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Volumn 29, Issue 4, 2008, Pages 858-865

SAG/ROC2/RBX2 E3 ligase promotes UVB-induced skin hyperplasia, but not skin tumors, by simultaneously targeting c-Jun/AP-1 and p27

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN D1; DNA; PROTEIN C FOS; PROTEIN C JUN; PROTEIN P27; PROTEIN P53; TRANSCRIPTION FACTOR AP 1; UBIQUITIN PROTEIN LIGASE E3;

EID: 41849091135     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgn021     Document Type: Article
Times cited : (31)

References (32)
  • 1
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan,D. et al. (2000) The hallmarks of cancer. Cell, 100, 57-70.
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1
  • 2
    • 0020565091 scopus 로고
    • Photocarcinogenesis, skin cancer, and aging
    • Epstein,J.H. (1983) Photocarcinogenesis, skin cancer, and aging. J. Am. Acad. Dermatol., 9, 487-502.
    • (1983) J. Am. Acad. Dermatol , vol.9 , pp. 487-502
    • Epstein, J.H.1
  • 3
    • 0346593194 scopus 로고    scopus 로고
    • Skin cancer chemoprevention: Strategies to save our skin
    • discussion 264-266
    • Einspahr,J.G. et al. (2003) Skin cancer chemoprevention: strategies to save our skin. Recent Results Cancer Res., 163 151-164; discussion 264-266.
    • (2003) Recent Results Cancer Res , vol.163 , pp. 151-164
    • Einspahr, J.G.1
  • 4
    • 0032932201 scopus 로고    scopus 로고
    • SAG, a novel zinc RING finger protein that protects cells from apoptosis induced by redox agents
    • Duan,H. et al. (1999) SAG, a novel zinc RING finger protein that protects cells from apoptosis induced by redox agents. Mol. Cell. Biol., 19, 3145-3155.
    • (1999) Mol. Cell. Biol , vol.19 , pp. 3145-3155
    • Duan, H.1
  • 5
    • 0032727343 scopus 로고    scopus 로고
    • The Rbx1 subunit of SCF and VHL E3 ubiquitin ligase-activates Rub1 modification of cullins Cdc53 and Cul2
    • Kamura,T. et al. (1999) The Rbx1 subunit of SCF and VHL E3 ubiquitin ligase-activates Rub1 modification of cullins Cdc53 and Cul2. Genes Dev., 13, 2928-2933.
    • (1999) Genes Dev , vol.13 , pp. 2928-2933
    • Kamura, T.1
  • 6
    • 0033120027 scopus 로고    scopus 로고
    • ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity
    • Ohta,T. et al. (1999) ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity. Mol. Cell, 3, 535-541.
    • (1999) Mol. Cell , vol.3 , pp. 535-541
    • Ohta, T.1
  • 7
    • 0034213598 scopus 로고    scopus 로고
    • Yeast homolog of human SAG/ROC2/Rbx2/Hrt2 is essential for cell growth, but not for germination: Chip profiling implicates its role in cell cycle regulation
    • Swaroop,M. et al. (2000) Yeast homolog of human SAG/ROC2/Rbx2/Hrt2 is essential for cell growth, but not for germination: Chip profiling implicates its role in cell cycle regulation. Oncogene, 19, 2855-2866.
    • (2000) Oncogene , vol.19 , pp. 2855-2866
    • Swaroop, M.1
  • 8
    • 0033120593 scopus 로고    scopus 로고
    • Recruitment of a ROC1-CUL1 ubiquitin ligase by Skp1 and HOS to catalyze the ubiquitination of IkBa
    • Tan,P. et al. (1999) Recruitment of a ROC1-CUL1 ubiquitin ligase by Skp1 and HOS to catalyze the ubiquitination of IkBa. Mol. Cell, 3, 527-533.
