메뉴 건너뛰기




Volumn 2, Issue 1, 2012, Pages

Angiotensin II type 1 receptor antagonists alleviate muscle pathology in the mouse model for laminin-α2-deficient congenital muscular dystrophy (MDC1A)

Author keywords

Angiotensin II; Fibrosis; losartan; Muscle regeneration; Notexin; Skeletal muscle; Smad2 3; TGF

Indexed keywords


EID: 84874716506     PISSN: None     EISSN: 20445040     Source Type: Journal    
DOI: 10.1186/2044-5040-2-18     Document Type: Article
Times cited : (47)

References (53)
  • 1
    • 33846946114 scopus 로고    scopus 로고
    • Angiotensin II type 1 receptor blockade attenuates TGF-beta-induced failure of muscle regeneration in multiple myopathic states
    • 10.1038/nm1536, 3138130, 17237794
    • Cohn RD, van Erp C, Habashi JP, Soleimani AA, Klein EC, Lisi MT, Gamradt M, AP-Rhys CM, Holm TM, Loeys BL, et al. Angiotensin II type 1 receptor blockade attenuates TGF-beta-induced failure of muscle regeneration in multiple myopathic states. Nat Med 2007, 13:204-210. 10.1038/nm1536, 3138130, 17237794.
    • (2007) Nat Med , vol.13 , pp. 204-210
    • Cohn, R.D.1    van Erp, C.2    Habashi, J.P.3    Soleimani, A.A.4    Klein, E.C.5    Lisi, M.T.6    Gamradt, M.7    AP-Rhys, C.M.8    Holm, T.M.9    Loeys, B.L.10
  • 2
    • 0031438047 scopus 로고    scopus 로고
    • TGF-beta signalling from cell membrane to nucleus through SMAD proteins
    • 10.1038/37284, 9393997
    • Heldin CH, Miyazono K, ten Dijke P. TGF-beta signalling from cell membrane to nucleus through SMAD proteins. Nature 1997, 390:465-471. 10.1038/37284, 9393997.
    • (1997) Nature , vol.390 , pp. 465-471
    • Heldin, C.H.1    Miyazono, K.2    ten Dijke, P.3
  • 3
    • 1242293760 scopus 로고    scopus 로고
    • Transforming growth factor-beta1 induces the differentiation of myogenic cells into fibrotic cells in injured skeletal muscle: a key event in muscle fibrogenesis
    • 10.1016/S0002-9440(10)63188-4, 1614716, 14982854
    • Li Y, Foster W, Deasy BM, Chan Y, Prisk V, Tang Y, Cummins J, Huard J. Transforming growth factor-beta1 induces the differentiation of myogenic cells into fibrotic cells in injured skeletal muscle: a key event in muscle fibrogenesis. Am J Pathol 2004, 164:1007-1019. 10.1016/S0002-9440(10)63188-4, 1614716, 14982854.
    • (2004) Am J Pathol , vol.164 , pp. 1007-1019
    • Li, Y.1    Foster, W.2    Deasy, B.M.3    Chan, Y.4    Prisk, V.5    Tang, Y.6    Cummins, J.7    Huard, J.8
  • 4
    • 0023571274 scopus 로고
    • Inhibition of skeletal muscle satellite cell differentiation by transforming growth factor-beta
    • 10.1002/jcp.1041330319, 3480289
    • Allen RE, Boxhorn LK. Inhibition of skeletal muscle satellite cell differentiation by transforming growth factor-beta. J Cell Physiol 1987, 133:567-572. 10.1002/jcp.1041330319, 3480289.
    • (1987) J Cell Physiol , vol.133 , pp. 567-572
    • Allen, R.E.1    Boxhorn, L.K.2
  • 5
    • 35048875855 scopus 로고    scopus 로고
    • TGF-beta signaling: a tale of two responses
    • 10.1002/jcb.21501, 17729308
    • Rahimi RA, Leof EB. TGF-beta signaling: a tale of two responses. J Cell Biochem 2007, 102:593-608. 10.1002/jcb.21501, 17729308.
