Anti-AIDS agents. Part 36: 17-carboxylated steroids as potential anti-HIV agents

Bioorganic and Medicinal Chemistry

Volumn 7, Issue 9, 1999, Pages 1907-1911

  Xia, Peng ^a   Yang, Zheng Yu ^b   Xia, Yi ^b   Zheng, Yun Qing ^a   Cosentino, L Mark ^c   Lee, Kuo Hsiung ^b  

^a School of Pharmacy Second Military Medical University Guohe Road 325   (China)

^b Sch P   (United States)

^c BBI Biotech Research Laboratories   (United States)

Author keywords

17 carboxylated steroid; Anti HIV

Indexed keywords

ANTIGEN P24; ANTIRETROVIRUS AGENT; N TERT BUTYL 3 OXOANDROST 4 ENE 17BETA CARBOXAMIDE; STEROID; UNCLASSIFIED DRUG; ZIDOVUDINE;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ANTIVIRAL ACTIVITY; ARTICLE; CARBOXYLATION; CONTROLLED STUDY; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LYMPHOID CELL LINE; T LYMPHOCYTE SUBPOPULATION;

ANTI-HIV AGENTS; CELL LINE; HIV-1; HUMANS; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; SPECTRUM ANALYSIS; STEROIDS;

EID: 0032862077     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(99)00169-8     Document Type: Article

References (13)

1. For part 35, see Lee, K. H.; Morris-Natschke, S. L. Pure Appl. Chem., in press.
2. Coffin J.M. Science. 267:1995;483.
3. Gulic R.M., Mellors J.W., Havlir D., Eron J.J., Gonzalez C., McMahon D., Richmann D.D., Valentine F.T., Jonas L., Meibohm A., Emini E.A., Chodakewitz J.A. N. Eng. J. Med. 337:1997;734.
4. Chun T.W., Carruth L., Finzi D., Shen X., DiGiuseppe J.A., Taylor H., Hermankova M., Chadwick K., Margolick J., Quinn T.C., Kuo Y.H., Brookmeyer R., Zeiger M.A., Bardith-Crovo P., Siliciano R.F. Nature. 387:1997;183.
5. Wong J.K., Hezareh M., Gunthard H.F., Havlir D.V., Ignacio C.C., Spina C.A., Richman D.D. Science. 278:1997;1291.
6. Finzi D., Hermankova M., Pierson T., Carruth L.M., Buck C., Chaisson R.E., Wuinn T.C., Chardwick K., Margolick J., Brookmyer R., Gallant J., Markowitz M., Ho D.D., Richman D.D., Siliciano R.F. Science. 278:1997;1295.
7. Li H.Y., Sun N.J., Kashiwada Y., Sun L., Snider J.V., Cosentino L.M., Lee K.H. J. Nat. Prod. 56:1993;1130.
8. McKee T.C., Cardellina J.H., Riccio R., D'Auria M.V., Iorizzi M., Minale L., Moran R.A., Gulakowski R.J., McMahon J.B., Buckheit R.W. Jr., Snader K.M., Boyd M.R. J. Med. Chem. 37:1994;793.
9. Cushman M., Insaf S., Ruell J.A., Schaeffer C.A., Rice W.G. Bioorg. Med. Chem. Lett. 8:1998;833.
10. Michne W.F., Schroeder J.D., Bailey T.R., Young D.C., Hughes J.V., Dutko F.J. J. Med. Chem. 36:1993;2701.
11. Rasmusson G.H., Reynolds G.F., Utne T., Jobson R.B., Primka R.L., Berman C., Brooks J.R. J. Med. Chem. 27:1984;1690.
12. Rasmusson G.H., Reynolds G.F., Steinberg N.G., Walton E., Patel G.F., Liang T., Cascieri M.A., Cheung A.H., Brooks J.R., Berman C. J. Med. Chem. 29:1986;2298.
13. Xia P., Yang Z.Y., Xia Y., Zhang H., Zhang K., Sun X., Chen Y., Zheng Y.Q. Heterocyclics. 47:1998;703.