J.M.6
  • 49
    • 0033996361 scopus 로고    scopus 로고
    • ErbB2 potentiates breast tumor proliferation through modulation of p27(Kip1)-Cdk2 complex formation: Receptor overexpression does not determine growth dependency
    • Lane HA, Beuvink I, Motoyama AB, Daly JM, Neve RM, Hynes NE. ErbB2 potentiates breast tumor proliferation through modulation of p27(Kip1)-Cdk2 complex formation: receptor overexpression does not determine growth dependency. Mol Cell Biol 2000;20:3210-23.
    • (2000) Mol Cell Biol , vol.20 , pp. 3210-3223
    • Lane, H.A.1    Beuvink, I.2    Motoyama, A.B.3    Daly, J.M.4    Neve, R.M.5    Hynes, N.E.6
  • 50
    • 77954690732 scopus 로고    scopus 로고
    • Advances in targeting SRC in the treatment of breast cancer and other solid malignancies
    • Mayer EL, Krop IE. Advances in targeting SRC in the treatment of breast cancer and other solid malignancies. Clin Cancer Res 2010;16:3526-32.
    • (2010) Clin Cancer Res , vol.16 , pp. 3526-3532
    • Mayer, E.L.1    Krop, I.E.2
  • 51
    • 77950951767 scopus 로고    scopus 로고
    • Role of BCR-ABL-Y177-mediated p27kip1 phosphorylation and cytoplasmic localization in enhanced proliferation of chronic myeloid leukemia progenitors
    • Chu S, McDonald T, Bhatia R. Role of BCR-ABL-Y177-mediated p27kip1 phosphorylation and cytoplasmic localization in enhanced proliferation of chronic myeloid leukemia progenitors. Leukemia 2010;24:779-87.
    • (2010) Leukemia , vol.24 , pp. 779-787
    • Chu, S.1    McDonald, T.2    Bhatia, R.3
  • 52
    • 16944363001 scopus 로고    scopus 로고
    • Decreased levels of the cell-cycle inhibitor p27Kip1 protein: Prognostic implications in primary breast cancer
    • Catzavelos C, Bhattacharya N, Ung YC, Wilson JA, Roncari L, Sandhu C, et al. Decreased levels of the cell-cycle inhibitor p27Kip1 protein:prognostic implications in primary breast cancer. Nat Med 1997;3:227-30.
    • (1997) Nat Med , vol.3 , pp. 227-230
    • Catzavelos, C.1    Bhattacharya, N.2    Ung, Y.C.3    Wilson, J.A.4    Roncari, L.5    Sandhu, C.6
  • 53
    • 0032796973 scopus 로고    scopus 로고
    • Reduced expression of p27Kip1 protein is associated with poor clinical outcome of breast cancer patients treated with systemic chemotherapy and is linked to cell proliferation and differentiation
    • Han S, Park K, Kim HY, Lee MS, Kim HJ, Kim YD. Reduced expression of p27Kip1 protein is associated with poor clinical outcome of breast cancer patients treated with systemic chemotherapy and is linked to cell proliferation and differentiation. Breast Cancer Res Treat 1999;55:161-7.
    • (1999) Breast Cancer Res Treat , vol.55 , pp. 161-167
    • Han, S.1    Park, K.2    Kim, H.Y.3    Lee, M.S.4    Kim, H.J.5    Kim, Y.D.6
  • 54
    • 0034791332 scopus 로고    scopus 로고
    • Implication of malignancy and prognosis of p27(kip1), Cyclin E, and Cdk2 expression in epithelial ovarian tumors
    • Sui L, Dong Y, Ohno M, Sugimoto K, Tai Y, Hando T, et al. Implication of malignancy and prognosis of p27(kip1), Cyclin E, and Cdk2 expression in epithelial ovarian tumors. Gynecol Oncol 2001;83:56-63.
    • (2001) Gynecol Oncol , vol.83 , pp. 56-63
    • Sui, L.1    Dong, Y.2    Ohno, M.3    Sugimoto, K.4    Tai, Y.5    Hando, T.6
  • 55
    • 0035998397 scopus 로고    scopus 로고
    • The combined evaluation of p27Kip1 and Ki-67 expression provides independent information on overall survival of ovarian carcinoma patients
    • Korkolopoulou P, Vassilopoulos I, Konstantinidou AE, et al. The combined evaluation of p27Kip1 and Ki-67 expression provides independent information on overall survival of ovarian carcinoma patients. Gynecol Oncol 2002;85:404-14.