    • (2007) J Cell Biochem , vol.102 , pp. 593-608
    • Rahimi, R.A.1    Leof, E.B.2
  • 6
    • 84857460345 scopus 로고    scopus 로고
    • Role of TGF-beta signaling in inherited and acquired myopathies
    • 10.1186/2044-5040-1-19, 3156642, 21798096
    • Burks TN, Cohn RD. Role of TGF-beta signaling in inherited and acquired myopathies. Skelet Muscle 2011, 1:19. 10.1186/2044-5040-1-19, 3156642, 21798096.
    • (2011) Skelet Muscle , vol.1 , pp. 19
    • Burks, T.N.1    Cohn, R.D.2
  • 7
    • 58149213801 scopus 로고    scopus 로고
    • Non-Smad pathways in TGF-beta signaling
    • 10.1038/cr.2008.328, 2635127, 19114990
    • Zhang YE. Non-Smad pathways in TGF-beta signaling. Cell research 2009, 19:128-139. 10.1038/cr.2008.328, 2635127, 19114990.
    • (2009) Cell research , vol.19 , pp. 128-139
    • Zhang, Y.E.1
  • 8
    • 7444244384 scopus 로고    scopus 로고
    • Localization and early time course of TGF-beta 1 mRNA expression in dystrophic muscle
    • 10.1002/mus.20150, 15389721
    • Gosselin LE, Williams JE, Deering M, Brazeau D, Koury S, Martinez DA. Localization and early time course of TGF-beta 1 mRNA expression in dystrophic muscle. Muscle Nerve 2004, 30:645-653. 10.1002/mus.20150, 15389721.
    • (2004) Muscle Nerve , vol.30 , pp. 645-653
    • Gosselin, L.E.1    Williams, J.E.2    Deering, M.3    Brazeau, D.4    Koury, S.5    Martinez, D.A.6
  • 10
    • 0028359187 scopus 로고
    • Expression of transforming growth factor-beta 1 and its relation to endomysial fibrosis in progressive muscular dystrophy
    • 1887141, 8311110
    • Yamazaki M, Minota S, Sakurai H, Miyazono K, Yamada A, Kanazawa I, Kawai M. Expression of transforming growth factor-beta 1 and its relation to endomysial fibrosis in progressive muscular dystrophy. Am J Pathol 1994, 144:221-226. 1887141, 8311110.
    • (1994) Am J Pathol , vol.144 , pp. 221-226
    • Yamazaki, M.1    Minota, S.2    Sakurai, H.3    Miyazono, K.4    Yamada, A.5    Kanazawa, I.6    Kawai, M.7
  • 12
    • 33645672459 scopus 로고    scopus 로고
    • Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome
    • 10.1126/science.1124287, 1482474, 16601194
    • Habashi JP, Judge DP, Holm TM, Cohn RD, Loeys BL, Cooper TK, Myers L, Klein EC, Liu G, Calvi C, et al. Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome. Science 2006, 312:117-121. 10.1126/science.1124287, 1482474, 16601194.
    • (2006) Science , vol.312 , pp. 117-121
    • Habashi, J.P.1    Judge, D.P.2    Holm, T.M.3    Cohn, R.D.4    Loeys, B.L.5    Cooper, T.K.6    Myers, L.7    Klein, E.C.8    Liu, G.9    Calvi, C.10
  • 14
    • 79959442500 scopus 로고    scopus 로고
    • Chronic losartan administration reduces mortality and preserves cardiac but not skeletal muscle function in dystrophic mice
    • 10.1371/journal.pone.0020856, 3120761, 21731628
    • Bish LT, Yarchoan M, Sleeper MM, Gazzara JA, Morine KJ, Acosta P, Barton ER, Sweeney HL. Chronic losartan administration reduces mortality and preserves cardiac but not skeletal muscle function in dystrophic mice. PLoS One 2011, 6:e20856. 10.1371/journal.pone.0020856, 3120761, 21731628.
