Kinetic intermediates en route to the final serpin-protease complex: Studies of complexes of α1-protease inhibitor with Trypsin

Journal of Biological Chemistry

Volumn 288, Issue 44, 2013, Pages 32020-32035

  Maddur, Ashoka A ^a,c   Swanson, Richard ^a   Izaguirre, Gonzalo ^a   Gettins, Peter G W ^b   Olson, Steven T ^a  

^a Center for Molecular Biology of Oral Diseases   (United States)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^c VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CONFORMATIONAL CHANGE; DOCKING SITES; INTERMEDIATE STAGE; MICHAELIS COMPLEX; PROTEASE INHIBITOR; REACTIVE CENTER LOOPS; SITE-SPECIFIC; TRAPPING MECHANISMS;

ENZYME INHIBITION; FLUOROPHORES; KINETIC THEORY; KINETICS;

REACTION INTERMEDIATES;

ALPHA 1 ANTITRYPSIN; CALCIUM; PROTEINASE; SERINE PROTEINASE INHIBITOR; TRYPSIN;

ARTICLE; BINDING SITE; ENZYME ACTIVITY; ENZYME BINDING; ENZYME CONFORMATION; ENZYME INACTIVATION; ENZYME KINETICS; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; MICHAELIS CONSTANT; PRIORITY JOURNAL;

Α1-PROTEASE INHIBITOR; CALCIUM; F HELIX; FLUORESCENCE RESONANCE ENERGY TRANSFER (FRET); PROTEASE INHIBITOR; SERINE PROTEASE; SERPIN; TRYPSIN;

ALPHA 1-ANTITRYPSIN; ANIMALS; CATALYTIC DOMAIN; CATTLE; HUMANS; KINETICS; MULTIPROTEIN COMPLEXES; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, SECONDARY; TRYPSIN;

EID: 84887033560     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.510990     Document Type: Article

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