    • (2002) Gynecol Oncol , vol.85 , pp. 404-414
    • Korkolopoulou, P.1    Vassilopoulos, I.2    Konstantinidou, A.E.3
  • 56
    • 0032008536 scopus 로고    scopus 로고
    • p27Kip1 in human lung cancers: Differential changes in small cell and non-small cell carcinomas
    • Yatabe Y, Masuda A, Koshikawa T, Nakamura S, Kuroishi T, Osada H, et al. p27Kip1 in human lung cancers: differential changes in small cell and non-small cell carcinomas. Cancer Res 1998;58:1042-7.
    • (1998) Cancer Res , vol.58 , pp. 1042-1047
    • Yatabe, Y.1    Masuda, A.2    Koshikawa, T.3    Nakamura, S.4    Kuroishi, T.5    Osada, H.6
  • 57
    • 0034848442 scopus 로고    scopus 로고
    • Reduced expression of cell-cycle regulator p27(Kip1) correlates with a shortened survival in non-small cell lung cancer
    • Tsukamoto S, Sugio K, Sakada T, Ushijima C, Yamazaki K, Sugimachi K. Reduced expression of cell-cycle regulator p27(Kip1) correlates with a shortened survival in non-small cell lung cancer. Lung Cancer 2001;34:83-90.
    • (2001) Lung Cancer , vol.34 , pp. 83-90
    • Tsukamoto, S.1    Sugio, K.2    Sakada, T.3    Ushijima, C.4    Yamazaki, K.5    Sugimachi, K.6
  • 58
    • 0036891964 scopus 로고    scopus 로고
    • Prognostic significance of p27KIP1 expression in resected nonsmall cell lung cancers: Analysis in combination with expressions of p16INK4A, pRB, and p53
    • Hirabayashi H, Ohta M, Tanaka H, Sakaguchi M, Fujii Y, Miyoshi S, et al. Prognostic significance of p27KIP1 expression in resected nonsmall cell lung cancers: analysis in combination with expressions of p16INK4A, pRB, and p53. J Surg Oncol 2002;81:177-84.
    • (2002) J Surg Oncol , vol.81 , pp. 177-184
    • Hirabayashi, H.1    Ohta, M.2    Tanaka, H.3    Sakaguchi, M.4    Fujii, Y.5    Miyoshi, S.6
  • 59
    • 0033762814 scopus 로고    scopus 로고
    • Prognostic value of cell cycle proteins p27(kip1) and MIB-1, and the cell adhesion protein CD44s in surgically treated patients with prostate cancer
    • Vis AN, Noordzij MA, Fitoz K, Wildhagen MF, Schroder FH, Van Der Kwast TH. Prognostic value of cell cycle proteins p27(kip1) and MIB-1, and the cell adhesion protein CD44s in surgically treated patients with prostate cancer. J Urol 2000;164:2156-61.
    • (2000) J Urol , vol.164 , pp. 2156-2161
    • Vis, A.N.1    Noordzij, M.A.2    Fitoz, K.3    Wildhagen, M.F.4    Schroder, F.H.5    Van Der Kwast, T.H.6
  • 60
    • 0032005978 scopus 로고    scopus 로고
    • Loss of cyclin-dependent kinase inhibitor p27Kip1 is a novel prognostic factor in localized human prostate adenocarcinoma
    • Tsihlias J, Kapusta LR, DeBoer G, Morava-Protzner I, Zbieranowski I, Bhattacharya N, et al. Loss of cyclin-dependent kinase inhibitor p27Kip1 is a novel prognostic factor in localized human prostate adenocarcinoma. Cancer Res 1998;58:542-8.
    • (1998) Cancer Res , vol.58 , pp. 542-548
    • Tsihlias, J.1    Kapusta, L.R.2    DeBoer, G.3    Morava-Protzner, I.4    Zbieranowski, I.5    Bhattacharya, N.6
  • 61
    • 0031930822 scopus 로고    scopus 로고
    • Low p27 expression predicts poor disease-free survival in patients with prostate cancer
    • Yang RM, Naitoh J, Murphy M, Wang HJ, Phillipson J, deKernion JB, et al. Low p27 expression predicts poor disease-free survival in patients with prostate cancer. J Urol 1998;159:941-5.