    • (2011) PLoS One , vol.6
    • Bish, L.T.1    Yarchoan, M.2    Sleeper, M.M.3    Gazzara, J.A.4    Morine, K.J.5    Acosta, P.6    Barton, E.R.7    Sweeney, H.L.8
  • 16
    • 3142738660 scopus 로고    scopus 로고
    • Glycosylation eases muscular dystrophy
    • 10.1038/nm0704-676, 15229511
    • Muntoni F, Brockington M, Brown SC. Glycosylation eases muscular dystrophy. Nat Med 2004, 10:676-677. 10.1038/nm0704-676, 15229511.
    • (2004) Nat Med , vol.10 , pp. 676-677
    • Muntoni, F.1    Brockington, M.2    Brown, S.C.3
  • 17
    • 0031456144 scopus 로고    scopus 로고
    • Distribution and function of laminins in the neuromuscular system of developing, adult, and mutant mice
    • 10.1083/jcb.139.6.1507, 2132624, 9396756
    • Patton BL, Miner JH, Chiu AY, Sanes JR. Distribution and function of laminins in the neuromuscular system of developing, adult, and mutant mice. J Cell Biol 1997, 139:1507-1521. 10.1083/jcb.139.6.1507, 2132624, 9396756.
    • (1997) J Cell Biol , vol.139 , pp. 1507-1521
    • Patton, B.L.1    Miner, J.H.2    Chiu, A.Y.3    Sanes, J.R.4
  • 18
    • 0033391990 scopus 로고    scopus 로고
    • Activation of the lama2 gene in muscle regeneration: abortive regeneration in laminin alpha2-deficiency
    • Kuang W, Xu H, Vilquin JT, Engvall E. Activation of the lama2 gene in muscle regeneration: abortive regeneration in laminin alpha2-deficiency. Lab Invest 1999, 79:1601-1613.
    • (1999) Lab Invest , vol.79 , pp. 1601-1613
    • Kuang, W.1    Xu, H.2    Vilquin, J.T.3    Engvall, E.4
  • 19
    • 33947721728 scopus 로고    scopus 로고
    • Linker molecules between laminins and dystroglycan ameliorate laminin-alpha2-deficient muscular dystrophy at all disease stages
    • 10.1083/jcb.200611152, 2064083, 17389231
    • Meinen S, Barzaghi P, Lin S, Lochmuller H, Ruegg MA. Linker molecules between laminins and dystroglycan ameliorate laminin-alpha2-deficient muscular dystrophy at all disease stages. J Cell Biol 2007, 176:979-993. 10.1083/jcb.200611152, 2064083, 17389231.
    • (2007) J Cell Biol , vol.176 , pp. 979-993
    • Meinen, S.1    Barzaghi, P.2    Lin, S.3    Lochmuller, H.4    Ruegg, M.A.5
  • 20
    • 0030610896 scopus 로고    scopus 로고
    • Laminin alpha2 chain-null mutant mice by targeted disruption of the Lama2 gene: a new model of merosin (laminin 2)-deficient congenital muscular dystrophy
    • 10.1016/S0014-5793(97)01007-7, 9326364
    • Miyagoe Y, Hanaoka K, Nonaka I, Hayasaka M, Nabeshima Y, Arahata K, Takeda S. Laminin alpha2 chain-null mutant mice by targeted disruption of the Lama2 gene: a new model of merosin (laminin 2)-deficient congenital muscular dystrophy. FEBS Lett 1997, 415:33-39. 10.1016/S0014-5793(97)01007-7, 9326364.
    • (1997) FEBS Lett , vol.415 , pp. 33-39
    • Miyagoe, Y.1    Hanaoka, K.2    Nonaka, I.3    Hayasaka, M.4    Nabeshima, Y.5    Arahata, K.6    Takeda, S.7
  • 21
    • 20444434366 scopus 로고    scopus 로고
    • Overexpression of mini-agrin in skeletal muscle increases muscle integrity and regenerative capacity in laminin-alpha2-deficient mice
    • 10.1096/fj.04-3376com, 15923403
    • Bentzinger CF, Barzaghi P, Lin S, Ruegg MA. Overexpression of mini-agrin in skeletal muscle increases muscle integrity and regenerative capacity in laminin-alpha2-deficient mice. FASEB J 2005, 19:934-942. 10.1096/fj.04-3376com, 15923403.
