Synthesis of D-ring-substituted (5′R)- and (5′S)-17β- pyrazolinylandrostene epimers and comparison of their potential anticancer activities

Steroids

Volumn 77, Issue 5, 2012, Pages 566-574

  Iványi, Zoltán ^a   Szabó, Nikoletta ^a   Huber, Judit ^a   Wölfling, János ^a   Zupkó, István ^a   Szécsi, Mihály ^a   Wittmann, Tibor ^a   Schneider, Gyula ^a  

^a UNIVERSITY OF SZEGED   (Hungary)

Author keywords

Aldol condensation; Anticancer activities; Epimers; Hydrazine; Pregnenolone; Pyrazoline

Indexed keywords

17BETA PYRAZOLINYLANDROSTENE DERIVATIVE; 3BETA HYDROXYPYRAZOLINYLANDROSTENE DERIVATIVE; ACETIC ACID; ANTINEOPLASTIC AGENT; CHALCONE DERIVATIVE; CISPLATIN; HYDRAZINE; PREGNENOLONE; PYRAZOLINE DERIVATIVE; PYRAZOLINYLANDROST 5 ENE DERIVATIVE; STEROID; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CARBON NUCLEAR MAGNETIC RESONANCE; CELL PROLIFERATION; CELL STRAIN MCF 7; CONTROLLED STUDY; DRUG DESIGN; DRUG EFFICACY; DRUG STRUCTURE; DRUG SYNTHESIS; EPIMER; GROWTH INHIBITION; GYNECOLOGIC CANCER; HELA CELL; HUMAN; HUMAN CELL; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; SKIN CANCER; TESTIS;

ACETIC ACID; ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; HELA CELLS; HUMANS; HYDRAZINES; ISOMERISM; MALE; MODELS, CHEMICAL; MOLECULAR STRUCTURE; PYRAZOLES; RATS; RATS, WISTAR; STEROID 17-ALPHA-HYDROXYLASE; STEROIDS; TESTIS;

RATTUS;

EID: 84858337486     PISSN: 0039128X     EISSN: 18785867     Source Type: Journal    
DOI: 10.1016/j.steroids.2012.02.001     Document Type: Article

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