    • (1998) J Urol , vol.159 , pp. 941-945
    • Yang, R.M.1    Naitoh, J.2    Murphy, M.3    Wang, H.J.4    Phillipson, J.5    De Kernion, J.B.6
  • 62
    • 0032540544 scopus 로고    scopus 로고
    • Association of p27Kip1 levels with recurrence and survival in patients with stage C prostate carcinoma
    • Cote RJ, Shi Y, Groshen S, Feng AC, Cordon-Cardo C, Skinner D, et al. Association of p27Kip1 levels with recurrence and survival in patients with stage C prostate carcinoma. J Natl Cancer Inst 1998;90:916-20.
    • (1998) J Natl Cancer Inst , vol.90 , pp. 916-920
    • Cote, R.J.1    Shi, Y.2    Groshen, S.3    Feng, A.C.4    Cordon-Cardo, C.5    Skinner, D.6
  • 63
    • 0035515234 scopus 로고    scopus 로고
    • Predictive value of altered p27Kip1 and p21WAF/Cip1 protein expression for the clinical prognosis of patients with localized prostate cancer
    • Kuczyk MA, Bokemeyer C, Hartmann J, Schubach J, Walter C, Machtens S, et al. Predictive value of altered p27Kip1 and p21WAF/Cip1 protein expression for the clinical prognosis of patients with localized prostate cancer. Oncol Rep 2001;8:1401-7.
    • (2001) Oncol Rep , vol.8 , pp. 1401-1407
    • Kuczyk, M.A.1    Bokemeyer, C.2    Hartmann, J.3    Schubach, J.4    Walter, C.5    Machtens, S.6
  • 64
    • 0031048716 scopus 로고    scopus 로고
    • Expression of cell cycle regulators p27kip1 and cyclin E, alone and in combination, correlate with survival in young breast cancer patients
    • Porter PL, Malone KE, Heagerty PJ, Alexander GM, Gatti LA, Firpo EJ, et al. Expression of cell cycle regulators p27kip1 and cyclin E, alone and in combination, correlate with survival in young breast cancer patients. Nat Med 1997;3:222-5.
    • (1997) Nat Med , vol.3 , pp. 222-225
    • Porter, P.L.1    Malone, K.E.2    Heagerty, P.J.3    Alexander, G.M.4    Gatti, L.A.5    Firpo, E.J.6
  • 65
    • 0030894787 scopus 로고    scopus 로고
    • The cell cycle inhibitor p27 is an independent prognostic marker in small (T1a,b) invasive breast carcinomas
    • Tan P, Cady B, Wanner M, Worland P, Cukor B, Magi-Galluzzi C, et al. The cell cycle inhibitor p27 is an independent prognostic marker in small (T1a,b) invasive breast carcinomas. Cancer Res 1997;57:1259-63.
    • (1997) Cancer Res , vol.57 , pp. 1259-1263
    • Tan, P.1    Cady, B.2    Wanner, M.3    Worland, P.4    Cukor, B.5    Magi-Galluzzi, C.6
  • 66
    • 0042710693 scopus 로고    scopus 로고
    • Prognostic implication of cyclin E expression and its relationship with cyclin D1 and p27Kip1 expression on tissue microarrays of node negative breast cancer
    • Han S, Park K, Bae BN, Kim KH, Kim HJ, Kim YD, et al. Prognostic implication of cyclin E expression and its relationship with cyclin D1 and p27Kip1 expression on tissue microarrays of node negative breast cancer. J Surg Oncol 2003;83:241-7.
    • (2003) J Surg Oncol , vol.83 , pp. 241-247
    • Han, S.1    Park, K.2    Bae, B.N.3    Kim, K.H.4    Kim, H.J.5    Kim, Y.D.6
  • 67
    • 33845640614 scopus 로고    scopus 로고
    • p27 (Kip1) and cyclin E expression and breast cancer survival after treatment with adjuvant chemotherapy
    • Porter PL, Barlow WE, Yeh IT, Lin MG, Yuan XP, Donato E, et al. p27 (Kip1) and cyclin E expression and breast cancer survival after treatment with adjuvant chemotherapy. J Natl Cancer Inst 2006;98:1723-31.