    • (1999) Mol. Cell , vol.3 , pp. 527-533
    • Tan, P.1
  • 9
    • 33646345376 scopus 로고    scopus 로고
    • Ubiquitin ligases: Cell-cycle control and cancer
    • Nakayama,K.I. et al. (2006) Ubiquitin ligases: Cell-cycle control and cancer. Nat. Rev. Cancer, 6, 369-381.
    • (2006) Nat. Rev. Cancer , vol.6 , pp. 369-381
    • Nakayama, K.I.1
  • 10
    • 0032877005 scopus 로고    scopus 로고
    • Alteration of SAG mRNA in human cancer cell lines: Requirement for the RING finger domain for apoptosis protection
    • Sun,Y. (1999) Alteration of SAG mRNA in human cancer cell lines: requirement for the RING finger domain for apoptosis protection. Carcinogenesis, 20, 1899-1903.
    • (1999) Carcinogenesis , vol.20 , pp. 1899-1903
    • Sun, Y.1
  • 11
    • 0034987067 scopus 로고    scopus 로고
    • Attenuation of ischemia-induced mouse brain injury by SAG, a redox- inducible antioxidant protein
    • Yang,G.Y. et al. (2001) Attenuation of ischemia-induced mouse brain injury by SAG, a redox- inducible antioxidant protein. J. Cereb. Blood Flow Metab., 21, 722-733.
    • (2001) J. Cereb. Blood Flow Metab , vol.21 , pp. 722-733
    • Yang, G.Y.1
  • 12
    • 0037348330 scopus 로고    scopus 로고
    • SAG attenuates apoptotic cell death caused by simulated ischaemia/reoxygenation in rat cardiomyocytes
    • Chanalaris,A. et al. (2003) SAG attenuates apoptotic cell death caused by simulated ischaemia/reoxygenation in rat cardiomyocytes. J. Mol. Cell. Cardiol., 35, 257-264.
    • (2003) J. Mol. Cell. Cardiol , vol.35 , pp. 257-264
    • Chanalaris, A.1
  • 13
    • 0035145738 scopus 로고    scopus 로고
    • Elevated expression of SAG/ROC2/Rbx2/Hrt2 in human colon carcinomas: SAG does not induce neoplastic transformation, but its antisense transfection inhibits tumor cell growth
    • Huang,Y. et al. (2001) Elevated expression of SAG/ROC2/Rbx2/Hrt2 in human colon carcinomas: SAG does not induce neoplastic transformation, but its antisense transfection inhibits tumor cell growth. Mol. Carcinog., 30, 62-70.
    • (2001) Mol. Carcinog , vol.30 , pp. 62-70
    • Huang, Y.1
  • 14
    • 0035923305 scopus 로고    scopus 로고
    • Expression of the sensitive to apoptosis gene, SAG, as a prognostic marker in nonsmall cell lung cancer
    • Sasaki,H. et al. (2001) Expression of the sensitive to apoptosis gene, SAG, as a prognostic marker in nonsmall cell lung cancer. Int. J. Cancer, 95, 375-377.
    • (2001) Int. J. Cancer , vol.95 , pp. 375-377
    • Sasaki, H.1
  • 15
    • 0035143141 scopus 로고    scopus 로고
    • Promotion of S-phase entry and cell growth under serum starvation by SAG/ROC2/Rbx2/Hrt2, an E3 ubiquitin ligase component: Association with inhibition of p27 accumulation
    • Duan,H. et al. (2001) Promotion of S-phase entry and cell growth under serum starvation by SAG/ROC2/Rbx2/Hrt2, an E3 ubiquitin ligase component: Association with inhibition of p27 accumulation. Mol. Carcinog., 30, 37-46.
    • (2001) Mol. Carcinog , vol.30 , pp. 37-46
    • Duan, H.1
  • 16
    • 34248547553 scopus 로고    scopus 로고
    • SAG/ROC2/Rbx2 is a novel activator protein-1 target that promotes c-Jun degradation and inhibits 12-O-tetradecanoylphorbol-13-acetate-induced neoplastic transformation
    • Gu,Q. et al. (2007) SAG/ROC2/Rbx2 is a novel activator protein-1 target that promotes c-Jun degradation and inhibits 12-O-tetradecanoylphorbol-13-acetate-induced neoplastic transformation. Cancer Res., 67, 3616-3625.