    • (2005) FASEB J , vol.19 , pp. 934-942
    • Bentzinger, C.F.1    Barzaghi, P.2    Lin, S.3    Ruegg, M.A.4
  • 23
    • 0031814662 scopus 로고    scopus 로고
    • Disruption of the lama2 gene in embryonic stem cells: laminin alpha 2 is necessary for sustenance of mature muscle cells
    • 10.1006/excr.1998.4025, 9633519
    • Kuang W, Xu H, Vachon PH, Engvall E. Disruption of the lama2 gene in embryonic stem cells: laminin alpha 2 is necessary for sustenance of mature muscle cells. Exp Cell Res 1998, 241:117-125. 10.1006/excr.1998.4025, 9633519.
    • (1998) Exp Cell Res , vol.241 , pp. 117-125
    • Kuang, W.1    Xu, H.2    Vachon, P.H.3    Engvall, E.4
  • 24
    • 0032528845 scopus 로고    scopus 로고
    • Merosin-deficient congenital muscular dystrophy. Partial genetic correction in two mouse models
    • 10.1172/JCI3705, 508948, 9710454
    • Kuang W, Xu H, Vachon PH, Liu L, Loechel F, Wewer UM, Engvall E. Merosin-deficient congenital muscular dystrophy. Partial genetic correction in two mouse models. J Clin Invest 1998, 102:844-852. 10.1172/JCI3705, 508948, 9710454.
    • (1998) J Clin Invest , vol.102 , pp. 844-852
    • Kuang, W.1    Xu, H.2    Vachon, P.H.3    Liu, L.4    Loechel, F.5    Wewer, U.M.6    Engvall, E.7
  • 25
    • 0035921981 scopus 로고    scopus 로고
    • An agrin minigene rescues dystrophic symptoms in a mouse model for congenital muscular dystrophy
    • 10.1038/35095054, 11565031
    • Moll J, Barzaghi P, Lin S, Bezakova G, Lochmuller H, Engvall E, Muller U, Ruegg MA. An agrin minigene rescues dystrophic symptoms in a mouse model for congenital muscular dystrophy. Nature 2001, 413:302-307. 10.1038/35095054, 11565031.
    • (2001) Nature , vol.413 , pp. 302-307
    • Moll, J.1    Barzaghi, P.2    Lin, S.3    Bezakova, G.4    Lochmuller, H.5    Engvall, E.6    Muller, U.7    Ruegg, M.A.8
  • 26
    • 4444354572 scopus 로고    scopus 로고
    • Laminin alpha1 chain reduces muscular dystrophy in laminin alpha2 chain deficient mice
    • 10.1093/hmg/ddh190, 15213105
    • Gawlik K, Miyagoe-Suzuki Y, Ekblom P, Takeda S, Durbeej M. Laminin alpha1 chain reduces muscular dystrophy in laminin alpha2 chain deficient mice. Hum Mol Genet 2004, 13:1775-1784. 10.1093/hmg/ddh190, 15213105.
    • (2004) Hum Mol Genet , vol.13 , pp. 1775-1784
    • Gawlik, K.1    Miyagoe-Suzuki, Y.2    Ekblom, P.3    Takeda, S.4    Durbeej, M.5
  • 27
    • 77954104087 scopus 로고    scopus 로고
    • Transgenic overexpression of laminin alpha1 chain in laminin alpha2 chain-deficient mice rescues the disease throughout the lifespan
    • 10.1002/mus.21616, 20544910
    • Gawlik KI, Durbeej M. Transgenic overexpression of laminin alpha1 chain in laminin alpha2 chain-deficient mice rescues the disease throughout the lifespan. Muscle Nerve 2010, 42:30-37. 10.1002/mus.21616, 20544910.