    • (2006) J Natl Cancer Inst , vol.98 , pp. 1723-1731
    • Porter, P.L.1    Barlow, W.E.2    Yeh, I.T.3    Lin, M.G.4    Yuan, X.P.5    Donato, E.6
  • 68
    • 0032587341 scopus 로고    scopus 로고
    • Kip1 and apoptosis in human breast cancer
    • Kip1 and apoptosis in human breast cancer. Br J Cancer 1999;79:1572-8.
    • (1999) Br J Cancer , vol.79 , pp. 1572-1578
    • Wu, J.1    Hen, Z.Z.2
  • 69
    • 0035170004 scopus 로고    scopus 로고
    • Expression of cellcycle regulator p27 is correlated to the prognosis and ER expression in breast carcinoma patients
    • Nohara T, Ryo T, Iwamoto S, Gon G, Tanigawa N. Expression of cellcycle regulator p27 is correlated to the prognosis and ER expression in breast carcinoma patients. Oncology 2001;60:94-100.
    • (2001) Oncology , vol.60 , pp. 94-100
    • Nohara, T.1    Ryo, T.2    Iwamoto, S.3    Gon, G.4    Tanigawa, N.5
  • 70
    • 0142008438 scopus 로고    scopus 로고
    • High p27Kip1 expression predicts superior relapse-free and overall survival for premenopausal women with early-stage breast cancer receiving adjuvant treatment with tamoxifen plus goserelin
    • Pohl G, Rudas M, Dietze O, Lax S, Markis E, Pirker R, et al. High p27Kip1 expression predicts superior relapse-free and overall survival for premenopausal women with early-stage breast cancer receiving adjuvant treatment with tamoxifen plus goserelin. J Clin Oncol 2003;21:3594-600.
    • (2003) J Clin Oncol , vol.21 , pp. 3594-3600
    • Pohl, G.1    Rudas, M.2    Dietze, O.3    Lax, S.4    Markis, E.5    Pirker, R.6
  • 71
    • 30344432999 scopus 로고    scopus 로고
    • Biological correlates of p27 compartmental expression in prostate cancer
    • Li R, Wheeler TM, Dai H, Sayeeduddin M, Scardino PT, Frolov A, et al. Biological correlates of p27 compartmental expression in prostate cancer. J Urol 2006;175:528-32.
    • (2006) J Urol , vol.175 , pp. 528-532
    • Li, R.1    Wheeler, T.M.2    Dai, H.3    Sayeeduddin, M.4    Scardino, P.T.5    Frolov, A.6
  • 73
    • 61449216263 scopus 로고    scopus 로고
    • The combination of low cytoplasmic and high nuclear expression of p27 predicts a better prognosis in high-grade astrocytoma
    • Hidaka T, Hama S, Shrestha P, Saito T, Kajiwara Y, Yamasaki F, et al. The combination of low cytoplasmic and high nuclear expression of p27 predicts a better prognosis in high-grade astrocytoma. Anticancer Res 2009;29:597-603.
    • (2009) Anticancer Res , vol.29 , pp. 597-603
    • Hidaka, T.1    Hama, S.2    Shrestha, P.3    Saito, T.4    Kajiwara, Y.5    Yamasaki, F.6
  • 74
    • 1942474587 scopus 로고    scopus 로고
    • The HER-2-targeting antibodies trastuzumab and pertuzumab synergistically inhibit the survival of breast cancer cells
    • Nahta R, Hung MC, Esteva FJ. The HER-2-targeting antibodies trastuzumab and pertuzumab synergistically inhibit the survival of breast cancer cells. Cancer Res 2004;64:2343-6.
    • (2004) Cancer Res , vol.64 , pp. 2343-2346
    • Nahta, R.1    Hung, M.C.2    Esteva, F.J.3
  • 75
    • 0034629485 scopus 로고    scopus 로고
    • Reversible G(1) arrest induced by inhibition of the epidermal growth factor receptor tyrosine kinase requires up-regulation of p27(KIP1) independent of MAPK activity
    • Busse D, Doughty RS, Ramsey TT, Russell WE, Price JO, Flanagan WM, et al. Reversible G(1) arrest induced by inhibition of the epidermal growth factor receptor tyrosine kinase requires up-regulation of p27(KIP1) independent of MAPK activity. J Biol Chem 2000;275:6987-95.
