An efficient approach to novel 17-5′-(1′,2′,4′)- oxadiazolyl androstenes via the cyclodehydration of cytotoxic O-steroidacylamidoximes, and an evaluation of their inhibitory action on 17α-hydroxylase/C17,20-lyase

European Journal of Medicinal Chemistry

Volumn 70, Issue , 2013, Pages 649-660

  Kovács, Dóra ^a   Wölfling, János ^a   Szabó, Nikoletta ^a   Szécsi, Mihály ^a   Kovács, Ida ^a   Zupkó, István ^a   Frank, Éva ^a  

^a UNIVERSITY OF SZEGED   (Hungary)

Author keywords

1,2,4 Oxadiazoles; Antiproliferative activity; O Acylamidoximes; Steroids

Indexed keywords

ANDROSTANE DERIVATIVE; ANTINEOPLASTIC AGENT; OXADIAZOLE DERIVATIVE; STEROID 17ALPHA MONOOXYGENASE;

ADHERENT CELL; ANIMAL TISSUE; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CONTROLLED STUDY; DEHYDRATION; DRUG EFFECT; DRUG INHIBITION; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; FEMALE; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; NONHUMAN; RAT; TESTIS;

1,2,4-OXADIAZOLES; ANTIPROLIFERATIVE ACTIVITY; O-ACYLAMIDOXIMES; P450(17Α) INHIBITOR; STEROIDS;

ANDROSTENES; ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLIZATION; DEHYDRATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; HELA CELLS; HUMANS; MALE; MCF-7 CELLS; MOLECULAR CONFORMATION; OXIMES; RATS; RATS, WISTAR; STEROID 17-ALPHA-HYDROXYLASE; STRUCTURE-ACTIVITY RELATIONSHIP; TESTIS;

EID: 84887045020     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.10.038     Document Type: Article

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