    • (2010) Muscle Nerve , vol.42 , pp. 30-37
    • Gawlik, K.I.1    Durbeej, M.2
  • 28
    • 24744467776 scopus 로고    scopus 로고
    • Amelioration of laminin-alpha2-deficient congenital muscular dystrophy by somatic gene transfer of miniagrin
    • 10.1073/pnas.0502137102, 1189311, 16103356
    • Qiao C, Li J, Zhu T, Draviam R, Watkins S, Ye X, Chen C, Xiao X. Amelioration of laminin-alpha2-deficient congenital muscular dystrophy by somatic gene transfer of miniagrin. Proc Natl Acad Sci U S A 2005, 102:11999-12004. 10.1073/pnas.0502137102, 1189311, 16103356.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 11999-12004
    • Qiao, C.1    Li, J.2    Zhu, T.3    Draviam, R.4    Watkins, S.5    Ye, X.6    Chen, C.7    Xiao, X.8
  • 29
    • 17744385764 scopus 로고    scopus 로고
    • Muscle-specific BCL2 expression ameliorates muscle disease in laminin {alpha}2-deficient, but not in dystrophin-deficient, mice
    • 10.1093/hmg/ddi095, 15757977
    • Dominov JA, Kravetz AJ, Ardelt M, Kostek CA, Beermann ML, Miller JB. Muscle-specific BCL2 expression ameliorates muscle disease in laminin {alpha}2-deficient, but not in dystrophin-deficient, mice. Hum Mol Genet 2005, 14:1029-1040. 10.1093/hmg/ddi095, 15757977.
    • (2005) Hum Mol Genet , vol.14 , pp. 1029-1040
    • Dominov, J.A.1    Kravetz, A.J.2    Ardelt, M.3    Kostek, C.A.4    Beermann, M.L.5    Miller, J.B.6
  • 30
    • 73349085584 scopus 로고    scopus 로고
    • Omigapil ameliorates the pathology of muscle dystrophy caused by laminin-alpha2 deficiency
    • 10.1124/jpet.109.160754, 19759319
    • Erb M, Meinen S, Barzaghi P, Sumanovski LT, Courdier-Fruh I, Ruegg MA, Meier T. Omigapil ameliorates the pathology of muscle dystrophy caused by laminin-alpha2 deficiency. J Pharmacol Exp Ther 2009, 331:787-795. 10.1124/jpet.109.160754, 19759319.
    • (2009) J Pharmacol Exp Ther , vol.331 , pp. 787-795
    • Erb, M.1    Meinen, S.2    Barzaghi, P.3    Sumanovski, L.T.4    Courdier-Fruh, I.5    Ruegg, M.A.6    Meier, T.7
  • 31
    • 60849118087 scopus 로고    scopus 로고
    • Pathology is alleviated by doxycycline in a laminin-alpha2-null model of congenital muscular dystrophy
    • 2639627, 19086074
    • Girgenrath M, Beermann ML, Vishnudas VK, Homma S, Miller JB. Pathology is alleviated by doxycycline in a laminin-alpha2-null model of congenital muscular dystrophy. Ann Neurol 2009, 65:47-56. 2639627, 19086074.
    • (2009) Ann Neurol , vol.65 , pp. 47-56
    • Girgenrath, M.1    Beermann, M.L.2    Vishnudas, V.K.3    Homma, S.4    Miller, J.B.5
  • 32
    • 85047693919 scopus 로고    scopus 로고
    • Inhibition of apoptosis improves outcome in a model of congenital muscular dystrophy
    • 529286, 15578095
    • Girgenrath M, Dominov JA, Kostek CA, Miller JB. Inhibition of apoptosis improves outcome in a model of congenital muscular dystrophy. J Clin Invest 2004, 114:1635-1639. 529286, 15578095.
    • (2004) J Clin Invest , vol.114 , pp. 1635-1639
    • Girgenrath, M.1    Dominov, J.A.2    Kostek, C.A.3    Miller, J.B.4
  • 33
    • 78651076693 scopus 로고    scopus 로고
    • Proteasome inhibition improves the muscle of laminin alpha2 chain-deficient mice
    • 10.1093/hmg/ddq499, 21084425
    • Carmignac V, Quere R, Durbeej M. Proteasome inhibition improves the muscle of laminin alpha2 chain-deficient mice. Hum Mol Genet 2011, 20:541-552. 10.1093/hmg/ddq499, 21084425.