    • (2000) J Biol Chem , Issue.275 , pp. 6987-6995
    • Busse, D.1    Doughty, R.S.2    Ramsey, T.T.3    Russell, W.E.4    Price, J.O.5    Flanagan, W.M.6
  • 76
    • 77956182872 scopus 로고    scopus 로고
    • Effects of the combined blockade of EGFR and ErbB-2 on signal transduction and regulation of cell cycle regulatory proteins in breast cancer cells
    • D'Alessio A, De LA, Maiello MR, Lamura L, Rachiglio AM, Napolitano M, et al. Effects of the combined blockade of EGFR and ErbB-2 on signal transduction and regulation of cell cycle regulatory proteins in breast cancer cells. Breast Cancer Res Treat 2010;123:387-96.
    • (2010) Breast Cancer Res Treat , vol.123 , pp. 387-396
    • D'Alessio, A.1    De, L.A.2    Maiello, M.R.3    Lamura, L.4    Rachiglio, A.M.5    Napolitano, M.6
  • 77
  • 78
    • 0347363828 scopus 로고    scopus 로고
    • Opposite long-term regulation of c-Myc and p27Kip1 through overactivation of Raf-1 and the MEK/ERK module in proliferating human choroidal melanoma cells
    • Lefevre G, Calipel A, Mouriaux F, Hecquet C, Malecaze F, MascarelliF. Opposite long-term regulation of c-Myc and p27Kip1 through overactivation of Raf-1 and the MEK/ERK module in proliferating human choroidal melanoma cells. Oncogene 2003;22:8813-22.
    • (2003) Oncogene , vol.22 , pp. 8813-8822
    • Lefevre, G.1    Calipel, A.2    Mouriaux, F.3    Hecquet, C.4    Malecaze, F.5    Mascarelli, F.6
  • 79
    • 19644388719 scopus 로고    scopus 로고
    • Pharmacologic inhibition of RAF!MEK!ERK signaling elicits pancreatic cancer cell cycle arrest through induced expression of p27Kip1
    • Gysin S, Lee SH, Dean NM, McMahon M. Pharmacologic inhibition of RAF!MEK!ERK signaling elicits pancreatic cancer cell cycle arrest through induced expression of p27Kip1. Cancer Res 2005;65:4870-80.
    • (2005) Cancer Res , vol.65 , pp. 4870-4880
    • Gysin, S.1    Lee, S.H.2    Dean, N.M.3    McMahon, M.4
  • 80
    • 56249147509 scopus 로고    scopus 로고
    • Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation
    • Choo AY, Yoon SO, Kim SG, Roux PP, Blenis J. Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation. Proc Natl Acad Sci USA 2008;105:17414-9.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 17414-17419
    • Choo, A.Y.1    Yoon, S.O.2    Kim, S.G.3    Roux, P.P.4    Blenis, J.5
  • 81
  • 82
    • 32944457518 scopus 로고    scopus 로고
    • mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt
    • O'Reilly KE, Rojo F, She QB, Solit D, Mills GB, Smith D, et al. mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt. Cancer Res 2006;66:1500-8.
    • (2006) Cancer Res , vol.66 , pp. 1500-1508
    • O'Reilly, K.E.1    Rojo, F.2    She, Q.B.3    Solit, D.4    Mills, G.B.5    Smith, D.6
  • 83
    • 68049137608 scopus 로고    scopus 로고
    • Biochemical, cellular, and in vivo activity of novel ATP-competitive and selective inhibitors of the mammalian target of rapamycin
    • Yu K, Toral-Barza L, Shi C, Zhang WG, Lucas J, Shor B, et al. Biochemical, cellular, and in vivo activity of novel ATP-competitive and selective inhibitors of the mammalian target of rapamycin. Cancer Res 2009;69:6232-40.
    • (2009) Cancer Res , vol.69 , pp. 6232-6240
    • Yu, K.1    Toral-Barza, L.2    Shi, C.3    Zhang, W.G.4    Lucas, J.5    Shor, B.6
  • 84
    • 61349141302 scopus 로고    scopus 로고
    • Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2
    • Feldman ME, Apsel B, Uotila A, Loewith R, Knight ZA, Ruggero D, et al. Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2. PLoS Biol 2009;7:e38.
