Synthesis, characterization and biological evaluation of some novel 17-isoxazoles in the estrone series

Steroids

Volumn 77, Issue 11, 2012, Pages 1075-1085

  Kovács, Dóra ^a   Kádár, Zalán ^a   Mótyán, Gerg ^a   Schneider, Gyula ^a   Wölfling, János ^a   Zupkó, István ^a   Frank, Éva ^a  

^a UNIVERSITY OF SZEGED   (Hungary)

Author keywords

Cycloaddition; Cytotoxic activity; Isoxazoles; Nitrile oxides

Indexed keywords

17ALPHA ISOXAZOLE; 3 METHOXY 17ALPHA (3' PHENYLISOXAZOL 5' YL)ESTRA 1,3,5 (10)TRIEN 17BETA OL; 3 METHOXY 17ALPHA [3' (2'' METHYL)PHENYLISOXAZOL 5' YL]ESTRA 1,3,5 (10)TRIEN 17BETA OL; 3 METHOXY 17ALPHA [3' (3'' METHYL)PHENYLISOXAZOL 5' YL]ESTRA 1,3,5 (10)TRIEN 17BETA OL; 3 METHOXY 17ALPHA [3' (3'',4'' DIMETHOXY)PHENYLISOXAZOL 5' YL]ESTRA 1,3,5 (10)TRIEN 17BETA OL; 3 METHOXY 17ALPHA [3' (3'',5'' DICHLORO 2'',4'',6'' TRIMETHOXY)PHENYLISOXAZOL 5' YL]ESTRA 1,3,5 (10)TRIEN 17BETA OL; 3 METHOXY 17ALPHA [3' (4'' BROMO)PHENYLISOXAZOL 5' YL]ESTRA 1,3,5 (10)TRIEN 17BETA OL; 3 METHOXY 17ALPHA [3' (4'' CHLORO)PHENYLISOXAZOL 5' YL]ESTRA 1,3,5 (10)TRIEN 17BETA OL; 3 METHOXY 17ALPHA [3' (4'' FLUORO)PHENYLISOXAZOL 5' YL]ESTRA 1,3,5 (10)TRIEN 17BETA OL; 3 METHOXY 17ALPHA [3' (4'' METHOXY)PHENYLISOXAZOL 5' YL]ESTRA 1,3,5 (10)TRIEN 17BETA OL; 3 METHOXY 17ALPHA [3' (4'' METHYL)PHENYLISOXAZOL 5' YL]ESTRA 1,3,5 (10)TRIEN 17BETA OL; 3 METHOXY 17ALPHA [3' (4'' NITRO)PHENYLISOXAZOL 5' YL]ESTRA 1,3,5 (10)TRIEN 17BETA OL; COPPER; HETEROCYCLIC COMPOUND; ISOXAZOLE DERIVATIVE; MESTRANOL; UNCLASSIFIED DRUG;

ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CANCER GROWTH; CATALYST; CELL STRAIN MCF 7; CLICK CHEMISTRY; CONTROLLED STUDY; CYCLOADDITION; DRUG SCREENING; DRUG SYNTHESIS; HELA CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; RING CLOSING METATHESIS;

ANTINEOPLASTIC AGENTS; CATALYSIS; CELL LINE, TUMOR; CELL SURVIVAL; COPPER; CYCLOADDITION REACTION; DRUG SCREENING ASSAYS, ANTITUMOR; ESTRONE; HUMANS; ISOXAZOLES; MESTRANOL; NITRILES; OXIDES; STEREOISOMERISM;

EID: 84865445982     PISSN: 0039128X     EISSN: 18785867     Source Type: Journal    
DOI: 10.1016/j.steroids.2012.05.003     Document Type: Article

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