Galangin inhibits proliferation of HepG2 cells by activating AMPK via increasing the AMP/TAN ratio in a LKB1-independent manner

European Journal of Pharmacology

Volumn 718, Issue 1-3, 2013, Pages 235-244

  Zhang, Haitao ^a   Li, Ning ^a   Wu, Jun ^a   Su, Lijuan ^a   Chen, Xiaoyi ^a   Lin, Biyun ^a   Luo, Hui ^a  

^a GUANGDONG MEDICAL UNIVERSITY   (China)

Author keywords

AMPK; Autophagy; Galangin; LKB1; mTOR

Indexed keywords

ADENOSINE DIPHOSPHATE; ADENOSINE PHOSPHATE; ADENOSINE TRIPHOSPHATE; CISPLATIN; GALANGIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MAMMALIAN TARGET OF RAPAMYCIN; PROTEIN KINASE B; PROTEIN KINASE LKB1; SMALL INTERFERING RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; AUTOPHAGY; CELL PROLIFERATION; CELL STRAIN HEPG2; CELL VIABILITY; CONTROLLED STUDY; DOWN REGULATION; DRUG DOSE COMPARISON; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; FEMALE; HUMAN; HUMAN CELL; MOUSE; NEOPLASM; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TUMOR VOLUME;

AMPK; AUTOPHAGY; GALANGIN; LKB1; MTOR;

ADENOSINE MONOPHOSPHATE; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; AUTOPHAGY; CELL PROLIFERATION; ENZYME ACTIVATION; FEMALE; FLAVONOIDS; HEP G2 CELLS; HUMANS; MICE; MICE, INBRED C57BL; PROTEIN-SERINE-THREONINE KINASES; RNA, SMALL INTERFERING; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84887036360     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2013.08.026     Document Type: Article

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