    • (2009) PLoS Biol , vol.7
    • Feldman, M.E.1    Apsel, B.2    Uotila, A.3    Loewith, R.4    Knight, Z.A.5    Ruggero, D.6
  • 85
    • 0034238115 scopus 로고    scopus 로고
    • Down-regulation of p21WAF1/CIP1 or p27Kip1 abrogates antiestrogen- mediated cell cycle arrest in human breast cancer cells
    • Cariou S, Donovan JC, Flanagan WM, Milic A, Bhattacharya N, Slingerland JM. Down-regulation of p21WAF1/CIP1 or p27Kip1 abrogates antiestrogen-mediated cell cycle arrest in human breast cancer cells. Proc Natl Acad Sci USA 2000;97:9042-6.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 9042-9046
    • Cariou, S.1    Donovan, J.C.2    Flanagan, W.M.3    Milic, A.4    Bhattacharya, N.5    Slingerland, J.M.6
  • 86
    • 69249137029 scopus 로고    scopus 로고
    • Biological determinants of endocrine resistance in breast cancer
    • Musgrove EA, Sutherland RL. Biological determinants of endocrine resistance in breast cancer. Nat Rev Cancer 2009;9:631-43.
    • (2009) Nat Rev Cancer , vol.9 , pp. 631-643
    • Musgrove, E.A.1    Sutherland, R.L.2
  • 87
    • 66149160364 scopus 로고    scopus 로고
    • Combined Src and aromatase inhibition impairs human breast cancer growth in vivo and bypass pathways are activated in AZD0530-resistant tumors
    • Chen Y, Guggisberg N, Jorda M, Gonzalez-Angulo A, Hennessy B, Mills GB, et al. Combined Src and aromatase inhibition impairs human breast cancer growth in vivo and bypass pathways are activated in AZD0530-resistant tumors. Clin Cancer Res 2009;15:3396-405.
    • (2009) Clin Cancer Res , vol.15 , pp. 3396-3405
    • Chen, Y.1    Guggisberg, N.2    Jorda, M.3    Gonzalez-Angulo, A.4    Hennessy, B.5    Mills, G.B.6
  • 90
    • 34547134493 scopus 로고    scopus 로고
    • Src promotes estrogen-dependent estrogen receptor alpha proteolysis in human breast cancer
    • Chu I, Arnaout A, Loiseau S, Sun J, Seth A, McMahon C, et al. Src promotes estrogen-dependent estrogen receptor alpha proteolysis in human breast cancer. J Clin Invest 2007;117:2205-15.
    • (2007) J Clin Invest , vol.117 , pp. 2205-2215
    • Chu, I.1    Arnaout, A.2    Loiseau, S.3    Sun, J.4    Seth, A.5    McMahon, C.6
  • 91
    • 67349143116 scopus 로고    scopus 로고
    • Dual targeting of Src and ER prevents acquired antihormone resistance in breast cancer cells
    • Hiscox S, Jordan NJ, Smith C, James M, Morgan L, Taylor KM, et al. Dual targeting of Src and ER prevents acquired antihormone resistance in breast cancer cells. Breast Cancer Res Treat 2008;115:57-67.
    • (2008) Breast Cancer Res Treat , vol.115 , pp. 57-67
    • Hiscox, S.1    Jordan, N.J.2    Smith, C.3    James, M.4    Morgan, L.5    Taylor, K.M.6
  • 92
    • 28544433273 scopus 로고    scopus 로고
    • Subcellular localization and protein levels of cyclin-dependent kinase inhibitor p27 independently predict for survival in epithelial ovarian cancer
    • Psyrri A, Bamias A, Yu Z, Weinberger PM, Kassar M, Markakis S, et al. Subcellular localization and protein levels of cyclin-dependent kinase inhibitor p27 independently predict for survival in epithelial ovarian cancer. Clin Cancer Res 2005;11:8384-90.
    • (2005) Clin Cancer Res , vol.11 , pp. 8384-8390
    • Psyrri, A.1    Bamias, A.2    Yu, Z.3    Weinberger, P.M.4    Kassar, M.5    Markakis, S.6
  • 93
    • 0034351879 scopus 로고    scopus 로고
    • p27Kip1 expression is associated with clinical outcome in advanced epithelial ovarian cancer: Multivariate analysis
    • Masciullo V, Ferrandina G, Pucci B, Fanfani F, Lovergine S, Palazzo J, et al. p27Kip1 expression is associated with clinical outcome in advanced epithelial ovarian cancer: multivariate analysis. Clin Cancer Res 2000;6:4816-22.
    • (2000) Clin Cancer Res , vol.6 , pp. 4816-4822
    • Masciullo, V.1    Ferrandina, G.2    Pucci, B.3    Fanfani, F.4    Lovergine, S.5    Palazzo, J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.