    • (2011) Hum Mol Genet , vol.20 , pp. 541-552
    • Carmignac, V.1    Quere, R.2    Durbeej, M.3
  • 34
    • 81855205301 scopus 로고    scopus 로고
    • Autophagy is increased in laminin alpha2 chain-deficient muscle and its inhibition improves muscle morphology in a mouse model of MDC1A
    • 10.1093/hmg/ddr427, 21920942
    • Carmignac V, Svensson M, Korner Z, Elowsson L, Matsumura C, Gawlik KI, Allamand V, Durbeej M. Autophagy is increased in laminin alpha2 chain-deficient muscle and its inhibition improves muscle morphology in a mouse model of MDC1A. Hum Mol Genet 2011, 20:4891-4902. 10.1093/hmg/ddr427, 21920942.
    • (2011) Hum Mol Genet , vol.20 , pp. 4891-4902
    • Carmignac, V.1    Svensson, M.2    Korner, Z.3    Elowsson, L.4    Matsumura, C.5    Gawlik, K.I.6    Allamand, V.7    Durbeej, M.8
  • 36
    • 77955151335 scopus 로고    scopus 로고
    • Fibrosis inhibition and muscle histopathology improvement in laminin-alpha2-deficient mice
    • 10.1002/mus.21706, 20589893
    • Nevo Y, Halevy O, Genin O, Moshe I, Turgeman T, Harel M, Biton E, Reif S, Pines M. Fibrosis inhibition and muscle histopathology improvement in laminin-alpha2-deficient mice. Muscle Nerve 2010, 42:218-229. 10.1002/mus.21706, 20589893.
    • (2010) Muscle Nerve , vol.42 , pp. 218-229
    • Nevo, Y.1    Halevy, O.2    Genin, O.3    Moshe, I.4    Turgeman, T.5    Harel, M.6    Biton, E.7    Reif, S.8    Pines, M.9
  • 37
    • 84860186068 scopus 로고    scopus 로고
    • Losartan, a therapeutic candidate in congenital muscular dystrophy: Studies in the dy(2 J) /dy(2 J) Mouse
    • 10.1002/ana.22694, 22522482
    • Elbaz M, Yanay N, Aga-Mizrachi S, Brunschwig Z, Kassis I, Ettinger K, Barak V, Nevo Y. Losartan, a therapeutic candidate in congenital muscular dystrophy: Studies in the dy(2 J) /dy(2 J) Mouse. Ann Neurol 2012, 71:699-708. 10.1002/ana.22694, 22522482.
    • (2012) Ann Neurol , vol.71 , pp. 699-708
    • Elbaz, M.1    Yanay, N.2    Aga-Mizrachi, S.3    Brunschwig, Z.4    Kassis, I.5    Ettinger, K.6    Barak, V.7    Nevo, Y.8
  • 41
    • 0033961055 scopus 로고    scopus 로고
    • Merosin and congenital muscular dystrophy
    • 10.1002/(SICI)1097-0029(20000201/15)48:3/4<181::AID-JEMT6>3.0.CO;2-Q, 10679965
    • Miyagoe-Suzuki Y, Nakagawa M, Takeda S. Merosin and congenital muscular dystrophy. Microsc Res Tech 2000, 48:181-191. 10.1002/(SICI)1097-0029(20000201/15)48:3/4<181::AID-JEMT6>3.0.CO;2-Q, 10679965.
    • (2000) Microsc Res Tech , vol.48 , pp. 181-191
    • Miyagoe-Suzuki, Y.1    Nakagawa, M.2    Takeda, S.3
  • 42
    • 4444305799 scopus 로고    scopus 로고
    • Histological parameters for the quantitative assessment of muscular dystrophy in the mdx-mouse
    • 10.1016/j.nmd.2004.06.008, 15351425
    • Briguet A, Courdier-Fruh I, Foster M, Meier T, Magyar JP. Histological parameters for the quantitative assessment of muscular dystrophy in the mdx-mouse. Neuromuscul Disord 2004, 14:675-682. 10.1016/j.nmd.2004.06.008, 15351425.