    • (2007) Cancer Res , vol.67 , pp. 3616-3625
    • Gu, Q.1
  • 17
    • 0029162341 scopus 로고
    • Isolation and utilization of epidermal keratinocytes for oncogene research
    • Dlugosz,A.A. et al. (1995) Isolation and utilization of epidermal keratinocytes for oncogene research. Meth. Enzymol., 254, 3-20.
    • (1995) Meth. Enzymol , vol.254 , pp. 3-20
    • Dlugosz, A.A.1
  • 18
    • 0036038264 scopus 로고    scopus 로고
    • Ultraviolet irradiation alters transforming growth factor beta/smad pathway in human skin in vivo
    • Quan,T. et al. (2002) Ultraviolet irradiation alters transforming growth factor beta/smad pathway in human skin in vivo. J. Invest. Dermatol., 119, 499-506.
    • (2002) J. Invest. Dermatol , vol.119 , pp. 499-506
    • Quan, T.1
  • 19
    • 27744526342 scopus 로고    scopus 로고
    • A small molecule Smac-mimic compound induces apoptosis and sensitizes TRAIL- and etoposide-induced apoptosis in breast cancer cells
    • Bockbrader,K.M. et al. (2005) A small molecule Smac-mimic compound induces apoptosis and sensitizes TRAIL- and etoposide-induced apoptosis in breast cancer cells. Oncogene, 24, 7381-7388.
    • (2005) Oncogene , vol.24 , pp. 7381-7388
    • Bockbrader, K.M.1
  • 20
    • 0141430912 scopus 로고    scopus 로고
    • Expression of dominant negative c-jun inhibits ultraviolet B-induced squamous cell carcinoma number and size in an SKH-1 hairless mouse model
    • Cooper,S.J. et al. (2003) Expression of dominant negative c-jun inhibits ultraviolet B-induced squamous cell carcinoma number and size in an SKH-1 hairless mouse model. Mol. Cancer Res., 1, 848-854.
    • (2003) Mol. Cancer Res , vol.1 , pp. 848-854
    • Cooper, S.J.1
  • 21
    • 0035328633 scopus 로고    scopus 로고
    • Targeted expression of bcl-2 to murine basal epidermal keratinocytes results in paradoxical retardation of ultraviolet- and chemical-induced tumorigenesis
    • Rossiter,H. et al. (2001) Targeted expression of bcl-2 to murine basal epidermal keratinocytes results in paradoxical retardation of ultraviolet- and chemical-induced tumorigenesis. Cancer Res., 61, 3619-3626.
    • (2001) Cancer Res , vol.61 , pp. 3619-3626
    • Rossiter, H.1
  • 22
    • 0035899468 scopus 로고    scopus 로고
    • Different effects of p14ARF on the levels of ubiquitinated p53 and Mdm2 in vivo
    • Xirodimas,D. et al. (2001) Different effects of p14ARF on the levels of ubiquitinated p53 and Mdm2 in vivo. Oncogene, 20, 4972-4983.
    • (2001) Oncogene , vol.20 , pp. 4972-4983
    • Xirodimas, D.1
  • 23
    • 20144364293 scopus 로고    scopus 로고
    • Silibinin up-regulates DNA-protein kinase-dependent p53 activation to enhance UVB-induced apoptosis in mouse epithelial JB6 cells
    • Dhanalakshmi,S. et al. (2005) Silibinin up-regulates DNA-protein kinase-dependent p53 activation to enhance UVB-induced apoptosis in mouse epithelial JB6 cells. J. Biol. Chem., 280, 20375-20383.