    • (2004) Neuromuscul Disord , vol.14 , pp. 675-682
    • Briguet, A.1    Courdier-Fruh, I.2    Foster, M.3    Meier, T.4    Magyar, J.P.5
  • 43
    • 0022522240 scopus 로고
    • PITC derivatives in amino acid analysis
    • 10.1038/320769a0, 3703004
    • Cohen SA, Bidlingmeyer BA, Tarvin TL. PITC derivatives in amino acid analysis. Nature 1986, 320:769-770. 10.1038/320769a0, 3703004.
    • (1986) Nature , vol.320 , pp. 769-770
    • Cohen, S.A.1    Bidlingmeyer, B.A.2    Tarvin, T.L.3
  • 44
    • 0942301311 scopus 로고    scopus 로고
    • Angiotensin II induces thrombospondin-1 production in human mesangial cells via p38 MAPK and JNK: a mechanism for activation of latent TGF-beta1
    • 10.1152/ajprenal.00139.2003, 14583433
    • Naito T, Masaki T, Nikolic-Paterson DJ, Tanji C, Yorioka N, Kohno N. Angiotensin II induces thrombospondin-1 production in human mesangial cells via p38 MAPK and JNK: a mechanism for activation of latent TGF-beta1. Am J Physiol Renal Physiol 2004, 286:F278-287. 10.1152/ajprenal.00139.2003, 14583433.
    • (2004) Am J Physiol Renal Physiol , vol.286
    • Naito, T.1    Masaki, T.2    Nikolic-Paterson, D.J.3    Tanji, C.4    Yorioka, N.5    Kohno, N.6
  • 45
    • 28444464515 scopus 로고    scopus 로고
    • Thrombospondin 1 mediates angiotensin II induction of TGF-beta activation by cardiac and renal cells under both high and low glucose conditions
    • 10.1016/j.bbrc.2005.11.060, 16310163
    • Zhou Y, Poczatek MH, Berecek KH, Murphy-Ullrich JE. Thrombospondin 1 mediates angiotensin II induction of TGF-beta activation by cardiac and renal cells under both high and low glucose conditions. Biochem Biophys Res Commun 2006, 339:633-641. 10.1016/j.bbrc.2005.11.060, 16310163.
    • (2006) Biochem Biophys Res Commun , vol.339 , pp. 633-641
    • Zhou, Y.1    Poczatek, M.H.2    Berecek, K.H.3    Murphy-Ullrich, J.E.4
  • 46
    • 0034518844 scopus 로고    scopus 로고
    • Elevated plasma levels of transforming growth factor beta1 in patients with muscular dystrophy
    • 10.1097/00001756-200012180-00026, 11192624
    • Ishitobi M, Haginoya K, Zhao Y, Ohnuma A, Minato J, Yanagisawa T, Tanabu M, Kikuchi M, Iinuma K. Elevated plasma levels of transforming growth factor beta1 in patients with muscular dystrophy. Neuroreport 2000, 11:4033-4035. 10.1097/00001756-200012180-00026, 11192624.
    • (2000) Neuroreport , vol.11 , pp. 4033-4035
    • Ishitobi, M.1    Haginoya, K.2    Zhao, Y.3    Ohnuma, A.4    Minato, J.5    Yanagisawa, T.6    Tanabu, M.7    Kikuchi, M.8    Iinuma, K.9
  • 47
    • 79960955062 scopus 로고    scopus 로고
    • Apoptosis inhibitors and mini-agrin have additive benefits in congenital muscular dystrophy mice
    • 10.1002/emmm.201100151, 3377088, 21674808
    • Meinen S, Lin S, Thurnherr R, Erb M, Meier T, Ruegg MA. Apoptosis inhibitors and mini-agrin have additive benefits in congenital muscular dystrophy mice. EMBO Mol Med 2011, 3:465-479. 10.1002/emmm.201100151, 3377088, 21674808.
    • (2011) EMBO Mol Med , vol.3 , pp. 465-479
    • Meinen, S.1    Lin, S.2    Thurnherr, R.3    Erb, M.4    Meier, T.5    Ruegg, M.A.6
  • 48
    • 47949097215 scopus 로고    scopus 로고
    • Imbalance between pSmad3 and Notch induces CDK inhibitors in old muscle stem cells
    • 10.1038/nature07034, 18552838
    • Carlson ME, Hsu M, Conboy IM. Imbalance between pSmad3 and Notch induces CDK inhibitors in old muscle stem cells. Nature 2008, 454:528-532. 10.1038/nature07034, 18552838.
    • (2008) Nature , vol.454 , pp. 528-532
    • Carlson, M.E.1    Hsu, M.2    Conboy, I.M.3
  • 49
    • 79957521292 scopus 로고    scopus 로고
    • Muscle-specific expression of insulin-like growth factor 1 improves outcome in Lama2Dy-w mice, a model for congenital muscular dystrophy type 1A
    • 10.1093/hmg/ddr126, 3098729, 21441569
    • Kumar A, Yamauchi J, Girgenrath T, Girgenrath M. Muscle-specific expression of insulin-like growth factor 1 improves outcome in Lama2Dy-w mice, a model for congenital muscular dystrophy type 1A. Hum Mol Genet 2011, 20:2333-2343. 10.1093/hmg/ddr126, 3098729, 21441569.
    • (2011) Hum Mol Genet , vol.20 , pp. 2333-2343
    • Kumar, A.1    Yamauchi, J.2    Girgenrath, T.3    Girgenrath, M.4
  • 50
    • 84859075862 scopus 로고    scopus 로고
    • Laminin-111 protein therapy reduces muscle pathology and improves viability of a mouse model of merosin-deficient congenital muscular dystrophy
    • 10.1016/j.ajpath.2011.12.019, 22322301
    • Rooney JE, Knapp JR, Hodges BL, Wuebbles RD, Burkin DJ. Laminin-111 protein therapy reduces muscle pathology and improves viability of a mouse model of merosin-deficient congenital muscular dystrophy. Am J Pathol 2012, 180:1593-1602. 10.1016/j.ajpath.2011.12.019, 22322301.
    • (2012) Am J Pathol , vol.180 , pp. 1593-1602
    • Rooney, J.E.1    Knapp, J.R.2    Hodges, B.L.3    Wuebbles, R.D.4    Burkin, D.J.5
  • 51
    • 79951987952 scopus 로고    scopus 로고
    • Molecular mechanisms and treatment options for muscle wasting diseases
    • 10.1146/annurev-pharmtox-010510-100537, 20936944
    • Ruegg MA, Glass DJ. Molecular mechanisms and treatment options for muscle wasting diseases. Annu Rev Pharmacol Toxicol 2011, 51:373-395. 10.1146/annurev-pharmtox-010510-100537, 20936944.
    • (2011) Annu Rev Pharmacol Toxicol , vol.51 , pp. 373-395
    • Ruegg, M.A.1    Glass, D.J.2
  • 53
    • 33750719088 scopus 로고    scopus 로고
    • TCH346 as a neuroprotective drug in Parkinson"s disease: a double-blind, randomised, controlled trial
    • 10.1016/S1474-4422(06)70602-0, 17110281
    • Olanow CW, Schapira AH, LeWitt PA, Kieburtz K, Sauer D, Olivieri G, Pohlmann H, Hubble J. TCH346 as a neuroprotective drug in Parkinson"s disease: a double-blind, randomised, controlled trial. Lancet Neurol 2006, 5:1013-1020. 10.1016/S1474-4422(06)70602-0, 17110281.
    • (2006) Lancet Neurol , vol.5 , pp. 1013-1020
    • Olanow, C.W.1    Schapira, A.H.2    LeWitt, P.A.3    Kieburtz, K.4    Sauer, D.5    Olivieri, G.6    Pohlmann, H.7    Hubble, J.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.