    • (2005) J. Biol. Chem , vol.280 , pp. 20375-20383
    • Dhanalakshmi, S.1
  • 24
    • 34548846689 scopus 로고    scopus 로고
    • SAG/ROC2 E3 ligase regulates skin carcinogenesis by stage dependent targeting of c-Jun/AP1 and IkB/NF-kB
    • Gu,Q. et al. (2007) SAG/ROC2 E3 ligase regulates skin carcinogenesis by stage dependent targeting of c-Jun/AP1 and IkB/NF-kB. J. Cell Biol., 178, 1009-1023.
    • (2007) J. Cell Biol , vol.178 , pp. 1009-1023
    • Gu, Q.1
  • 25
    • 0031464286 scopus 로고    scopus 로고
    • p53CP, a putative p53 competing protein that specifically binds to the consensus p53 DNA binding sites: A third member of the p53 family?
    • Bian,J. et al. (1997) p53CP, a putative p53 competing protein that specifically binds to the consensus p53 DNA binding sites: A third member of the p53 family? Proc. Natl Acad. Sci. USA, 94, 14753-14758.
    • (1997) Proc. Natl Acad. Sci. USA , vol.94 , pp. 14753-14758
    • Bian, J.1
  • 26
    • 0029055808 scopus 로고
    • Activation of p53 sequence-specific DNA binding by short single strands of DNA requires the p53 C-terminus
    • Jayaraman,J. et al. (1995) Activation of p53 sequence-specific DNA binding by short single strands of DNA requires the p53 C-terminus. Cell, 81, 1021-1029.
    • (1995) Cell , vol.81 , pp. 1021-1029
    • Jayaraman, J.1
  • 27
  • 28
    • 33750460897 scopus 로고    scopus 로고
    • Phosphorylation-dependent ubiquitination of cyclin D1 by the SCF(FBX4-alphaB crystallin) complex
    • Lin,D.I. et al. (2006) Phosphorylation-dependent ubiquitination of cyclin D1 by the SCF(FBX4-alphaB crystallin) complex. Mol. Cell, 24, 355-366.
    • (2006) Mol. Cell , vol.24 , pp. 355-366
    • Lin, D.I.1
  • 29
    • 0030905284 scopus 로고    scopus 로고
    • Mdm2 promotes the rapid degradation of p53
    • Haupt,Y. et al. (1997) Mdm2 promotes the rapid degradation of p53. Nature, 387, 296-299.
    • (1997) Nature , vol.387 , pp. 296-299
    • Haupt, Y.1
  • 30
    • 33749057086 scopus 로고    scopus 로고
    • Spatiotemporal regulation of c-Fos by ERK5 and the E3 ubiquitin ligase UBR1, and its biological role
    • Sasaki,T. et al. (2006) Spatiotemporal regulation of c-Fos by ERK5 and the E3 ubiquitin ligase UBR1, and its biological role. Mol. Cell 24, 63-75.
    • (2006) Mol. Cell , vol.24 , pp. 63-75
    • Sasaki, T.1
  • 31
    • 0033956753 scopus 로고    scopus 로고
    • The SCF(HOS/beta-TRCP)-ROC1 E3 ubiquitin ligase utilizes two distinct domains within CUL1 for substrate targeting and ubiquitin ligation
    • Wu,K. et al. (2000) The SCF(HOS/beta-TRCP)-ROC1 E3 ubiquitin ligase utilizes two distinct domains within CUL1 for substrate targeting and ubiquitin ligation. Mol. Cell. Biol., 20, 1382-1393.
    • (2000) Mol. Cell. Biol , vol.20 , pp. 1382-1393
    • Wu, K.1
  • 32
    • 18344391432 scopus 로고    scopus 로고
    • Structure of the Cull-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex
    • Zheng,N. et al. (2002) Structure of the Cull-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex. Nature, 416, 703-709.
    • (2002) Nature , vol.416 , pp. 703-709
    • Zheng, N.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.